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*  IDEALS @ Illinois: Re-localization of SNARE proteins in mouse sperm prior to the acrosome reaction
The principal role of SNARE proteins is to arbitrate vesicle fusion to a target membrane. Formation of tripartite SNARE protein ... re-localize within the sperm plasma membrane prior to the acrosome reaction to form SNARE complexes and promote membrane fusion ... complexes between SNARE proteins on opposing membranes is the minimal requirement for membrane fusion. The SNARE protein family ... During the sperm acrosome reaction, the outer acrosomal membrane fuses at hundreds of points with the overlying plasma membrane ...
https://www.ideals.illinois.edu/handle/2142/78670
*  Respiratory Syncytial Virus fusion protein Antibody (10B6) [DyLight 488] (NB100-63020G): Novus Biologicals
Mouse Monoclonal Anti-Respiratory Syncytial Virus fusion protein Antibody (10B6) [DyLight 488]. Validated: ELISA, Flow. Tested ... Recognises the Respiratory Syncytial Virus (RSV) Fusion protein, also known as F-protein. The F-protein is a membrane- ... Additional Respiratory Syncytial Virus fusion protein Products. Respiratory Syncytial Virus fusion protein NB100-63020G * ... Blogs on Respiratory Syncytial Virus fusion protein. There are no specific blogs for Respiratory Syncytial Virus fusion protein ...
https://www.novusbio.com/products/respiratory-syncytial-virus-fusion-protein-antibody-10b6_nb100-63020g
*  Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release | JCB
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. EMBO J. 13:5051-5061. ... SNAREs-engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 7:631-643. ... SNARE-mediated membrane fusion. Nat. Rev. Mol. Cell Biol. 2:98-106. ... Membrane fusion. SNARE the rod, coil the complex. Nature. 395:328-329. ...
http://jcb.rupress.org/content/183/2/323
*  VAPA - Wikipedia
This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative ... The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles ... Vesicle-associated membrane protein-associated protein A is a protein that in humans is encoded by the VAPA gene. Together with ... Weir ML, Klip A, Trimble WS (Sep 1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)- ...
https://en.wikipedia.org/wiki/VAPA
*  Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis |...
Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, College of Life Science, South‐Central ... synaptic vesicle fusion. *syntaxin. *Received September 22, 2016.. *Revision received January 1, 2017. ... Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, College of Life Science, South‐Central ... Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, College of Life Science, South‐Central ...
http://d2ni3bh4dzb2ig.cloudfront.net/content/early/2017/02/01/embj.201695775
*  Studies of membrane fusion. VI. Mechanism of the membrane fusion and cell swelling stages of Sendai virus-mediated cell fusion ...
Sites of membrane fusion have been detected in human erythrocytes arrested at the membrane fusion stage of cell fusion and in ... Studies of membrane fusion. VI. Mechanism of the membrane fusion and cell swelling stages of Sendai virus-mediated cell fusion ... Studies of membrane fusion. VI. Mechanism of the membrane fusion and cell swelling stages of Sendai virus-mediated cell fusion ... Studies of membrane fusion. VI. Mechanism of the membrane fusion and cell swelling stages of Sendai virus-mediated cell fusion ...
http://jcs.biologists.org/content/43/1/103
*  Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. | Department of...
... which in turn promoted fusogenic protein engagement and plasma membrane fusion. This de novo cell fusion culture system reveals ... Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion.. ... it remains unclear whether and how they coordinate to promote plasma membrane fusion. We reconstituted a high-efficiency, ... Cell-cell fusion is critical for the conception, development, and physiology of multicellular organisms. Although cellular ...
http://mbg.jhmi.edu/research/actin-propelled-invasive-membrane-protrusions-promote-fusogenic-protein-engagement-during
*  Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis |...
The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes Katherine Fletcher, ... synaptic vesicle fusion. *syntaxin. *Received September 22, 2016.. *Revision received January 1, 2017. ... Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, College of Life Science, South‐Central ... Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, College of Life Science, South‐Central ...
http://emboj.embopress.org/content/early/2017/02/01/embj.201695775
*  Anti Vapa Antibody (PrecisionAb™ Polyclonal Antibody) | Bio-Rad Antibodies (formerly AbD Serotec)
VAPA antibody for detecting human vesicle-associated membrane protein-associated protein A. Validated on up to 12 cell lysates ... This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative ... The protein encoded by the VAPA gene is a type IV membrane protein. It is present in the plasma membrane and intracellular ... Rabbit anti human VAPA antibody recognizes vesicle-associated membrane protein-associated protein A, also known as 33 kDa VAMP- ...
https://www.bio-rad-antibodies.com/human-vapa-antibody-vpa00417.html
*  A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction...
