Strain 129 Mouse Embryonic Stem Cells | Creative Bioarray
Mouse Embryonic Stem Cell Growth Medium;Embryoid Body (EB) Formation Medium;NCR Protein-Free Cryopreservation Medium ... Ability to form teratoma in severe combined immunodeficient (SCID) mice.. - ex. pression of OCT-4, SSEA-1, and nanog.. - ...https://www.creative-bioarray.com/Strain-129-Mouse-Embryonic-Stem-Cells-CSC-C1303-item-2347.htm
Frontiers | Licensed and Unlicensed NK Cells: Differential Roles in Cancer and Viral Control | Immunology
Unlicensed NK cells dominate responses to MCMV infection in MCMV-resistant mouse strains. In MCMV-resistant mouse strain, NK ... Ly-49 receptor expression and functional analysis in multiple mouse strains. J Leukoc Biol (1999) 66:512-20. ... 1. Kiessling R, Klein E, Wigzell H. 'Natural' killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney ... In MCMV-resistant mouse strains, such as C57BL/6 (B6), the activating Ly49H receptor is able to recognize the MCMV m157 ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00166/full
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.
Mice. Mice, 129 Strain. Mice, Knockout. Mitogen-Activated Protein Kinase 1 / metabolism*. Mitogen-Activated Protein Kinase 3 / ... mouse; EC 188.8.131.52/Proto-Oncogene Proteins c-akt; EC 184.108.40.206/Proto-Oncogene Proteins c-raf; EC 220.127.116.11/Mapk1 protein, mouse ... IQGAP1-null mice show strongly impaired phosphorylation of MEK1/2-ERK1/2 and AKT following 4 days of pressure overload, but ... Next Document: Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosc.... ...http://www.biomedsearch.com/nih/IQGAP1-regulates-AKT-signaling-in/21493702.html
Upregulation of cell-cycle associated genes in resident | Open-i
... proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse ... proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569637_emmm0005-0191-f6&req=4
WASP and N-WASP negatively regulates each other.(A-D) | Open-i
Both the MFI of pWASP in the contact zone of cNKO B cells (Figure 7A,C) and the cellular MFI of wiskostatin-treated mouse B ... Both the MFI of pWASP in the contact zone of cNKO B cells (Figure 7A,C) and the cellular MFI of wiskostatin-treated mouse B ... E-G) Flow cytometry analysis of the cellular MFI of pWASP or pN-WASP in splenic B cells from WKO and littermate control mice (F ... E-G) Flow cytometry analysis of the cellular MFI of pWASP or pN-WASP in splenic B cells from WKO and littermate control mice (F ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3818172_pbio.1001704.g007&req=4
ICA69null Nonobese Diabetic Mice Develop Diabetes, but Resist Disease Acceleration by Cyclophosphamide | The Journal of...
... which kill β cells and cause diabetes in any strain, while CY-accelerated diabetes requires the NOD host with established ... NOD.scid mice were pretreated with CY 2 days before adoptive transfer of spleen cells from 12-wk-old nondiabetic wild-type mice ... The 129SvJ mice with ICA69 deficiency had no obvious phenotype and aged normally. However, speed-congenic ICA69null NOD mice ... Generation of ICA69null mice. The ICA69 locus occupies approximately 100 kb on mouse chromosome 6 (27, 29). A murine 129SvJ ...http://www.jimmunol.org/content/168/1/475?ijkey=a4b631689bcdfc55b60327951325c78afe6e7fa8&keytype2=tf_ipsecsha
Keratinocyte responses to TPA treatment.(A) H&E sta | Open-i
H&E stained skin sections of mice treated three times with acetone or TPA. Asterisk: neutrophil containing pustu ... mice treated with TPA or DMBA/TPA than in WT mice, and this correlated with a greater number of suprabasal layers (Figure 3A,D ... mice treated with TPA or DMBA/TPA than in WT mice, and this correlated with a greater number of suprabasal layers (Figure 3A,D ... Mentions: EPI−/− mice exhibited an exacerbated response to TPA (Figure 3A). Their skin was reddened, dry and scaly, whereas ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4007207_elife01888f003&req=4
Role of HSPBP1 and BAG2 as regulators of CHIP-mediated | Open-i
Mice, 129 Strain. *Mice, Inbred C57BL. *Mice, Knockout. *Proteolysis. *Testis/metabolism/pathology ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4116300_2260fig7&req=4
Caspase-7 Expanded Function and Intrinsic Expression Level Underlies Strain-Specific Brain Phenotype of Caspase-3-Null Mice |...
