Matrix metalloproteinase 27 | definition of matrix metalloproteinase 27 by Medical dictionary
Looking for online definition of matrix metalloproteinase 27 in the Medical Dictionary? matrix metalloproteinase 27 explanation free. What is matrix metalloproteinase 27? Meaning of matrix metalloproteinase 27 medical term. What does matrix metalloproteinase 27 mean?http://medical-dictionary.thefreedictionary.com/matrix+metalloproteinase+27
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory...
Using a competitive PCR technique we have established a system for rapid and simultaneous measurement of multiple genes involved in the metabolism of the ECM within a single colonic biopsy. To gain further insight into their biological function in inflammatory bowel disease we analysed relative mRNA expression of collagen type III, matrix metalloproteinases MMP-1 and MMP-2, their respective major activators MMP-3 and MMP-14, as well as their physiological inhibitors TIMP-1 and TIMP-2 in endoscopic biopsies from inflamed and non-inflamed colon of IBD patients.. We observed that mRNA expression of all MMPs was significantly increased in inflamed compared with non-inflamed colonic mucosa of these patients. This increase was most pronounced in ulcerated colonic mucosa. By performing westerns blots, increased expression of MMP-1, MMP-2, and MMP-3 was also demonstrated at the protein level, which supports previous in vitro studies showing a close correlation between mRNA and ...http://gut.bmj.com/content/47/1/63
Patent US5022750 - Active matrix reflective projection system - Google Patents
An active matrix reflective projection system utilizing a conventional wafer includes a reflective image plane module. The reflective image plane module includes light directing and reflecting structures and a wafer based active matrix mated thereto. A source of light is directed to the reflective image plane module wherein the wafer based active matrix imparts information onto a light beam reflected therefrom. The reflective image plane module projects the reflected beam for viewing, such as through one or more lens. The active matrix reflective projection system can be a monochrome projector including a single reflective image plane module or can be a full color system including three reflective image plane modules. Each color reflective image plane module operates on a single color component, red, green or blue, which then are combined on a screen or before projecting on the screen to form the full color projection image. The wafer based ...http://www.google.com/patents/US5022750?dq=4740761
Prediction on the Inhibition Ratio of Pyrrolidine Derivatives on Matrix Metalloproteinase Based on Gene Expression Programming ...
Prediction on the Inhibition Ratio of Pyrrolidine Derivatives on Matrix Metalloproteinase Based on Gene Expression Programming. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.http://libros.duhnnae.com/2017/jun8/149836239082-Prediction-on-the-Inhibition-Ratio-of-Pyrrolidine-Derivatives-on-Matrix-Metalloproteinase-Based-on-Gene-Expression-Programming.php
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase...
The hydrolysis of collagen (collagenolysis) is one of the committed steps in extracellular matrix turnover. Within the matrix metalloproteinase (MMP) family distinct preferences for collagen types are seen. The substrate determinants that may guide these specificities are unknown. In this study, we have utilized 12 triple-helical substrates in combination with 10 MMPs to better define the contributions of substrate sequence and thermal stability toward triple helicase activity and collagen specificity. In general, MMP-13 was found to be distinct from MMP-8 and MT1-MMP(Delta279-523), in that enhanced substrate thermal stability has only a modest effect on activity, regardless of sequence. This result correlates to the unique collagen specificity of MMP-13 compared with MMP-8 and MT1-MMP, in that MMP-13 hydrolyzes type II collagen efficiently, whereas MMP-8 and MT1-MMP are similar in their preference for type I collagen. In turn, MMP-1 was the least efficient ...https://www.kennedy.ox.ac.uk/publications/227294
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase...
The hydrolysis of collagen (collagenolysis) is one of the committed steps in extracellular matrix turnover. Within the matrix metalloproteinase (MMP) family distinct preferences for collagen types are seen. The substrate determinants that may guide these specificities are unknown. In this study, we have utilized 12 triple-helical substrates in combination with 10 MMPs to better define the contributions of substrate sequence and thermal stability toward triple helicase activity and collagen specificity. In general, MMP-13 was found to be distinct from MMP-8 and MT1-MMP(Delta279-523), in that enhanced substrate thermal stability has only a modest effect on activity, regardless of sequence. This result correlates to the unique collagen specificity of MMP-13 compared with MMP-8 and MT1-MMP, in that MMP-13 hydrolyzes type II collagen efficiently, whereas MMP-8 and MT1-MMP are similar in their preference for type I collagen. In turn, MMP-1 was the least efficient ...https://www.ndorms.ox.ac.uk/publications/227294
DBGET Search Result: KEGG Matrix metalloproteinase
matrilysin; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; ...http://www.genome.jp/dbget-bin/www_bfind_sub?mode=bfind&max_hit=1000&dbkey=kegg&keywords=Matrix+metalloproteinase
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14...
