Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis. Sacilotto N., Chouliaras KM., Nikitenko ...

We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ... We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ... We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ... We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity ...

MEF2, Myocyte Enhancer Factor 2, is a transcription factor with four specific numbers such as MEF2A, B, C, and D. Each MEF2 ... Mef2 proteins contain both MADS-box and Mef2 DNA-binding domains. Mef2 was originally identified as a transcription factor ... Mammalian Mef2 can cooperate with bHLH transcription factors to turn non-muscle cells in culture into muscle. bHLH factors can ... In the field of molecular biology, myocyte enhancer factor-2 (Mef2) proteins are a family of transcription factors which ...

Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. ... 4, group I) and was strongly enriched for transcription factor-binding motifs for CTF/NF1 and MEF2 (Fig. 4b). These DM-LMRs ... enriched motifs contained binding sites for the CCCTC-binding factor and transcription factors of the myocyte enhancer factor-2 ... b-e Transcription factor enrichment within LMRs (b, d) and Gene Ontology analysis of adjacent genes (c, e). The depicted GO ...

Regulation of synapse development by the activity-regulated transcription factor MEF2 Advisor: Michael Greenberg. ... Neurotrophic Factor Regulation of Immediate Early Gene Expression. Advisor: Michael Greenberg. Cole, Rebecca Leah. ... TLF is a Functional Regulator or Transcription with Targets that are Distinct from the TATA-Box Binding Protein (TBP). Advisor ... Extrinsic and Intrinsic Factors Impacting Local Circuit Inhibition in the Neocortex. Advisor: Takao Hensch. ...

... while a loss-of-function study of the activity-regulated MEF2 transcription factor also revealed a role for MEF2 in suppression ... 2012) The transcription factor MEF2 directs developmental visually driven functional and structural metaplasticity. Cell 151:41 ... 2003) Excitation-transcription coupling: signaling by ion channels to the nucleus. Sci STKE 2003:PE4, pmid:12538881. ... 2011) Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat Neurosci 14:848-856, ...

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell ... BHLH transcription factor (MYC). Adult skeletal muscle. [119]. miR-345-5p. ↑. DLK1. GREM1. CYR61. NOV. COL1A1. SOD2. BLNK. ... The transcription of myomiRs is mainly controlled by myogenic regulatory factors, implicating them in the regulation of ... Xu, J.; Li, R.; Workeneh, B.; Dong, Y.; Wang, X.; Hu, Z. Transcription factor FoxO1, the dominant mediator of muscle wasting in ...

Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 1996 Jun 7;272(5267):1476-80. ...

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (New York, N.Y.). 311 ... Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW, Kim TK, Greenberg ME, Schratt G. Mef2-mediated transcription of ... Widespread transcription at neuronal activity-regulated enhancers. Nature. 465: 182-7. PMID 20393465 DOI: 10.1038/Nature09033 ... New Molecular Insights into the Excitation-Transcription Coupling. Neuron. 98: 453-456. PMID 29723495 DOI: 10.1016/j.neuron. ...

2007) Control of the SOST bone enhancer by PTH using MEF2 transcription factors Journal of Bone and Mineral Research 22:1957- ... 2021) Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors eLife 10:e55361. ... validate the results from cell trajectory inference (Tnn and Mfge8 expression, Figure 4), transcription factor calculation ( ... transcription factors (Kult et al., 2021). In the later embryonic and postnatal stages, cells from the enthesis progenitor pool ...

A single MEF2 site governs desmin transcription in both heart and skeletal muscle during mouse embryogenesis ... The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation ... The transcription factor Nkx2.5 and the intermediate filament protein desmin are simultaneously expressed in cardiac progenitor ... Desmin is a component of transcription factor complexes interacting with enhancers of the nkx2.5 gene at the beginning of ...

Human myocyte enhancer factor 2C (MEF2C), transcript variant 1 ... Transcription Factors. Protein Pathways. MAPK signaling pathway ... This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in ... Lenti ORF clone of Human myocyte enhancer factor 2C (MEF2C), transcript variant 1, Myc-DDK-tagged. * * 10 ug. 10 ug ... Lenti ORF clone of Human myocyte enhancer factor 2C (MEF2C), transcript variant 1, Myc-DDK-tagged. * * 10 ug. 10 ug ...

Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the ... Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.. Return to Grants ...