... we observed that the Casp3 deletion phenotype is mouse strain specific. B6 mice are resistant to this mutation because they ... B, Genotype frequencies for each strain for E18.5 embryos and postnatal mice. p values show that 129-Casp3-/-, but not B6-Casp3 ... Only 4 of 36 B6-Casp3-/- mice had overt hydrocephalus (data not shown). The B6 strain is therefore more resistant to Casp3 ... A broad genetic study including other backcrossed mouse strains is underway to identify genes other than caspase-7 that may be ...http://www.jneurosci.org/content/24/44/9977
Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma.
Strains of mice arising from a parental inbred stock that was subsequently used to produce substrains of knockout and other ... A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from radiation-induced lymphomas in C57BL mice. It is ... Mice, Inbred Sencar. Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also ... Home » Topics » Women's Health » Research » Concomitant administration of radiation with eribulin improves the survival of mice ...https://www.bioportfolio.com/resources/pmarticle/2044123/Concomitant-administration-of-radiation-with-eribulin-improves-the-survival-of-mice-harboring.html
Role of CD44 and Hyaluronan in Neutrophil Recruitment | The Journal of Immunology
WT mice that received CD44−/− bone marrow were deficient in leukocyte CD44 (leukocyte CD44−/− mice), whereas CD44−/− mice that ... mice relative to WT mice. In fact, the number of rolling leukocytes was increased by ∼30% in the mutant mice. Rolling ... mice compared with wild-type mice. Leukocyte emigration was also greatly decreased in the CD44−/− mice. The same decrease in ... 4⇓). When compared with tissues from untreated mice (Fig. 4⇓, A and B), staining was less intense in tissues taken from mice ...http://www.jimmunol.org/content/173/12/7594.long
Key to the Chart of Strain Genealogies
Festing, M.F.W. Origins and characteristics of inbred strains of mice. in Genetic variants and strains of the laboratory mouse ... Festing, M.F.W. Inbred strains of mice. Mouse Genome Database (MGD), Mouse Genome Informatics, The Jackson Laboratory, Bar ... Inbred strains of mice, no. 6. Companion to Mouse News Letter, 75 (1969). 47.. Abujiang, P. et al. The origin of SL family mice ... Evolution in inbred strains of mice appears to berapid. Science 228, 1169-1175 (1985). 9.. Nishida, S. Inbred strains of mice, ...http://www.informatics.jax.org/downloads/datasets/misc/genealogy/genealogy_key.html
Resection of the endolymphatic sac.A: Diagram of the in | Open-i
B: Photograph of an inner ear obtained from an E17.5 Slc26a4−/− mouse. Abbreviations: S, sac ... Enlargement was immediately evident in Slc26a4(-/-) compared to Slc26a4(+/-) mice. In Slc26a4(+/-) and Slc26a4(-/-) mice, ... Enlargement was immediately evident in Slc26a4(-/-) compared to Slc26a4(+/-) mice. In Slc26a4(+/-) and Slc26a4(-/-) mice, ... 9). In contrast, the cochlear lumen of inner ears harvested at E14.5 from Slc26a4−/− mice was enlarged and no difference was ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2984494_pone.0014041.g008&req=4
Origins of postnatal cardiomyogenesis in the adult mous | Open-i
Origins of postnatal cardiomyogenesis in the adult mouse heart by flow cytometryA. FACS-sorted GFP+ and GFP− cardiomyocytes ... Mice were subsequently pulsed with daily BrdU injections for 5 weeks, at which point hearts were explanted and enzymatically ... Mice were subsequently pulsed with daily BrdU injections for 5 weeks, at which point hearts were explanted and enzymatically ... 4-OH-Tamoxifen-pulsed 6-8 week-old bitransgenic mice were randomized to undergo: (a) sham surgery; (b) induction of MI by ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569637_emmm0005-0191-f7&req=4
Method and composition for inhibition of angiogenesis using antagonists based on MMP-9 and β1 integrins - University of...