Membrane type 1 matrix metalloproteinase (MT1-MMP) is a potent modulator of the pericellular environment and promotes tumor cell invasion and proliferation in many types of tumor. The activation of proMMP-2 and processing of collagen I by MT1-MMP have been thought to be important for its tumor-promoting function. These activities can be inhibited by mutant forms of MT1-MMP lacking the catalytic domain. However, the effect of such dominant-negative mutants has never been evaluated in vivo. Various mutants lacking the catalytic domain (dCAT) were prepared and confirmed to inhibit MT1-MMP activity in human fibrosarcoma HT1080 cells, and tumor cells expressing these mutants were implanted s.c. into nude mice to monitor tumor formation. Only the membrane-anchored form of a dCAT construct through the transmembrane domain [dCAT(1)] showed potent antitumor activity not only in HT1080 cells but also in gastric carcinoma MKN28 and MKN45 cells expressing MT1-MMP. A soluble form of dCAT ...https://oacentre.kennedy.ox.ac.uk/publications/224438
Matrix Metalloproteinase-9 and Airway Remodeling in Asthma | BenthamScience
Title: Matrix Metalloproteinase-9 and Airway Remodeling in Asthma. VOLUME: 4 ISSUE: 2. Author(s):Hiroyuki Ohbayashi and Kaoru Shimokata. Affiliation:Department of Internal Medicine, Tohno-Kousei Hospital, 76-1, Toki-cho, Mizunami City, Gifu Pref. 509-6101, Japan.. Keywords:matrix metalloproteinase, asthma, the extracellular matrix, tissue inhibitor of metalloproteinase. Abstract: Airway remodeling is a major change responsible for irreversible asthmatic airflow restriction. The Th-2 cytokines-dominant eosinophilic inflammatory mechanism cannot fully explain the progressive subepithelial fibrosis and structural changes in the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are the key enzymes responsible for ECM degradation. MMPs are normally produced and secreted under the tight regulation of, at least, 3 different levels: the gene ...http://www.eurekaselect.com/90337/article
Frontiers | Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in...
It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role of MMP-9 in amygdala-dependent learning and memory. Nothing is known, however, about its physiological correlates in the specific pathways in the amygdala. In the present study we show that LTP in the basal and central but not lateral amygdala is affected by MMP-9 knock-out. The MMP-9 dependency of LTP was confirmed in brain slices treated with a specific MMP-9 inhibitor. The results suggest that MMP-9 plays different roles in synaptic plasticity in different nuclei of the amygdala.https://www.frontiersin.org/articles/10.3389/fncel.2015.00073/full
Holdings: Role of Inflammation in Estrogen Induced Matrix Turnover and Matrix Metalloproteinase (MMP) Regulation in the...
Role of Inflammation in Estrogen Induced Matrix Turnover and Matrix Metalloproteinase (MMP) Regulation in the Immature Rat Uterus ...https://digital.library.villanova.edu/Record/vudl:189773
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016 ...https://pharos.nih.gov/idg/targets/Q9NRE1
Abstract P601: Matrix Metalloproteinase 2 Plays An Important Role In Angiotensin Ii-induced Vascular Injury Mediated In Part...
