Assessments of inflammatory state and T-cell activity. | Open-i
Mice, Inbred C57BL. *Mice, Inbred MRL lpr. *Organ Specificity/genetics. *Osteoclasts/pathology ... lpr) /J mice had elevated Treg cells in both spleens and bones of B6.MRL/Fas(lpr) /J but decreased percentage of activated T ... lpr) /J mice had elevated Treg cells in both spleens and bones of B6.MRL/Fas(lpr) /J but decreased percentage of activated T ... Bottom Line: The reduced bone fraction was related to elevated rates of coupled bone turnover in the B6.MRL/Fas(lpr) /J ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4305200_jbmr0029-1478-f6&req=4
SU5416 induces infiltration of ER-TR7 into the B cell a | Open-i
SU5416 induces infiltration of ER-TR7 into the B cell areas within ectopic follicles.MRL-lpr-lpr mice were treated with SU5416 ... Mice. *Mice, Inbred MRL lpr. *Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors ... pone-0032828-g004: SU5416 induces infiltration of ER-TR7 into the B cell areas within ectopic follicles.MRL-lpr-lpr mice were ... pone-0032828-g004: SU5416 induces infiltration of ER-TR7 into the B cell areas within ectopic follicles.MRL-lpr-lpr mice were ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3295768_pone.0032828.g004&req=4
Only TCR-CD28-stimulated DP thymocytes die in respons | Open-i
Mice, Inbred C57BL. *Mice, Inbred MRL lpr. *Mice, Knockout. *Mice, Mutant Strains ... DP thymocytes from wild-type mice (CD28+Ly5.2+) were mixed in a 1:1 ratio with DP thymocytes from CD28-deficient mice (CD28−/− ... DP thymocytes from wild-type mice (CD28+Ly5.2+) were mixed in a 1:1 ratio with DP thymocytes from CD28-deficient mice (CD28−/− ... Individual populations of DP thymocytes from wild-type B6 mice and CD28 KO mice were cultured and stimulated independently with ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199155_JEM.971308f3d&req=4
Find Research Projects - Albert Einstein College of Medicine
Inbred MRL lpr Mouse Epigenetic regulation by microRNA of MDS pathogenesis. Ito, K. ...https://einstein.pure.elsevier.com/en/projects/?format=&page=5
NAVER Academic | Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and...
Mice, Mice, Inbred MRL lpr, Mortality, Skin. ... and lethality in MRL/lpr mice.. Author. Alberta Y Hoi, Michael ...https://academic.naver.com/article.naver?doc_id=147095696
MPD: Mouse strain: MRL/MpJ-Fas
Mouse strain: MRL/MpJ-Faslpr/J JAX 000485 inbred Availability: Level 2 • List all studies involving this strain (5) • Find ...https://phenome.jax.org/strains/876
List of MeSH codes (B01) - Wikipedia
... mice, inbred hrs MeSH B01.050.157.520.510 --- mice, inbred icr MeSH B01.050.157.520.555 --- mice, inbred mrl lpr MeSH B01.050. ... mice, inbred hrs MeSH B01.050.199.520.520.510 --- mice, inbred icr MeSH B01.050.199.520.520.555 --- mice, inbred mrl lpr MeSH ... mice, inbred icr MeSH B01.150.900.649.865.635.505.500.400.555 --- mice, inbred mrl lpr MeSH B01.150.900.649.865.635.505.500. ... mice, inbred a MeSH B01.050.157.520.318 --- mice, inbred akr MeSH B01.050.157.520.338 --- mice, inbred balb c MeSH B01.050. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)
MUSC Faculty Journal Articles
Autoimmune Diseases;Nitric Oxide Synthase;Nitric Oxide Synthase Type II;Mice, Inbred MRL lpr;Arthritis;Inflammation; ... Mice, Inbred BALB C;Mice, Inbred C57BL;Mice, Inbred CBA;Receptors,... ... Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2 ... Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice: ...http://digital.library.musc.edu/cdm/search/collection/muscfja
Genetic basis of tissue specificity of vasculitis in MRL/lpr mice - Yamada - 2003 - Arthritis & Rheumatology - Wiley Online...
... in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains ... Vasculitis in individual MRL/lpr, C3H/HeJ-lpr/lpr (C3H/lpr), (MRL/lpr × C3H/lpr)F1, and (MRL/lpr × C3H/lpr)F2 intercross mice ... Using MRL/lpr and C3H/lpr strains, (MRL/lpr × C3H/lpr)F1 and (MRL/lpr × C3H/lpr)F2 intercross mice were produced and housed at ... C3H/lpr, (MRL/lpr × C3H/lpr)F1 intercross (MCF1), and (MRL/lpr × C3H/lpr)F2 intercross (MCF2) mice. Tissue, progeny, sex. ...http://onlinelibrary.wiley.com/doi/10.1002/art.10952/full
Lupus nephritis in the absence of renal major histocompatibility comp" by R Mukherjee, Z Zhang et al.