... role in regulated exocytosis in neurons and neuroendocrine cells through modulation of vesicle docking and membrane fusion. The ... vesicle-associated membrane protein; Vps, vacuolar protein sorting ...
http://www.biochemj.org/content/409/2/407
*  Somatic Cell Fusion - Animal Biotech
This suggests that there is no compatibility between membranes, nuclei, organelles of two different groups of animal cells ( ... Somatic Cell Fusion. In animals fusion of two different cells and production of a hybrid cell have been successfully achieved. ... Bone cells are also known to undergo somatic cell fusion. Cells growing in culture are induced by some of the viruses such as ' ... Some chemicals such as polyethylene glycol also induce somatic cell fusion. It is interesting to note that the cells of ...
http://www.biocyclopedia.com/index/biotechnology/animal_biotechnology/animal_cell_tissue_and_organ_culture/biotech_somatic_cell_culture.php
*  Lipid Flip-Flop and Pore Nucleation on Zwitterionic Bilayers are Asymmetric under Ionic Imbalance | MIT Department of Materials...
... vesicle fusion, and transportation of biomolecules on cell membranes. ... on the cytoplasmic side of cell membranes; 2) ion permeation across a lipid membrane is moderated by lipid flip-flop; 3) the ... cell-membranes, channels, chloride flux, conductance, electrical breakdown, electroporation, model, molecular-dynamics ... However, there is a lack of understanding of whether ionic imbalance that exists ubiquitously across cell membranes affects ...
http://dmse.mit.edu/publications/lipid-flip-flop-and-pore-nucleation-zwitterionic-bilayers-are-asymmetric-under-ionic
*  Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells | JCB
A fusion event, leading to the delivery of all membrane proteins of a vesicle to the plasma membrane, is determined by two ... as the vesicular membrane proteins diffuses into the plasma membrane; Schmoranzer et al., 2000). Upon fusion the rate at which ... Although in CHO and other cell lines only a small proportion of the membrane proximal lysosomes underwent fusion, in primary ... For labeling the lumen and the membrane of lysosomes two complementary approaches were used. The membrane was labeled by ...
http://jcb.rupress.org/content/159/4/625.long
*  Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread
HSV presumably spreads via intercellular junctions created by local fusion events between the plasma membranes of infected and ... Additional compounds in development include fusion inhibitors, natural antimicrobial peptides, and a mandelic acid condensation ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC415621/?lang=en-ca
*  HOPS prevents the disassembly of trans‐SNARE complexes by Sec17p/Sec18p during membrane fusion | The EMBO Journal
SNARE‐dependent membrane fusion requires the disassembly of cis‐SNARE complexes (formed by SNAREs anchored to one membrane) ... The block is relieved on fusion as HOPS no longer binds two membranes, allowing post‐fusion cis‐SNARE complex to be primed for ... Membrane fusion, the merger of two biological membranes without content leakage, is essential for protein transport along the ... Mima J, Hickey CM, Xu H, Jun Y, Wickner W (2008) Reconstituted membrane fusion requires regulatory lipids, SNAREs and ...
http://emboj.embopress.org/content/29/12/1948
*  SMALP mini project
2. The fusion proteins prepared in objective 1 will form the basis of a biophysical study of FtsW with membrane mimicking ... bjectives:1. We now wish to adapt an existing Green Fluorescent Protein (GFP) fusion vector system for membrane proteins 2, 3 ... Optimization of membrane protein overexpression and purification using GFP fusions, Nat Methods3, 303-313. 3.Drew, D., Slotboom ... The study of membrane proteins is complicated by the fact that these proteins are generally difficult to isolate and study. ...
https://warwick.ac.uk/fac/sci/moac/people/staff/alison/smalpminiproject/
*  Adenosine Triphosphate and the Late Steps in Calcium-dependent Exocytosis at a Ribbon Synapse | JGP
1994) Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals. Nature 367:735-739, pmid:7906397.. ... 1 Abbreviations used in this paper: Gm, membrane conductance; Gs, series conductance; NSF, N-ethylmaleimide-sensitive fusion ... The N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase identified as an essential component in studies of membrane ... The identification of a number of highly conserved proteins that are important for membrane trafficking and fusion, combined ...
http://jgp.rupress.org/content/111/2/225
*  Membrane fusion protein - Wikipedia
Membrane fusion proteins (not to be confused with chimeric or fusion proteins) are proteins that cause fusion of biological ... such as VAMP Gp41 Interbilayer forces in membrane fusion Classification of viral fusion proteins in TCDB database Membrane ... fusion proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... membranes. Most of them are viral proteins. Examples include: SNARE (protein), ...
https://en.wikipedia.org/wiki/Membrane_fusion_protein
*  Interbilayer forces in membrane fusion - Wikipedia
Random fusion can result in severe problems to the normal functioning of the human body. Fusion of biological membranes is ... Membrane fusion is a key biophysical process that is essential for the functioning of life itself. It is defined as the event ... In living beings, cells are made of an outer coat made of lipid bilayers; which then cause fusion to take place in events such ... biological phenomena including folding and stabilization of macromolecules such as proteins and fusion of cell membranes. The ...
https://en.wikipedia.org/wiki/Interbilayer_forces_in_membrane_fusion
*  Membrane fusion during phage lysis | PNAS
2012) Cell-cell membrane fusion induced by p15 fusion-associated small transmembrane (FAST) protein requires a novel fusion ... Membrane Fusion as the Last Step in Lysis.. Here we have presented results that phage spanins can mediate efficient membrane ... Mechanism of Membrane Fusion.. The results presented here allow inferences to be drawn about the mechanism of IM-OM fusion. ... This suggests that these alleles are defective in a final step in membrane fusion, beyond bringing the target membranes into ...
https://www.pnas.org/content/112/17/5497?ijkey=65299ef76c6e39b42a828d06f0ca9b1997bffd8f&keytype2=tf_ipsecsha
*  Membrane fusion a mystery no more
... fusion model »membrane fusion model »membrane structure »single protein »vesicles ... fusion model , membrane fusion model , membrane structure , single protein , vesicles ... Membrane fusion a mystery no more. 25.01.2012. The many factors that contribute to how cells communicate and function at the ... Accepter SNARE proteins then form, allowing fusion with another vesicle membrane. How this mechanistically happens has been ...
http://www.innovations-report.com/html/reports/life-sciences/membrane-fusion-a-mystery-189176.html
*  Grappling with Membrane Fusion | Science Signaling
The process of membrane fusion is fundamental to cellular organization and has been the focus of a vast literature. Südhof and ... T. C. Südhof, J. E. Rothman, Membrane fusion: Grappling with SNARE and SM proteins. Science 323, 474-477 (2009). [Abstract] [ ... Two further papers also shed light on complexin's role in regulating SNARE-mediated membrane fusion. Giraudo et al. show that a ... The protein complexin may act as a force-transferring switch during membrane fusion. ...
http://stke.sciencemag.org/content/2/55/ec33
*  Membrane Fusion Triggered by Opposite Surface Charges
... fusion of the outer leaflets (hemifusion), opening and expansion of the fusion neck and finally full fusion. In our study, we ... It consists of consecutive steps including docking of the two bilayers, membrane destabilization, ... investigated the fusion between small cationic liposomes (~100 nm) and giant vesicles (tens of microns in diameter) containing ... Membrane fusion is a ubiquitous process, essential for cellular development, communication, and drug delivery. ...
https://www.biophysics.org/blog/membrane-fusion-triggered-by-opposite-surface-charges
*  Observation of a Membrane Fusion Intermediate Structure | Science
The widely accepted model for membrane fusion suggests that there is an intermediate state in which the two contacting ... The observation of the stalk structure supports the stalk hypothesis for membrane fusion and enables the measurement of these ... efforts have been made to estimate the free energy for such a state in order to understand the functionality of membrane fusion ... phospholipid that contains a structure similar to the commonly postulated interbilayer state that is crucial to membrane fusion ...
http://science.sciencemag.org/content/297/5588/1877
*  VIRUS BIOPHYSICS, DYNAMICS and STRUCTURE: Lee Lab (Membrane Fusion, Glycoprotein)
In studies of influenza virus, we are focused on understanding the process of membrane fusion and fusion protein activation. In ... membrane fusion, genome expulsion, assembly, and cell egress. The changes often involve concerted changes among hundreds of ... protein components and in the case of enveloped viruses, membranes as well. From this perspective, virions are intricate, nano- ...
http://faculty.washington.edu/kklee/Welcome.html