Typically, a mouse of the strain 129 GIX+ is the preferred mammal. Suitable mouse myelomas for use in the present invention ... A fourth assay measures angiogenesis in the chimeric mouse:human mouse model and is referred to as the chimeric mouse assay. ... An exemplary inbred mouse strain is the Balb/c.. Other methods of producing a monoclonal antibody, a hybridoma cell, or a ... The chimeric mouse is exposed to any test reagent, and therefore the health of the mouse is an indication of toxicity. ...http://www.freepatentsonline.com/7101975.html
Patent US6887473 - Inhibition of angiogenesis in disease states with an anti-αvβ3 monoclonal ... - Google Patents
An exemplary inbred mouse strain is the Balb/c.. Other methods of producing a monoclonal antibody, a hybridoma cell, or a ... Typically, a mouse of the strain 129 GlX+ is the preferred mammal. Suitable mouse myelomas for use in the present invention ... Reynolds et al., "Enhanced pathological angiogenesis in mice lacking beta,SUB,3 ,/SUB,integrin or beta,SUB,3 ,/SUB,and beta,SUB ... Yan, et al., "Human/Severe Combined Immunodeficient Mouse Chimeras: An Experimental in Vivo Model System to Study the ...http://www.google.com.au/patents/US6887473
Bone Marrow Graft Rejection as a Function of TNK Cells | SpringerLink
F1 hybrid mice transplanted with parental bone marrow from either parent A or... ... I. Determinant-specific difference of reactivity in two pairs of inbred mouse strains. J Exp Med 134: 281-293CrossRefGoogle ... The two mouse strains 129 and C57BL/6 which are of H-2b haplotype, provide an interesting experimental model because they show ... Specific inhibition of hybrid resistance in F1 hybrid mice pretreated with parent-strain spleen cells. J Immunol 143: 3484-3491 ...https://link.springer.com/chapter/10.1007/978-1-4684-6814-4_39
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant...
Generation of CERT knockout mice. The BayGenomics mouse (strain 129/Ola) ES cell line RRF047 was obtained and confirmed by RT- ... Generation of Certgt/gt mice. The mouse Cert gene is on chromosome 13 and is encoded by 18 exons. The transcript has a short ... Mice were genotyped by a three-primer PCR using mouse tail DNA as a template. The primer sequences used were as follows: ... Heterozygous mice were backcrossed to C57BL/6 mice and kept in a 129/Ola cross C57BL/6 background. Therefore, all of the ...http://jcb.rupress.org/content/184/1/143
JCI - A mouse model of juvenile hemochromatosis
Targeted disruption of the murine Hjv gene. We isolated Hjv genomic clones from a strain 129/SvJ mouse library (Stratagene). To ... By 6 to 7 weeks of age, Hjv-/- mice had accumulated significantly more iron than 12-week-old Hfe-/- mice of the same genetic ... However, similar to other mouse models of iron overload (refs. 23-25, and our unpublished observations), Hjv-/- mice did not ... Young, female Hjv-/- mice were fertile and able to give birth to pups that were indistinguishable from normal mice. Six- to 7- ...https://www.jci.org/articles/view/JCI25049
A germ cell origin of embryonic stem cells? | Development
Indeed, the malignant phenotype of EC cells often depends on the strain of the host mouse, and not on the tumor strain. EC ... Stevens, L. C. (1970b). Experimental production of testicular teratomas in mice of strains 129, A/He, and their F1 hybrids. J. ... Stevens, L. C. and Little, C. C. (1954). Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. ... Moreover, the culture of primitive ectoderm allows the isolation of ES cell lines from mouse strains that have been previously ...http://dev.biologists.org/content/132/2/227
Frontiers | Mouse Lipocalins (MUP, OBP, LCN) Are Co-expressed in Tissues Involved in Chemical Communication | Ecology and...
