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*  Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of...
These results demonstrate for the first time that MT-MMP-1 is a gelatinolytic enzyme and secreted from cells in a complex with ... delta MT1 isolated in a complex form with tissue inhibitor of metalloproteinases 2 (TIMP-2) from the stable transfectants ... also secreted MT-MMP-1 into culture media, which was purified in a complex form with TIMP-2 and showed gelatinolytic activity ... The processing mechanism and gelatinolytic activity of the membrane-type matrix metalloproteinase 1 (MT-MMP-1) were examined by ...
https://www.semanticscholar.org/paper/Membrane-type-matrix-metalloproteinase-1-is-a-gela-Imai-Ohuchi/aeec9daaca3b34b60e4d5db57413a7ddd08ec41d
*  Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers | Gut
1990) Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (Pump-1), secreted from ... matrix metalloproteinase. MT1-MMP. membrane type-1 matrix metalloproteinase. SDS. sodium dodecyl sulphate. ... 1996) Matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer. ... 1995) Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human ...
http://gut.bmj.com/content/45/2/252
*  TIMP-3 Antibody | Abbiotec
TIMP-3 (Tissue inhibitor of metalloproteinases 3) is a secreted extracellular matrix protein, metalloprotease inhibitor. It ... Metalloproteinase inhibitor 3; Tissue inhibitor of metalloproteinases 3; TIMP-3; Protein MIG-5; TIMP3 ... forms complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic ... to angiogenic factors and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. ...
http://abbiotec.com/antibodies/timp-3-antibody-1
*  Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome
... minocycline is known to inhibit matrix metalloproteinases (MMPs), a family of secreted and membrane-tethered zinc-dependent ... Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome. Saul S. Siller1,2 and Kendal Broadie1 ... A. Page-McCaw, A. J. Ewald, and Z. Werb, "Matrix metalloproteinases and the regulation of tissue remodelling," Nature Reviews ... A. Page-McCaw, J. Serano, J. M. Santë, and G. M. Rubin, "Drosophila matrix metalloproteinases are required for tissue ...
https://www.hindawi.com/journals/np/2012/124548/
*  Articles by Nicoletta Gagliano : Anti-Cancer Drugs
Effect of Ukrain on matrix metalloproteinase-2 and Secreted Protein Acidic and Rich in Cysteine (SPARC) expression in human ...
https://journals.lww.com/anti-cancerdrugs/pages/author.aspx?firstName=Nicoletta&lastName=Gagliano
*  McCarroll JA[au] - PubMed - NCBI
Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=McCarroll+JA%5Bau%5D&dispmax=50
*  Physiology and Pathology of Autoimmune Diseases: Role of CD4+ T cells in Rheumatoid Arthritis | IntechOpen
FLSs secrete matrix metalloproteinases (MMPs) and collagenase, promoting cartilage destruction [37]. Leukocyte infiltration and ... Th17 cells differentiate in the presence of IL-1β, IL-6 and IL-23 [73], which are secreted by activated macrophages and ... These cells are key regulators of the immune response secreting pro-inflammatory cytokines and cooperating with B cells for ... In addition, RA FLSs secrete high amounts of proteases, which trigger cartilage destruction, and pro-inflammatory cytokines. ...
https://www.intechopen.com/books/physiology-and-pathology-of-immunology/physiology-and-pathology-of-autoimmune-diseases-role-of-cd4-t-cells-in-rheumatoid-arthritis
*  Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Secreted Proteinases in Cancer: The Matrix Metalloproteinase Experience. Ralph Weissleder, Massachusetts General Hospital, USA ... Secreted Proteases in Cancer Meeting has ended...abstracts no longer viewable online. ...
http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=585
*  The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic...
Malignant fly tumors express the secreted matrix metalloproteinase 1 (Mmp1). Mmp1 degrades the basement membrane of the ... The secreted growth factors Dpp and Wg are important regulators of tissue growth and cell proliferation in the wing disc ( ... Discs were labeled with antibody to Matrix metalloprotease 1 (Mmp1, red) as well as UAS-GFP to mark the Yki-expressing tissue ( ...
http://dmm.biologists.org/content/10/10/1201?rss=1
*  Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis | Science...
