Metabolic Detoxication, DrugMetabolic Networks and Pathways • Metabolome • Metamorphosis • Metamorphosis, Biological • ... Currently metabolic networks (e.g. folate metabolism) are being used to develop a deeper understanding of the functional ... Currently metabolic networks (e.g. folate metabolism) are being used to develop a deeper understanding of the functional ... Callier, V; Nijhout, HF, Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the ...
Metabolic Detoxication, Drug. Pupa / drug effects, physiology. Respiration / drug effects*. Respiratory Physiological Phenomena ...
Metabolic Syndrome Drug: Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin Dietary Supplement: Analimentary detoxication ... MedlinePlus related topics: Metabolic Syndrome Drug Information available for: Diltiazem Orlistat Atorvastatin Diltiazem malate ... Experimental: Analimentary detoxication Weight loss Vegetables and salt diet. Dietary Supplement: Analimentary detoxication ... Metabolic Syndrome. Disease. Pathologic Processes. Insulin Resistance. Hyperinsulinism. Glucose Metabolism Disorders. Metabolic ...
Vincent-Viry M, Fournier B, and Galteau MM (2000) The effects of drinking and smoking on the CYP2D6 metabolic capacity. Drug ... Williams RT (1959) Detoxication Mechanisms. John Wiley & Sons Inc., New York.. *↵ Wilson ID, Nicholson JK, Castro-Perez J, ... In turn, this may have implications for studies in which the metabolic ratio is correlated with the metabolism of a second drug ... both metabolic and nonmetabolic, that surely dictate the pattern of urinary metabolites of a drug such as debrisoquine. The ...
Metabolic Detoxication, Phase I. Functionalization of exogenous substances to prepare them for conjugation in PHASE II ... Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS. ... All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology ... All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology ...
Metabolic Detoxication, Phase I. Functionalization of exogenous substances to prepare them for conjugation in PHASE II ... Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS. ... RATIONALE: Drugs used in chemotherapy, such as E7389, work in different ways to stop the growth of tumor cells, either by ... All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology ...
... detoxication explanation free. What is detoxication? Meaning of detoxication medical term. What does detoxication mean? ... Looking for online definition of detoxication in the Medical Dictionary? ... metabolic detoxification reduction of the toxic properties of a substance by chemical changes induced in the body, producing a ... 2. treatment designed to assist in recovery from the toxic effects of a drug. ...
The major organ for drug metabolism is the liver. The metabolic products are often less active than the parent drug or inactive ... Thus drug metabolism may include both "detoxication" and "toxication" processes. One of the major enzyme systems that determine ... For each experiment, controls (containing no drug) and a blank incubation (containing no cells or drugs) were run in parallel. ... For each experiment, controls (containing no drug) and a blank incubation (containing no cells or drugs) were run in parallel. ...
Metabolic and Detoxication Mechanisms. (3-0). Credit 3. Fate of foreign compounds; their inhibitory and antagonistic action ... physiochemical or physiologic effects of drugs at sites from molecular to whole body. Prerequisite: Approval of instructor. ... toward normal metabolic processes of the animal body. Prerequisites: BICH 603; approval of instructor and department head. ...
Implications for the catechol-O-methyl transferase-mediated detoxication of catechol estrogens. Drug Metab Dispos 24: 588-594. ... Metabolic pathway model and functional annotations. Metabolic reactions were imported from three independent human metabolic ... The comprehensive metabolic picture provided by GGMs in combination with GWAS allows for the detailed analysis of metabolic ... Acharya KR, Sturrock ED, Riordan JF, W MR (2003) Ace revisited: a new target for structure-based drug design. Nat Rev Drug ...
The term drug is used here in its widest sense and includes any... ... In this report I will give a brief overview of drug-dependent metabolic reactions that can generate reactive oxygen species in ... D.S. Hewick, Reductive metabolism of nitrogen-containing functional groups, In: "Metabolic Basis of Detoxication," W.B. Jakoby ... In this report I will give a brief overview of drug-dependent metabolic reactions that can generate reactive oxygen species in ...
... the biliary excretion of drugs was extensively studied as were species differences in drug metabolism and detoxication. Besides ... In particular, the concepts of phase 1 and phase II metabolic pathways were introduced by Williams; ... Drug metabolism; detoxication; history; toxicology; xenobiotics National Category Health Sciences Identifiers. URN: urn:nbn:se: ... Faculty of Medicine and Health SciencesDivision of Drug Research In the same journal. Drug metabolism reviews (Softcover ed.) ...
... detoxication by inducible cytochrome P450 is more important than metabolic activation". Molecular Pharmacology. 65 (5): 1225-37 ... Ma Q, Lu AY (Jul 2007). "CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies". Drug ... He J, Wang C, Zhu Y, Ai D (Dec 2015). "Soluble epoxide hydrolase: A potential target for metabolic diseases". Journal of ... CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by ...
... metabolism of the antimalarial drug amodiaquine was investigated in order to gain further insight into the postulated metabolic ... Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.. Jewell H1, Maggs JL, Harrison AC, ONeill PM ... After intraportal (i.p.) administration (54 mumol/kg) to the anaesthetized rat, the drug was excreted in bile (23 +/- 3% dose ... 6. Substitution of a fluorine for the phenolic hydroxyl group in amodiaquine blocked bioactivation of the drug in vivo. ...
Metabolic Detoxication, Drug. Oxidation-Reduction. Oxidative Stress. Related mentions per year. Related mentions per year. 1936 ...
1991) Metabolic aspects of peroxisomal β-oxidation. Biochim Biophys Acta 1085:141-158. ... It has even been suggested that the primary function of peroxisomal β-oxidation is detoxication (Osmundsen et al., 1991). ... 1982) The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Drug Metab ... 1985) Studies on the β-oxidative metabolism of Δ1- and Δ6-tetrahydrocannabinol in the mouse. Drug Metab Dispos 13:215-219. ...
... detoxication by inducible cytochrome P450 is more important than metabolic activation". Molecular Pharmacology. 65 (5): 1225-37 ... Beresford, AP (1993). "CYP1A1: friend or foe?". Drug Metab Rev. 25 (4): 503-17. doi:10.3109/03602539308993984. PMID 8313840. ...
Williams, R.T. (1959) Detoxication Mechanisms: The Metabolism and Detoxication of Drugs, Toxic Substances and Other Organic ... Drug Metab. Disposition, 16, 721-727. Duterte-Catella, H., Nguyen, P., Dang, Q. & Truhaut, R. (1978) Metabolic transformations ... Williams, R.T. (1939) Studies in detoxication. III. The use of the glucuronic acid detoxication mechanism of the rabbit for the ... and the metabolic fate of trans-methyl styryl ketone in the male Fischer 344 rat. Drug Metab. Disposition, 25, 732-739. Savary ...
Booser D. J., Hortobagyi G. N. Anthracycline antibiotics in cancer therapy: focus on drug resistance. Drugs, 47: 223-258, 1994. ... Bartoszek A. Metabolic activation of Adriamycin by NADPH-cytochrome P450 reductase: overview of its biological and biochemical ... it is important to keep in mind that CYPRED also plays an important role in the detoxication of this anthracycline via the ... 4A) ⇓ . As a positive control, we also tested the MDA231 cell lines for their sensitivity to tirapazamine, a drug that is known ...
... or cytochrome P-450 detoxication of xenobiotics are metabolic processes which can lead to increased production of ROS causing ... drugs, toxins, radiation, hypoxia, and hyperoxia [14]. In ESRD patients, kidney filtration is significantly impaired, which ... Physical activity increases metabolic processes and free radicals are the by-product of intensified mitochondrial processes. ... and metabolic acidosis [3]. Numerous studies, however, emphasize that what lies at the root of CVD pathogenesis is oxidative ...
... intermediates in metabolic pathways, drugs and other environmental factors, integrating homeostatic control over many metabolic ... Concerning anticancer agents, CYPs are involved not only in cytotoxic drugs detoxication but also in the activation of prodrugs ... modification of drug target expression or function, drug compartmentalization in cellular organelles, altered repair of drug- ... 3. Anticancer drug metabolism and resistance. 3.1. Anticancer drug metabolism. In vivo, after absorption in the organism, ...
Detoxication of Xenobiotics. Kulinskii, V.I.. * Genetic Factors in Drug Therapy: Clinical and Molecular Pharmacogenetics ... Aromatic DNA Adducts in Coke-Oven Workers, in Relation to Exposure, Lifestyle and Genetic Polymorphism of Metabolic Enzymes ... Polymorphisms in Drug-Metabolizing Enzymes: What Is Their Clinical Relevance and Why Do They Exist ... Urinary 1-Hydroxypyrene in Coke-Oven Workers Relative to Exposure, Alcohol Consumption, and Metabolic Enzymes ...
White IN (2003) Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans. Curr Drug ... Comparative metabolic capabilities of CYP3A4, CYP3A5 and CYP3A7. Drug Metab Dispos 30: 883-891. ... Together, our data point to an important role of CYP3A in all metabolic routes of N-desmethyl- and 4-hydroxy-TAM, except in N- ... Prior to metabolic incubation, the methanol was evaporated to dryness under reduced pressure using a Speedvac SC110 Model RH40- ...
... the difficulty in predicting whether metabolism will result in detoxication or activation, the different metabolic roles of ... and the hepatotoxic drugs: benoxaprofen and tienilic acid. Two novel methods for the prospective evaluation of chemical ...