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*  Targets
metalloendopeptidase activity. 115 , 115 unfolded protein binding. 113 , 113 integrin binding. 112 , 112 ...
https://pharos.nih.gov/idg/targets?facet=GO+Function/NAD-dependent+histone+deacetylase+activity+%28H3-K14+specific%29
*  Targets
metalloendopeptidase activity. 112 , 112 transcriptional repressor acti.... 110 , 110 structural constituent of cyto.... 108 , ...
https://pharos.nih.gov/idg/targets?facet=GO+Function/delta4-3-oxosteroid+5beta-reductase+activity
*  Astacin-like metalloendopeptidase
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity ...
https://pharos.nih.gov/idg/targets/Q6HA08
*  Primary biliary cirrhosis
Membrane metallo-endopeptidase-like 1. Tchem. Enzyme. Transportin-3. Tbio. Non-IDG. ...
https://pharos.nih.gov/idg/diseases/umls:C0008312
*  Targets
metalloendopeptidase activity. 115 , 115 unfolded protein binding. 113 , 113 histone binding. 111 , 111 ...
https://pharos.nih.gov/idg/targets?facet=GO+Function/integrin+binding
*  Targets
Astacin-like metalloendopeptidase. ASTL Tbio. Enzyme. -1.41302. 25.0. 29. Proto-oncogene tyrosine-protein kinase Src. SRC Tclin ...
https://pharos.nih.gov/idg/targets?facet=GO+Process/positive+regulation+of+protein+processing
*  Disintegrin and metalloproteinase domain-containing protein 18
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016 ...
https://pharos.nih.gov/idg/targets/Q9Y3Q7
*  Disintegrin and metalloproteinase domain-containing protein 19
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013 ...
https://pharos.nih.gov/idg/targets/Q9H013
*  A disintegrin and metalloproteinase with thrombospondin motifs 14
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016 ...
https://pharos.nih.gov/idg/targets/ADAMTS14
*  Matrix metalloproteinase-26
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016 ...
https://pharos.nih.gov/idg/targets/Q9NRE1
*  Kell blood group glycoprotein
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/KEL
*  Membrane-bound transcription factor site-2 protease
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009 ...
https://pharos.nih.gov/idg/targets/O43462
*  A disintegrin and metalloproteinase with thrombospondin motifs 10
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/Q9H324
*  Transmembrane protease serine 6
Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis ...
https://pharos.nih.gov/idg/targets/Q8IU80
*  Membrane-bound transcription factor site-1 protease
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014 ...
https://pharos.nih.gov/idg/targets/MBTPS1
*  Endothelin-converting enzyme-like 1
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014 ...
https://pharos.nih.gov/idg/targets/O95672
*  CAAX prenyl protease 1 homolog
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/O75844
*  Disintegrin and metalloproteinase domain-containing protein 20
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/O43506
*  Mitochondrial intermediate peptidase
The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/MIPEP
*  Matrix metalloproteinase-27
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/Q9H306
*  A disintegrin and metalloproteinase with thrombospondin motifs 19
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/Q8TE59
*  Matrix metalloproteinase-21
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013 ...
https://pharos.nih.gov/idg/targets/Q8N119
*  Disintegrin and metalloproteinase domain-containing protein 23
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013 ...
https://pharos.nih.gov/idg/targets/O75077
*  Disintegrin and metalloproteinase domain-containing protein 17
metalloendopeptidase activity 115 metallopeptidase activity 62 Notch binding 21 interleukin-6 receptor binding 5 ...
https://pharos.nih.gov/idg/targets/P78536
*  Paraplegin
This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2014 ...
https://pharos.nih.gov/idg/targets/SPG7