Additionally, older rTg4510B6 mice had gross forebrain neurodegeneration that was equivalent to age-matched rTg4510 mice. ... we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) ... aggregation and cognitive impairments as age-matched rTg4510 mice. At 6.5 months of age, rTg4510B6 mice displayed ... These studies support the use of the rTg4510 mouse model on a partial C57BL/6 strain background without losing fidelity of the ...

Bacteria:, Hereditary Factors:, Serology:, Congenic Resistant Lines:, Strains:. Original Citation. Infect Immun 1980; 27:61-7. ... Resistance to listeriosis in mice that are deficient in the fifth component of complement. ...

Investigation of the effects of the chromosomal regions of mouse chromosome 2 on susceptibility to dental caries using congenic ... Jan 12, 2020 by drzezo in General Dentistry Comments Off on Investigation of the effects of the chromosomal regions of mouse ... chromosome 2 on susceptibility to dental caries using congenic strains Abstract Background Dental caries is a widespread ...

... which makes fine-mapping them by use of a conventional congenic approach impractical. In this study, we demonstrate that it is ... As many of the linked chromosome regions that predispose to type 1 diabetes in the NOD mouse have been dissected, it has become ... Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. ... Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. ...

Homozygous congenic mice exhibited up to 4.5-fold greater lesion area compared to noncongenic littermates (PϽ0.0001). Analysis ... Interestingly, comparative mapping revealed that the Athsq1 congenic interval contains the mouse region homologous to a widely- ... the existence of atherosclerosis susceptibility loci in the mouse model was suggested using recombinant inbred strains of mice ... A mouse genetics approach can simplify the genetic analysis and provide tools for mechanistic studies. Methods and Results-We ...

... than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. In addition, MRL-lpr/lpr peritoneal macrophages ... By using interspecific backcross mice, the gene for inducible NOS (Nosi) was mapped to mouse chromosome 11. This chromosomal ... MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) ... MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune ...

Using congenic mice, we have determined that genes on Chrs. 4 and 8 of the mouse modulate the presence of spontaneous ... 2003 The Mouse Brain Library: Analysis of Complex Traits of the Mouse Nervous System, Human Brain Project Annual Meeting, [ ... 2006-2011 P.I., N.I.H., 1 R01 NS052397-01A2, QTL mapping of cell number in the mouse CNS. 2007-2012 Investigator, N.I.H., R01 ... A behavior profile of the MRL/Mp lpr/lpr mouse and its association with hydrocephalus. Brain Behav Immun. 1992;6(1):40-9.. ...

1997). Functional dissection of SLE pathogenesis using congenic mouse strains. J Immunol 158:6019-6028. ... Genetics of autoimmunity in man and mice. Book Chapter in Genes, Genomes and Genomics. Regency Publications. ... Enhanced immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56 ... Lesson in lupus from congenic strains. Archivum Immunologiae et Therapiae Experimentalis. 53:207-212. ...

As in humans with TB, M. tuberculosis-infected mice have increased numbers of blood monocytes; this is due to increased egress ... tuberculosis infection in mice. We found that Ly6Chi monocytes traffic rapidly to the lungs, where a subpopulation become ... We used a combination of congenic monocyte adoptive transfer, and pulse-chase labeling of DNA, to determine the kinetics and ... We used a combination of congenic monocyte adoptive transfer, and pulse-chase labeling of DNA, to determine the kinetics and ...

129 congenic, B6 congenic, and A/J congenic Ucp2 KO mice, only 129/B6 mixed genetic background, the one used in the two ... Ucp2 KO mice showed significantly lower fat mass and higher lean mass than WT mice (Fig. 1G). WAT in KO mice was lesser than it ... was increased in HFD KO mice compared to that in NCD KO mice, but the expression level in HFD KO mice was also significantly ... Ucp2-depleted mice showed a tendency to lose more weight than WT mice (Fig. 3B and 4B), but the actual weights of WAT and ...

Studies of B6 Csf1(op/op) (lacking macrophages) mice, Rag1(-/-) mice, and wild-type mice treated with neutrophil-specific Gr1 ... A congenic strain (called ZORI here) with defects in Rag1 and Rag2 expression, thymocyte maturation and peripheral T cell ... mice and TgTDeltaN transgenic mice, a strain in which 100% of the mice develop thymoma due to thymocyte-specific inactivation ... Compared to control mice, RAG-1-knockout mice exhibited increased locomotor activity in an open field under both dim and bright ...

Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus. Kidney Int. 2009 Feb. 75(4):366-72 ... Researchers created transgenic mice by inserting HIV DNA constructs into the mices genomes. The mice developed proteinuria and ... Experiments using transgenic mice have provided perhaps the strongest evidence for a direct role by HIV type 1 (HIV-1) in the ... Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202. J Am Soc Nephrol. 2004 May. 15 ...

What is the term used for mice that are genetically identical except for one single locus? - NET Life Sciences ... https://en.wikipedia.org/wiki/Congenic. Rogner, U., Avner, P. Congenic mice: cutting tools for complex immune disorders. Nat ... Congenic: two strains/species that differ in only one locus and a linked segment of chromosome.. ... What is the term used for mice that are genetically identical except for one single locus? ...

However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression… ... Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC ... Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. ...

... mice are low responders while H-2 congenic BALB.C3H (H-2k) mice are high responders. Immunization of adult BALB/c mice with the ... which are better responders than genetically high-responder BALB.C3H mice, although completely different in the expression of ...

