Vacuolization and alterations of lysosomal membrane proteins in cochlear marginal cells contribute to hearing loss in...
... knockout mouse model is a phenocopy of the lysosomal storage disease (LSD) sialidosis, characterized by multisystemic and ... Changes in lysosomal membrane proteins in Neu1−/− cochleae. Left panel shows immunoblot analyses of selected lysosomal membrane ... Changes in lysosomal membrane proteins in Neu1 −/− cochleae. Left panel shows immunoblot… ... Vacuolization and alterations of lysosomal membrane proteins in cochlear marginal cells contribute to hearing loss in ...
Sialin - Wikipedia
Winchester BG (2001). "Lysosomal membrane proteins". Eur. J. Paediatr. Neurol. 5 Suppl A: 11-9. doi:10.1053/ejpn.2000.0428. ... Member 5, also known as SLC17A5 or sialin is a lysosomal membrane sialic acid transport protein which in humans is encoded by ... 2002). "Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis". Clin. ... A multiple lysosomal transport defect for acidic monosaccharides". J. Clin. Invest. 87 (4): 1329-35. doi:10.1172/JCI115136. PMC ...
MedlinePlus: Genes: L
DNA Methylation Patterns in CD4+ T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl...
... lysosomal-associated membrane protein 1; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; FITC, fluorescein isothiocyanate ... Note: CD107a, lysosomal-associated membrane protein 1; IAV, influenza A virus; KLRG1, killer cell lectin-like receptor ... Anti-CD107a [LAMP-1 (lysosomal-associated membrane protein 1)] was added, and the cells were incubated for an additional 4 h at ... T-cell exhaustion, the expression of cytotoxic T-lymphocyte-associated protein 4 (CTLA4), programmed cell death protein 1 (PD1 ...
Human CD63 Alexa Fluor® 700-conjugated Antibody IC5048N-100UG: R&D Systems
Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; ME491; melanoma 1 antigen; Melanoma- ... but following cell activation is also present on the plasma membrane. Interaction of CD63 with other membrane proteins or ... is a 30-60 kDa member of the tetraspanin superfamily of protein trafficking proteins. CD63 is ubiquitously expressed and found ... CD_antigen: CD63; CD63 antigen (melanoma 1 antigen); CD63 antigen; CD63 molecule; CD63; Granulophysin; Lamp-3; ...
influenza - Ontology Report - Rat Genome Database
lysosomal-associated membrane protein 3. ISO. CTD Direct Evidence: marker/mechanism. CTD. PMID:23326326. NCBI chr11:81,153,491 ... C-reactive protein. ISO. protein:increased expression:serum. RGD. PMID:21509252. RGD:5131277. NCBI chr13:85,135,384... ... protein:increased expression:respiratory system fluid/secretion. protein:increased expression:lung, serum. RGD. PMID:20656925 ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine ...
Publication Detail
... green fluorescent protein; HBSS: hanks balanced salt solution; LAMP: lysosomal-associated membrane protein; LDH: lactate ... dehydrogenase; Lys Inh: lysosomal inhibitors; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK: mitogen- ... We further show that Mn exposure suppresses autophagic-lysosomal degradation of mitochondria and induces accumulation of ... activated protein kinase; Mn: manganese; MTOR: mechanistic target of rapamycin kinase; OCR: oxygen consumption rate; PBS: ...
Biomarkers Search
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.. Jung J; Genau HM; Behrends C. Mol Cell Biol ... 5. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.. Sancak Y ... amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. ... Nat Rev Mol Cell Biol; 2013 Mar; 14(3):133-9. PubMed ID: 23361334. [TBL] ...
3D ultrastructural analysis of α-granule, dense granule, mitochondria, and canalicular system arrangement in resting human...
... late endosomal/lysosomal membrane protein 2; PF4, platelet factor 4; TGF. ‐β, transforming growth factor‐β; VAMP‐8, vesicle‐ ... 2 (late endosome/lysosomal membrane marker). Twenty platelets were scored for each pairing. For co‐localization details, see ... Protein distribution data indicated that all α-granules likely contained the same major set of proteins, albeit at varying ... 8 (α‐granule membrane marker) in comparison to VWF. (M‐O). PF. 4 was detected using goat polyclonal antibodies directed ...
