Membrane-type matrix metalloproteinase-1 (EC 3.4.24.80, matrix metalloproteinase 14) is an enzyme. This enzyme catalyses the ... Membrane-type+matrix+metalloproteinase-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Metalloproteinase Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M (September 2001). "Homophilic complex ...

Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in ... Aberrant matrix metalloproteinase (MMP) activity is a well-known contributor to synaptic dysfunction and neuronal loss in CNS ... A clan of metalloproteinases comprising matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs) and ... involvement of matrix metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced ...

The membrane-bound matrix metalloproteinase MT1-MMP (MMP14) is internalized by endocytosis and recycled in endosomal ... This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and ... Cancer cells secrete matrix metalloproteinases to remodel the extracellular matrix, which enables them to overcome tissue ... Cancer cells secrete matrix metalloproteinases to remodel the extracellular matrix, which enables them to overcome tissue ...

The mechanisms underlying the neutrophil reparative role involved rapid degranulation and matrix metalloproteinases (MMPs) ... Mott, J.D.; Werb, Z. Regulation of matrix biology by matrix metalloproteinases. Curr. Opin. Cell Biol. 2004, 16, 558-564. [ ... Ohnishi, K.; Takagi, M.; Kurokawa, Y.; Satomi, S.; Konttinen, Y.T. Matrix metalloproteinase-mediated extracellular matrix ... Paradoxical Role of Matrix Metalloproteinases in Liver Injury and Regeneration after Sterile Acute Hepatic Failure by Débora ...

Li X, Liu Y, Liu Q, Wang S, Ma Y and Jin Q: Recombinant human irisin regulated collagen II, matrix metalloproteinase‑13 and the ... Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M and Zafarullah M: Induction of matrix metalloproteinase-13 gene ... Li, X., Liu, Y., Liu, Q., Wang, S., Ma, Y., Jin, Q.Recombinant human irisin regulated collagen II, matrix metalloproteinase‑13 ... Li, X., Liu, Y., Liu, Q., Wang, S., Ma, Y., Jin, Q.Recombinant human irisin regulated collagen II, matrix metalloproteinase‑13 ...

Fibulin-5 Suppresses Lung Cancer Invasion by Inhibiting Matrix Metalloproteinase-7 Expression Wen Yue; Wen Yue ... Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small ... Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol ... Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer. Oncol Rep ...

Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9 Alvaro A. Ordonez, Alvaro A. ... Distribution of matrix metalloproteinases in human atherosclerotic carotid plaques and their production by smooth muscle cells ... A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in ... Post-mortem analyses were performed to characterize lung lesions and to localize matrix metalloproteinases (MMPs) previously ...

MMI270B is a matrix metalloproteinase inhibitor (MMPI) with in vitro and in vivo activity. To exert optimal target inhibition, ... Seventeen patients were entered into the study. Doses of MMI270B were 150, 400, and 600 mg. The first day, patients ingested ... Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor. Publication. ...

Matrix metalloproteinase-7 (MMP-7) facilitates degradation of the extracellular matrix, promoting the invasion of tumour cells ... Expression of matrix metalloproteinases-2 and -9 by cells isolated from the peritoneal fluid of women with ovarian carcinoma. ... Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E- ... Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2000;2:737-44 ...

MT4-MMP appeared to be shed from the cell surface by the action of an endogenous metalloproteinase. GPI anchoring of MT4-MMP on ... Among the five membrane-type matrix metalloproteinases (MT-MMPs), MT1-, MT2-, MT3-, and MT5-MMPs have about a 20-amino acid ... Matrix Metalloproteinases, Matrix Metalloproteinases, Membrane-Associated, Metalloendopeptidases, Mice, Microscopy, Confocal, ... Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. ...

Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis. Tuberculosis ( ... Matrix metalloproteinases in tuberculosis. P.T. Elkington, C.A. Ugarte-Gil, J.S. Friedland ... Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002; 3: 207-214. ... Expression of matrix metalloproteinase-9 in pleural effusions of tuberculosis and lung cancer. Respiration 2005; 72: 166-175. ...

Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. ... Dive into the research topics of Association of cytokine and matrix metalloproteinase profiles with disease activity and ... Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. / ... Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. In ...

... matrix metalloproteinase; sICAM-1, soluble intercellular adhesion molecule 1; VEGF-A, vascular endothelial growth factor A. ...

resistancemultifunctional effector moleculesPTImatrix metalloproteinases2- MMP overexpressor plants5-MMP4-MMP3-5- mmp plants ... Matrix metalloproteinases (MMPs) are evolutionarily conserved and multifunctional effector molecules playing pivotal roles in ... Matrix metalloproteinases operate redundantly in Arabidopsis immunity against necrotrophic and biotrophic fungal pathogens. ... suggesting that matrix metalloproteinases contribute to pattern-triggered immunity (PTI) in interactions of Arabidopsis with ...

Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res. 2012. doi:10.1007/s00441-012-1410-z. ... Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. ... Nilsson UW, Dabrosin C. Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast ... Extracellular Matrix Remodeling and Fibrosis. The extracellular matrix is essential for the architecture of the tissue and a ...

