Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and...Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and...

These results show that in TN-C knockout mice OP cells appear sooner in the optic nerve than in wild-type animals and are then ... We now report such an analysis for TN-C knockout mice. To examine precursor cell behaviour we focused on the OP cells that give ... At all stages in both wild-type and knockout mice, no PDGFαR mRNA-positive cells entered the part of the optic nerve ... Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and ...
more infohttp://dev.biologists.org/content/128/13/2485

CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor...CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor...

C57BL/6 mice. Our results indicate that CD5 knock out mice elicit a delayed tumor growth as compared to wt mice, which is ... CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor- ... CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor- ... CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor- ...
more infohttp://www.jimmunol.org/content/184/1_Supplement/101.21

Neuropeptide S precursor knockout mice display memory and arousal deficits.  | Eur J Neurosci;46(1): 1689-1700, 2017 Jul.    |...Neuropeptide S precursor knockout mice display memory and arousal deficits. | Eur J Neurosci;46(1): 1689-1700, 2017 Jul. |...

Overall, phenotypical changes in NPS-/- mice are similar to those observed in NPS receptor knockout mice and support earlier ... we generated NPS precursor knockout mice by homologous recombination in embryonic stem cells. NPS-/- mice were viable, fertile ... Neuropeptide S precursor knockout mice display memory and arousal deficits.. Liu, Xiaobin; Si, Wei; Garau, Celia; Jüngling, Kay ... NPS precursor knockout mice displayed attenuated arousal in the hole board test, visible as reduced total nose pokes and number ...
more infohttps://pesquisa.bvs.br/brasil/resource/pt/mdl-28548278

Research ResourceResearch Resource

Studies in M1R knockout mice show that M1 receptors may be involved in cortical memory functions that require interactions ... M1R knockout mice are viable and fertile, and have no major morphological abnormalities. ... is virtually abolished in primary cortical cultures or CA1 hippocampal pyramidal neurons in M1R knockout mice. ... Acronym: Mutant Mouse: Chrm1 (Cholinergic Receptor, muscarinic 1) NIDDK Contact: [email protected] Principal Investigator(s): ...
more infohttps://www.niddk.nih.gov/pages/RRSplash.aspx?ID=286

Knockout mouse - WikipediaKnockout mouse - Wikipedia

A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or " ... Creating Knockout Mice for Targeting Vector from Knockout Mice Research(KMR) - A website for ordering embryonic stem cells, ... The Knock Out Mouse Project (KOMP) Repository website - The website for ordering ES cells, vectors, and mice generated by the ... There are several thousand different strains of knockout mice.[3] Many mouse models are named after the gene that has been ...
more infohttps://en.wikipedia.org/wiki/Knockout_mouse

Completion of a Comprehensive Mouse Knockout Resource: HG-05-007 | NHGRICompletion of a Comprehensive Mouse Knockout Resource: HG-05-007 | NHGRI

Completion of a Comprehensive Mouse Knockout Resource: HG-05-007 Frequently Asked Questions (FAQs) *If an applicant is ... I want to propose to make knockouts for a particular gene family. Can I propose to do so under this RFA? No. The RFA calls for ... The actual balance of the program and costs per knockout will be determined as a result of peer review, Council discussion and ... For purposes of consistency, 22,000 genes should be considered the total number of genes in the mouse genome. ...
more infohttps://www.genome.gov/17015661/faq-for-completion-of-a-comprehensive-mouse-knockout

Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.  - PubMed - NCBIAlcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models. - PubMed - NCBI

Mice generated from double-targeted ES cells were mated to a germ-line Cre to create homozygous Adh-del knockout mice lacking ... Deletion of entire mouse ADH gene family. The Adh-del strain was made possible by the fact that all six ADH genes in the mouse ... Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.. Kumar S1, Sandell LL, Trainor PA, ... Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models. Biochim Biophys Acta. ;1821(1):198- ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/21515404

MGI - Knockout Mice SummaryMGI - Knockout Mice Summary

Deltagen and Lexicon Knockout Mice The NIH has recently announced an agreement that will allow the distribution of mutant mice ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ... private collections of knockout mice. These stocks have been created and characterized by Deltagen Incorporated and Lexicon ...
more infohttp://www.informatics.jax.org/knockout_mice/

Cdk2 knockout mice are viable.  - PubMed - NCBICdk2 knockout mice are viable. - PubMed - NCBI