Mucopolysaccharidoses Types I-VII: Practice Essentials, Pathophysiology, Epidemiology
... are a group of lysosomal storage diseases, each of which is produced by an inherited deficiency of an enzyme involved in the ... which is consistent with the expression patterns of lysosomal proteins. A total of 27 TMEM76 mutations were identified in the ... this enzyme belongs to a new structural class of proteins that transport the activated acetyl residues across the cell membrane ... The transmembrane protein gene TMEM76, which encodes a 73-kd protein with predicted multiple transmembrane domains and ...
Glucocerebrosidase Is Shaking Up the Synucleinopathies
... is one of the most abundant transmembrane proteins in the lysosomal membrane (Eskelinen et al., 2003); mutation and over- ... which reaches the lysosome via lysosomal integral membrane protein type 2 (LIMP-2) mediated trafficking (Reczek et al., 2007) ( ... lifts glucocerebroside from the lysosomal membrane and/or membranes within the lysosome and makes it available for ... lifts glucocerebroside from the lysosomal membrane and/or membranes within the lysosome and makes it available for ...
GPR155 G protein-coupled receptor 155 [Homo sapiens (human)] - Gene - NCBI
lysosomal cholesterol signaling protein. Names. G-protein coupled receptor PGR22. integral membrane protein GPR155. ... Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. Title: Lysosomal GPCR-like protein LYCHOS signals ... mRNA and Protein(s) * XM_017003487.2 → XP_016858976.1 lysosomal cholesterol signaling protein isoform X1 ... mRNA and Protein(s) * XM_054340820.1 → XP_054196795.1 lysosomal cholesterol signaling protein isoform X1 ...
CLN5 gene: MedlinePlus Genetics
The CLN5 gene provides instructions for making a protein whose function is not well understood. Learn about this gene and ... Larkin H, Ribeiro MG, Lavoie C. Topology and membrane anchoring of the lysosomal storage disease-related protein CLN5. Hum ... Cells produce a CLN5 protein that is inactive and contains extra protein segments. This inactive protein is called a preprotein ... Proteolytic processing of the neuronal ceroid lipofuscinosis related lysosomal protein CLN5. Exp Cell Res. 2015 Oct 15;338(1): ...
NIOSHTIC-2 Search Results - Full View
... and lysosomal-associated membrane protein-1 (LAMP-1) expression. Serum cytokines were analyzed by bead-based immunologic assays ... CAPs-exposed mice had elevations in macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, interleukin (IL)-6, IL-10, tumor ... The authors exposed mice to an average of 88.5 microg/m(3) of CAPs in a size range less than 2.5 microm for 6 h/day for 5 days ...
Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome...
... lysosomal-associated membrane protein 1; LC3: microtubule-associated protein 1 light chain 3; LEF: lymphoid enhancer binding ... and its direct target genes encoding components of lysosomal membrane vacuolar-type ATPase, thereby suppressing lysosome ... The resulting lysosomal dysfunction then impaired autophagic flux and activated SQSTM1-NFKB signaling to drive the expression ... Effects of TcdB on lysosomal function and the downstream pro-inflammatory SQSTM1/p62-NFKB (nuclear factor kappa B) signaling ...
William Trimble | SickKids Directory
Lysosomal Integral Membrane Protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Nature Comm. 10(1):3521 ... WS Trimble and S Grinstein (2015) Barriers to the free diffusion of proteins and lipids in the plasma membrane. J. Cell Biol. ... Richard Scheller where he identified the VAMP SNARE protein. In 1990, Trimble returned to the University of Toronto where he ... Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane. Developmental Cell. 50(3):283-295.e5 ...