Secreted tissue inhibitor of matrix metalloproteinase restricts trans-synaptic signaling to coordinate synaptogenesis. J. Cell ... A core family of secreted proteases, called matrix metalloproteinases (MMPs), occupies a key nexus of coordinated cell-to-cell ... Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural ... The breakdown of the extracellular matrix, such as by matrix metalloproteinases (MMPs), helps cells to make protrusions and ...
https://stke.sciencemag.org/content/10/504/eaan3181
*  Table of Contents | Cancer Research
Oncolytic Efficacy and Enhanced Safety of Measles Virus Activated by Tumor-Secreted Matrix Metalloproteinases ... Tumor-Derived Matrix Metalloproteinase-1 Targets Endothelial Proteinase-Activated Receptor 1 Promoting Endothelial Cell ...
http://cancerres.aacrjournals.org/content/66/15
*  A novel integrin α5β1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration...
Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut2003;52:275 ... Hashimoto G, Inoki I, Fujii Y, et al. Matrix metalloproteinases cleave connective tissue growth factor and reactivate ... Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc Natl Acad Sci U S A ... CCN2 proteolysis is promoted by matrix metalloproteases (MMPs), several of which are produced by PSC.18-22 Although the ...
https://gut.bmj.com/content/55/6/856?ijkey=e5b72dff550a24c04f2fc31095edb43f407d82c3&keytype2=tf_ipsecsha
*  Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells | BMC Complementary and Alternative Medicine | Full...
Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 2003;52: ... high levels of cytokines and chemotactic factors accompanied with the overwhelmed ECM proteins secreted by PSCs create a ... pancreas while exhibiting numerous retinoid-containing droplets and synthesizing relatively low amounts of extracellular matrix ...
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0789-y
*  BMP | Journal of Cell Science
Secreted tissue inhibitor of matrix metalloproteinase restricts trans-synaptic signaling to coordinate synaptogenesis Jarrod ... Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an ... Summary: At neuromuscular synapses, secreted Timp limits extracellular proteolytic activity to restrict BMP signaling from the ...
http://jcs.biologists.org/keyword/bmp
*  Matrix Metalloproteinases (MMPs) Regulate Fibrin-invasive Activity via MT1-MMP-dependent and -independent Processes | JEM
Secreted and membrane-associated matrix metalloproteinases of IL-2-activated NK cells and their inhibitors. J. Immunol. 164: ... Expression of matrix metalloproteinases during rat skin wound healing: Evidence that membrane type-1 matrix metalloproteinase ... Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3 and membrane type 1-matrix metalloproteinase impair ... Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of ...
http://jem.rupress.org/content/195/3/295
*  Frontiers | Risk factors for pancreatic cancer: underlying mechanisms and potential targets | Physiology
2003). Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut 52 ... PSCs synthesize matrix degradation enzymes like matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of ... 2013). Prognostic significance of extracellular matrix degrading enzymes-cathepsin L and matrix metalloproteases-2 [MMP-2] in ... The pancreas is a glandular organ of the digestive system consisting of (a) an endocrine component which secretes insulin, ...
https://www.frontiersin.org/articles/10.3389/fphys.2013.00415/full
*  Polyphenols from Chilean Propolis and Pinocembrin Reduce MMP-9 Gene Expression and Activity in Activated Macrophages
... matrix metalloproteinases are mainly secreted by macrophages. These enzymes are involved in vascular remodeling allowing the ... macrophages play important roles including matrix metalloproteinases synthesis involved in degradation of matrix extracellular ... W. R. Jae, K.-W. Lee, D. Kim et al., "NF-κB-dependent regulation of matrix metalloproteinase-9 gene expression by ... Y.-S. Lee, H. T. L. Tran, and V. T. Quang, "Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: ...
https://www.hindawi.com/journals/bmri/2016/6505383/
*  Glaucoma: A Disease of Early Cellular Senescence | IOVS | ARVO Journals
Normal TM cells secrete matrix metalloproteinases, phagocytose debris, and provide fluid transport into Schlemm's canal. ... Harper MM Grozdanic SD Blits B Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically ... 43 Stem cells injected into the vitreous and manipulated to secrete BDNF or other survival factors may be used to deliver these ...
