0 (Mannosephosphates); 0 (Polysaccharides); 0 (Recombinant Proteins); 3672-15-9 (mannose-6-phosphate); EC 3.2.1.20 (GAA protein ...
Use of mannose phosphates for the treatment of fibrotic disorders Kirsner et al. 1993. The wound healing process. ...
... mannosephosphates MeSH D09.894.480.350 --- inositol 1,4,5-trisphosphate MeSH D09.894.480.700 --- phytic acid MeSH D09.894. ...
Method of using mannose phosphates for the treatment of fibrotic disorders US5529987A (en) 1993-08-04. 1996-06-25. Patent ... Method of using mannose phosphates for the treatment of fibrotic disorders US5663160A (en) 1992-09-17. 1997-09-02. Lvmh ...
... and deletion of both resulted in phenotypes that suggest a role in cell wall integrity with loss of cell wall mannose phosphates ...
Mannosephosphates. *Receptor, IGF Type 2. *Receptors, Cell Surface/metabolism. *Receptors, LDL/biosynthesis ...
Mannosephosphates. *Orosomucoid. *Receptor, IGF Type 2. *Receptors, Cell Surface. *Receptors, Immunologic. Grant support. *GM ...
... mannose into mannose phosphates, GDP-mannose, GDP-fucose,... ...
Mannose 6-phosphate (Man-6-P)-dependent trafficking is vital for normal development. The biogenesis of lysosomes, a major cellular site of protein, carbohydrate, and lipid catabolism, depends on the 300-kDa cation-independent Man-6-P receptor (CI-MPR) that transports newly synthesized acid hydrolases from the Golgi. The CI-MPR recognizes lysosomal enzymes bearing the Man-6-P modification, which arises by the addition of GlcNAc-1-phosphate to mannose residues and subsequent removal of GlcNAc by the uncovering enzyme (UCE). The CI-MPR also recognizes lysosomal enzymes that elude UCE maturation and instead display the Man-P-GlcNAc phosphodiester. This ability of the CI-MPR to target phosphodiester-containing enzymes ensures lysosomal delivery when UCE activity is deficient. The extracellular region of the CI-MPR is comprised of 15 repetitive domains and contains three distinct Man-6-P binding sites located in domains 3, 5, and 9, with only domain 5 exhibiting a marked preference for ...
mannosephosphates. mannoses. mannosidase. mannosidases. mannoside. mannosidestreptomycin hydrolase. mannosidoses. mannosidosis ...
Alternative Splicing , Brain , Cerebral Cortex , DNA, Complementary , Exons , Humans , Lysosomes , Mannosephosphates , ...