Mucopolysaccharidoses Types I-VII: Practice Essentials, Pathophysiology, Epidemiology
... are a group of lysosomal storage diseases, each of which is produced by an inherited deficiency of an enzyme involved in the ... which is consistent with the expression patterns of lysosomal proteins. A total of 27 TMEM76 mutations were identified in the ... this enzyme belongs to a new structural class of proteins that transport the activated acetyl residues across the cell membrane ... The transmembrane protein gene TMEM76, which encodes a 73-kd protein with predicted multiple transmembrane domains and ...
Chronic Inhalation Exposure to Coal Dust and/or Diesel Exhaust:
Effects on the Alveolar Macrophages of Rats
... constant cell volume and absence of protein and lysosomal enzymes in acellular fluid from the pulmonary lavage; (2) viability, ... The results of these tests suggested that chronic exposure to coal dust and/or diesel exhaust did not alter the membrane ... as indicated by lack of affect on cellular protein content, cellular lysosomal enzyme activity, or oxygen consumption; (3) ... The following physiologic parameters of these cells were measured: (1) membrane integrity, as indicated by maintenance of a ...
Macroautofagia
... lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; LRSAM1: leucine rich repeat and sterile ... in lysosomal membrane repair. Lysosomal damage promotes TECPR1 recruitment to damaged membranes via its N-terminal dysferlin ... Vacuole Membrane Protein 1 (VMP1) is an essential autophagy protein. The expression of VMP1 in pancreatic cancer stem cells ... Lysosomal membrane damage represents a threat to cell viability. As such, cells have evolved sophisticated mechanisms to ...
MeSH Browser
Lysosomal-Associated Membrane Protein 1 [D12.776.395.550.550.500] * Lysosomal-Associated Membrane Protein 2 [D12.776.395.550. ... Lysosomal-Associated Membrane Protein 1 [D12.776.543.550.527.500] * Lysosomal-Associated Membrane Protein 2 [D12.776.543.550. ... Proteins [D12.776] * Membrane Proteins [D12.776.543] * Membrane Glycoproteins [D12.776.543.550] * Lysosome-Associated Membrane ... Lysosomal-Associated Membrane Protein 3 Preferred Term Term UI T633630. Date03/17/2005. LexicalTag NON. ThesaurusID NLM (2006) ...
MeSH Browser
Proteins [D12.776] * Membrane Proteins [D12.776.543] * Membrane Glycoproteins [D12.776.543.550] * Lysosomal Membrane Proteins [ ... Lysosomal-Associated Membrane Protein 1 [D09.400.430.890.550.500] * Lysosomal-Associated Membrane Protein 2 [D09.400.430.890. ... Lysosomal-Associated Membrane Protein 1 [D12.776.395.550.550.500] * Lysosomal-Associated Membrane Protein 2 [D12.776.395.550. ... Lysosomal-Associated Membrane Protein 1 [D12.776.543.550.527.500] * Lysosomal-Associated Membrane Protein 2 [D12.776.543.550. ...
Multiplexed strategies toward clinical translation of extracellular vesicles
... lysosomal-associated membrane protein 2), a well-characterized and abundantly expressed exosomal membrane protein, is a perfect ... Y-box protein 1; EXPLOR, exosomes for protein loading via optically reversible protein-protein interaction; CRY2, cryptochrome ... CD, cluster of differentiation; Lamp2b, Lysosomal-associated membrane protein 2b; DOPE-NHS, dioleoylphosphatidylethanolamine N- ... Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein ...
Unraveling lysosomal acidification defect in a lysosomal storage disorder model | NIH Research Festival
... a multi-subunit protein complex, consisting of a cytosolic V1 sector and lysosomal membrane-anchored V0 sector. Despite intense ... Unraveling lysosomal acidification defect in a lysosomal storage disorder model. Thursday, September 15, 2016. - Poster Session ... Dysregulation of lysosomal acidification contributes to pathogenesis of virtually all lysosomal storage disorders (LSD) and ... facilitates steady-state membrane localization required for function of many important proteins. Using Cln1-/- mice, which ...