Morin S, Pozzulo G, Robitaille L, Cross J and Nemer M: MEF2-dependent recruitment of the HAND1 transcription factor results in ... via a system of transcription factors and co-factors (GATA binding protein 4, NK2 homeobox 5, calmodulin binding transcription ... Myocyte enhancer factor 2 (MEF2) family proteins (MEF2A, MEF2C, MEF2D) are involved as intermediate signal responses of the ... Patients with type 1 DM face a two to four times higher mortality rate than non-diabetic people (7-10). The main risk factor ...

and Meyer, Magdalena (2020) Anxiolytic and Anxiogenic? How the Transcription Factor MEF2 Might Explain the Manifold Behavioral ... 2020) Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in ...

The ability of MEF2 factors to activate transcription from the XMLC2 promoter is assayed using microinjection of oocytes. ... Characterisation of a 3kb XMLC2 promoter fragment reveals the presence of four MEF2 and four GATA transcription factor binding ... This Sbp sequence does not conform to any known transcription factor binding site involved in contractile isoform regulation, ... Mutation of the MEF2 elements indicate that they might play redundant roles in XMLC2 regulation. Gel shift experiments reveal ...

MEF2 transcription factors are key regulators of sprouting angiogenesis. Journal article Sacilotto N. et al, (2016), Genes Dev ... Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis. Journal article ... Enhancers are densely clustered groups of transcription factor binding motifs and are the principal regulators of spatio- ... The Transcription Factor KLF2 and Cardiovascular Disease Current Funders. British Heart Foundation (Personal Senior Fellowship ...

We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 ... To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes ... genetic transcription, macrophage, microarray analysis, molecular mechanics, nonlymphoid gene, phagocytosis, pre B lymphocyte, ...

Proteasome activity is also affected by neuronal activity, via increased expression of UBE3A through transcription factor MEF2 ... The mTOR pathway is also regulated by the brain‐derived neurotrophic factor (BDNF), which plays a key role in the development ... Changes in mTOR activation is believed to be a risk factor for ASD. mTOR is regulated by the TCS1/2 complex, and several ... and the plasticity of the central nervous system and is considered a risk factor for ASD. Increased levels of BDNF ...

MEF2 transcription factors in human placenta and involvement in cytotrophoblast invasion and differentiation. ... ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells. ... The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. ... Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 ...

Muscle Proteins - MEF2 Transcription Factors PubMed MeSh Term * Muscle Proteins - MyoD Protein PubMed MeSh Term ... Myocyte enhancer factor-2 and serum response factor binding elements regulate fast myosin heavy chain transcription in vivo ... Muscle Proteins - Myogenic Regulatory Factors PubMed MeSh Term *Overview. Overview. subject area of * Cardiomyopathy in ... Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly Journal Article ...

The transcription factor Mef2 (myocyte enhancer factor-2) is increased in HCM, particularly in myocytes that reside near ... Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy ... Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy ... Notably, the expression of RNAs encoding Tgf-β1 and 2, periostin, collagen, and connective tissue growth factor was increased, ...

"MEF2 Transcription Factors", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nitric ... Myocyte enhancer factor-2 (MEF2) family activation is reported to be involved in pitavastatin-dependent KLF4 induction. We ... Myocyte enhancer factor-2 (MEF2) family activation is reported to be involved in pitavastatin-dependent KLF4 induction. We ... family transcription factors. To dissect the mechanism of gene regulation, we sought to determine molecular targets by ...

Snail Family Transcription Factors. *Signal Transduction. *Rhabdomyosarcoma, Embryonal. *Receptor, Notch1. *MEF2 Transcription ... a myogenic differentiation transcription factor. Our data implicate the NOTCH1/SNAI1/MEF2C signaling axis as a major ...

MEF2 Transcription Factors/genetics * Mutation * Mutation Rate * Neoplasms/genetics * Peptide Elongation Factor 1/genetics ...

MEF2 Transcription Factors 45% * Leukemic Gene Expression Regulation 37% * MADS Domain Proteins 32% ...

MEF2 Transcription Factors 93% * Human T-lymphotropic virus 1 77% * T-Lymphocytes 38% ... Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing ... Role of the proteasome in the downregulation of transcription factors NFκB and C/EBP in macrophages from tumor hosts. Perry, G. ... Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway. Shembade, ...

MEF2 Transcription Factors 21% * Visual Cortex 20% * Synaptic Transmission 20% * Neuronal Plasticity 17% ...

Prognostic significance of plasma scatter factor/hepatocyte growth factor levels in patients with metastatic hormone-refractory ...

Reaction Name: ERK5 activates the transcription factor MEF2 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA- ... Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome ...