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*  CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor...
C57BL/6 mice. Our results indicate that CD5 knock out mice elicit a delayed tumor growth as compared to wt mice, which is ... CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor- ... CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor- ... CD5 knock out mice display a strong antitumor immune response associated with tumor infiltration by hyperactivated tumor- ...
http://www.jimmunol.org/content/184/1_Supplement/101.21
*  abnormal mast cell morphology Mammalian Phenotype Term (MP:0000359)
Deltagen and Lexicon Knockout Mice. * International Mouse Phenotyping Consortium (IMPC). * Deciphering the Mechanisms of ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
http://www.informatics.jax.org/vocab/mp_ontology/MP:0000359
*  Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and...
These results show that in TN-C knockout mice OP cells appear sooner in the optic nerve than in wild-type animals and are then ... We now report such an analysis for TN-C knockout mice. To examine precursor cell behaviour we focused on the OP cells that give ... At all stages in both wild-type and knockout mice, no PDGFαR mRNA-positive cells entered the part of the optic nerve ... Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and ...
http://dev.biologists.org/content/128/13/2485
*  Abstract LB-52: Increased incidence of cancer in the transgenic mice with 8-Lipoxygenase knocked out. | Cancer Research
It's observed that homozygous female ALOX8 knockout mice are infertile but male ALOX8 knockout mice are fertile. Increased ... at mRNA level was abolished in homozygous knockout mice and reduced to half of wild type in heterozygous knockout mice. ... prostate and in the mesentery region of homozygous and heterozygous ALOX8 knockout mice, when compared with little mate wild ... The transgenic mice could be a good model to study the role of 8-lipoxygenase in carcinogenesis and may provide insights into ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/LB-52
*  Frontiers | Neurobehavioral phenotyping of Gαq knockout mice reveals impairments in motor functions and spatial working memory...
Lastly, use of the Y-maze revealed spatial memory deficits in Gaq knockout mice, indicating that receptors signaling through ... We observed significant increases in drug-induced locomotor activity in Gaq knockout mice from the dopaminergic agonists but ... We observed significant increases in drug-induced locomotor activity in Gaq knockout mice from the dopaminergic agonists but ... we replicated and extended findings showing clear motor deficits in Gaq knockout mice as assessed on an accelerating rotarod ...
https://www.frontiersin.org/articles/10.3389/fnbeh.2012.00029/full
*  Research Resource
Studies in M1R knockout mice show that M1 receptors may be involved in cortical memory functions that require interactions ... M1R knockout mice are viable and fertile, and have no major morphological abnormalities. ... is virtually abolished in primary cortical cultures or CA1 hippocampal pyramidal neurons in M1R knockout mice. ... Acronym: Mutant Mouse: Chrm1 (Cholinergic Receptor, muscarinic 1) NIDDK Contact: tao@niddk.nih.gov Principal Investigator(s): ...
https://www.niddk.nih.gov/pages/RRSplash.aspx?ID=286
*  postnatal lethality, complete penetrance Mammalian Phenotype Term (MP:0011085)
Deltagen and Lexicon Knockout Mice. * International Mouse Phenotyping Consortium (IMPC). * Deciphering the Mechanisms of ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
http://www.informatics.jax.org/vocab/mp_ontology/MP:0011085
*  decreased B cell apoptosis Mammalian Phenotype Term (MP:0008783)
Deltagen and Lexicon Knockout Mice. * International Mouse Phenotyping Consortium (IMPC). * Deciphering the Mechanisms of ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
http://www.informatics.jax.org/vocab/mp_ontology/MP:0008783
*  Knockout mouse - Wikipedia
A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or " ... Creating Knockout Mice for Targeting Vector from Knockout Mice Research(KMR) - A website for ordering embryonic stem cells, ... The Knock Out Mouse Project (KOMP) Repository website - The website for ordering ES cells, vectors, and mice generated by the ... There are several thousand different strains of knockout mice.[3] Many mouse models are named after the gene that has been ...
