To validate our findings in vivo, C57BL/6 mice were infected with H. pylori strain PMSS1 or its cagE- isogenic mutant and ... pylori strain PMSS1 and its cagE- isogenic mutant for 8 weeks (3 mice/group). Graphs show the densitometric analysis. Western ... pylori-infected mice. Mice were challenged with H. pylori strain PMSS1 (n = 8), which successfully colonizes the murine stomach ... pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We ...

congenic mice, which carry the protective Idd3. allele from a diabetes-resistant mouse strain. Further, APCs from NOD and NOD. ... Furthermore, mice with knockin of a mutant Mlk3 allele that is resistant to activation by FGD1/CDC42 displayed similar skeletal ... Disease linkage studies have revealed many susceptibility loci for T1D in mice and humans. The mouse T1D susceptibility locus ... Intramyocardial or intravenous injection of FGF23 in wild-type mice resulted in LVH, and klotho-deficient mice demonstrated ...

... in CD PRR-KO mice (Figure 8B) and by 58% in RT PRR-KO mice (Figure 8D). Subsequently, we administered sPRR-His to the 2 strains ... AVP signaling in the TAL has recently been elegantly tested by using transgenic rats expressing a dominant negative V2R mutant ... 5 mice per group). (D) Urine osmolality in CD PRR-KO mice (n = 5 mice per group). (E) Urine volume in RT PRR-KO mice (n = 6 ... 6 mice per group) (A) and RT PRR-KO mice (n = 6-7 mice per group) (B). (C) Twenty-four-hour urinary AVP excretion in floxed, CD ...

... by performing immunohistochemical analyses in 2 strains of ihCD59BEC-TGCx3cr1GFP and ihCD59BEC-TGColl1GFP double-mutant mice, ... ihCD59LIV-TG Itgb6KO double-mutant mice were generated via several steps of crossing of ihCD59LIV-TG mice with Itgb6KO mice. ... Coll1GFP mice expressing GFP under the Col1a1 promoter were described previously in the C3H/C57B1 strain (51). All mouse ... Homozygous Ccr2RFP mice were used as Ccr2-KO animals, and heterozygous Ccr2RFP mice were used as CCR2 reporter mice. Cx3cr1GFP ...

... mice was verified by Sanger sequencing of genomic DNA and mutant mice were subsequently crossed with C57BL/6J mice to generate ... F) Peak myocardial strain rate (dV/dT max) was increased in Kir6.1wt/VM mice as determined from speckle tracking measurements ... mice reveal increased diameters in mutant mice across full pressure range (n = 4 for WT, 5 for SUR2wt/AV, and 5 for SUR2AV/AV ... Reflecting the generally weaker phenotype in the SUR2-mutant mice, AI was not observed in any of 5 SUR2wt/AV mice, but was ...

Dietary obesity in nine inbred mouse strains. Am J Physiol 1992. 262:R1025-R1032. View this article via: PubMed Google Scholar ... Transplantation of mutant adipose tissue into A-ZIP/F-1 mice will enable investigation of the antidiabetic effects of fat. For ... 2 μmol/g in wild-type mice). Adult A-ZIP/F-1 mice have larger bodies and organs than wild-type mice, presumably due to the IGF- ... After surgery, the mice were housed individually for a week, and then, at 2-3 mice per cage. Tail venous blood (∼200 μL) was ...

Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol. Endocrinol. 2002. 16 ... a major limit of longevity in this strain (34). Therefore, it is tempting to speculate that Ink4a/Arf expression limits the ... p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002. 415:45-53. View this article via: PubMed ... mice (37) that had been fed ad libitum or CR diets. The age-induced expression of Ink4a/Arf in mice from this cohort of mixed ...

We next tested sNasp S158A-KI mice in a septic shock model. WT mice (C57BL/6J, n = 10) and sNasp S158A-KI mice (n = 10) ... There was a clear interaction between phosphorylation-deficient sNASP S158A mutant, but not phosphomimetic sNASP S158E mutant, ... LCMV infection model. The Armstrong strain of LCMV (LCMVarm) was propagated on BHK-21 cells and LCMV titers were determined by ... Mice. WT (C57BL/6) and sNASP S158A-KI mice were bred and maintained under pathogen-free conditions. The sNASP S158A-KI mice ...

Most inbred strains of mice do not develop atherosclerotic lesions, even when fed a high-fat, high-cholesterol diet (32-34). ... Piedrahita, JA, Zhang, SH, Hagaman, JR, Oliver, PM, Maeda, N. Generation of mice carrying a mutant apolipoprotein E gene ... mice were crossed with female HuBTg+/0 mice to generate double heterozygotes (MCP-1+/-HuBTg+/0). The latter mice were ... In general, the lesions were both thinner and less extensive in the MCP-1-/-HuBTg+/0 mice than in the MCP-1+/+HuBTg+/o mice. We ...

Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of mice. Our previous work has ... In this study, susceptibility of wild-type and lamivudine-resistant HBV M552I, M552V, and L528M/M552V mutants to other reverse ... The mean aortic lesion area was reduced by 55% in LPL-/-→C57BL/6 mice compared with LPL+/+→C57BL/6 mice and by 45% compared ... HLA-DQ6 and HLA-DQ8 transgenic mice lacking endogenous mouse class II gene expression were actively immunized and later ...

Mutant mice lacking the p53 C-terminal domain model telomere syndromes. Cell Rep. 2013;3(6):2046-2058.. View this article via: ... 24) described a strain of mice that is homozygous for a Trp53 allele that results in production of a truncated p53, which lacks ... Most of these mice died 14-43 days after birth and exhibited DC-associated features, including BM failure, dark skin, ... The PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts. PLoS Genet. 2012 ...

RRV-infected mouse treated with PBS (B), RRV-infected mouse treated with MucoRice-ARP1 (C), and RRV-infected mouse treated with ... and G12 strains (31). In this study, we showed that ARP1 produced in rice (MucoRice-ARP1) neutralizes RV strains in a range ... Tada Y, Utsumi S, Takaiwa F. Foreign gene products can be enhanced by introduction into low storage protein mutants. Plant ... All of the mice developed diarrhea and chronic infection. The litters were weaned by removing each mouse from the dam at 21 ...

... and stained with mouse monoclonal anti-Pro-Collagen I (clone PCIDG10, catalog MAB1913, Millipore) and mouse monoclonal anti- ... BMPR2-mutant) PASMC on polyacrylamide gels. Interestingly, BMPR2-mutant PASMC had significantly enhanced proliferation compared ... Traction fields, moments, and strain energy that cells exert on their surroundings. Am J Physiol Cell Physiol. 2002;282(3):C595 ... Normal and BMPR2-mutant PASMC were derived at the Cleveland Clinic Foundation from a control subject and a subject with BMPR2 ...

Mutants of both sexes showed no deficits in locomotion, but rather increased locomotion compared with WT mice (Figure 4A). We ... Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. ... In contrast to WT mice, Scn2aΔ1898/+ mice failed to show an increase in fluorescence [Ca2+] signal when mice entered the open ... mice spent more time with a novel mouse than with a novel object (Figure 4, C and D). However, male Scn2aΔ1898/+ mice spent ...

... quetiapine led to activation of wild-type GCase and reduction of α-synuclein in a GBA mutant mouse model (Gba1D409V/+ mice). ... Most H7 antibodies exhibited little heterosubtypic breadth, but many recognized a wide diversity of unrelated H7 strains. We ... To test this hypothesis, we utilized unilateral and 5/6th nephrectomy models in Shroom3-KD mice. Knockdown mice exhibited less ... mice. The CAG-hACE2 mice showed several severe symptoms of SARS-CoV-2 infection, with definitive weight loss and subsequent ...

The following fly strains used in this study were obtained from the Bloomington Drosophila Stock Center: OK371-GAL4, yw, Sodh2 ... Synaptic deficits at neuromuscular junctions in two mouse models of Charcot-Marie-Tooth type 2d. J Neurosci. 2016;36(11):3254- ... Cosens DJ, Manning A. Abnormal electroretinogram from a Drosophila mutant. Nature. 1969;224(5216):285-287.. View this article ... The following primary antibodies were used: mouse anti-BRP antibody (nc82, Developmental Studies Hybridoma Bank, NC82, 1:250), ...

Senescence is enhanced in BubR1 mutant mice that show accelerated aging phenotypes (11), and the lifelong elimination of p16 ... The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621.. View this article via: PubMed CrossRef ... ARF-DTR transgenic mice. ARF-DTR mice were generated by a pronuclear injection of C57BL/6J mouse embryos (CLEA Japan Inc.). The ... Fifteen independent transgenic founder mice were bred with C57BL/6J mice. Genomic DNA isolated from each founder mouse was ...

Mutant huntingtins effects on striatal gene expression in mice recapitulate changes observed in human Huntingtons disease ... maintained on the FVB/N strain were used. Mice were bred at the Biological Resource Centre (A*STAR) and group housed with ... WT mice were administered vehicle (ddH2O) only, whereas YAC128 HD mice were administered either vehicle (ddH2O) or an ... WT mice were administered vehicle (ddH2O) only, whereas YAC128 HD mice were administered either vehicle (ddH2O) or pridopidine ...