Identifying how Merkel cell polyomavirus infection can cause a lethal carcinomaIdentifying how Merkel cell polyomavirus infection can cause a lethal carcinoma

... merkel_cell_polyomavirus_can_lead_to_merkel_cell_carcinoma_in_immunecompromised_individuals_researchers_have_now_identified_a_ ... type_of_skin_cell_as_the_target_of_the_virus_in_humans_this_study_from_the_perelman_school_of_medicine_at_the_university_of_ ... Specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. ... catenin proteins stimulate Merkel cell polyomavirus infection. "This suggests that Merkel cell carcinoma risk factors such as ...
more infohttp://www.biologynews.net/archives/2016/05/31/identifying_how_merkel_cell_polyomavirus_infection_can_cause_a_lethal_carcinoma.html

Cancers | Free Full-Text | Phosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus ReplicationCancers | Free Full-Text | Phosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus Replication

... was recently discovered as a novel human polyomavirus that is associated with ~80% of Merkel Cell Carcinomas. The Large Tumor ... LT activity is regulated and provides tools for better exploring this regulation in both natural host cells and Merkel cells. ... Although the natural host cell of MCPyV has not yet been established, this work provides a foundation for understanding how ... Phosphorylation plays a critical regulatory role for polyomavirus LT proteins, but no investigation of MCPyV LT phosphorylation ...
more infohttp://www.mdpi.com/2072-6694/6/3/1464

Cancers | Free Full-Text | Phosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus ReplicationCancers | Free Full-Text | Phosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus Replication

... was recently discovered as a novel human polyomavirus that is associated with ~80% of Merkel Cell Carcinomas. The Large Tumor ... LT activity is regulated and provides tools for better exploring this regulation in both natural host cells and Merkel cells. ... Although the natural host cell of MCPyV has not yet been established, this work provides a foundation for understanding how ... Phosphorylation plays a critical regulatory role for polyomavirus LT proteins, but no investigation of MCPyV LT phosphorylation ...
more infohttp://www.mdpi.com/2072-6694/6/3/1464/xml

Figure - Merkel Cell Polyomavirus in Cutaneous Swabs - Volume 16, Number 4-April 2010 - Emerging Infectious Disease journal -...Figure - Merkel Cell Polyomavirus in Cutaneous Swabs - Volume 16, Number 4-April 2010 - Emerging Infectious Disease journal -...

... we analyzed swabs from persons with Merkel cell carcinoma (MCC), others with skin diseases, and healthy volunteers. MCPyV was ... To assess the usefulness of using cutaneous swabs to detect Merkel cell polyomavirus (MCPyV) DNA, ... Merkel Cell Polyomavirus in Cutaneous Swabs Vincent Foulongne. , Nicolas Kluger, Olivier Dereure, Grégoire Mercier, Jean-Pierre ... Comparison of Merkel cell polyomavirus DNA levels in cutaneous swabs obtained from 46 study participants. A) Patients with ...
more infohttps://wwwnc.cdc.gov/eid/article/16/4/09-1278-f1

JCI -
Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirusJCI - Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus

A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) ... Western blot with Ab3 or CM2B4 of cell lysates prepared from MCC cell lines showing a predominant signal for truncated large T ... MCPyV genome copy number in cell lines with indicated qPCR primer sets. All values were normalized to MKL-2. Error bars ... genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated ...
more infohttps://www.jci.org/articles/view/64116/figure/1

Role of a new polyomavirus in Merkel cell carcinoma - Patrick MooreRole of a new polyomavirus in Merkel cell carcinoma - Patrick Moore

We have recently discovered a new human polyomavirus monoclonally-integrated into human Merkel cell carcinomas (MCC) that we ... 2015) Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse ... 2015) Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression. J Gen Virol 96: ... Role of a new polyomavirus in Merkel cell carcinoma Moore, Patrick S. University of Pittsburgh, Pittsburgh, PA, United States ...
more infohttp://grantome.com/grant/NIH/R01-CA136806-04

Merkel Cell Carcinoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - North Kansas City Hospital, Kansas...Merkel Cell Carcinoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - North Kansas City Hospital, Kansas...