... we generated Cdk2 knockout mice. Surprisingly, these mice are viable, and therefore Cdk2 is not an essential gene in the mouse ... Cdk2 knockout mice are viable.. Berthet C1, Aleem E, Coppola V, Tessarollo L, Kaldis P. ... Although Cdk2 is not an essential gene in the mouse, it is required for germ cell development and meiosis. Loss of Cdk2 affects ... However, Cdk2 is required for germ cell development; both male and female Cdk2(-/-) mice are sterile. Immunoprecipitates of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/14561402?dopt=Abstract

Knockout mouse | medical research | Britannica.comKnockout mouse | medical research | Britannica.com

Knockout mouse, genetically engineered laboratory mouse (Mus musculus) in which a specific gene has been inactivated, or ... Knockout mouse models also give a better understanding of the role of similar genes involved in human diseases. Knockout mouse ... Generation of knockout mice. Technologies used to generate knockout mice include homologous recombination (or gene targeting) ... In order to generate a pair of true knockout mice (homologous knockouts), the mice must be bred over several generations. ...
more infohttps://www.britannica.com/topic/knockout-mouse

Knockout mouse - WikipediaKnockout mouse - Wikipedia

A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or " ... Creating Knockout Mice for Targeting Vector from Knockout Mice Research(KMR) - A website for ordering embryonic stem cells, ... The Knock Out Mouse Project (KOMP) Repository website - The website for ordering ES cells, vectors, and mice generated by the ... There are several thousand different strains of knockout mice.[3] Many mouse models are named after the gene that has been ...
more infohttps://en.m.wikipedia.org/wiki/Knockout_mouse

Knockout Mouse PhenotypingKnockout Mouse Phenotyping

... to undertake standardized phenotyping of 20,000 knockout mouse strains. The International Mouse Phenotyping Consortium (IMPC) ... The Common Funds Knockout Mouse Phenotyping Program (KOMP2) provides broad, standardized phenotyping of a genome-wide ... Mouse Data Could Help Wildlife Conservation. Learn how mouse genetic data may help in wildlife conservation efforts ... opportunities presented by the large number of mouse mutants generated by global efforts of the International Mouse Knockout ...
more infohttps://commonfund.nih.gov/KOMP2/

Knockout Mouse PhenotypingKnockout Mouse Phenotyping

The Knockout Mouse Phenotyping Program (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to ... Mouse Data Could Help Wildlife Conservation. Learn how mouse genetic data may help in wildlife conservation efforts ... knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable ... clues about what that gene normally does but creating mice with gene knockouts is a time-consuming and difficult process, and ...
more infohttps://commonfund.nih.gov/KOMP2

Knockout Mice Help Researchers Find Ways To Knockout Incontinence - RedorbitKnockout Mice Help Researchers Find Ways To Knockout Incontinence - Redorbit

When the researchers tested the bladders of the integrin knockout mice, they found the bladders were constantly squeezing and ... They also found that the mice overfilled their bladders and took much longer to urinate than the normal mice. ... while the second group of mice was normal. Both groups of mice had normal appearing bladders, but the group without the ... The research team tested two groups of mice. One group were genetically modified to be missing an important member of the ...
more infohttp://www.redorbit.com/news/health/1112780817/bladder-incontinence-study-of-the-epithelium-and-integrins-020913/

Characteristics of Skeletal Muscle Fibers of SOD1 Knockout MiceCharacteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice

... Hiroshi Nagahisa,1 Kazuma Okabe,1 Yoshihito Iuchi,2 Junichi ... "Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice," Oxidative Medicine and Cellular Longevity, vol. 2016, Article ...
more infohttps://www.hindawi.com/journals/omcl/2016/9345970/cta/

Human Genetic Disorders and Knockout Mice Deficient in GlycosaminoglycanHuman Genetic Disorders and Knockout Mice Deficient in Glycosaminoglycan

... Shuji Mizumoto,1 Shuhei Yamada,1 and Kazuyuki ... phosphosulfate formation in brachymorphic mice," Proceedings of the National Academy of Sciences of the United States of ... D. H. Lum, J. Tan, S. D. Rosen, and Z. Werb, "Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2 ... C. L. R. Merry, S. L. Bullock, D. C. Swan et al., "The Molecular Phenotype of Heparan Sulfate in the Hs2st-/- Mutant Mouse," ...
more infohttps://www.hindawi.com/journals/bmri/2014/495764/ref/

Medical Xpress - knockout miceMedical Xpress - knockout mice

Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice ... Institutet in Sweden have found a protein that is a critical regulator in the development of fatty liver disease in mice, ...
more infohttps://medicalxpress.com/tags/knockout+mice/

Medical Xpress - knockout miceMedical Xpress - knockout mice

Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
more infohttps://medicalxpress.com/tags/knockout+mice/sort/popular/1d/