Kidneys from MRL-lpr B2m-/- or MRL-lpr Ab-/- mice as well as control wild-type mice transplanted into MRL-lpr wt/- recipients ... Spontaneously proliferating autoreactive T cells were found in wild-type MRL-lpr and MRL-lpr B2m-/- but not MRL-lpr Ab-/- mice ... By using either MHC Class I (MRL-lpr B2m-/-) or MHC Class II deficient (MRL-lpr Ab-/-) kidneys in a transplant model, we tested ... MRL-lpr) mice develop an aggressive autoimmune disorder characterized by arthritis, vasculitis, and glomerulonephritis. Renal ...https://mouseion.jax.org/stfb1990_1999/779/
Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1...
Since MRL-lpr/lpr mice but not C57BL/6-lpr/lpr mice develop severe autoimmune disease, defects in BCR-mediated apoptosis in the ... MRL background, together with lpr mutation, may contribute to the development of severe autoimmune disease in MRL-lpr/lpr mice ... extensive BCR ligation induces death of mature B cells from C57BL/6-lpr/lpr mice as efficiently as those from C57BL/6 mice, ... In contrast, BCR ligation-induced apoptosis is reduced in mature B cells from MRL mice and this is not affected by the lpr ...https://www.semanticscholar.org/paper/Rapid-B-cell-apoptosis-induced-by-antigen-receptor-Yoshida-Higuchi/d760f3014fc0ae0a787466edd7d948b34d80b353
Vascular Calcification | Circulation
Several genetically distinct inbred mouse strains, including C57BL/6, Balb/C, C3H/HeJ, DBA/2J, SM/J, and MRL-lpr/lpr mice, ... In apoE−/− and ldlr−/− mice, as well as mice on high-fat/high-carbohydrate diets, aortic valve leaflets have osteogenic ... Pathology of atheromatous lesions in inbred and genetically engineered mice: genetic determination of arterial calcification. ... Vascular calcification occurs spontaneously in genetically modified mice such as apoE-deficient mice, which were recently shown ...http://circ.ahajournals.org/content/117/22/2938.full
"Accelerated wound healing of alkali-burned corneas in MRL mice is asso" by M Ueno, B L. Lyons et al.
... mice. Effects of neutrophil depletion of B6 mice and allogeneic reconstitution of B6 mice with MRL bone marrow on wound healing ... CONCLUSIONS: Alkali-burned corneas heal faster and more completely in MRL mice than in B6 mice, by means of rapid ... Marked inflammatory cell infiltration and fibrosis were evident in the corneas and anterior chambers of B6 mice. MRL mice ... MRL) mice. METHODS: Gross, clinical, and histologic criteria were used to compare healing of alkali-burned corneas in MRL and ...https://mouseion.jax.org/stfb2000_2009/1205/
Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted...
... in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains ... In the whole genome analysis of rheumatic-disease-susceptibility loci in MRL/lpr mice, Sdc2 (encoding syndecan 2) was a ... Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic ... Accelerating effect of an MRL gene locus on the severity and onset of arthropathy in DBA/1 mice. Arthritis Rheum. 2005, 52: 959 ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar1751
Mesenchymal Stromal Cells | ISHAR Online
Mice, Inbred C57BL. Mice, Inbred MRL lpr. Mice, Inbred Strains. Multipotent Stem Cells ... Fancd2(-/-) mice exhibit many features of human Fanconi anemia including cellular DNA repair defects. Whether the DNA repair ... defect in Fancd2(-/-) mice results in radiologic changes in all cell lineages is unknown. We measured stress of hematopoiesis ...http://isharonline.org/tags/mesenchymal-stromal-cells
Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic...
Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic ... Mice, Inbred C57BL * Mice, Inbred MRL lpr * Synovial Fluid * Tibia * Wounds and Injuries ... Additionally, we examined the hypothesis that MSCs from the MRL/MpJ (MRL) 'superhealer' mouse strain would show increased ... Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic ...https://scholars.duke.edu/display/pub821206
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus | Orphanet Journal of Rare...
