DSpace at EWHA: Comparison of BALB/c and CBA/J mice for the local lymph node assay using bromodeoxyuridine with flow cytometry ...DSpace at EWHA: Comparison of BALB/c and CBA/J mice for the local lymph node assay using bromodeoxyuridine with flow cytometry ...

Local lymph node assay; LLNA; BrdU-FCM; Skin sensitization; BALB/c; CBA/J; Flow cytometry. Publisher. ACADEMIC PRESS INC ... The local lymph node assay using 5-bromo-2-deoxyuridine (BrdU) with flow cytometry (LLNA: BrdU-FCM) is a modified LLNA that is ... Comparison of BALB/c and CBA/J mice for the local lymph node assay using bromodeoxyuridine with flow cytometry (LLNA: BrdU-FCM) ... Comparison of BALB/c and CBA/J mice for the local lymph node assay using bromodeoxyuridine with flow cytometry (LLNA: BrdU-FCM) ...
more infohttp://dspace.ewha.ac.kr/handle/2015.oak/233878

NIOSHTIC-2  Publications Search - 20031680 - QSAR study of skin sensitization using local lymph node assay data.NIOSHTIC-2 Publications Search - 20031680 - QSAR study of skin sensitization using local lymph node assay data.

In this work sensitization data for the murine Local Lymph Node Assay ( LLNA) were used. In principle, LLNA provides a ...
more infohttps://www.cdc.gov/niosh/nioshtic-2/20031680.html

Local lymph node assay - WikipediaLocal lymph node assay - Wikipedia

The murine local lymph node assay (LLNA) is an in vivo test for skin sensitisation. LLNA has largely superseded the guinea pig ... The REACH Regulation, Annex VII, paragraph 8.3 states "The Murine Local Lymph Node Assay (LLNA) is the first-choice method for ... The animals are euthanized and their lymph node cells are removed and analyzed. The ratio of tracer incorporation in lymph ... The principle underlying the LLNA is that skin sensitizers induce growth of lymphocytes in the lymph nodes draining the site of ...
more infohttps://en.wikipedia.org/wiki/Local_lymph_node_assay

Evaluation of radioisotopic and non-radioisotopic versions of local lymph node assays for subcategorization of skin sensitizers...Evaluation of radioisotopic and non-radioisotopic versions of local lymph node assays for subcategorization of skin sensitizers...

Evaluation of radioisotopic and non-radioisotopic versions of local lymph node assays for subcategorization of skin sensitizers ... Evaluation of radioisotopic and non-radioisotopic versions of local lymph node assays for subcategorization of skin sensitizers ... of the murine local lymph node assay (LLNA) is used as criteria. Non-radioisotopic variants of LLNA, LLNA: DA, LLNA: BrdU-ELISA ...
more infohttp://www.nextbio.com/b/search/article.nb?id=28193562

Refubium - Investigation of the sensitisation potential of various textile dyes using a
biphasic mice local lymph node assay ...Refubium - Investigation of the sensitisation potential of various textile dyes using a biphasic mice local lymph node assay ...

... local lymph node assay" (LLNA) bei Mäusen und eines in-vitro Assays („loose-fit co-culture based sensitisation assay", LCSA) ... the lymph nodes were prepared and various end points, such as ear thickness, ear punch weight, lymph node weight, lymph node ... local lymph node assay" (LLNA) und eines in- vitro Assays („loose-fit co-culture") (LCSA) zu untersuchen. Im zweiphasischen ... Investigation of the sensitisation potential of various textile dyes using a biphasic mice local lymph node assay (LLNA) and an ...
more infohttps://refubium.fu-berlin.de/handle/fub188/7692

NIOSHTIC-2  Publications Search - 20035118 - Increased cell proliferation in spleen and lymph nodes peripheral to contact...NIOSHTIC-2 Publications Search - 20035118 - Increased cell proliferation in spleen and lymph nodes peripheral to contact...

