Loading...
*  KAKEN - Research Projects | Characterization of the structure and function of new membrane-type matrix metalloproteinase ...
Publications] Itoh Y, Kajita M, Kinoh H, Mori H, Okada A, Seiki M: 'Membrane-type 4 matrix metalloproteinase (MT4-MMP, MMP-17) ... Publications] Davis V,Persidskaia R,Baca RL,Itoh Y,Nagase H et al.: 'Matrix Metalloproteinase-2 Production and Its Binding to ... Publications] Kajita, M., et al.: 'Human Membrane Type-4 Matrix Metalloproteinase (MT4-MMP) is encoded by a novel major ... Publications] Kajita M. et al.: 'Human Membrane Type-4 Matrix Metalloproteinase (MT4-MMP) is encoded by a novel major ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680596/
*  Regulation of the extracellular matrix by microRNA: impact on cancer metastases - QIAGEN
Altered expression of miRNAs that regulate extracellular matrix gene expression is associated with development of metastatic ... Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by ... 2002) The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and ... 2008) microRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol. Cell. Biol. 28, 5369. ...
https://www.qiagen.com/au/shop/genes-and-pathways/knowledgehub/reviews/reviews-online-mirna-ecm/
*  Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers | Gut
matrix metalloproteinase. MT1-MMP. membrane type-1 matrix metalloproteinase. SDS. sodium dodecyl sulphate. ... 1995) Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human ... 1996) Matrix metalloproteinases and tumour invasion: from correlation and causality to the clinic. Semin Cancer Biol 7:147-154. ... 1996) Matrix metalloproteinase-1 is associated with poor prognosis in colon cancer. Nat Med 2:461-462. ...
http://gut.bmj.com/content/45/2/252
*  The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter - Digital Library
Sternlicht, Mark D; Bissell, Mina J & Werb, Zena. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor ... The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter ...
https://digital.library.unt.edu/ark:/67531/metadc1012678/
*  Publications [#134188] of Mark W. Dewhirst
Antineoplastic Agents • Biopsy • Humans • Imidazoles • Matrix Metalloproteinase Inhibitors* • Neoplasms • Neovascularization, ... a broad-spectrum matrix metalloproteinase inhibitor, and to determine whether the wound angiogenesis assay was able to detect ... a broad spectrum matrix metalloproteinase inhibitor., Clinical cancer research : an official journal of the American ... 2 (February, 2003), pp. 586-93, ISSN 1078-0432 (last updated on 2013/05/16) Abstract:. OBJECTIVE: The purpose of this study was ...
http://fds.duke.edu/db/pratt/FIP/dewhirst/publications/134188
*  Matrix Metalloproteinase-2 | SpringerLink
Type IV collagenase Matrix metalloproteinase-2 (MMP-2), previously named 72 kDa type IV collagenase or gelatinase A, belongs to ... Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev. 2007;87: ... Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry ... a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase ...
https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101708
*  Frontiers | Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection | Pharmacology
The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection.In a series of pilot ... The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot ... Based on the MMP-2 inhibitory tests using gelatin zymography, 7 compounds were then selected and tested in neonatal rat cardiac ... Based on the MMP-2 inhibitory tests using gelatin zymography, 7 compounds were then selected and tested in neonatal rat cardiac ...
https://www.frontiersin.org/articles/10.3389/fphar.2018.00296/full
*  Matrix Metalloproteinase 2 - Gelatinase A Summary Report | CureHunter
Matrix Metalloproteinase 2: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an ... Matrix Metalloproteinases: 8496*Secreted Matrix Metalloproteinases: 9*Matrix Metalloproteinase 2: 2215*human Col-1 peptide ... Matrix Metalloproteinases: 8496*Secreted Matrix Metalloproteinases: 9*Matrix Metalloproteinase 2: 2215*human Col-1 peptide ... 10/01/2013 - "Epithelial expression of extracellular matrix metalloproteinase inducer/CD147 and matrix metalloproteinase-2 in ...
http://www.curehunter.com/public/keywordSummaryD020778-Matrix-Metalloproteinase-2-Gelatinase-A.do
*  The Involvement of miR-29b-3p in Arterial Calcification by Targeting Matrix Metalloproteinase-2
M. Wang, D. Zhao, G. Spinetti et al., "Matrix metalloproteinase 2 activation of Transforming Growth Factor-β1 (TGF-β1) and TGF- ... The Involvement of miR-29b-3p in Arterial Calcification by Targeting Matrix Metalloproteinase-2. Wenhong Jiang,1 Zhanman Zhang, ... A. Azevedo, A. F. Prado, R. C. Antonio, J. P. Issa, and R. F. Gerlach, "Matrix metalloproteinases are involved in ... E. Hecht, C. Freise, K. V. Websky et al., "The matrix metalloproteinases 2 and 9 initiate uraemic vascular calcifications," ...