https://en.wikipedia.org/wiki/Knockout_mouse
*  MGI - Knockout Mice Summary
Deltagen and Lexicon Knockout Mice The NIH has recently announced an agreement that will allow the distribution of mutant mice ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ... private collections of knockout mice. These stocks have been created and characterized by Deltagen Incorporated and Lexicon ...
http://www.informatics.jax.org/knockout_mice/
*  Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models. - PubMed - NCBI
Mice generated from double-targeted ES cells were mated to a germ-line Cre to create homozygous Adh-del knockout mice lacking ... Deletion of entire mouse ADH gene family. The Adh-del strain was made possible by the fact that all six ADH genes in the mouse ... Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.. Kumar S1, Sandell LL, Trainor PA, ... Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models. Biochim Biophys Acta. ;1821(1):198- ...
https://www.ncbi.nlm.nih.gov/pubmed/21515404
*  Knockout mouse | medical research | Britannica.com
Knockout mouse, genetically engineered laboratory mouse (Mus musculus) in which a specific gene has been inactivated, or ... Knockout mouse models also give a better understanding of the role of similar genes involved in human diseases. Knockout mouse ... Generation of knockout mice. Technologies used to generate knockout mice include homologous recombination (or gene targeting) ... In order to generate a pair of true knockout mice (homologous knockouts), the mice must be bred over several generations. ...
https://www.britannica.com/topic/knockout-mouse
*  Knockout Mouse Phenotyping
... to undertake standardized phenotyping of 20,000 knockout mouse strains. The International Mouse Phenotyping Consortium (IMPC) ... The Common Fund's Knockout Mouse Phenotyping Program (KOMP2) provides broad, standardized phenotyping of a genome-wide ... Mouse Data Could Help Wildlife Conservation. Learn how mouse genetic data may help in wildlife conservation efforts ... opportunities presented by the large number of mouse mutants generated by global efforts of the International Mouse Knockout ...
https://commonfund.nih.gov/KOMP2/
*  Knockout Mice Help Researchers Find Ways To Knockout Incontinence - Redorbit
When the researchers tested the bladders of the integrin knockout mice, they found the bladders were constantly squeezing and ... They also found that the mice overfilled their bladders and took much longer to urinate than the normal mice. ... while the second group of mice was normal. Both groups of mice had normal appearing bladders, but the group without the ... The research team tested two groups of mice. One group were genetically modified to be missing an important member of the ...
http://www.redorbit.com/news/health/1112780817/bladder-incontinence-study-of-the-epithelium-and-integrins-020913/
*  Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice
... Hiroshi Nagahisa,1 Kazuma Okabe,1 Yoshihito Iuchi,2 Junichi ... "Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice," Oxidative Medicine and Cellular Longevity, vol. 2016, Article ...
https://www.hindawi.com/journals/omcl/2016/9345970/cta/
*  Human Genetic Disorders and Knockout Mice Deficient in Glycosaminoglycan
... Shuji Mizumoto,1 Shuhei Yamada,1 and Kazuyuki ... phosphosulfate formation in brachymorphic mice," Proceedings of the National Academy of Sciences of the United States of ... D. H. Lum, J. Tan, S. D. Rosen, and Z. Werb, "Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2 ... C. L. R. Merry, S. L. Bullock, D. C. Swan et al., "The Molecular Phenotype of Heparan Sulfate in the Hs2st-/- Mutant Mouse," ...
https://www.hindawi.com/journals/bmri/2014/495764/ref/
*  Medical Xpress - knockout mice
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
https://medicalxpress.com/tags/knockout+mice/sort/popular/1d/
*  Knockout Mouse Phenotyping - Funded Research
Knockout Mouse Production and Phenotyping Project (UM1) RFA-RM-15-017 PI Name Institution Name Title BEAUDET, ARTHUR L. ( ... Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) RFA-RM-15-017. PI Name. Institution Name. Title. ... The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2). LLOYD, KC KENT. UNIVERSITY OF CALIFORNIA ... Knockout Mouse Production and Cryopreservation (U42) RFA-RM-10-013. PI Name. Institution Name. Title. ...
