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*  Mibefradil - Wikipedia
Mibefradil (Posicor) is a drug for the treatment of hypertension and chronic angina pectoris. It belongs to a group known as ... The mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (T-type) ... blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil ...
https://en.wikipedia.org/wiki/Mibefradil
*  T-Type and Tetrodotoxin-Sensitive Ca2+ Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil |...
Therefore, we aimed to suppress ICa(T) with the T-type Ca2+ channel blocker mibefradil. However, mibefradil may be used as a ... This was investigated by applying mibefradil (10 μmol/L) in the presence of TTX or Ni2+. Mibefradil reversibly reduced not only ... by mibefradil was 85±2% (n=6), whereas the mean block of ICa(TTX) was 48±8% (n=5). Mibefradil blocked ICa(TTX) over the whole ... by mibefradil. We found that mibefradil not only blocked ICa(T) but also decreased ICa(TTX). Thus, the compound is not a ...
http://circres.ahajournals.org/content/86/6/628
*  State-Dependent Inhibition of Inactivation-Deficient CaV1.2 and CaV2.3 Channels By Mibefradil, The Journal of Membrane Biology ...
"State-Dependent Inhibition of Inactivation-Deficient CaV1.2 and CaV2.3 Channels By Mibefradil, The Journal of Membrane Biology ... Mibefradil significantly delayed the onset of channel recovery from inactivation in CEEE (Repeat I + part of the I-II linker ... Mibefradil significantly delayed the onset of channel recovery from inactivation in CEEE (Repeat I + part of the I-II linker ... Mibefradil inhibited the faster inactivating chimera EC(IS1-6)EEE with an IC 50= 7 ± 1 μm (n= 3), whereas the slower ...
https://www.deepdyve.com/lp/springer_journal/state-dependent-inhibition-of-inactivation-deficient-cav1-2-and-cav2-3-pKvIo0hDCV
*  Transporters | Kinase Inhibitors on Signaling Pathways
Mibefradil dihydrochloride Calcium channel blocker Mibefradil 2Hcl is calcium channel blocker with moderate selectivity for T- ... NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 ...
http://www.adooq.com/transporters.html
*  Norpramin Advanced Patient Information - Drugs.com
Detailed drug Information for Norpramin. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
https://www.drugs.com/cons/norpramin.html
*  Atenolol And Chlorthalidone (Oral Route) Precautions - Mayo Clinic
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .. Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .. Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous .. ...
https://www.mayoclinic.org/drugs-supplements/atenolol-and-chlorthalidone-oral-route/precautions/drg-20071037?p=1
*  Labetalol (Intravenous Route) Description and Brand Names - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
https://www.mayoclinic.org/drugs-supplements/labetalol-intravenous-route/description/DRG-20071176?p=1
*  Nebivolol (Oral Route) Description and Brand Names - Mayo Clinic
This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine. This medicine may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking nebivolol. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin ...
http://www.mayoclinic.org/drugs-supplements/nebivolol-oral-route/description/DRG-20071459?p=1
*  Carisoprodol, Aspirin, And Codeine (Oral Route) Description and Brand Names - Mayo Clinic
If your condition does not improve or becomes worse, check with your doctor. Do not use this medicine for more than 2 to 3 weeks (14 to 21 days) to treat pain unless your doctor told you to. Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) such as isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]) within the past 14 days. Using this medicine during late pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. This medicine can cause serious unwanted effects in your newborn baby, including neonatal withdrawal syndrome. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine. This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine ...
https://www.mayoclinic.org/drugs-supplements/carisoprodol-aspirin-and-codeine-oral-route/description/drg-20071917?p=1
*  Asymmetric hydrogenation - Wikipedia
Roche's synthesis of mibefradil was likewise improved by replacing resolution with asymmetric hydrogenation, reducing the step ... Asymmetric hydrogenation in the industrial synthesis of mibefradil Akabori, S.; Sakurai, S.; Izumi, Y.; Fujii, Y. (1956). "An ...
