Epidermotropism in melanoma
Multiple malignant melanocytic lesions developed in a 54-year-old man 4 years after a primary malignant melanoma (Clark level ... Epidermotropism in melanoma J Cutan Pathol. 1980 Feb;7(1):50-4. doi: 10.1111/j.1600-0560.1980.tb00977.x. ... Multiple malignant melanocytic lesions developed in a 54-year-old man 4 years after a primary malignant melanoma (Clark level ... Several of the recurrent lesions that showed junctional melanocytic components were considered primary melanomas and it was ...
Melanoma genetics
... of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk ... Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of ... Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with ... It is likely that melanoma risk genes will impact on mutation screening and genetic counselling not only for melanoma but ...
Amelanotic melanoma: the great masquerader
The clinician should be familiar with the presentation of amelanotic melanoma to facilitate prompt diagnosis. ... Amelanotic melanoma: the great masquerader J Am Acad Dermatol. 2000 May;42(5 Pt 1):731-4. doi: 10.1067/mjd.2000.103981. ... Results: Amelanotic melanoma may masquerade as a variety of other conditions leading to a delay in the diagnosis or an ... Background: Cutaneous melanoma is often recognized by its dark color, but some tumors have little or no pigmentation. ...
Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of...
A case is presented of an intraocular T-cell lymphoma mimicking a ring melanoma of the iris and being the first manifestation ... A case is presented of an intraocular T-cell lymphoma mimicking a ring melanoma of the iris and being the first manifestation ... Nodules had developed in the circumference and the lesion now imitated a malignant melanoma of the iris, which was also the ... Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of ...
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
Melanoma treatment is being revolutionized by the development of effective immunotherapeutic approaches. These strategies ... Here we identify a melanoma-cell-intrinsic oncogenic pathway that contributes to a lack of T-cell infiltration in melanoma. ... Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity Nature. 2015 Jul 9;523(7559):231-5. doi: 10.1038/ ... Using autochthonous mouse melanoma models we identified the mechanism by which tumour-intrinsic active β-catenin signalling ...
Validation of THIN data for non-melanoma skin cancer
Aim: To investigate the validity of THIN data for non-melanoma skin cancer (NMSC). We defined NMSC as basal cell carcinoma (BCC ... Validation of THIN data for non-melanoma skin cancer Qual Prim Care. 2008;16(1):49-52. ...
Improved survival with ipilimumab in patients with metastatic melanoma
... improved overall survival in patients with previously treated metastatic melanoma. Adverse events can be severe, long-lasting, ... Improved survival with ipilimumab in patients with metastatic melanoma N Engl J Med. 2010 Aug 19;363(8):711-23. doi: 10.1056/ ... Methods: A total of 676 HLA-A*0201-positive patients with unresectable stage III or IV melanoma, whose disease had progressed ... Background: An improvement in overall survival among patients with metastatic melanoma has been an elusive goal. In this phase ...
Temozolomide and interferon alpha 2b in metastatic melanoma stage IV
... Br J Dermatol. 2004 Jul;151(1):91-8. doi: 10.1111/j.1365- ... alpha 2b was carried out to study the therapeutic effect in patients with metastatic melanoma stage IV. ...
Melanoma genetics: recent findings take us beyond well-traveled pathways
Genetic linkage and candidate gene studies have identified a number of genes involved in melanoma susceptibility, such as MC1R ... The most recent wave of melanoma GWASs has uncovered genes functioning independently of the known melanoma-associated ... Melanoma genetics: recent findings take us beyond well-traveled pathways J Invest Dermatol. 2012 Jul;132(7):1763-74. doi: ... Genetic linkage and candidate gene studies have identified a number of genes involved in melanoma susceptibility, such as MC1R ...
Sun-related behaviour and melanoma awareness among Swedish university students
... Eur J Cancer Prev. 1999 Feb;8(1):27-34. doi: ... The overall knowledge of melanoma was high. No difference in knowledge was found between the high- and low-exposure group. ...