Expression of IL-1α, IL-1β, IL-6, IL-8, IL-16, IL-18 as well as matrix metalloproteinase (MMP)-1 and MMP-3 were investigated in ... Laminin type 1 augments the transforming growth factor beta-induced expression of matrix metalloproteinase 3 in synovial ... Laminin type 1 augments the transforming growth factor beta-induced expression of matrix metalloproteinase 3 in synovial ... Laminin type 1 augments the transforming growth factor beta-induced expression of matrix metalloproteinase 3 in synovial ...

Cover Story (view full-size image): The extracellular matrix metalloproteinase-2 (MMP-2) is associated with several important ... The Role of Extracellular Matrix Expression, ERK1/2 Signaling and Cell Cohesiveness for Cartilage Yield from iPSCs by Justyna ... The uMSCs abrogated TGF-β1-induced fibrosis by reducing extracellular matrix components including fibronectin-1, collagen (COL ... This article belongs to the Special Issue Extracellular Matrix in Development and Disease 2.0). ...

Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of ... Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs ... are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. ... Stetler-Stevenson WG, Liotta LA, Kleiner DE: Extra cellular matrix 6: role of matrix metalloproteinases in tumor invasion and ...

... are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor ... Kato Y, Yamashita T, Ishikawa M: Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 ... Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. ... Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus ...

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of ... Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of ...

The balance between Matrix metalloproteinase (MMP)-9 and MMP-2/tissue inhibitor of metalloproteinase (TIMP)-1 is closely ... 2020). The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int. J. Mol. Sci. 21, 9739. doi:10.3390/ ... Burrage, P. S., Mix, K. S., and Brinckerhoff, C. E. (2006). Matrix metalloproteinases: role in arthritis. Front. Biosci. 11, ... Cui, N., Hu, M., and Khalil, R. A. (2017). Biochemical and Biological Attributes of Matrix Metalloproteinases. Prog. Mol. Biol ...

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. ... Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and ... stimulate the elaboration of chemotactic cytokines called chemokines and proteolytic enzymes called matrix metalloproteinases ( ... 17). Since IL-13 may be a final common pathway for Th2 cytokines (9), approaches that control IL-13 are particularly appealing ...

Matrix metalloproteinase 3 (MMP-3) and MMP-9 may play a role in the development of this disease. One recent study by Browning ... Tissue biopsy in an affected patient has revealed the presence of matrix metalloproteinase, indicating a potential immune ... Doxycycline for treatment of blepharochalasis via inhibition of matrix metalloproteinases. Ophthal Plast Reconstr Surg. May-Jun ...

3. HL1-1 E2: matrix metalloproteinase 17 (membrane-inserted). 4. 905K-1 E2: SMT3 suppressor of mif two 3 homologue 1 (yeast) ... Results of this study will: (1) determine whether these cell lines are transcriptionally responsive to TCDD and 17β-estradiol ... TCDD and 17β-estradiol (E2), for the AhR and ER, respectively. Specifically, they have shown that normal human HL1-1 liver and ...

Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nat Genet. 2001 ... A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with ... Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2. Clin Genet. 2005 ... The activity of matrix metallopeptidase 2 appears to be important for a variety of body functions, including bone remodeling, ...

Human Matrix Metalloproteinase 11 (MMP11) ELISA Kit. SEA224Hu-5x96wellstestplate Cloud-Clone 5x96-wells test plate. 2799.54 EUR ... Human Matrix Metalloproteinase 11 (MMP11) ELISA Kit. SEA224Hu-10x96wellstestplate Cloud-Clone 10x96-wells test plate. 5128.02 ... Description: A sandwich ELISA kit for detection of Matrix Metalloproteinase 11 from Human in samples from blood, serum, plasma ... Description: A sandwich quantitative ELISA assay kit for detection of Rat Matrix Metalloproteinase 11 (MMP11) in samples from ...

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis. Int J Mol Sci. 2016 Jun 2;17(6). ... Dynamic interactions of epidermal collagen XVII with the extracellular matrix: laminin 332 as a major binding partner. Am J ... Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc. 2009 Aug;14(1):20-4. ... These peptides were shown to increase production of collagen types I, IV, VII, and XVII.24 ...

Metalloproteinases. Matrix metalloproteinases play a vital role in premature skin aging induced by chronic exposure to UV light ... Matrix-degrading metalloproteinases in photoaging. The journal of investigative dermatology. Symposium proceedings / the ... This study also found that the topical DHEA applications decreased expression of matrix metalloproteinase-1, and increased ... UV radiation increases the expression of several different matrix metalloproteinases in the skin (Quan 2009). ...

Explore the mechanisms of hemostasis and matrix degradation. Read now! ... 2002) Thrombin-enhanced matrix metalloproteinase-1 expression: A mechanism linking placental abruption with premature rupture ... Westermarck, J. and Kahari, V.M. (1999) Regulation of matrix metalloproteinase expression in tumor invasion. The FASEB Journal ... Nagase, H., Visse, R. and Murphy, G. (2006) Structure and function of matrix metalloproteinases and TIMPs. Cardiovascular ...

Umbilical Cord Blood Matrix Metalloproteinase-9 Levels are associated with Funisitis Shim SS, Kang HS, Maeng YH, Kim YD ... Although matrix metalloproteinase-8 (MMP-8) and intercellular adhesion molecule-1 (ICAM-1) are known to be related with IUI, it ... Bone matrix is properly maintained by osteoclasts and osteoblasts. In the tumor microenvironment, osteoclasts are increasingly ...