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*  A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility | Clinical...
A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility. Giorgio ... A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility ... A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility ... A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility ...
http://clincancerres.aacrjournals.org/content/8/12/3820.figures-only
*  Table of Contents | Clinical Cancer Research
Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 3: In vivo Evaluation of Cyclopentylcarbamoylphosphonic Acid in ... Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027, Given on Days 1 and 8 of a 3-Week Cycle in Patients ...
http://clincancerres.aacrjournals.org/content/11/10
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Stetler-Stevenson W. G., Liotta L. A., Kleiner D. E. Extracellular matrix 6: role of matrix metalloproteinases in tumor ... Matrix metalloproteinases as stromal effectors of human carcinoma progression: therapeutic implications. Matrix Biol., 15: 535- ... Matrix metalloproteinases (MMPs) play a crucial role in tumor cell invasion and metastasis due to their ability to digest ... Chambers A. F., Matrisian L. A. Changing views on the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst., ...
http://clincancerres.aacrjournals.org/content/5/1/203
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19), mouse anti-human matrix metalloproteinase (MMP)2 (5 μg/mL; Thermo Scientific), mouse anti-human MMP9 (2 μg/mL; Chemicon), ... Figure 3. Regulation of ERα and AIB1 recruitment to target genes is promoter-specific. A, diagrammatic representation of ... AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer ... S6) to all 3 target gene promoters was increased by treatment with estrogen or androstenedione. This ligand-induced recruitment ...
http://clincancerres.aacrjournals.org/content/18/12/3305
*  Table of Contents | Clinical Cancer Research
A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility ... Clinical Significance of Insulin-like Growth Factor-binding Protein-3 Expression in Stage I Non-Small Cell Lung Cancer ... Down-Regulation of PIK3CG, a Catalytic Subunit of Phosphatidylinositol 3-OH Kinase, by CpG Hypermethylation in Human Colorectal ... Correlation between Insulin-like Growth Factor-binding Protein-3 Promoter Methylation and Prognosis of Patients with Stage I ...
http://clincancerres.aacrjournals.org/content/8/12
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... matrix metalloproteinase; RT-PCR, reverse transcription-PCR. ... 3⇓ . As shown in Table 3⇓ , MET was overexpressed in ESCC in 56 ... The MMP family has been shown to be involved in proteolytic degradation of the extracellular matrix to enhance tumor cell ... 3. Photomicrographs of MET expression by IHC staining in morphologically normal esophageal epithelium and ESCC. A, MET IHC in ... Some of the differentially expressed genes are indicated: 1, MET (B6h); 2, Jagged 2 (C3k); 3, MMP13 (E1j); 4, MMP14 (E1k); 5, ...
http://clincancerres.aacrjournals.org/content/7/11/3519
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13-15). Matrix metalloproteinases (MMP), a family of endopeptidases capable of degrading extracellular matrix, have been shown ... Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice. Am J Respir Cell Mol Biol ... Matrix metalloproteinase assays. MMP secretion by tumor cells in vitro was quantified by multiplex bead assays (Millipore) for ... Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura. Br J Cancer ...
http://clincancerres.aacrjournals.org/content/18/9/2478
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... integrin-mediated adhesion to the extracellular matrix, and invasion of basement membranes (39). These are all essential steps ... Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. ... melanoma an ideal system to study the ability of tumor cells to create vascular-like channels and three-dimensional matrices ( ... Phosphoinositide 3-kinase regulates membrane type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell ...
http://clincancerres.aacrjournals.org/content/14/4/951
*  Continuous Delivery of Endogenous Inhibitors from Poly(Lactic-Co-Glycolic Acid) Polymeric Microspheres Inhibits Glioma Tumor...
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with αvβ3 integrin. Cell 1996;85 ... The protein released from the PLGA microspheres occurs by the degradation of the polymeric matrix. The composition of the PLGA ... a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 1998;92:391-400. ... and invasion by a naturally occurring fragment of human metalloproteinase-2. Cancer Res 2001;61:8730-6. ...
http://clincancerres.aacrjournals.org/content/11/2/768.long
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Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with ... Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and ... Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat Med 1996;2:461-2. ... Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 1998;185:256-61. ...
http://clincancerres.aacrjournals.org/content/11/12/4437
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Regulation of extracellular matrix metalloproteinase inducer matrix metalloproteinase expression by amphiregulin in transformed ... positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix ... Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res 2003;1:420 ... Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas. J Pathol 2004;202:341-51 ...
http://clincancerres.aacrjournals.org/content/14/2/494
*  Marked Inhibition of Tumor Growth in a Malignant Glioma Tumor Model by a Novel Synthetic Matrix MetalloproteinaseInhibitor...