... lpr , BXSB.Yaa, the F1 hybrid between NZB and NZW, and inbred derivatives of these strains . Over 100 regions in the mouse ... and include the strains MRL-Fas ... Mouse models for SLE. Several mouse strains spontaneously ... the number of mouse models available to study SLE is on the increase: a comprehensive list of 45 mouse models currently ... With extensive progress in generating knock-out mouse models and using new technologies to define existing mouse models, ...https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-8-2
The Current Concept of T H 17 Cells and Their Expanding Role in Systemic Lupus Erythematosus
IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice," Journal of Immunology, vol. 184 ... The SNF1 mouse model, derived from the F1 outcross of the New Zealand Black and SWR recombinant inbred strains, develops a ... The MRL/lpr strain is a classical model of spontaneous lupus. It exhibits a lymphoproliferative disorder which manifests with ... BXD2 is one of 20 BXD recombinant inbred strains derived from a cross between C57BL/6J (B6) and DBA/2J. These mice develop a ...https://www.hindawi.com/journals/arthritis/2011/810649/
The CD95 mutant Ipr arose spontaneously during inbreeding of the MRL Mp strain (100-102) because of a disabling insertion of an ... Place mouse on plastic wrap. c. After 10-15 s, remove the mouse. d. Collect urine with a micropipet or Pasteur pipet. 2. ... 1.6.1. lpr gld and Other CD95 Pathway Mutations This group of recessive mutations share in common defective signaling via the ... The Lupus Oriented Mouse Necropsy Wed, 22 Feb 2017 , Autoimmune Disease Collect urine for analysis (e.g., 248), if desired (see ...https://www.clicktocurecancer.info/autoimmune-disease/
BMT for Severe Autoimmune Diseases: An Idea Whose Time Has Come | Cancer Network | The Oncology Journal
Transplantation of hematopoietic stem cells from MRL/lpr mice into an unaffected strain of mice results in the MRL/lpr ... In general, spontaneously occurring autoimmune diseases are restricted to inbred strains and arise from genetic defects in the ... MRL/lpr mice and in the offspring between New Zealand black/New Zealand white mice (NZB/NZW F1 hybrid [B/W])[5-7]; a ... mice[13,14] (Table 2). With the exception of the MRL/lpr mouse, the exact genetic defect(s) remain(s) enigmatic. ...http://www.cancernetwork.com/review-article/bmt-severe-autoimmune-diseases-idea-whose-time-has-come
B Cell Tolerance and Positive Selection in Lupus | The Journal of Immunology
... the anti-DNA transgenic B/W mice differed somewhat from anti-MHC class I transgenic MRL/lpr/lpr mice. In these mice, Feeney and ... This even holds for inbred mice, such as the lupus-prone New Zealand Black/New Zealand White F1 mice, which are all genetically ... The disease in B/W mice is apparently not dominated by a single gene product, such as Fas (as in MRL/lpr/lpr mice) or TLR7 (as ... Selection of anti-double-stranded DNA B cells in autoimmune MRL-lpr/lpr mice. J. Immunol. 176: 5183-5190. ...http://www.jimmunol.org/content/189/2/503
NMRI Outbred Mouse Model | Taconic Biosciences
NMRI mice are an outbred strain commonly used as controls in selection experiments and as experimental animals in biology, ... with the development of glomerulonephritis in NMRI mice in contrast to the glomerulonephritis in ZBWF1 and MRL/Mp-lpr mice ... The mice were inbred as NIH/P1. The Naval Medical Research Institute (NMRI) received stock from Lynch. Zentralinstitut für ... The mice were random bred. M&B A/S (now Taconic Europe) received stock from Han in 1961 and again in 1985. The mice are ...https://www.taconic.com/mouse-model/nmri
Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review |...
Multiparametric, semiquantitative scoring systems for mouse models histopathology are a common approach to handle these ... criteria identified 153 originally designed semiquantitative scoring systems for the analysis of morphologic changes in mouse ... Genetic basis of tissue specificity of vasculitis in MRL/lpr mice. Arthritis Rheum. 2003, 48 (5): 1445-1451.PubMedGoogle ... Chen SM, Mukoyama T, Sato N, Yamagata SI, Arai Y, Satoh N, Ueda S: Induction of nephrotoxic serum nephritis in inbred mice and ...https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-9-123
Heavy chain sequence of B cells that have edited the H | Open-i
In 3H9H/56R MRL/lpr mice, the expression of anti-dsDNA is vastly accelerated. Anti-dsDNA B cells use noneditor kappas but, in ... Mice, Inbred BALB C. *Mice, Inbred Strains. *Mice, Transgenic. *Molecular Sequence Data ... In 3H9H/56R MRL/lpr mice, the expression of anti-dsDNA is vastly accelerated. Anti-dsDNA B cells use noneditor kappas but, in ... Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196070_20021560f3b&req=4
Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases
2012) Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. ... Srivastava PK, DeLeo AB, Old LJ (1986) Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad ... Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse ... 2000) Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol 47: 782-791. [ ...https://www.oatext.com/Regulatory-role-of-heat-shock-proteins-in-autoimmune-and-inflammatory-diseases.php