LAMP2 Antibodies
lysosomal-associated membrane protein 2 (Lamp2) Antibodies. lysosomal-associated membrane protein 2 S homeolog (lamp2.S) ... lysosomal-associated membrane protein 2 (LAMP2) Antibodies. lysosomal associated membrane protein 2 (Lamp2) Antibodies. CD107b ... Lysosomal-Associated Membrane Protein 2 (LAMP2)). The protein encoded by this gene is a member of a family of membrane ... lysosomal-associated membrane protein 2 (lamp2) Antibodies. lysosomal membrane glycoprotein 2 (lamp2) Antibodies. ...
![The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter semiSWEET[v5] | Preprints.org](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAA0AAAAQCAMAAAD6fQULAAAAS1BMVEVHcEz/vwD1yyf9vwf/vgD+vgH5wRP/vgAABzj+vwj7whIABzj7vw3+vgT+vgX+0hX+vwsAADr9vwf8wA38vwYAAD6mfSKMfDT/vgBFulgmAAAAGHRSTlMA+g6x890j7bGGN2p61MkWkE6bbkko3Rhzgv8fAAAAc0lEQVQImV2OSRbEIAgFQTHG2Qzd4f4nDair1Ip6/z8AQIn3bWDRWanbkMKXBLFyFMnc4EjpB9Zr1GFXjsbSdeFraTRpmPk/uoXKzFAvWDubJl85B0c4jUnwXs12g36Acm87l2EYrzWWmdiut0N15Yzw5QXqAAXjnm3RwAAAAABJRU5ErkJggg==)
The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter semiSWEET[v5] | Preprints.org
... mediates movement of basic amino acids across lysosomal membranes, and is also involved in phospholipase flippase function. The ... The structural proteins of SARS include, membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N) and the ... The M protein of SARS-CoV-2 interacts with S, E and N protein. The S protein of the virus is glycosylated. It could be ... The M protein of SARS-CoV-2 is 98.6% similar to the M protein of bat SARS-CoV, maintains 98.2% homology with pangolin SARS-CoV ...
Identification of PIKfyve kinase as a target in multiple myeloma
| Haematologica
Lysosomal cell death is promoted by leakage of lysosomal contents following permeabilization of the lysosomal membrane;32 ... lysosome-associated membrane protein 1 (Lamp-1), and sequestosome 1 (SQSTM1)/p62 protein levels (B). (C) The ration of SQSTM1: ... as well as lysosome-associated membrane protein 1 (Lamp-1), a protein present in lysosomes and autophagolysosomes. An increase ... Higher basal protein levels of TFEB, a regulator of lysosomal function and autophagy,29 was shown in two HMCL (KMS26 and JJN3) ...
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. - Oxford Neuroscience
... lysosomal associated membrane protein 1; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MCOLN1/TRPML1: ... lysosomal, V0 subbunit A1; ATP6V1A: ATPase, H+ transporting, lysosomal, V0 subbunit A; BSA: bovine serum albumin; CCCP: ... AMPK is found to be necessary for basal lysosomal function, and AMPK deactivation in RC-deficiency inhibits lysosomal function ... P2-MCOLN1 pathway causes lysosomal Ca2+ accumulation and impaired lysosomal catabolism. Besides unveiling a novel role of AMPK ...
DeCS
Lysosomal-Associated Membrane Protein 3 - Preferred Concept UI. M0142867. Scope note. A lysosomal-associated membrane ... Lysosomal-Associated Membrane Protein 3 Entry term(s). Antigens, CD208 CD208 Antigens DC LAMP Protein DC-LAMP Protein LAMP 3 ... A lysosomal-associated membrane glycoprotein that is expressed at high levels in mature DENDRITIC CELLS.. ... Lysosome-Associated Membrane Glycoproteins (2006-2011). Public MeSH Note:. 2012; see LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS ...
Global, quantitative and dynamic mapping of protein subcellular localization | eLife
A spatial proteomics method can capture physiological protein subcellular localization changes in response to a stimulus, ... nuclear protein, and 40% protein from other membranes. As a consequence, genuine organellar proteins tend to be recovered ... For example, lysosomes are released very effectively from cells by our lysis conditions; lumenal lysosomal proteins are ... 1984) Density of newly synthesized plasma membrane proteins in intracellular membranes II. Biochemical studies Journal of Cell ...