Nakano A., Tani E., Miyazaki K., et al Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. ... Nakagawa T., Kabota T., et al Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human ... Woessner J. F. Matrix metalloproteinases and their inhibitors in connective tissue remodelling. FASEB J., 5: 2145-2154, 1991. ... Brown P. D., Giavazzi R. Matrix metalloproteinase inhibition: a review of anti-tumor activity. Ann. Oncol., 6: 967-974, 1995. ...
https://clincancerres.aacrjournals.org/content/5/4/845?ijkey=b6cacf31fdd8ebec469eb023a778d3e4d8a81905&keytype2=tf_ipsecsha
*  Immediate Gene Expression Changes After the First Course of Neoadjuvant Chemotherapy in Patients with Primary Breast Cancer...
... the expression levels of matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinase-3 (TIMP3) genes were often ... A, matrix representation of expression levels and the dendrogram of samples. On the right side, black bars from a to e, the ... and cell adhesion/extracellular matrix, as well as several growth-arrest and DNA-damage-inducible proteins (e.g., GAS, GADD45 ... Each cell in the color matrix represents the relative expression level of a single gene transcript in a single sample. ...
https://clincancerres.aacrjournals.org/content/10/19/6418?ijkey=534cfc93ecff305d6e57ed85f5c9b2f956e3a0ed&keytype2=tf_ipsecsha
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... glioblastoma multiforme cells have elevated expression of matrix metalloproteinases and extracellular matrix components when ... and the extracellular matrix. Under normal conditions, these same interacting factors drive CNS growth and development. We are ... For example, phosphatidylinositol 3-kinase is an enzyme critical to the activation of Akt. Activation occurs as a consequence ... The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501. ...
http://clincancerres.aacrjournals.org/content/12/24/7261
*  Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study | Clinical Cancer...
Thrombospondin-1 modulates angiogenesis in vitro by up-regulation of matrix metalloproteinase-9 endothelial cells. Exp. Cell ... 3, A and C)⇓ and 8 weeks later (Fig. 3, B and D)⇓ by these two complementary imaging modalities. Fig. 3, A and B⇓ , shows ... 3B⇓ . In comparison, the color pixel density shown in Fig. 3, C and D⇓ , is the fraction of image voxels within the margins of ... 3⇓ . Tumor lysis may result in the release of additional copper from the dying cells. In the case of the patient whose mass is ...
http://clincancerres.aacrjournals.org/content/6/1/1.full
*  The Difficulty of Targeting Cancer Stem Cell Niches | Clinical Cancer Research
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. Oncogene 2000;19:1102-13. ... Increased expression of matrix metalloproteinase-3, which is frequently observed in breast cancers, led to genomic instability ... An extracellular matrix microarray for probing cellular differentiation. Nat Methods 2005;2:119-25. ... How does the extracellular matrix direct gene expression? J Theor Biol 1982;99:31-68. ...
http://clincancerres.aacrjournals.org/content/16/12/3121.long
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have developed a series of agents activated by tumor-associated proteases [e.g., cathepsin D and matrix metalloproteinase-2 ( ... By 3 h after injection, the fluorescence intensity of the tumor nodules was visually higher with GmSA-20ROX than with GmSA-1ROX ... 3. Serial side-by-side in vivo spectral fluorescence images of peritoneally disseminated cancer model after injection with 50 ... At 3 h after injection, aggregated tumor foci as well as submillimeter peritoneal implants were more clearly visualized by GmSA ...
http://clincancerres.aacrjournals.org/content/13/21/6335
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... and matrix metalloproteinases (8, 9). In vitro, low-dose IFN-α inhibits B16 melanoma cell proliferation by interference with an ... After 3 weeks, the same dose was given if the plasma FGF-2 concentration had declined by 30% or more, or if it had been ... The six Peg-IFN doses designated in this study were 1 (0.5 μg/kg/wk), 2 (1.0 μg/kg/wk), 3 (2.0 μg/kg/wk), 4 (3.0 μg/kg/wk), 5 ( ... When grade 3 or 4 toxicities occurred, Peg-IFN was held until toxicity returned to grade ≤1. Treatment was then restarted at ...
