Frontiers | Mutation-related differences in exploratory, spatial, and depressive-like behavior in pcd and Lurcher cerebellar...
However, the overall performance of Lurcher mice was better than that of pcd mutants. Lurcher mice showed the ability of visual ... Nevertheless, they differ in pathogenesis of manifestation of the particular mutation and also in the strain background. The ... However, the overall performance of Lurcher mice was better than that of pcd mutants. Lurcher mice showed the ability of visual ... There is a wide spectrum of cerebellar mutant mice which are used as models of hereditary cerebellar degenerations. ...https://www.frontiersin.org/articles/10.3389/fnbeh.2015.00116/full
Identification of a Rat Model for Usher Syndrome Type 1B by N-Ethyl-N-nitrosourea Mutagenesis-Driven Forward Genetics | Genetics
Keays, D. A., and P. M. Nolan, 2003 N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric ... Mutant phenotype:. Rat models for human disease traditionally result from breeding of inbred strains that were specifically ... In this study, we describe the identification and characterization of the first autosomal recessive mutant rat strain from an ... Deafness in the mutants was observed by a negative Preyer's reflex. Moreover, the mutant rats show locomotory hyperactivity, ...http://www.genetics.org/content/170/4/1887
An Allelic Series of Mutations in the Kit ligand Gene of Mice. I. Identification of Point Mutations in Seven Ethylnitrosourea...
Northern blot of Kitl mRNA levels in tissues of KitlSl mutant mice. Poly(A)+ mRNA isolated from kidney and lung of newborn mice ... F1 male mice, followed by mating of mutagenized mice to T-strain females (Russell 1951). KitlSl-39R was generated in zygotes by ... In mice, Kitl is encoded by the Sl locus and there are at least 80 different KitlSl mutant alleles (Mouse Genome Database 2002 ... Here we describe eight mutant alleles at the Steel (Sl) locus of mice that were induced with N-ethyl-N-nitrosourea (ENU). The ...http://www.genetics.org/content/162/1/331
Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator | Development
Mouse. INTRODUCTION. Lurcher (Lc) is a neurological mutant mouse strain. Homozygous Lurcher (Lc/Lc) mice die within a few hours ... Mice. Lurcher mice (B6CBACaAW-J/A-Grid2Lc) were purchased from the Jackson Laboratory, and mated with tPA-/- (Plat-/- - Mouse ... We generated Lc heterozygous mice on a tPA-deficient background by first mating Lc/+ mice to tPA-/- mice, and then crossing the ... we set out to examine the impact of its ablation on the exaggerated-apoptosis-prone mutant mouse strain, Lurcher. As tPA ...http://dev.biologists.org/content/129/8/2043
'mice mutant strains' Protocols and Video...
Mice, Mutant Strains: Mice bearing mutant genes which are phenotypically expressed in the animals. ...https://www.jove.com/keyword/mice+mutant+strains
Evaluation of unmarked deletion mutants as improved Brucella vaccine strains in the mouse and goat models - OpenThesis
Evaluation of unmarked deletion mutants as improved Brucella vaccine strains in the mouse and goat models. by Kahl, Melissa ... Survival and efficacy of these novel deletion mutants were then evaluated in the mouse model. The asp24 mutants, which persist ... In an effort to develop improved vaccine strains, we have screened signature tagged mutagenesis banks to identify mutants with ... We demonstrated that the most persistent mutant, delta-asp24, affords the greatest protection in mice against virulent ...http://www.openthesis.org/documents/Evaluation-unmarked-deletion-mutants-as-220105.html
Fragile X Resources for Scientists, Pharma Partners
Mutant Mouse Strains Available. Fmr1 KO - This is the original Fmr1 knockout animal that carries an insertion in exon 5 (Bakker ... Mutant Mouse Models - FMR1 and Paralogs. A Fragile X Mutant Mouse facility was established in 2009 at Baylor College of ... Additional strains can be made available upon request. Please inquire.. Knockout Mice are also available from Jackson ... More than a dozen advanced mouse strains are available to researchers; the laboratory of David L. Nelson, PhD, is accepting ...https://www.fraxa.org/fragile-x-research/resources/
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular...
Mutant mouse strains. The strategy for homologous recombination in ES cells used to target Fgf8, and the other loci noted below ... Jerome, L. A. and Papaioannou, V. E. (2001). DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat. Genet. ... Schwenk, F., Baron, U. and Rajewsky, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene ... In marked contrast to both Fgf8 hypomorphs and Fgf8;AP2α-IRESCre mutants, all Fgf8;hoxa3-IRESCre mutants survive to birth and ...http://dev.biologists.org/content/130/25/6361?ijkey=f490b5bc7c4f5edbe0106cd2cb753b1c16debba4&keytype2=tf_ipsecsha
ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in...