... primary small cell carcinoma of the skin, primary cutaneous neuroendocrine tumor, and malignant trichodiscoma.[2] MCC is an ... Merkel cell carcinoma (MCC) was originally described by Toker in 1972 as trabecular carcinoma of the skin.[1] Other names ... Kassem A, Schöpflin A, Diaz C, et al.: Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and ... Sihto H, Kukko H, Koljonen V, et al.: Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell ...
more infohttps://www.nkch.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000062884

Avelumab for metastatic Merkel cell carcinoma after chemotherapy. Avelumab for metastatic Merkel cell carcinoma after...Avelumab for metastatic Merkel cell carcinoma after chemotherapy. Avelumab for metastatic Merkel cell carcinoma after...

This is a unique tumour in that it is associated with a virus thats been called the Merkel cell polyomavirus and somewhere ... Interestingly, the presence of the Merkel cell polyomavirus did not have any impact on responses. ... So T-cells and will then cause deletion of those T-cells or at least the energy of those T-cells and really prevent clearance ... group that many Merkel cell carcinomas were associated with the expression of PD-L1 either on the tumour cell or other cells ...
more infohttp://ecancer.org/video/5866/avelumab-for-metastatic-merkel-cell-carcinoma-after-chemotherapy.php

Merkel Cell Cancer: June 2009Merkel Cell Cancer: June 2009

Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas.. Br J Dermatol. 2009 May. Varga E, Kiss M, Szabó K, Kemény ... Labels: basal cell, basosquamous carcinomas, Merkel Cell Carcinoma, polymerase chain reaction, polyomavirus, squamous cell, ... Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC ... Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid ...
more infohttp://merkelcellcancer.blogspot.com/2009/06/

Merck Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma | Pressemitteilung...Merck Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma | Pressemitteilung...

MCC also is associated with the presence of the Merkel cell polyomavirus, which may have a role in tumor formation.[6] Globally ... About Merkel cell carcinoma (MCC) MCC is a rare and aggressive disease in which cancer cells form in the top layer of the skin ... Merck Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma. 29.07.2014 - 08: ... Merkel cell carcinoma (mMCC) - mMCC is a rare and aggressive skin cancer lacking effective treatments - MSB0010718C is also ...
more infohttps://www.presseportal.de/pm/68084/2794762

Findings Support Use of Avelumab in Metastatic Merkel Cell CarcinomaFindings Support Use of Avelumab in Metastatic Merkel Cell Carcinoma

... according to findings from the phase II JAVELIN Merkel 200 trial presented at the 2016 ASCO Annual Meeting. ... Avelumab showed early positive survival data and lasting responses for patients with pretreated advanced or metastatic Merkel ... Overall, 65.9% of patients were PD-L1-positive and 52.3% were positive for the Merkel cell polyomavirus (MCPyV). Eight percent ... in patients with metastatic Merkel cell carcinoma previously treated with chemotherapy: Results of the phase 2 JAVELIN Merkel ...
more infohttp://www.targetedonc.com/conference/asco-immune-2016/findings-support-use-of-avelumab-in-metastatic-merkel-cell-carcinoma

Merkel Cell Carcinoma of Lymph Node Without Skin Primary Can - and Should - Be Distinguished from Others Metastatic...Merkel Cell Carcinoma of Lymph Node Without Skin Primary Can - and Should - Be Distinguished from Others Metastatic...

69 Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas. Introduction: Merkel cell ... Keywords: Merkel cell polyoma virus, Merkel cell carcinoma, neuroendocrine skin cancer, FISH, large T antigen ... 634 Merkel Cell Carcinoma in a Nine-Year-Old Girl. Introduction: Merkel cell carcinoma (MCC) of the skin is a rare ... 703 Cutaneous Merkel Cell Carcinoma Treatment: Our Experience. Introduction: Merkel cell carcinoma (MCC) is a rare ...
more infohttps://www.enets.org/merkel-cell-carcinoma-of-lymph-node-without-skin-primary-can-and-should-be-distinguished-from-others-metastatic-neuroendocrine-carcinoma.html

