Lucanthone is a drug used in chemotherapy. It is a prodrug and is converted to the active metabolite hycanthone. Hycanthone ...
Lucanthone potentiates the anti-tumor activity of pemetrexed in a lung cancer tumor model. Combination treatment of lucanthone ... Lucanthone is an orally available small molecule inhibitor of AP endonuclease. Inhibition of AP endonuclease by lucanthone ... lucanthone given orally at 80 mg/kg, and the combinations of pemetrexed and lucanthone at the same doses. The tumor growths and ... Lucanthone potentiates the anti-tumor activity of pemetrexed in a lung cancer model. Guru Reddy, Tuong Dang, Yang-Dar Yuan and ...
Drug: Lucanthone Lucanthone or Placebo will be given as an oral at 10-15 mg/kg/day for 6 weeks along with radiation and TMZ ... Active Comparator: Lucanthone + TMZ + Radiation Subjects will be randomly assigned to Lucanthone or Placebo arm in ratio of 1:1 ... Safety Profile of Lucanthone [ Time Frame: one year ]. Safety Profile of Lucanthone at 10-15 mg/kg/day. ... Lucanthone or Placebo will be given as an oral at 10-15 mg/kg/day for 6 weeks along with radiation and TMZ during the ...
Lucanthone HCl (studied as a reference drug) had only feeble to moderate effect in mice or monkeys even though several rigorous ... TAC pamoate, TAC hydroxide, TAC chloride, and lucanthone HCl were studied extensively in infected mice and monkeys, and the ... are directly schistosomicidal in vitro at lower concentrations than lucanthone HCl, exhibit a flat-dose response relationship, ... Lucanthone HCl (studied as a reference drug) had only feeble to moderate effect in mice or monkeys even though several rigorous ...
Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy ... Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, ... Lucanthone is orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic ... Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy ...
of lucanthone hydrochloride and 4 out of 4 cases were cured with 20 to 24 mg./kg. of sodium antimonyl gluconate. ... Summary In Schistosoma mansoni infections in Saudi Arabia a cure was obtained in 6 out of 12 cases with lucanthone ... Treatment with Lucanthone Hydrochloride (Nilodin) and with Sodium Antimonyl Gluconate (Triostam) * M. L. Tarizzo1 ... of lucanthone hydrochloride and 4 out of 4 cases were cured with 20 to 24 mg./kg. of sodium antimonyl gluconate. ...
It is a metabolite of lucanthone. Hycanthone interferes with parasite nerve function, resulting in paralysis and death. This ...
This is a randomized, double blind placebo controlled study to evaluate safety and efficacy of lucanthone administered as an ... Lucanthone/placebo will be given as an adjunct to the WBRT on days that WBRT is administered. Tumor assessments will be done ... Evaluation of Lucanthone to Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer ... Eligible patients for this trial will be randomized to lucanthone or placebo in a ratio of 1:1. The treatment will consist of ...
Hycanthone, a new active metabolite of lucanthone.. Rosi D, Peruzzotti G, Dennis EW, Berberian DA, Freele H, Tullar BF, Archer ... Schistosomicidal activity of lucanthone hydrochloride, hycanthone and their metabolites in mice and hamsters. ... A comparison of oral and parenteral activity of hycanthone and lucanthone in experimental infections with Schistosoma mansoni. ...
Lucanthone. investigational. yes. intercalation. Details. DB04961. Troxacitabine. investigational. unknown. Details. DB05706. ...
neo-antimosan  Astiban TW 56  Lucanthone-HCl. Obat-obat anti schistosoma :  Emetin (tartras emetikus)  Fuadin stibofen. ...
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Lucanthone Hydrochloride A Topoisomerase II inhibitor 548-57-2. sc-396381 sc-396381A 10 mg. 5 mg. $280.00 $140.00 0 ...
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J. Biol. Chem. 2010, 286, 6602-6613 ...
Abasic sites in DNA of HeLa cells induced by lucanthone. Cancer Investig 2002;20:983-91. ...
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem 2011;286:6602-13. ... block autophagosome degradation include the tricyclic antidepressant drug clomipramine and the anti-schistome agent lucanthone ...
Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. ...
... lucanthone, hycanthone, and niridazole generate autophagic activities in the gastrodermis (gut) of S. mansoni and induce ...
SuperGen Inc., of San Ramon, Calif., acquired rights to lucanthone, a radio-sensitizing topoisomerase II inhibitor in a Phase I ...
Including 7 Camptothecin Analogs and Lucanthone", J. Chem Inf. Model., 56:9 (2016), 1872-1883 →. ???????? ?????????? I II ...
... repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Research 24: 2127 ...
Lucanthone, Alvocidib, Imexon, Fosfestrol, Lurtotecan, Buthionine sulfoximine, Cell-cycle nonspecific antineoplastic agents, ...
Lucanthone, Lucatumumab, Lumefantrine, Luo Hang Guo extract and powder, Lysine Acetylsalicylate, Lysozyme, M-344, MDV3100, ... Lucanthone, Lucatumumab, Lumefantrine, Luo Hang Guo extract and powder, Lysine Acetylsalicylate, Lysozyme, M-344, MDV3100, ...
Lucanthone, Lucatumumab, Lumefantrine, Luo Hang Guo extract and powder, Lysine Acetylsalicylate, Lysozyme, M-344, MDV3100, ... Lucanthone, Lucatumumab, Lumefantrine, Luo Hang Guo extract and powder, Lysine Acetylsalicylate, Lysozyme, M-344, MDV3100, ...
Carew JS, Espitia CM, Esquivel JA 2nd, Mahalingam D, Kelly KR, Reddy G, Giles FJ, Nawrocki ST (2011b) Lucanthone is a novel ...
Lucanthone (substance). Code System Preferred Concept Name. Lucanthone (substance). Concept Status. Published. ...
Lucanthone: "Small-molecule which inhibits Topoisomerase II and AP endonuclease" - phase 1 for cancer. 2010 10k: abandoned anti ...
... lucanthone, lucartamide, lucimycin, lufenuron, lufironil, lufuradom, luliconazole, lumefantrine, lumiliximab, lumiracoxib, ... lucanthone, lucartamide, lucimycin, lufenuron, lufironil, lufuradom, luliconazole, lumefantrine, lumiliximab, lumiracoxib, ... lucanthone, lucartamide, lucimycin, lufenuron, lufironil, lufuradom, lumefantrine, lupitidine, luprostiol, lurosetron, ...
... lucanthone, LY 317615, neuradiab, vitespan, Rta 744, Sdx 102, talampanel, atrasentan, Xr 311, romidepsin, ADS-100380, sunitinib ... lucanthone, LY 317615, neuradiab, vitespan, Rta 744, Sdx 102, talampanel, atrasentan, Xr 311, romidepsin, ADS-100380, sunitinib ...
... lucanthone, lucartamide, lucimycin, lufuradom, lupitidine, luprostiol, luxabendazole, lyapolate sodium, lycetamine, lydimycin, ...