https://en.wikipedia.org/wiki/Asymmetric_hydrogenation
*  Calcium channel blocker - Wikipedia
These include mibefradil, bepridil, flunarizine (BBB crossing), fluspirilene (BBB crossing), and fendiline. Gabapentinoids, ... Blockade of Diverse Types of Voltage-Gated Ca2+ Channels Expressed in Xenopus Oocytes by the Ca2+ Channel Antagonist Mibefradil ...
https://en.wikipedia.org/wiki/Calcium_channel_blocker
*  R-type calcium channel - Wikipedia
2.3 channels by mibefradil". J. Membr. Biol. 184 (2): 143-59. doi:10.1007/s00232-001-0083-4. PMID 11719851. Pereverzev A, Leroy ...
https://en.wikipedia.org/wiki/R-type_calcium_channel
*  Grapefruit-drug interactions - Wikipedia
... and mibefradil (Posicor). Drugs that interact with grapefruit compounds at CYP3A4 include: benzodiazepines: triazolam (Halcion ...
https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions
*  T-type calcium channel - Wikipedia
Calcium channel blockers (CCB) such as mibefradil can also block L-type calcium channels, other enzymes, as well as other ...
https://en.wikipedia.org/wiki/T-type_calcium_channel
*  Bepridil - Wikipedia
... blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil ...
https://en.wikipedia.org/wiki/Bepridil
*  List of drugs: Meu-Mi - Wikipedia
... mibefradil (INN) mibolerone (INN) miboplatin (INN) Micardis micinicate (INN) miconazole (INN) Micort-HC Micrainin Micro-K ...
https://en.wikipedia.org/wiki/List_of_drugs:_Meu-Mi
*  List of MeSH codes (D03) - Wikipedia
... mibefradil MeSH D03.438.103.637 --- nocodazole MeSH D03.438.103.675 --- omeprazole MeSH D03.438.103.732 --- pimozide MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
*  Felodipine - Wikipedia
... mibefradil 41, felodipine 12; nifedipine 7, amlodipine 5, and verapamil 0.2. Felodipine is a member of the 1,4-dihydropyridine ...
https://en.wikipedia.org/wiki/Felodipine
*  FIASMA - Wikipedia
Fluvoxamine Hydroxyzine Imipramine Lofepramine Loperamid Loratadin Maprotiline Mebeverine Mebhydrolin Mepacrine Mibefradil ...
https://en.wikipedia.org/wiki/FIASMA
*  ATC code C08 - Wikipedia
... combinations C08CX01 Mibefradil C08DA01 Verapamil C08DA02 Gallopamil C08DA51 Verapamil, combinations C08DB01 Diltiazem C08EA01 ...
https://en.wikipedia.org/wiki/ATC_code_C08
*  List of MeSH codes (D04) - Wikipedia
... mibefradil MeSH D04.615.638.960.675 --- podophyllotoxin MeSH D04.615.638.960.675.250 --- etoposide MeSH D04.615.638.960.837 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)
*  Mibefradil dihydrochloride | C29H40Cl2FN3O3 - PubChem
Mibefradil dihydrochloride , C29H40Cl2FN3O3 , CID 60662 - structure, chemical names, physical and chemical properties, ...
https://pubchem.ncbi.nlm.nih.gov/compound/60662
*  Mibefradil (Ro 40-5967) inhibits several Ca2+ and K+ currents in human fusion-competent myoblasts | Archive ouverte UNIGE
The IC50 of mibefradil for I(Ca)(T) and I(Ca)(L) are 0.7 and 2 microM, respectively. 3. At low concentrations, mibefradil ... LIU, J. H. et al. Mibefradil (Ro 40-5967) inhibits several Ca2+ and K+ currents in human fusion-competent myoblasts. In: ... 1. The effect of mibefradil (Ro 40-5967), an inhibitor of T-type Ca2+ current (I(Ca)(T)), on myoblast fusion and on several ... 4. Mibefradil blocked three voltage-gated K+ currents expressed by human fusion-competent myoblasts: a delayed rectifier K+ ...
https://archive-ouverte.unige.ch/unige:10335
*  SPHINX - Drugs - Mibefradil
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https://www.emergesphinx.org/drugs/mibefradil