https://iovs.arvojournals.org/article.aspx?articleid=2127414
*  Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation | Thorax
The ability of cells to deposit extracellular matrix, secrete matrix metalloproteinases (MMPs) and invade collagen was ... secrete an increased level of pro-matrix metalloproteinase 9 (pro-MMP-9) into the cell culture media compared with untreated ... PBECs treated with increasing concentrations of TGF-β1 secrete increased levels of pro-matrix metalloproteinase-9 (pro-MMP-9) ... cells lose epithelial properties and gain properties of mesenchymal cells including production of matrix metalloproteinases ( ...
http://thorax.bmj.com/content/64/9/770
*  RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs | EMBO...
Quantification of secreted matrix metalloproteinase‐related proteins. Confluent BC cells were cultured in serum‐free medium for ... Deregulation of matrix‐degrading proteases, including matrix metalloproteinases (MMPs), is one of the mechanisms used by cancer ... Zhai Y, Hotary KB, Nan B, Bosch FX, Munoz N, Weiss SJ, Cho KR (2005) Expression of membrane type 1 matrix metalloproteinase is ... Hotary KB, Allen ED, Brooks PC, Datta NS, Long MW, Weiss SJ (2003) Membrane type I matrix metalloproteinase usurps tumor growth ...
http://embor.embopress.org/content/17/7/1061
*  Michael Fischbein | Stanford Medicine Profiles
These immune cells secrete proteases such as matrix metalloproteinases and cathepsins that contribute to disease formation and ... matrix metalloproteinase) activity. Pravastatin and MA significantly reduced aneurysm growth compared with vehicle control (n=8 ... decreased matrix metalloproteinase activity and decreased elastin breakdown. Prenatal LNA-anti-miR-29b inhibitor treatment ... ascending aorta in association with repressed elastin mRNA and increased matrix metalloproteinase-2 expression and activity, ...
https://med.stanford.edu/profiles/michael-fischbein?tab=teaching
*  Frontiers | Melanoma Biomolecules: Independently Identified but Functionally Intertwined | Oncology
This review focuses on five putative biomarkers - melanoma cell adhesion molecule (MCAM), galectin-3 (gal-3), matrix ... metalloproteinase 2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4) and paired box 3 (PAX3). The goal is to provide context ... Matrix Metalloproteinase-2 is synthesized and secreted as a 72 kDa pro-enzyme. It is activated primarily at the cell surface by ... Matrix Metalloproteinase-2. Matrix metalloproteinases are a family of zinc-dependent enzymes that degrade different ECM ...
https://www.frontiersin.org/articles/10.3389/fonc.2013.00252/full
*  Volume 83, Issue 2 | Acta Dermato-Venereologica
... matrix metalloproteinase (MMP)-2 was constitutively secreted from fibroblasts, whereas both MMP-2 and MMP-9 were secreted from ... Matrix Metalloproteinases-2 and -9 are Secreted from Human Fibroblasts. TAKASHI KOBAYASHI A1, SHUNJI HATTORI A2, HIROSHI ... Matrix metalloproteinases (MMPs) have been associated with the remodeling of the extracellular matrix during inflammation, ... Matrix Metalloproteinase-19 is Expressed by Keratinocytes in Psoriasis. SARI SUOMELA A2, ARJA-LEENA KARINIEMI A3, ULLA IMPOLA ...
https://www.medicaljournals.se/acta/content/issue/83-2
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Matrix metalloproteinase (MMP)-9 secreted from cancer stroma populated by CAFs is a prerequisite for cancer angiogenesis and ... Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids ... We show examples of vessel remodeling caused by local matrix contraction. We also found that fibrillar matrix of the tumor ... Bioengineering, Issue 86, Intravital imaging, epifluorescence, two-photon imaging, Tumor matrix, Matrix remodeling ...
https://www.jove.com/visualize/abstract/24586907/matrix-metalloproteinase-mmp-9-cancer-associated-fibroblasts-cafs-is