Uveitis, poliosis, hypomelanosis, and alopecia in a patient with malignant melanoma
... developed spontaneously in a 57-year-old woman following operation for metastatic malignant melanoma. She has been disease-free ... Uveitis, poliosis, hypomelanosis, and alopecia in a patient with malignant melanoma Arch Dermatol. 1978 Mar;114(3):439-41. ... Within the framework of current concepts of cell-mediated and humoral immunity in patients with malignant melanoma, activity of ... developed spontaneously in a 57-year-old woman following operation for metastatic malignant melanoma. She has been disease-free ...
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
Among previously untreated patients with metastatic melanoma, nivolumab alone or combined with ipilimumab resulted in ... Melanoma Oncology Unit, Veneto Region Oncology Research Institute, Padua (V.C.-S.), Oncology of Melanoma Unit, European ... Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma N Engl J Med. 2015 Jul 2;373(1):23-34. doi: 10.1056/ ... Methods: We assigned, in a 1:1:1 ratio, 945 previously untreated patients with unresectable stage III or IV melanoma to ...
Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors
P-gp levels were 70% and 95% lower in brain metastases from melanomas and lung adenocarcinomas, respectively, than in normal ...
Determinants of human and mouse melanoma cell sensitivities to oleandrin
Using human BRO and mouse B16 melanoma cell lines, we explored … ... Determinants of human and mouse melanoma cell sensitivities to oleandrin J Exp Ther Oncol. 2008;7(3):195-205. ... Using human BRO and mouse B16 melanoma cell lines, we explored several possible determinants of cell sensitivity to oleandrin ...
1PSK: THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE
... ...
Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases
The absolute NK deficiency in NOD-scid IL2Rgamma(null) animals makes this strain an excellent recipient of melanoma and ... NK cells kill human melanoma lines and primary melanoma cells. Expression of human NKG2D ligands MHC class I chain-related A ... Results: Melanoma metastases growth is delayed and variable in scid and NOD-scid mice. In contrast, NOD-scid beta2m(null) and ... Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases Clin Cancer Res. 2009 May ...
Wang E[au] - Search Results - PubMed
What Is Melanoma? Wang JY, Wang EB, Swetter SM. Wang JY, et al. Among authors: wang eb. JAMA. 2023 Mar 21;329(11):948. doi: ...
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
... melanoma, and renal-cell cancer. (Funded by Bris … ... 55 with melanoma, 18 with colorectal cancer, 17 with renal-cell ... was observed in 9 of 52 patients with melanoma, 2 of 17 with renal-cell cancer, 5 of 49 with non-small-cell lung cancer, and 1 ... melanoma, and renal-cell cancer. (Funded by Bristol-Myers Squibb and others; ClinicalTrials.gov number, NCT00729664.). ...
Rivers J[au] - Search Results - PubMed
Melanoma. Rivers JK. Rivers JK. Lancet. 1996 Mar 23;347(9004):803-6. doi: 10.1016/s0140-6736(96)90873-9. Lancet. 1996. PMID: ... Unusual melanoma types. Rivers JK. Rivers JK. Dermatol Clin. 2002 Oct;20(4):727-33, x. doi: 10.1016/s0733-8635(02)00036-0. ...
Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin
... cutaneous melanoma, and squamous cell carcinoma. CSCPs are a high-efficacy anti-SP natural active substance and CS/CSCPs/β-GP ... Conclusion: SP can cause many clinical skin diseases, such as solar freckle-like nevus, solar keratosis, cutaneous melanoma, ...
Analysis of local recurrence and optimizing excision margins for cutaneous melanoma
p,Development of local recurrence in melanomas , or = 4 mm thick is due to inadequate treatment. It signifies progressive ... Analysis of local recurrence and optimizing excision margins for cutaneous melanoma Br J Surg. 2001 Jan;88(1):137-42. doi: ... Methods: An analysis of the Auckland Melanoma Unit database was performed. Patients with local recurrence were identified and ... Conclusion: Development of local recurrence in melanomas , or = 4 mm thick is due to inadequate treatment. It signifies ...
MAGEH1 MAGE family member H1 [Homo sapiens (human)] - Gene - NCBI
melanoma-associated antigen H1. Names. apoptosis-related protein 1. melanoma antigen family H, 1. melanoma antigen family H1. ... This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded ... The induction of APR-1 expression caused apoptosis of melanoma cells via the interaction with the juxtamembrane region of p75 ... Title: Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 ...
T311--an anti-tyrosinase monoclonal antibody for the detection of melanocytic lesions in paraffin embedded tissues
However, in primary melanomas of the desmoplastic/spindle cell type, T311 revealed a poor immunoreactivity. Nevi showed intense ... Eighty-four percent of metastatic malignant melanomas were immunoreactive with T311 and showed predominantly a homogeneous ... and we assessed its sensitivity in a large number of metastatic and primary malignant melanomas, nevi, three angiomyolipomas, ...
A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma
... the radial growth phase of primary melanoma; 5) the vertical growth phase of primary melanoma; and 6) metastatic melanoma. The ... The resultant primary melanoma itself does not follow a pathway of inexorable expansion of a population of melanoma cells in ... Rather, primary melanomas, with the exception of nodular melanoma, also evolve in a stepwise fashion. The first step, termed ... For a melanoma to acquire competence for metastasis it must progress to the next step of tumor progression--the vertical growth ...
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma
... into the mechanisms of anti-tumor immunity has generated great enthusiasm for the treatment of patients with advanced melanoma ... Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma Cancer J. 2012 Mar-Apr ... into the mechanisms of anti-tumor immunity has generated great enthusiasm for the treatment of patients with advanced melanoma ...
PubMed (Bookshelf cited) for id: 419514 - Search Results - PubMed
Li W, Hao CJ, Hao ZH, Ma J, Wang QC, Yuan YF, Gong JJ, Chen YY, Yu JY, Wei AH. Li W, et al. Pigment Cell Melanoma Res. 2022 May ... Epub 2022 Feb 13. Pigment Cell Melanoma Res. 2022. PMID: 35129281 Review. ...
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression
Additionally, expression of PD-L1 on dendritic cells and macrophages in ovarian cancer and melanoma patients correlated with ...
Kurli M[au] - Search Results - PubMed
Among authors: kurli m. Melanoma Res. 2020 Dec;30(6):590-593. doi: 10.1097/CMR.0000000000000655. Melanoma Res. 2020. PMID: ... PET/CT imaging: detection of choroidal melanoma. Reddy S, Kurli M, Tena LB, Finger PT. Reddy S, et al. Among authors: kurli m. ... Whole body PET/CT for initial staging of choroidal melanoma. Finger PT, Kurli M, Reddy S, Tena LB, Pavlick AC. Finger PT, et al ... Genomic profiling proves metastasis of cutaneous melanoma to vitreal fluid. Padrnos LJ, Houghton OM, Iacob CE, Kurli M, Ocal IT ...
Hongbin Yu - Search Results - PubMed
Among authors: yu h. Melanoma Res. 2023 Dec 1;33(6):454-461. doi: 10.1097/CMR.0000000000000922. Epub 2023 Sep 4. Melanoma Res. ... Recent advances of artificial intelligence in melanoma clinical practice. Lin Z, Shen H, Liu X, Ma W, Wang M, Ruan J, Yu H, Ma ...
PubMed for id: 1790038 - Search Results - PubMed
Ovarian melanoma. An interesting case. Ben David M, Feldberg D, Dicker D, Kessler H, Goldman JA. Ben David M, et al. Int J ... Metastatic ovarian melanoma in a 26-year-old patient]. Jaluvka V, Weitzel HK, Endrikat J. Jaluvka V, et al. Zentralbl Gynakol. ... Metastatic malignant ovarian melanoma--a case report. Berisavac M, Kotlica BK, Pilić I, Atanacković J. Berisavac M, et al. ... Primary ovarian melanoma arising in a dermoid stage IIIc: long-term disease-free survival with aggressive surgery and platinum ...