Merkel Cell Cancer - Premilife - Homeopathic RemediesMerkel Cell Cancer - Premilife - Homeopathic Remedies

The majority of Merkel cell carcinomas appear to be caused in part by a newly discovered virus, Merkel cell polyomavirus or MCV ... inhibition of MCV proteins causes MCV-infected Merkel carcinoma cells to die but has no effect on tumor cells from Merkel cell ... Merkel cell carcinoma (also known as a "Cutaneous apudoma," "Primary neuroendocrine carcinoma of the skin," Primary small cell ... Merkel cell carcinoma (also known as a "Cutaneous apudoma," "Primary neuroendocrine carcinoma of the skin," Primary small cell ...
more infohttps://www.premilife.com/diseases/skin-hair-and-nails/merkel-cell-cancer/

Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma - Full Text View - ClinicalTrials.govCabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma - Full Text View - ClinicalTrials.gov

Polyomavirus Infections. DNA Virus Infections. Virus Diseases. Tumor Virus Infections. Carcinoma, Neuroendocrine. ... Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma. The safety and scientific validity of this study is the ... Carcinoma, Merkel Cell. Carcinoma. Skin Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms ... Must have histologically or cytologically confirmed Merkel Cell Carcinoma that is metastatic or unresectable and for which ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02036476

Merkel Cell Cancer: January 2013Merkel Cell Cancer: January 2013

Labels: Merkel Cell Carcinoma, Merkel cell polyomavirus MCPyV, neuroendocrine cells, orgin cells, skin, skin tumour ... Merkel cell carcinomas and 0/10 (0%) pulmonary small cell carcinomas. TdT was expressed in 21/27 (78%) Merkel cell carcinomas ... We report 2 cases of incipient Merkel cell carcinoma. Both cases of incipient Merkel cell carcinoma measured approximately 5mm ... Labels: CD8 lymphocyte infiltration, Merkel Cell Carcinoma, polyomavirus-linked skin cancer, T cell, Vascular E-selectin ...
more infohttp://merkelcellcancer.blogspot.com/2013_01_01_archive.html

Merkel cell polyomavirus - WikipediaMerkel cell polyomavirus - Wikipedia

"Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens". Journal of Virology. 84 ... 2009). "Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and ... 2009). "Merkel Cell Polyomavirus Expression in Merkel Cell Carcinomas and Its Absence in Combined Tumors and Pulmonary ... "Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the ...
more infohttps://en.wikipedia.org/wiki/Merkel_cell_polyomavirus

LT-Ag - Large T antigen - Merkel cell polyomavirus - LT-Ag gene & proteinLT-Ag - Large T antigen - Merkel cell polyomavirus - LT-Ag gene & protein

tr,B8ZX42,B8ZX42_9POLY Large T antigen OS=Merkel cell polyomavirus OX=493803 GN=LT-Ag PE=4 SV=1 ... Merkel cell polyomavirus. 260. UniRef100_B8ZX42. Truncated large T antigen (Fragment). Merkel cell polyomavirus ...
more infohttps://www.uniprot.org/uniprot/B8ZX42

Merkel cell carcinoma subgroups by merkel cell polyomavirus DNA relative abundance and oncogene expression | RTIMerkel cell carcinoma subgroups by merkel cell polyomavirus DNA relative abundance and oncogene expression | RTI

... was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically heterogeneous malignancy of dermal ... to characterize immunohistochemical staining of candidate tumor cell proteins and a quantitative PCR assay to detect MCPyV and ... neuroendocrine cells. To investigate this heterogeneity, we developed a tissue microarray (TMA) ... Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically ...
more infohttps://www.rti.org/publication/merkel-cell-carcinoma-subgroups-merkel-cell-polyomavirus-dna-relative-abundance-and

Case-control Study of Merkel Cell Polyomavirus Infection and Cutaneous Squamous Cell Carcinoma | Cancer Epidemiology,...Case-control Study of Merkel Cell Polyomavirus Infection and Cutaneous Squamous Cell Carcinoma | Cancer Epidemiology,...

Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. J Natl Cancer Inst 2009;101:1510-22. ... Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas. Br J Dermatol 2009;161:930-2. ... Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest ... Merkel cell polyomavirus (MCV) was first discovered in Merkel cell carcinoma (MCC) tumor tissues, with 80% of MCC tissues ...
more infohttp://cebp.aacrjournals.org/content/21/1/74

Design of potential siRNA molecules for T antigen gene silencing of Merkel Cell PolyomavirusDesign of potential siRNA molecules for T antigen gene silencing of Merkel Cell Polyomavirus

Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell ... Design of potential siRNA molecules for T antigen gene silencing of Merkel Cell Polyomavirus. Kazi Muhammad Ahasanul Hoque,* Md ... polyomavirus (MCV) is clonally integrated in 80% of MCC tumors. Genetic studies of MCV have shown that T antigen protein is ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC3488834/?report=abstract

Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma - Volume 15, Number 9-September 2009 - Emerging...Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma - Volume 15, Number 9-September 2009 - Emerging...

... of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) ... Merkel cell polyomavirus (MCPyV) DNA was detected in 88% ... Merkel cell polyomavirus and Merkel cell carcinoma, France. ... Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma. Emerging Infectious Diseases. 2009;15(9):1496-1498. doi: ... Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. ...
more infohttps://wwwnc.cdc.gov/eid/article/15/9/08-1575_article

Welcome to CDC stacks | Merkel Cell Polyomavirus in Cutaneous Swabs - 18070 | Emerging Infectious DiseasesWelcome to CDC stacks | Merkel Cell Polyomavirus in Cutaneous Swabs - 18070 | Emerging Infectious Diseases

Merkel Cell Carcinoma Merkel Cell Polyomavirus Merkel Cells Middle Aged Polyomavirus Polyomavirus Infections Skin Skin Diseases ... Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. ... To assess the usefulness of using cutaneous swabs to detect Merkel cell polyomavirus (MCPyV) DNA, we analyzed swabs from ... We investigated the presence of 4 human polyomaviruses (PyVs) (WU, KI, Merkel cell, and Malawi) in respiratory specimens from a ...
more infohttps://stacks.cdc.gov/view/cdc/18070

Merkel Cell Polyomavirus Infection, Large T Antigen, Retinoblastoma Protein and Outcome in Merkel Cell Carcinoma | Clinical...Merkel Cell Polyomavirus Infection, Large T Antigen, Retinoblastoma Protein and Outcome in Merkel Cell Carcinoma | Clinical...

Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol 2010;84:7064-72. ... Merkel Cell Polyomavirus Infection, Large T Antigen, Retinoblastoma Protein and Outcome in Merkel Cell Carcinoma. Harri Sihto, ... Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression. Int J Cancer 2010; ... Purpose: Merkel cell carcinoma (MCC) is rare skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) ...
more infohttps://clincancerres.aacrjournals.org/content/17/14/4806

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell...Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell...

ABSTRACT Merkel cell polyomavirus is the primary etiological agent of the aggressive skin cancer Merkel cell carcinoma (MCC). ... Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell ... "Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell ... Collectively, our studies indicate that Merkel cell polyomavirus is capable of hijacking cellular processes and driving ...
more infohttps://dash.harvard.edu/handle/1/30371064

Epitopes of Merkel Cell PolyomavirusEpitopes of Merkel Cell Polyomavirus

MD of Seattle Cancer Care Alliance explains what epitopes are in merkel cell carcinoma. This was recorded at the 2017 ASCO ... Tags: Kelly Garneski Paulson MD Seattle Cancer Care Alliance Epitopes Merkel Cell Polyomavirus Merkel Cell Carcinoma T-Cells ... Description: Kelly Garneski Paulson, MD of Seattle Cancer Care Alliance explains what epitopes are in merkel cell carcinoma. ... Epitopes of Merkel Cell Polyomavirus - 102164. .page{ clear:both;background: white;min-height:1349px;padding: 10px; } .rssdog ...
more infohttp://www.oncologytube.com/video/epitopes-of-merkel-cell-polyomavirus/10001607