Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts | Diabetes
... matrix metalloproteinase 7, membrane-bound aminopeptidase P, heat shock 27 kDa proteins, and cathepsin B. ... thus contributing to fibrinolysis and extracellular matrix remodeling. It also acts as a proinflammatory cytokine (30). ... and its main effects include intracellular protein turnover and extracellular matrix breakdown. Altered expression of the ... Table 3 Cox regression results for 10-year incident T2D and logistic regression results for 5-year risk of worse glycemia ...
TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1 | Diabetes
In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta. Diabetes 2008;57:476-483 ... Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res 2001;88:1291-1298 ... and other matrix metalloproteinases (MMPs), as a gene modifier for insulin resistance and vascular inflammation in mice. We ... We and others have shown that chronic hyperglycemia increases matrix metalloproteinase (MMP) and A disintegrin and ...
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... and matrix metalloproteinase (MMP) 2 and 9 mRNA were measured quantitatively by the TaqMan real-time RT-PCR technique (Applied ... 3B). We found scattered localization of Mac-3 both inside the matrigel and in the fascia around the matrigel, with the numbers ... 3. A: Immunohistochemistry of pro- and antiangiogenic factors in and outside of the matrigel. The matrigel was implanted to ... 3A). The intensity of immunostaining for VEGF and angiopoietin-2 inside the matrigel was rather decreased in the diabetic mouse ...
Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization,...
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2 : 737 -744,2000. ... and extracellular matrix (50). Our data provide several lines of evidence pointing to distinct phenotypic characteristics of ... 3C and D). 3D reconstructed islet vasculature (Fig. 3D) and data in Fig. 3E and F show that vessels in VEGF-A-deficient islets ... 3A), which was consistent with β-cell abundance/islet and our finding that VEGF-A is also expressed by non-β-cells (Fig. 1A and ...
Metabolic Effects of 1200-kcal Diet in Obese Pregnant Women With Gestational Diabetes | Diabetes
Matrix Metalloproteinase Expression in Human Retinal Microvascular Cells. Show more Original Articles ... fasting plasma glucose and glucose tolerance measured by the 3-h oral glucose tolerance test did not change within or between ...