Background: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced blood pressure (BP) rise and vascular injury.. Methods: Ten to 12-week-old male Mmp2 knockout (Mmp2-/-) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic BP was measured by telemetry, mesenteric arteries (MA) endothelial function and vascular remodeling by pressurized myography. In aortic wall or perivascular fat (PVAT), reactive oxygen species (ROS) generation was determined using dihydroethidium staining, and vascular cell adhesion protein 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) expression and monocyte/macrophage infiltration by immunofluorescence. Spleen T cells and monocyte profile were assessed by flow cytometry. Vascular smooth muscle cells (VSMCs) were isolated from MA of WT and Mmp2 ...http://hyper.ahajournals.org/content/66/Suppl_1/AP601
Expression of matrix metalloproteinase 13 (MMP-13) in h | Open-i
Expression of matrix metalloproteinase 13 (MMP-13) in human rheumatoid arthritis (RA) (A) synovial tissue (magnification ×200) and (B) the isotype control (maghttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2925150_ard-69-05-0898-fig1&req=4
Matrix Metalloproteinase 2 - Gelatinase A Summary Report | CureHunter
Matrix Metalloproteinase 2: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.http://www.curehunter.com/public/keywordSummaryD020778-Matrix-Metalloproteinase-2-Gelatinase-A.do
Matrix metalloproteinase expression and function in urothelial carcinoma - Nuffield Department of Surgical Sciences
AID 108320 - Inhibition of collagen IV degradation by matrix metalloprotease-9 at 10 uM (no data) - PubChem
BioAssay record AID 108320 submitted by ChEMBL: Inhibition of collagen IV degradation by matrix metalloprotease-9 at 10 uM (no data).https://pubchem.ncbi.nlm.nih.gov/bioassay/108320
MMP11 (matrix metalloproteinase 11 (stromelysin 3))
... , Authors: Paul Basset, Marie-Christine Rio. Published in: Atlas Genet Cytogenet Oncol Haematol.http://atlasgeneticsoncology.org/Genes/ST3ID200.html
Matrix Metalloproteinase- 2 (MMP-2) | Pan Laboratories
Name of the Test: Matrix Metalloproteinase- 2 (MMP-2) Alias names: Gelatinase-A Clinical Research applications: Matrix metalloproteinaseshttp://panlaboratories.com/matrix-metalloproteinase-2-mmp-2/
Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino...
The consequences of improper regulation of collagen turnover include diseases such as tumor cell metastasis and arthritis. Several fluorogenic triple-helical peptide (fTHP) substrates have been constructed presently to examine collagenolytic behavior. These substrates incorporate L- or D-2-amino-3-(7-methoxy-4-coumaryl)propionic acid (Amp) or L- or D-2-amino-3-(6,7-dimethoxy-4-coumaryl)propionic acid (Adp) as the fluorophore and N-2,4-dinitrophenyl (Dnp) as the quencher. The desired sequences were C6-(Gly-Pro-Hyp)5-Gly-Pro-[Amp/Adp]-Gly-Pro-Gln-Gly approximately Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2. All four fTHPs formed stable triple-helices. Matrix metalloproteinase-2 (MMP-2) rates of hydrolysis for all fTHPs were considerably more rapid than corresponding MMP-1 rates. Evaluation of individual kinetic parameters indicated that MMP-2 bound to the fTHPs more efficiently than MMP-1. Comparison to a triple-helical substrate incorporating the same sequence ...https://www.kennedy.ox.ac.uk/publications/226982
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013 ...https://pharos.nih.gov/idg/targets/Q8N119
DigitalCommons@PCOM - Research Day: Roles of Zinc-binding Protein-89 and NF-kB in Regulation of Matrix Metalloproteinase-3...
May 13th, 1:00 PM Roles of Zinc-binding Protein-89 and NF-kB in Regulation of Matrix Metalloproteinase-3 Expression in Response to Cytokines. Philadelphia. ...http://digitalcommons.pcom.edu/research_day/research_day_PA_2015/researchPA2015/34/
Matrix metalloproteinase 9 production by monocytes is enhanced by TNF and participates in the pathology of human cutaneous...
Sigma-Aldrich offers abstracts and full-text articles by [Taís M Campos, Sara T Passos, Fernanda O Novais, Daniel P Beiting, Rúbia S Costa, Adriano Queiroz, David Mosser, Phillip Scott, Edgar M Carvalho, Lucas P Carvalho].https://www.sigmaaldrich.com/catalog/papers/25393535
MMP17 - Matrix metalloproteinase - Homo sapiens (Human) - MMP17 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...http://www.uniprot.org/uniprot/F5GWR3
Effect of interleukin (IL)-17A and IL-17E on the produc | Open-i
Effect of interleukin (IL)-17A and IL-17E on the production of matrix metalloproteinase (MMP)-3, MMP-12, and tissue inhibitor of metalloproteinase (TIMP)-1 by ihttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3733737_1755-1536-6-13-5&req=4