The assay involves dosing mice with the chemical on both ears and pooling the superficial parotid lymph nodes for assessment of ... The local lymph node assay (LLNA) is widely used to identify chemicals that are contact sensitizers. ... Local lymph node assay; Spleen; Peripheral lymph nodes ... The local lymph node assay (LLNA) is widely used to identify ... and in the lymph node draining the contra-lateral vehicle-dosed ear (SI = 6), as well as the proper axillary lymph nodes (SI = ...
more infohttps://www.cdc.gov/niosh/nioshtic-2/20035118.html

Publications - OECDPublications - OECD

442A: Skin Sensitization - Local Lymph Node Assay: DA The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive ... The procedure from excision of lymph nodes to ATP measurement should be kept uniform for each animal and completed within 20 ... skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ... reviews SME and entrepreneurship issues and policies at national and local levels, and provides observations and ...
more infohttp://www.oecd.org/publications/172/

March/April 2014 - Volume 25 - Issue 2 - Contributor Index : DermatitisMarch/April 2014 - Volume 25 - Issue 2 - Contributor Index : Dermatitis

The Local Lymph Node Assay in 2014. Basketter, David A.; Gerberick, G. Frank; Kimber, Ian ... The Local Lymph Node Assay in 2014. Basketter, David A.; Gerberick, G. Frank; Kimber, Ian ... The Local Lymph Node Assay in 2014. Basketter, David A.; Gerberick, G. Frank; Kimber, Ian ...
more infohttp://journals.lww.com/dermatitis/pages/contributorindex.aspx?year=2014&issue=03000

In Silico Toxicology (RSC Publishing)In Silico Toxicology (RSC Publishing)

Skin Sensitisation (Local Lymph Node Assay) Data. Mark T. D. Cronin and Judith C. Madden ...
more infohttps://pubs.rsc.org/en/content/ebook/978-1-84973-004-4

September 2001 - Volume 12 - Issue 3 : DermatitisSeptember 2001 - Volume 12 - Issue 3 : Dermatitis

Contact Allergenic Potency: Correlation of Human and Local Lymph Node Assay Data. Gerberick, Frank G.; Robinson, Michael K.; ...
more infohttps://journals.lww.com/dermatitis/toc/2001/09000

Toxicology and Safety | SRI InternationalToxicology and Safety | SRI International

Local lymph node assay Immunotoxicology Biological product testing Vaccine safety Immunogenicity 510(k) medical device safety ... Local lymph node assay. * Immunotoxicology. * Biological product testing. * Vaccine safety. * Immunogenicity. * 510(k) medical ...
more infohttps://www.sri.com/research-development/toxicology-and-safety

Toxicology of Crop Protection AgentsToxicology of Crop Protection Agents

LOCAL LYMPH NODE ASSAY (LLNA). *Eurofins Advinus has more than a decade of experience in conducting LLNA studies in mice. ...
more infohttp://www.advinus.com/services/agrochemical-discovery-and-development-services/toxicology-of-agrochemicals/

Cosmetics  | Free Full-Text | Safety Evaluation of Cosmetic Ingredients: In Vitro Opportunities for the Identification of...Cosmetics | Free Full-Text | Safety Evaluation of Cosmetic Ingredients: In Vitro Opportunities for the Identification of...

Other assays (i.e., KeratinoSens™ assay) will follow shortly. While a number of methods are at various stages of development ... published its Recommendation on the Direct Peptide Reactivity Assay (DPRA) for skin sensitization, capable of distinguishing ... Kimber, I.; Weisenberger, C. A murine local lymph node assay for the identification of contact allergens. Assay development and ... The evaluation of the contact sensitization potential of chemicals is currently done using the local lymph node assay (LLNA), ...
more infohttp://www.mdpi.com/2079-9284/1/1/61/htm

Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine...Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine...

Combined Local Lymph Node and Irritancy Assay. To determine the irritancy and sensitization potential of PCBTF, a combined ... M. R. Woolhiser, A. E. Munson, and B. J. Meade, "Comparison of mouse strains using the local lymph node assay," Toxicology, vol ... NIEHS, "National Institute of Environmental Health Sciences; the murine local lymph node assay: a test method for assessing the ... Evaluation of the sensitization potential, conducted using the local lymph node assay (LLNA) at concentrations ranging from 50 ...
more infohttps://www.hindawi.com/journals/ja/2011/238513/

4-phenylbutenone - Registration Dossier - ECHA4-phenylbutenone - Registration Dossier - ECHA

Local lymph node assay results. Chemical and testing lab. Vehicleaand concentrations. dpm/node or *mean dpm (±SEM). Stimulation ... mouse local lymph node assay (LLNA). Species:. mouse. Strain:. CBA. Sex:. female. Details on test animals and environmental ... mouse local lymph node assay (LLNA). Species:. mouse. Strain:. CBA. Sex:. female. Details on test animals and environmental ... A standard local lymph node assay (LLNA) protocol was used by the laboratories. One laboratory employed the standard protocol ...
more infohttps://echa.europa.eu/registration-dossier/-/registered-dossier/5367/7/5/1

NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View

To identify the causative agent(s) of the occupational dermatitis, the murine local lymph node assay (LLNA) was used to ... local lymph node assay; occupational contact dermatitis; ink ribbon manufacturing ... Lymph-nodes; Lymphatic-system; Patch-tests; Skin-sensitivity; Allergens; Allergic-reactions; Industrial-exposures; Author ...
more infohttp://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=mead&f1=AU&Startyear=&terms=3&Adv=1&ct=&B1=Search&Limit=500&Sort=DP+DESC&whichdate=DP&D1=10&EndYear=&PageNo=9&RecNo=81&View=f&

NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View

BQ and BQD skin allerginicity was evaluated in the murine local lymph node assay (LLNA). BQD with electron withdrawing groups ... Local lymph node assay; Michael addition; SNV; Nucleophilic vinylic substitution; Stimulation index ... The effects of inserting substituents on the BQ ring has not been studied in animal assays. However, mandated reduction/ ...
more infohttp://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=chlorine&f1=%2A&Adv=0&terms=1&PageNo=3&RecNo=21&View=f&

The Human T Cell Priming Assay (hTCPA) | SpringerLinkThe Human T Cell Priming Assay (hTCPA) | SpringerLink

MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node ... The local lymph node assay: past, present and future. Contact Dermatol. 2002;47:315-28.CrossRefGoogle Scholar ... production by lymph node cells of CD4+ T-cell-depleted mice. J Invest Dermatol. 2008;129:1185-91.CrossRefPubMedGoogle Scholar ... This key event that concludes the skin sensitization process is monitored in an in vitro assay, the human T cell priming assay ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-50353-0_31

N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-... - Registration Dossier - ECHAN-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-... - Registration Dossier - ECHA

Local Lymph Node Assay). Deviations:. no. GLP compliance:. yes. Type of study:. mouse local lymph node assay (LLNA). Species:. ... The Local Lymph Node Assay (LLNA) with radionuclides was used. The testing was conducted according to the Method B.42 - Skin ... EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay). Deviations:. no. Qualifier:. according to. Guideline:. OECD ... Lymph node cell counts: Incorporation of 3H-methyl thymidine. The tissues of both of the lymph nodes were prepared by gentle ...
more infohttps://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/5682/7/5/1

2-(2-hexyloxyethoxy)ethanol - Registration Dossier - ECHA2-(2-hexyloxyethoxy)ethanol - Registration Dossier - ECHA

Local Lymph Node Assay). Deviations:. not applicable. GLP compliance:. yes (incl. certificate). Type of study:. mouse local ... The Local Lymph Node Assay (LLNA) was conducted to assess the potential of the test substance to cause contact sensitization by ... The Local Lymph Node Assay (LLNA) was conducted to assess the potential of diethylene glycol monohexyl ether (DEGHE) to cause ... lymph node assay (LLNA). Species:. mouse. Strain:. CBA. Sex:. female. Details on test animals and environmental conditions:. ...
more infohttps://echa.europa.eu/registration-dossier/-/registered-dossier/5882/7/5/1

Sophorolipids: fermentation products of glucose... - Registration Dossier - ECHASophorolipids: fermentation products of glucose... - Registration Dossier - ECHA

Local Lymph Node Assay). Deviations:. not specified. GLP compliance:. yes (incl. certificate). Type of study:. mouse local ... Name of test method: Local Lymph Node Assay (LLNA). - Criteria used to consider a positive response: The test material will be ... A = Dpm/node obtained by dividing the Dpm value by 8 (total number of lymph nodes) ... lymph node assay (LLNA). Species:. mouse. Strain:. CBA. Sex:. female. Details on test animals and environmental conditions:. ...
more infohttps://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/12734/7/3/4

Immunotoxicity Testing - Methods and Protocols | Rodney R. Dietert | ApressImmunotoxicity Testing - Methods and Protocols | Rodney R. Dietert | Apress

The Local Lymph Node Assay and Skin Sensitization Testing. Pages 221-231 ... for the most well-established immunotoxicity assays, focusing very much on the procedures at the laboratory bench. It will be a ...
more infohttps://www.apress.com/us/book/9781607614005