https://www.hindawi.com/journals/bmri/2017/6713606/ref/
*  Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis
"Regulation of matrix metalloproteinase gene expression," in Matrix Metalloproteinases, W. C. Park and R. P. Mecham, Eds., pp. ... R. Visse and H. Nagase, "Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and ... "Measurement of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with knee ... decreased production of extracellular matrix (ECM).. The matrix metalloproteinases (MMPs) are a family of Zn2+-dependent ...
https://www.hindawi.com/journals/aorth/2012/834208/
*  Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2 | PNAS
matrix metalloproteinase;. HUVECs,. human umbilical vein endothelial cells;. LTR,. long terminal repeat;. PEX,. hemopexin ... invasive endothelial cells recruit matrix metalloproteinases (MMPs) to remodel the extracellular matrix and the basal lamina-an ... Matrix Metalloproteinase 2-Integrin {alpha}v{beta}3 Binding Is Required for Mesenchymal Cell Invasive Activity but Not ... alpha}v{beta}3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen ...
https://www.pnas.org/content/97/22/12227
*  Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport.
Matrix metalloproteinase (MMP)-2 plays an important role in tissue remodelling during peritoneal injury caused by peritoneal ... dialysis (PD), but MMP-2 inhibitors have not yet been used clinically. Recently, it was reported that captopril, an angiotens ... Matrix metalloproteinase-2 activity in peritoneal effluents was directly inhibited by temocaprilat (IC(50) 0.47 μmol/L). In one ... Matrix metalloproteinase (MMP)-2 plays an important role in tissue remodelling during peritoneal injury caused by peritoneal ...
http://www.biomedsearch.com/nih/Matrix-metalloproteinase-2-inhibition-by/23013132.html
*  RCSB PDB - 1J7M: The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2 Literature Report Page
Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain ... MATRIX METALLOPROTEINASE 2 A 72 Homo sapiens EC#: 3.4.24.24 IUBMB Fragment: third fibronectin type II module Mutation: E11G ... The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2. *DOI: 10.2210/pdb1j7m/pdb ...
http://www.rcsb.org/pdb/explore/litView.do?structureId=1J7M
*  Matrix metalloproteinase-2 (MMP-2) generates soluble HLA-G1 by cell surface proteolytic shedding. | Sigma-Aldrich
Matrix metalloproteinase-2 (MMP-2) generates soluble HLA-G1 by cell surface proteolytic shedding.. [Roberta Rizzo, Alessandro ... Among this class of enzymes, matrix metalloproteinases (MMPs) might be involved in the HLA-G1 membrane cleavage. Of particular ... The results obtained by both cell lines showed the role of MMP-2 in HLA-G1 shedding. On the contrary, MMP-9 was not involved in ... We evaluated the effect of MMP-9 and MMP-2 on HLA-G1 membrane shedding. In particular, we analyzed the in vitro effect of these ...
https://www.sigmaaldrich.com/catalog/papers/23737137
*  Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione
Matrix metalloproteinase-2 (MMP-2) has emerged as a key protease in various pathologies associated with oxidative stress, ... Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Domenii publicaţii > Ştiinţe ... Cuvinte cheie: matrix metalloproteinase-2, oxidative stress; peroxynitrite; S-glutathiolation; troponin I ... Treating MMP-2 zymogen with ONOO(-) resulted in a concentration-dependent regulation of MMP-2, with 0.3-1 microM ONOO(-) ...
https://ad-astra.ro/2008/12/08/activation-and-modulation-of-72kda-matrix-metalloproteinase-2-by-peroxynitrite-and-glutathione/
*  Structure Cluster - 1KS0: The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2 3D Similarity...
MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle ... 2] The all vs. all comparisons are based on jFATCAT (a Java port of the original FATCAT algorithm Yuzhen Ye & Adam Godzik (2003 ... Cov2: The coverage, or %, of aligned residues in chain 2. Table Info. The table is sorting is by P-value by default. Clicking ... Domain 2: Domain name of 2nd domain. Can be either a SCOP ID (d,PDB ID,,Chains,,Domain ID,), ProteinDomainParser ID (PDP:,PDB ...
http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1KS0
*  Frontiers | A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse...
... plays a role in turnover of the cardiac extracellular matrix. FL-MMP-2 is also present intracellularly in association with ... plays a role in turnover of the cardiac extracellular matrix. FL-MMP-2 is also present intracellularly in association with ... NTT-MMP-2 expression caused a 50% reduction of force development by intact myocardium. However, NTT-MMP-2 expression did not ... NTT-MMP-2 expression caused a 50% reduction of force development by intact myocardium. However, NTT-MMP-2 expression did not ...
https://www.frontiersin.org/articles/10.3389/fphys.2014.00363/full
*  Clinicopathologic significance of β-catenin and matrix metalloproteinase-2 expression in non-small cell lung cancer.
