The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
... matrix metalloproteinases-9; MAPK, mitogen activate protein kinase; ECM, extracellular matrix proteins; PLC-γ, phospholipase C ... contributes to GDNF-induced Matrix metalloproteinase-9 (MMP-9) expression, which strongly correlates with the desmoplastic ... matrix metalloprotein 9) and MMP-13, an enzyme family destroying the histological barrier of tumor cell invasion. Further ... thus strongly influencing adhesion to and invasion of the extracellular matrix (ECM). Subsequently, these cancer cells exhibit ...
KLF6 inhibited oral cancer migration and invasion via downregulation of mesenchymal markers and inhibition of MMP-9 activities
Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002;2:161-74 ... Matrix metalloproteinases (MMPs) play a critical role in cancer migration and invasion [14]. To determine whether the decreased ... Itoh Y, Nagase H. Matrix metalloproteinases in cancer. Essays Biochem. 2002;38:21-36 ... Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the ...