Frontiers | Urea Transporter Physiology Studied in Knockout Mice | PhysiologyFrontiers | Urea Transporter Physiology Studied in Knockout Mice | Physiology

Over the past few years, multiple UT knockout mouse models have been generated enabling us to explore the physiological roles ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... Since UT-B has a wide distribution, multiple phenotypic abnormalities were found in UT-B null mice, such as defective urine ...
more infohttps://www.frontiersin.org/articles/10.3389/fphys.2012.00217/full

Enhanced Blood Pressure Variability in eNOS Knockout Mice | HypertensionEnhanced Blood Pressure Variability in eNOS Knockout Mice | Hypertension

... blood pressure variance was significantly larger in eNOS knockout mice than in controls, and only 2 out of 10 knockout mice had ... During resting conditions, blood pressure variability was markedly enhanced in knockout mice compared with wild-type mice (10.5 ... Statistical comparisons between eNOS knockout mice and wild-type mice were performed by unpaired t tests. ... amount of sequences in the eNOS knockout mice would suggest that the larger blood pressure variability in eNOS knockout mice is ...
more infohttp://hyper.ahajournals.org/content/33/6/1359

JCI -
Pdx1 restores β cell function in Irs2 knockout miceJCI - Pdx1 restores β cell function in Irs2 knockout mice

... mice. Before the onset of diabetes, Pdx1 was reduced in islets from Irs2-/- mice, whereas it was expressed normally in islets ... mice. By contrast, transgenic expression of Pdx1 restored β cell mass and function in Irs2-/- mice and promoted glucose ... To investigate whether β cell failure in Irs2-/- mice might be related to dysfunction of MODY-related transcription factors, we ... Whereas male Irs2-/-Pdx1+/+ mice developed diabetes between 8 and 10 weeks of age, haploinsufficiency for Pdx1 caused diabetes ...
more infohttps://jci.org/articles/view/14439/pdf

JCI -
Pdx1 restores β cell function in Irs2 knockout miceJCI - Pdx1 restores β cell function in Irs2 knockout mice

Mice. Irs1 knockout (2), Irs2 knockout (2), Pdx1 knockout (8), and wild-type Pdx1 transgene (16) mice were maintained on a ... mice with Pdx1tg mice to increase the Pdx1 gene dosage in the Irs2-/- mice. As previously described, Pdx1tg mice have multiple ... To test the role of Pdx1 in Irs2-/- mice, we intercrossed Irs2+/- mice with Pdx1+/- mice and backcrossed the compound ... mice were slightly smaller by comparison with littermates (Figure 2a). Irs2-/-Pdx1+/- mice and mice lacking Pdx1 (Pdx1-/-, Irs2 ...
more infohttps://www.jci.org/articles/view/14439

Knockout Mice Essay - 2549 Words - AvroArrowKnockout Mice Essay - 2549 Words - AvroArrow

Knockout Mice Technology , Submitted By : Wasman ID : 11136007Course ID : BTE 402 , Knockout Mice Technology ... ... One of these is the knockout mouse. What are knockout mice? A knockout mouse is a genetically engineered mouse in which ... Knockout Mice Essay. 2549 words - 11 pages Knockout Mice Technology , Submitted By : Wasman ID : 11136007Course ID : BTE 402 , ... However, cocaine still produces reward in dopamine transporter knockout mice (DAT-KO mice) [9-11]. Importantly, DAT-KO mice ...
more infohttps://www.avroarrow.org/essay/knockout-mice

Knockout MiceKnockout Mice

Design your own conditional and constitutive knockout mice or use existing strains. ... Accelerate your research with custom-engineered knockout mouse models. ... Knockout Mice. start an order , print this page , share this page Knockout Mice. Use custom-engineered knockout mouse models to ... Design your own conditional and constitutive knockout mice or search Taconics knockout repository. Constitutive Knockout Mice ...
more infohttps://www.taconic.com/genetically-engineered-animal-models/knockout-mice/

Biology-Online • View topic - Knockout miceBiology-Online • View topic - Knockout mice

If one parent is a wild-type mouse and the other is a homozygous knockout mouse, their offspring will be heterozygous at the ... Knockout mice. by cassieconte » Tue Feb 05, 2013 4:54 pm Can someone please explain how it is possible to have a heterozygous ... knock out mouse? If a gene is knocked-out, how can the mouse be heterozygous for the gene? Will the mouse still produce ... If there is some of the protein made, the mouse is a knock-down and not a knock-out. Watch out for the other meaning of ...
more infohttp://www.biology-online.org/biology-forum/post-149536.html