We identified new members of the mouse odorant binding protein gene family in two subspecies, M. m. musculus and M. m. ... We identified new members of the mouse odorant binding protein gene family in two subspecies, M. m. musculus and M. m. ... in the nasal and lacrimal tissues of mice with the newly detected OBPs that further expand the already diverse mouse lipocalin ... across different tissues in wild mice (Mus musculus) to assess the importance of these proteins based on their quantity in ...https://www.frontiersin.org/articles/10.3389/fevo.2016.00047/full
Frontiers | Signaling mechanisms and behavioral function of the mouse basal vomeronasal neuroepithelium | Frontiers in...
However, analysis of mutant mouse lines for signal transduction components together with identification of defined chemosensory ... ligands has revealed a fundamental role of the basal part of the mouse VNO in mediating a wide range of instinctive behaviors, ... together with identification of defined chemosensory ligands has revealed a fundamental role of the basal part of the mouse VNO ... However, analysis of mutant mouse lines for signal transduction components ...https://www.frontiersin.org/articles/10.3389/fnana.2014.00135/full
Frontiers | Gene Targeting Using Homologous Recombination in Embryonic Stem Cells: The Future for Behavior Genetics? | Genetics
One, the null mutant mice carry the null allele and the wild type mice do not, and two, the null mutant mice have strain 129 ... to a female mouse of the preferred strain origin, most often the C57BL/6 mouse to create an F1 hybrid. While this cross did ... C) Shows the genotype of gametes (sperm or egg) of the F1 mice. During meiosis, recombination will shuﬄe the strain 129-type ... Since both the heterozygous null mutant and the wild type F1 mouse has one set of chromosomes from strain 129 and the other ...https://www.frontiersin.org/articles/10.3389/fgene.2016.00043/full
Mistakes in mouse models of nonalcoholic steatophepatitis and how to avoid them
Although most models rely on C57BL/6 mice, it is important to recognize that other strains or recombinant inbred strains could ... C57BL/6J mice are more insulin resistant compared with C57BL/6N mice.13 Intriguingly, it has been reported that C57BL/6J mice ... nor C57BL/6N mice.15 This calls for awareness when selecting the supplier of any given mouse strain. ... Of note, NAFLD activity and liver fibrosis in these mice was more pronounced when compared with either parental strain, of ...https://www.ueg.eu/education/latest-news/article/article/mistakes-in-mouse-models-of-nonalcoholic-steatophepatitis-and-how-to-avoid-them/?type=title%3DLinks&cHash=98c4516fe7eac19e38b10f7843e7905d
Inhaled Anesthetic Responses of Recombinant Receptors and Knockin Mice Harboring α2(S270H/L277A) GABAA Receptor Subunits That...
1999) Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130:94-107. ... Mice were housed in a controlled environment with lights on at 7:00 AM and off at 7:00 PM. Mice had unlimited access to water ... D, HA/HA mice displayed increased performance on the fear to tone test compared with SL/SL mice after the six, but not the ... The targeting vector was created with mouse genomic DNA (Strain 129 × 1). A 6.2-kb PstI fragment containing exon 9 was isolated ...http://jpet.aspetjournals.org/content/336/1/134