https://commonfund.nih.gov/KOMP2/fundedresearch
*  Frontiers | Urea Transporter Physiology Studied in Knockout Mice | Physiology
Over the past few years, multiple UT knockout mouse models have been generated enabling us to explore the physiological roles ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... Since UT-B has a wide distribution, multiple phenotypic abnormalities were found in UT-B null mice, such as defective urine ...
https://www.frontiersin.org/articles/10.3389/fphys.2012.00217/full
*  Enhanced Blood Pressure Variability in eNOS Knockout Mice | Hypertension
... blood pressure variance was significantly larger in eNOS knockout mice than in controls, and only 2 out of 10 knockout mice had ... During resting conditions, blood pressure variability was markedly enhanced in knockout mice compared with wild-type mice (10.5 ... Statistical comparisons between eNOS knockout mice and wild-type mice were performed by unpaired t tests. ... amount of sequences in the eNOS knockout mice would suggest that the larger blood pressure variability in eNOS knockout mice is ...
http://hyper.ahajournals.org/content/33/6/1359
*  Knockout Mouse Phenotyping | NIH Common Fund
NIH…Turning Discovery Into Health®. National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892. U.S. Department of Health and Human Services. ...
https://commonfund.nih.gov/multimedia/videos/knockout-mouse-phenotyping
*  JCI - Pdx1 restores β cell function in Irs2 knockout mice
Mice. Irs1 knockout (2), Irs2 knockout (2), Pdx1 knockout (8), and wild-type Pdx1 transgene (16) mice were maintained on a ... mice with Pdx1tg mice to increase the Pdx1 gene dosage in the Irs2-/- mice. As previously described, Pdx1tg mice have multiple ... To test the role of Pdx1 in Irs2-/- mice, we intercrossed Irs2+/- mice with Pdx1+/- mice and backcrossed the compound ... mice were slightly smaller by comparison with littermates (Figure 2a). Irs2-/-Pdx1+/- mice and mice lacking Pdx1 (Pdx1-/-, Irs2 ...
https://www.jci.org/articles/view/14439
*  Knockout Mice Essay - 2549 Words - AvroArrow
Knockout Mice Technology , Submitted By : Wasman ID : 11136007Course ID : BTE 402 , Knockout Mice Technology ... ... One of these is the knockout mouse. What are knockout mice? A knockout mouse is a genetically engineered mouse in which ... Knockout Mice Essay. 2549 words - 11 pages Knockout Mice Technology , Submitted By : Wasman ID : 11136007Course ID : BTE 402 , ... However, cocaine still produces reward in dopamine transporter knockout mice (DAT-KO mice) [9-11]. Importantly, DAT-KO mice ...
https://www.avroarrow.org/essay/knockout-mice
*  Biology-Online • View topic - Knockout mice
If one parent is a wild-type mouse and the other is a homozygous knockout mouse, their offspring will be heterozygous at the ... Knockout mice. by cassieconte » Tue Feb 05, 2013 4:54 pm Can someone please explain how it is possible to have a heterozygous ... knock out mouse? If a gene is 'knocked-out,' how can the mouse be heterozygous for the gene? Will the mouse still produce ... If there is some of the protein made, the mouse is a knock-down and not a knock-out. Watch out for the other meaning of ...
http://www.biology-online.org/biology-forum/post-149536.html
*  2007 Nobel Prize in Physiology or Medicine: Knockout Mice - The Scientific Activist
2007 Nobel Prize in Physiology or Medicine: Knockout Mice. Posted by Nick Anthis on October 8, 2007 ... Since then, the number of reported knockout mouse strains has risen exponentially. Gene targeting has developed into a highly ... Ongoing international efforts will make "knockout mice" for all genes available within the near future. ... all for their work contributing to knockout (and knock-in) mice becoming one of the most powerful scientific tools available to ...
http://scienceblogs.com/scientificactivist/2007/10/08/2007-nobel-prize-in-physiology/