Bogue MA, Grubb SC (2004) The mouse phenome project. Genetica 122:71-74 [One of two key papers on the Mouse Phenome Project and ... Bryant CD, Kole LA, Guido MA, Sokoloff G, Palmer AA (2012) Congenic dissection of a major QTL for methamphetamine sensitivity ... Mouse Phenotype Database Integration Consortium (2007) Integration of mouse phenome data resources. Mammalian Genome, 18:157- ... A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice. J ...

Inhibition of the IgG Response to noncongenic cells by preimmunization with congenic cells. D Wernet,H Shafran,F Lilly ... Loss of suppressor T cells in adult NZB/NZW mice. R S Krakauer,T A Waldmann,W Strober ... View Articletitled, Genetic regulation of the antibody response to H-2Db alloantigens in mice. III. Inhibition of the IgG ... Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special ...

Learn about different types of inbred mouse strains and the inbred breeding scheme. ... What are the unique advantages of using inbred mice in genetic and genomic research? ... Learn about breeding schemes that generate coisogenic, recombinant inbred, consomic and congenic mice. ... Mouse as a Model for Understanding Human Biology and Disease Find out what makes the inbred mouse an ideal research model for ...

Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. Yokoi M 2006 DNA repair ... UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA ... E2F regulates growth-dependent transcription of genes encoding both catalytic and regulatory subunits of mouse primase. Yokoi M ... Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related ...

congenic animal * congenic animals * congenic mice * congenious *congenital. * congenital abnormalities * congenital ...

Components and Strategies Mice, Parasites, and Problem. 5C6-wk-old feminine C57BL/6 and congenic Thy1.1 mice were from The ... Congenic C57BL/6 Thy1.1 mice were contaminated perorally with 10C15 cysts of = 5) were killed and spleen cells were collected 2 ... 40 mg/mouse). The procedure continued daily for any 10-d period. The control mice had been treated with an comparative quantity ... Mice missing IL-15 or its receptor IL-15R cannot generate a complete memory space Compact disc8+ T cell response (13, 14). ...

Development of hippocampal alpha 7 nicotinic receptors C3H and DBA/2 congenic mice Journal Article ... Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6J x C3H/HeJ F2 intercross mice ... Maximizing the effect of an alpha 7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits ... alpha-7 Nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion Journal ...

RESULTS Congenic mice expressing H-2k and H-2u molecules demonstrated rapid clearance of Typhimurium. We initially examined ... The present study therefore examined whether H-2 congenic mouse strains with enhanced resistance to infection elicited superior ... whether MHC congenic mice displayed different Graveoline rates of clearance, as had been previously reported (27). Mice ... Previous work has shown that different mouse strains eliminate Typhiumurium at vastly different rates, with C57BL/6 mice among ...

Congenic mice overexpressed VDR selectively in T cells, and thus did not suffer from calcemic effects. VDR overexpression ... We isolated these polymorphisms in a congenic mouse line, allowing us to study the immunomodulatory properties of VDR in a ... leading to female-specific differences in T cell-dependent mouse models of autoimmunity. Female mice with reduced Cd2 ... Here, in mice carrying pathogenic C5024T in mt-tRNAAla and in patients with mitochondrial encephalomyopathy, lactic acidosis, ...

Congenic Mice Provide In Vivo Evidence for a Genetic Locus That Modulates Intrinsic Transforming Growth Factor β1―Mediated ... Demonstration of Osteocytic Perilacunar/Canalicular Remodeling in Mice During LactationHAI QING; ARDESHIRPOUR, Laleh; PAJEVIC, ... Increases Bone Mineral Density by Suppressing RANKL Expression in Mouse Trabecular BoneHARADA, Suguru; MIZOGUCHI, Toshihide; ...

Eaves IA, Wicker LS, Ghandour G, Lyons P, Peterson LB, Todd JA, Glynne RJ: Combining mouse congenic strains and microarray gene ... Most of the QTLs were isolated in congenic strains [40-45] and work is ongoing to clone the genes positionally. Gene expression ... Jagodic M, Kornek B, Weissert R, Lassman H, Olsson T, Dahlman I: Congenic mapping confirms a locus on rat chromosome 10 ... Holm BC, Xu HW, Jacobsson L, Larsson A, Luthman H, Lorentzen JC: Rats made congenic for Oia3 on chromosome 10 become ...

Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help ... However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. Few studies have assessed the ... A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine ... For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal ...

We then produced DOR-1 KO mice isogenic/congenic on both the C57Bl6 and 129S6 backgrounds. Remarkably, we have found that the ... produced robust analgesia reaching cut-off in single and combinatorial mouse genotypes lacking DOR-1 KO but not in mice lacking ... In addition, atypical opioid agonists such as the non-peptide BW-373U86, which had no analgesic potency in wild type mice, ... First synapses are formed within the prenatal neocortices of both mice and human in two specialized zones, the marginal zone ...

Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice 1999 ... USE OF REPEATED-MEASURES IN AN ANALYSIS OF ETHANOL-INDUCED LOSS OF RIGHTING REFLEX IN INBRED LONG-SLEEP AND SHORT-SLEEP MICE ... Neurocircuitry of excessive alcohol drinking in mice. 2006 * QTL mapping for the psychomotor stimulant effect of alcohol in LXS ... on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice 2004 ...

... gummosa essential oil was assessed by using a mouse models. Methods:Lorkes method was used to access the acute toxicity of the ... Differences in measures of exploration and fearin MHC-congenic C57BL/6J and B6-H-2K mice. Behav Genet. 1999; 29: 263-271. ... gummosa essential oil was assessed by using a mouse models. Methods:Lorkes method was used to access the acute toxicity of the ... Antinociceptive and anti-inflammatory activity of the seed and root extracts of Ferula gummosa in mice and rats. Daru. 2004; 12 ...