... replication of the mutant was also restricted in the mouse cornea in vivo and in confluent primary mouse embryo cells and mouse ... ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in ... ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in ... ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in ...https://jvi.asm.org/content/68/1/48?ijkey=158da183e29cb4b52c51458ff589ce0773f0f2a0&keytype2=tf_ipsecsha
Inhibition of the Plasma SCUBE1, a Novel Platelet Adhesive Protein, Protects Mice Against ThrombosisSignificance |...
Generation of a New Genetic Mutant Mouse Strain With Deficiency in Producing Plasma SCUBE1. Based on the in vitro deletion data ... mice were generated by crossing male protamine (Prm)-Cre; Scube1Flox/+ mice to wild-type female mice. Mice homozygous for the ... mice and 14.5±2.2% for Δ/Δ mice (47% lower than +/+; P,0.01). Similarly, the thrombus volume obtained from Δ/Δ mice was 56% ... mice; Figure 5D). Thus, thrombus formation in Δ/Δ mice did not develop as rapidly or as extensively as in +/+ mice. Indeed, ...http://atvb.ahajournals.org/content/34/7/1390
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the...
Recombination efficiency is similar for the two mutant mouse strains. Representative blot for n = 3 mice of each genotype, ... TSLPR−/− mice were indistinguishable from wild type mice and therefore only the results of TSLPR−/− mice are shown. (A) ... mice (* p,0.01; ** p,0.001) showing relative increased expression of a wide panel of cytokines in mutant mice. TSLP shows the ... mice revealing a 400 fold increase of this cytokine in mutant mice. The experiment was performed in triplicates. (C-D) Control ...https://www.ncbi.nlm.nih.gov/pubmed/20174635?access_num=20174635&link_type=MED&dopt=Abstract
A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration.
Mice. Mice, Mutant Strains. Pyridinium Compounds / metabolism. Receptors, Chemokine / genetics. Retinal Pigment Epithelium / ... 0/A2E compound; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Cx3cr1 protein, mouse; 0/Fatty Acids, Omega-3; 0/Interleukin-6; 0/ ... Some mice that were given high levels of n-3 fatty acids had lesion reversion. We found a shunted arachidonic acid metabolism ... Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared ...http://www.biomedsearch.com/nih/high-omega-3-fatty-acid/19608872.html
The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis.
Mice. Mice, Mutant Strains. Mutation, Missense*. Neoplasm Proteins / genetics, metabolism*. Period Circadian Proteins / ... mice and their littermates were derived from PER2S662 mutants and ClockΔ19 mutants33 by crossing with p53R175H/+ mice. All ... we mated PER2S662 mutant mice with p53R172H knock-in mice. These knock-in mice have a mutation that corresponds to the p53R175H ... compound mutant mice. These mice all had the same genetic background of C57BL/6. We monitored these mice for tumor development ...http://www.biomedsearch.com/nih/circadian-mutation-PER2S662G-linked-to/21818120.html
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity | JEM
Differential CHS response to TNCB in TLR4−/− and IL-12Rβ2−/− mice. (A) Different CHS responses in mutant mouse strains. Mice of ... Inability of lymph node cells from sensitized mutant mice to passively transfer CHS sensitization. The indicated mouse strains ... DC fail to sensitize WT mice. WT mice were sensitized by i.c. injection of TNP-modified BM-DC from the indicated mouse strains ... C and D) Lack of CHS to oxazolone and FITC in TLR4/IL-12Rβ2 double-deficient mice. The indicated mouse strains were sensitized ...http://jem.rupress.org/content/205/9/2151
Category:B6CBACa Aw-J/A-Kcnj6wv/J mouse
Type: JAX GEMM Strain - Mutant Strain Ty … Type: JAX GEMM Strain - Mutant Strain Type: JAX GEMM Strain - Spontaneous Mutation ... Type: JAX GEMM Strain - Mutant Strain Ty … Type: JAX GEMM Strain - Mutant Strain Type: JAX GEMM Strain - Spontaneous Mutation ... Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in ... Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in ...http://neurolex.org/wiki/Special:Browse/Category:B6CBACa-20Aw-2DJ-2FA-2DKcnj6wv-2FJ-20mouse
JCI - Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat. Genet. 1998. 18:374-377. View this article via: ... C57BL/6J mice were infused with DHA/BSA or OA/BSA for 6 hours. The mice were then injected via the jugular vein with [35S]-Met/ ... Automated measurement of mouse apolipoprotein B: convenient screening tool for mouse models of atherosclerosis. Clin. Chem. ... This line of reasoning provides an attractive explanation for the pathophysiology of a spontaneously mutant mouse proposed to ...https://www.jci.org/articles/view/19197
Impairment of Mossy Fiber Long-Term Potentiation and Associative Learning in Pituitary Adenylate Cyclase Activating Polypeptide...