http://clincancerres.aacrjournals.org/content/19/23/6597
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Coexpression of Matrix Metalloproteinase-7 (MMP-7) and Epidermal Growth Factor (EGF) Receptor in Colorectal Cancer ... Coexpression of Matrix Metalloproteinase-7 (MMP-7) and Epidermal Growth Factor (EGF) Receptor in Colorectal Cancer ... matrix metalloproteinase 11, v-Ral, and integrin β4) were highly expressed in tumor cells. In contrast, genes underexpressed in ... matrix metalloproteinase 11 (MMP11), and syndecan 2 (SDC2). Interestingly, genes involved in Ras/Ral signaling pathways, RalA, ...
http://clincancerres.aacrjournals.org/content/10/15/4944
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The expression levels of survivin, livin, Akt-1, caveolin, histone deacetylase(HDAC)1, matrix metalloproteinases(MMP)-2, MMP-7 ... tissue inhibitors of metalloproteinase(TIMP)-1 and EphB2 were determined by reverse-transcription polymerase chain reaction(RT- ... each having a lifespan of 3-4days, are shed daily from the lower two-thirds of colon crypts; thus, using colonocytes to develop ... ring-3, enolase-1α, insulin-like growth factor binding protein(IGFBP)-2, ...
http://clincancerres.aacrjournals.org/content/12/19_Supplement/A29
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... matrix metalloproteinases, and cyclooxygenase-2. EGF is an important gene for proliferation and differentiation of epithelial ... We also did exploratory stratified risk analyses (Table 3 ). For continuous variables such as age and pack-years, we stratified ... Color development was monitored after the addition of 100 μL of 3,3′,5,5′-tetramethylbenzidine (R&D Systems) using a ... 3). The majority of patients have unresectable tumors or detectable metastases at the time of diagnosis (4). Many clinical risk ...
http://clincancerres.aacrjournals.org/content/14/10/3216
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Matrix metalloproteinase 2 or 9 (MMP-2 and MMP-9) activities in conditioned medium were visualized by electrophoresis on ... as well as the increase of matrix metalloproteinase 2. However, silencing β-catenin in these hypoxic cells reversed epithelial- ... GSK-3β is a vital suppressor of β-catenin and is modulated by PI3K/Akt signaling (23). This is one of the most important ... 3. Effect of silencing β-catenin on the invasion and metastasis of MHCC97 and Hep3B cells under normoxic and hypoxic conditions ...
http://clincancerres.aacrjournals.org/content/16/10/2740
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In vitro, IL-19 induced transcripts of IL-1β, IL-6, TGF-β, matrix metalloproteinase (MMP)2, MMP9, and CXCR4 in 4T1 breast ... matrix metalloproteinase (MMP)2, MMP9, and CXCR4 were amplified using PCR with gene-specific primers (Supplementary Table S2). ... and migration of cancer cells but also was indirectly involved in tumor progression mediated through matrix metalloproteinase ( ... Role of reactive oxygen species (ROS), metalloproteinase-2 (MMP-2) and interleukin-6 (IL-6) in direct interactions between ...
http://clincancerres.aacrjournals.org/content/18/3/713
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Hypoxia level and matrix metalloproteinases-2 and -9 activity in Lewis lung carcinoma: correlation with metastasis. Exp Oncol ... matrix metalloproteinases (MMP), and lysyl oxidase (LOX), which is involved in the establishment of the premetastatic niche (30 ... The metastatic score for each animal was calculated using the formula: (p1 × 1) + (p2 × 1) + (p3 × 2) + (p4 × 3) where p1 is ... 3), knockdown of LAMP3 did not adversely affect tumor growth, and in fact both sham- and hypoxia-treated groups showed a trend ...
http://clincancerres.aacrjournals.org/content/19/22/6126
*  A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous...
... showed that they can specifically bind to tumors with high matrix metalloproteinase (MMP) activity in xenograft models (40). ... POSTN, an extracellular matrix protein that is highly expressed in late-stage ovarian cancer (9), is thought to play a role in ... Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 2009;139:891-906. ... Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response. Clin Cancer ...
http://clincancerres.aacrjournals.org/content/20/3/711.full