The purpose of this study was to analyze β-catenin and matrix metalloproteinase-2 (MMP-2) expression in non-small cell lung ... The purpose of this study was to analyze β-catenin and matrix metalloproteinase-2 (MMP-2) expression in non-small cell lung ... Additionally, MMP-2 expression in N (1-2) NSCLC tissues is higher than that in N (0) lung tissue. There is no correlation ... Immunohistochemistry was performed to examine β-catenin and MMP-2 protein expression in 39 resected NSCLC samples and 8 ...
http://www.biomedsearch.com/nih/Clinicopathologic-significance-catenin-matrix-metalloproteinase/23292837.html
*  Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7 | SpringerLink
Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase and has been found to be a tumor ... Here, the IDH2 and matrix metalloproteinase 7 (MMP7) levels in the specimens from 30 GC patients were investigated by Western ... NF-κB Matrix metalloproteinase 7 (MMP7) Gastric cancer (GC) Metastases This is a preview of subscription content, log in to ... 2.. Liu G, Jiang C, Li D, Wang R, Wang W. Mirna-34a inhibits egfr-signaling-dependent mmp7 activation in gastric cancer. Tumour ...
https://link.springer.com/article/10.1007/s13277-015-4358-2
*  Akt1 Induces Extracellular Matrix Invasion and Matrix Metalloproteinase-2 Activity in Mouse Mammary Epithelial Cells | Cancer...
Akt1 Induces Extracellular Matrix Invasion and Matrix Metalloproteinase-2 Activity in Mouse Mammary Epithelial Cells. Bae-Keun ... Akt1 Induces Extracellular Matrix Invasion and Matrix Metalloproteinase-2 Activity in Mouse Mammary Epithelial Cells ... Akt1 Induces Extracellular Matrix Invasion and Matrix Metalloproteinase-2 Activity in Mouse Mammary Epithelial Cells ... Akt1 Induces Extracellular Matrix Invasion and Matrix Metalloproteinase-2 Activity in Mouse Mammary Epithelial Cells ...
http://cancerres.aacrjournals.org/content/61/20/7647
*  Acupuncture decreases matrix metalloproteinase-2 activity in patients with migraine | Acupuncture in Medicine
Objective To evaluate the effect of acupuncture on the serum matrix metalloproteinase-2 (MMP-2) level and activity in patients ... 2Research and Practice Center for Acupuncture and Complementary Therapy Modalities, Erzurum, Turkey. ... Blood samples were taken before treatment and after the first and last sessions of acupuncture for measurement of MMP-2 ... Conclusions The results of this study showed a clinically relevant decrease in MMP-2 activity in patients with migraine treated ...
http://aim.bmj.com/content/early/2014/08/27/acupmed-2014-010612
*  IJMS | Free Full-Text | Enhancement of Matrix Metalloproteinase-2 (MMP-2) as a Potential Chondrogenic Marker during...
Matrix metalloproteinases (MMPs) are one family of proteolytic enzymes that plays a pivotal role in regulating the biology of ... It is concluded that proteolytic enzyme activity and the level of the active form of MMP-2 were increased during chondrogenic ... During chondrogenic differentiation, mRNA expression of MMP-2 and the level of the active form of MMP-2 were increased, which ... According to our findings, MMP-2 could be a candidate maker for real-time detection of chondrogenic differentiation of hASCs. ...
http://www.mdpi.com/1422-0067/17/6/963
*  Molecules | Free Full-Text | Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell...
The matrix degrading inhibitory capacity was the same for both NSPE and PSPE, despite their different polyphenolic profiles. ... we sought to evaluate whether supplementation with polyphenol-rich red grape skin extracts modulated the matrix-degrading ... are endopeptidases responsible for the hydrolysis of various components of extracellular matrix. MMPs, namely gelatinases MMP-2 ... kaempferol and quercetin exhibited the most significant inhibitory effects on matrix-degrading enzyme activities. Our findings ...
http://www.mdpi.com/1420-3049/21/9/1147
*  Molecular Vision: Suppression of IκBα increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells
... membrane type1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulatesMT1-MMPprocessing ... Suppression of IκBα increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells. Yu-Qing Lan,1 Chi ... Matrix metalloproteinases and their inhibitors in connective tissueremodeling. FASEB J. 1991; 5:2145-54. [PMID: 1850705] ... Matrix metalloproteinases: a review. Crit Rev Oral Biol Med. 1993; 4:197-250. [PMID: 8435466] ...
http://www.molvis.org/molvis/v15/a211/
*  Abstract P4-06-21: Matrix Metalloproteinase 2 in Tumor Cell-Induced Platelet Aggregation: Regulation by Cryptotanshinone |...
Abstract P4-06-21: Matrix Metalloproteinase 2 in Tumor Cell-Induced Platelet Aggregation: Regulation by Cryptotanshinone. Y ... It is well documentedthat matrix metalloproteinases (MMPs) play an integral part in tumor spread and the metastatic cascade. ... Abstract P4-06-21: Matrix Metalloproteinase 2 in Tumor Cell-Induced Platelet Aggregation: Regulation by Cryptotanshinone ... Abstract P4-06-21: Matrix Metalloproteinase 2 in Tumor Cell-Induced Platelet Aggregation: Regulation by Cryptotanshinone ...
http://cancerres.aacrjournals.org/content/70/24_Supplement/P4-06-21