Mesangial CellsGlomerular MesangiumCells, CulturedKidney GlomerulusGlomerulonephritis, MembranoproliferativeGlomerulonephritisGlomerulonephritis, IGADiabetic NephropathiesRNA, MessengerTransforming Growth Factor betaAntigens, Thy-1Rats, Sprague-DawleyCell DivisionPlatelet-Derived Growth FactorCollagen Type IVTransforming Growth Factor beta1Glomerulosclerosis, Focal SegmentalFibronectinsInterleukin-1GlucoseKidneyExtracellular MatrixNephritisProtein Kinase CGene ExpressionAngiotensin IIEnzyme ActivationHypertrophyPodocytesCollagenProteinuriaMitogen-Activated Protein KinasesConnective Tissue Growth FactorSignal TransductionImmune Complex DiseasesEnzyme InhibitorsExtracellular Matrix ProteinsDiabetes Mellitus, ExperimentalPhospholipases ARats, WistarPhosphorylationPhospholipases A2Dose-Response Relationship, DrugThymidineGene Expression RegulationChemokine CCL2Blotting, WesternIsoantibodiesUp-RegulationBlotting, NorthernProto-Oncogene Proteins c-sisImmunoglobulin ANeutral CeramidaseDinoprostoneKidney DiseasesGroup II Phospholipases A2EndothelinsDNAIntercellular Signaling Peptides and ProteinsLupus NephritisIsoenzymesTrimeresurusFluorescent Antibody TechniqueImmunohistochemistryEndothelin-1Nitric OxideIntegrin alpha1beta1Mitogen-Activated Protein Kinase 1ActinsNitric Oxide SynthaseApoptosisCollagen Type INephrotic SyndromeReverse Transcriptase Polymerase Chain ReactionBasement MembraneReactive Oxygen SpeciesImmediate-Early ProteinsRats, Inbred StrainsHyperglycemiaAntibodiesCulture Media, ConditionedPurinergic AgonistsNF-kappa BTetradecanoylphorbol AcetatePlasminogen Activator Inhibitor 1Tumor Necrosis Factor-alphaCell LineMitogen-Activated Protein Kinase 13Base SequenceCalcium-Calmodulin-Dependent Protein KinasesTime FactorsCalciumNitric Oxide Synthase Type IITranscription Factor AP-1Receptors, AngiotensinCyclic AMPp38 Mitogen-Activated Protein KinasesAlbuminuriaThrombospondin 1Cell Line, Transformed