We used the Cre/loxP recombination system (Gu et al., 1994) to generate two different mutant mouse strains on the same genetic ... PAC1−/− mice [n = 14 mutants (black bars), 14 wild types (white bars); p , 0.005] as well as PAC1CaMKCre2 mice [n = 12 mutants ... For the interpretation of the results, it is noteworthy that in the conditioning chambers mutant mice of both strains showed ... For direct comparison of both mutant mouse strains, all experiments of this study were performed on the same genetic background ...http://www.jneurosci.org/content/21/15/5520
000259 - JE/LeJ
... show behavior typical of the circling mutants - head-tossing, circling, and hyperactivity. Homozygous mutant mice are deaf from ... JE/Le mice are also homozygous for the nonagouti (,i,a,/i,) and ruby-eye (,i,Hps6,sup,ru,/sup,,/i,) mutations. ... Heterozygous jerker mice undergo a similar type of degeneration, but the onset is delayed. Auditory brainstem response is ... totally absent in homozygotes while heterozygous mice undergo a progressive impairment with age.,br,,br,Flexed tail homozygotes ...https://www.jax.org/strain/000259
TSA induces Vγ3 rearrangements in adult-derived thymoc | Open-i
Mice. *Mice, Inbred C57BL. *Mice, Mutant Strains. *Reverse Transcriptase Polymerase Chain Reaction ... Here, we investigate the role for histone acetylation in the developmentally regulated rearrangements of the mouse TCR-gamma ... Here, we investigate the role for histone acetylation in the developmentally regulated rearrangements of the mouse TCR-gamma ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2193365_JEM002022.f2&req=4
High oxygen prevents fetal lethality due to lack of catecholamines.
When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble ... Mice. Mice, Inbred Strains. Mice, Mutant Strains. Norepinephrine / blood*, deficiency. Oxygen / pharmacology*. Oxygen ... When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble ... supporting the notion that mutants experience lower oxygen tension or have an enhanced response to hypoxia. Hypoxia induces a ...http://www.biomedsearch.com/nih/High-oxygen-prevents-fetal-lethality/18635452.html
Pabpc4 poly(A) binding protein, cytoplasmic 4 [Mus musculus (house mouse)] - Gene - NCBI
Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm ... A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID ... Pabpc4 poly(A) binding protein, cytoplasmic 4 [ Mus musculus (house mouse) ] Gene ID: 230721, updated on 12-Aug-2018 ...https://www.ncbi.nlm.nih.gov/gene/?term=230721
This mutant mouse strain may be useful in studies of Alzheimer's disease. ... These transgenic mice exhibit increasing expression of human amyloid beta precursor protein in the cortex, hippocampus, brain ... "MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or ... This mutant mouse strain may be useful in studies of Alzheimer's disease and cerebral amyloid angiopathy. ...https://www.jax.org/strain/007027
005439 - B6.129S-Mecp2|tm1Hzo|/J
This mutant mouse strain may be useful in studies of Rett Syndrome. ... male mutant mice of this strain begin to exhibit tremors, progressive motor dysfunction, oily disheveled fur, hypoactivity, ... "MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or ... Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available ...https://www.jax.org/strain/005439
Malfunction of Gene Causes Schizophrenia, Depression ( An international team of researchers ha...)
... theory was that different mutant variations of DI...To test this theory they screened a large population of mouse mut..., ... The researchers said their findings in mice offer a possible anima...In their experiments the researchers sought to explore the ... Additionally, these symptoms could be alleviated in the mice by anti-psychotic drugs. Similarly, the other mutant mouse strain ... They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the ...http://www.bio-medicine.org/medicine-news/Malfunction-of-Gene-Causes-Schizophrenia--Depression-20451-1/
George Michael str vil dva m s ce v luxusn psychiatrick klinice - iDNES.cz
Pracha ov : S m mou se uvid me a po V noc ch, na sv tky bude v Izraeli ... lov k, nebo koza? Filip nsk mutant. * Blog. Jste d chodce? Jen v tramvaji p kn st jte! ... George Michael str vil dva m s ce v luxusn psychiatrick klinice. * sd let na FB ... Ode el proto na soukromou kliniku v Austr lii, kde podle den ku The Sun str vil dva m s ce. ...https://revue.idnes.cz/george-michael-musel-po-nemoci-na-psychiatrii-fan-/lidicky.aspx?c=A130408_104133_lidicky_nh