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Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A ... Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A ...

... made by the liver in response to brain injury, as important regulators of the CNS inflammatory response. ... made by the liver in response to brain injury, as important regulators of the CNS inflammatory response. ...

The presence and severity of fibrosis are the most important prognostic factors in non-alcoholic fatty liver disease. This ... This review summarises the current concepts in diagnosis and disease progression of non-alcoholic liver disease, focusing on ... Patients with non-alcoholic fatty liver disease show variable rates of disease progression through a histological spectrum ... Despite the current lack of licensed, liver-targeted pharmacotherapy, several promising agents are undergoing late-phase ...

This is a living systematic review. We search monthly for new evidence and update the review when we identify relevant new ... and to maintain the currency of the evidence using a living systematic review approach. SEARCH METHODS: To identify completed ... This is a living systematic review. We search monthly for new evidence and update the review when we identify relevant new ... Convalescent plasma for people with COVID-19: a living systematic review. Iannizzi C., Chai KL., Piechotta V., Valk SJ., Kimber ...

Correspondingly, KRAS mutation was associated with lung relapse (HR = 2.1; 95% CI, 1.2 to 3.5, P = 0.007) but not liver relapse ... than in liver metastases (32.3%; P = 0.003). Mutation status was highly concordant between primary cancer and metastasis from ... Mutation prevalence was compared between (a) metastases from liver (n = 65), lung (n = 50), and brain (n = 46), (b) metastases ... Correspondingly, KRAS mutation was associated with lung relapse (HR = 2.1; 95% CI, 1.2 to 3.5, P = 0.007) but not liver relapse ...

Accumulation of fat within the liver underlies the spectrum of conditions known as non-alcoholic fatty liver disease (NAFLD) ... The liver is a major player in fat metabolism; it integrates endogenous and exogenous fatty acids and the accumulation or loss ... Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models. Journal article ... Detection and alterations of acetylcarnitine (AC) in human liver by 1 H MRS at 3T after supplementation with l-carnitine. ...

Increases in liver aminotransferase levels were the most common FLT180a-related adverse events. Late increases in ... is a liver-directed adeno-associated virus (AAV) gene therapy that uses a synthetic capsid and a gain-of-function protein to ... Increases in liver aminotransferase levels were the most common FLT180a-related adverse events. Late increases in ... BACKGROUND: FLT180a (verbrinacogene setparvovec) is a liver-directed adeno-associated virus (AAV) gene therapy that uses a ...

The treatment of choice for hepatocellular carcinoma remains surgical resection or liver transplantation, in carefully selected ... However, because almost every individual who develops liver cancer dies of the disease, HCC is the third most common cause of ... However, because almost every individual who develops liver cancer dies of the disease, HCC is the third most common cause of ... The treatment of choice for hepatocellular carcinoma remains surgical resection or liver transplantation, in carefully selected ...

In effect, part of the liver received regional chemotherapy, whereas the remainder of the organ was exposed to systemic ... Postoperative hepatic arterial perfusion scintigraphy showed that only part of the liver was being perfused by this route. ... Ultrasonography demonstrated shrinkage of the metastases in the area of liver receiving regional therapy, whereas disease ... A 48-year-old man with colorectal liver metastases underwent insertion of an hepatic arterial infusion catheter for regional ...

Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A ... Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A ...

The liver-produced hormone hepcidin dictates systemic iron homeostasis. We measured hepcidin, iron parameters, cytokines, and ... The liver-produced hormone hepcidin dictates systemic iron homeostasis. We measured hepcidin, iron parameters, cytokines, and ...

Circadian regulation of liver energy metabolism: translational studies in diabetes.. PIs: Professor David Ray and Dr Maxwell ...

"My research aims to understand how liver cells cope with such damage. This will provide insight into the origin of liver cancer ... "The liver is a vital organ that detoxifies many harmful substances which can damage DNA - the blueprint of life" says Dr Gogola ...

Verapamil/nitroglycerin is short-lived in vivo but lasts longer in vitro. Measurements of antispasmodic duration of action in ... Verapamil/nitroglycerin is short-lived in vivo but lasts longer in vitro. Measurements of antispasmodic duration of action in ...

These findings were functionally validated with live-cell imaging. We demonstrated that treatment with Gc reduced the activity ... These findings were functionally validated with live-cell imaging. We demonstrated that treatment with Gc reduced the activity ...

RUVBL1 REGULATES LIVER GLUCOSE METABOLISM VIA THE AKT/MTOR PATHWAY: IMPLICATIONS FOR HEPATOCELLULAR CARCINOMA PROGRESSION ... RUVBL1 REGULATES LIVER GLUCOSE METABOLISM VIA THE AKT/MTOR PATHWAY: IMPLICATIONS FOR HEPATOCELLULAR CARCINOMA PROGRESSION ...

We found that some techniques that measure liver stiffness had a good performance for the diagnosis of severe liver scarring. ... have been suggested as alternatives to liver biopsy in assessing the severity of liver scarring (fibrosis) and fatty ... LAY SUMMARY: Non-invasive tests that measure liver stiffness or use magnetic resonance imaging (MRI) ... we summarise the results of previously published studies on how accurately these non-invasive tests can diagnose liver fibrosis ...

... features of B19 infection were examined using haemopoietic cell suspension cultures derived from human fetal liver. ... Apoptosis, Cell Nucleus, Cells, Cultured, Cytoplasm, Erythema Infectiosum, Erythroid Precursor Cells, Humans, Liver, Parvovirus ... features of B19 infection were examined using haemopoietic cell suspension cultures derived from human fetal liver. ...

... about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV- ... Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring ...

His prediction failed spectacularly, but nonetheless it helped him to make a good living out of it. Today, many politicians ...

Most living things have an internal body clock which regulates when they sleep and when they wake up. A complex set of genes ...

Each year a new theme is chosen by the IDF and for 2015 the theme is healthy living. ...

Furthermore, recombinant ERFE suppressed the hepatic BMP/SMAD pathway independently of changes in serum and liver iron. In ... The BMP/SMAD pathway in the liver is critical for hepcidin control, and we show that EPO suppressed hepcidin and other BMP ... The BMP/SMAD pathway in the liver is critical for hepcidin control, and we show that EPO suppressed hepcidin and other BMP ... Furthermore, recombinant ERFE suppressed the hepatic BMP/SMAD pathway independently of changes in serum and liver iron. In ...

... evaluated by an activity of daily living questionnaire, in atrioventricular synchronous and ventricular pacing. Mean distance ... Activities of Daily Living, Adaptation, Physiological, Aged, Aged, 80 and over, Cardiac Pacing, Artificial, Cross-Over Studies ... evaluated by an activity of daily living questionnaire, in atrioventricular synchronous and ventricular pacing. Mean distance ...

Adult, Aged, Antimetabolites, Antineoplastic, Carcinoma, Hepatocellular, Female, Folic Acid Antagonists, Humans, Liver ...

The system generated sound quality similar to live bedside listening, a feature rarely seen in cervical auscultation studies ... The system generated sound quality similar to "live" bedside listening, a feature rarely seen in cervical auscultation studies ...

... both indices were higher in liver metastase compared to other anatomic sites (MI, P = 0.034 and CI, P = 0.022). The CI of the ... both indices were higher in liver metastase compared to other anatomic sites (MI, P = 0.034 and CI, P = 0.022). The CI of the ... Liver Neoplasms, Male, Multivariate Analysis, Neoplasm Recurrence, Local, Predictive Value of Tests, Prognosis ...