Increased risk of colorectal neoplasia in asymptomatic liver-transplant recipients (22 May, 2007) J J Koornstra, J Wesseling, A ... Liver disease. *. Diastolic dysfunction is associated with poor survival in patients with cirrhosis with transjugular ...

... which increases the risk of perioperative morbidity and mortality for liver surgery. The molecular mechanisms of this ... in mice treated with irinotecan and in liver specimens from irinotecan-treated compared with control patients. ... but significantly reduced ERK phosphorylation and inflammatory response in irinotecan-treated hepatocytes and murine livers. ...

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease Silvia Sookoian, Adrian Salatino, Gustavo ...

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites Xiang Zhang, ...

Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 ...

Aric J Hui, James Y Lau, Phyllis P Y Lam, Alman O M Chui, Alice S H Fan, Thomas Y T Lam, Yee-kit Tse, Raymond S Y Tang, Siew C Ng, Justin C Y Wu, Jessica Y L Ching, Martin C S Wong, Francis K L Chan, Joseph Sung ...

7 Liver Failure Group, Institute for Liver Disease Health, University College London, Royal Free Hospital, London, UK ... method for diagnostic and/or prognostic of acute on-chronic liver failure syndrome in patients with liver disorders pending. ... 6 Liver Unit, Hospital Clínic, Universitat de Barcelona, Institut dInvestigacions Biomèdiques August Pi-Sunyer (IDIBAPS) and ... The exacerbation of these processes underlies the development of acute-on-chronic liver failure. A further mechanism promoting ...

Liver transplantation for CC. Historically, liver transplantation for CC was associated with rapid recurrence of disease and ... Portal vein embolisation of the liver lobe to be removed is a safe method for increasing the future liver remnant and permits ... EASL Clinical Practice Guidelines: management of cholestatic liver diseases. European Association for the Study of the Liver. J ... volume of the putative remnant liver after resection and underlying liver disease.21 Although more complex than the Bismuth- ...

Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial ...

Effects of gender, liver function test and BMI on duct diameters in healthy subjects. Multivariable adjusted quantile ... All subjects who died, were lost to follow-up or had incident pathologies (ie, pancreatic cancer or newly diagnosed liver ... Moreover, it demonstrated that an increase in CBD diameters is not associated with underlying liver or bile duct disease. This ... The pathologies were: two cases of pancreatic ductal adenocarcinoma, one case with liver metastases of unknown primary and one ...

Results For HBeAg+ve patients (Group 1, n=25, 6 East Asian, 4 Bangladeshi, 5 African 6 other): 4 patients (17%) seroconverted, one of whom became anti-HBs+ on treatment. 28% of patients suppressed viral load and normalised ALT while on treatment. 50% of patients progressed to oral antivirals, 25% of whom then seroconverted. Hence 50% of patients either seroconverted or moved to a disease state where therapy was not required. All ethnic groups had a similar response and no pre-treatment factors influenced outcome. For HBeAg-ve disease (Group 2, n=9, 3 Bangladeshi 2 Pakistani 4 other): 3 patients (33%) met the criteria for treatment success at 48 weeks which was upheld over follow-up, one of whom underwent HBsAg seroconversion. Two patients had a sustained reduction in viraemia and inflammation that led to a decision to withhold further therapy. Four patients (44%) required oral antiviral therapy. Hence 56% of patients were managed by interferon alone. Success was most marked in patients from ...

Conclusion These data confirm that OPN is upregulated in the blood and livers of CHB patients. We also show that OPN directly ... This study aimed to evaluate the role of OPN in HBV replication, HBsAg secretion and HBV-driven liver injury. ... In addition, expression of OPN was assessed in explanted livers from healthy and HBV-cirrhotic patients. ...

Dig Liver Dis2002;34:22-8.. OpenUrlCrossRefPubMedWeb of Science ...

13Andreas Digestive, Colon, Liver and Gallbladder Clinic Pte Ltd, Singapore. *. 14Department of Pathology, Tan Tock Seng ... Dig Liver Dis 2008;40:650-8.doi:10.1016/j.dld.2008.02.030pmid:http://www.ncbi.nlm.nih.gov/pubmed/18424244. ...

Patients with cirrhosis were found to be extremely sensitive to tranylcypromine, and the use of this drug for the treatment of depression in such patients is contraindicated. Amitriptyline has a wider margin of safety in such patients, but caution is necessary when the higher therapeutic doses are prescribed.. ...

Infliximab (grade of recommendation: 1A) and adalimumab (1B) are moderately effective for the induction and maintenance of fistula closure. Evidence for efficacy of certolizumab pegol is weaker (1C). Anti-TNF and thiopurine combination therapy may lead to higher fistula healing response and closure rate compared to monotherapy (2C).. Vote: A+=26%, A=42%, A−=16%, D=11%, D+=5%.. Discussion. Infliximab Two RCTs have assessed the efficacy of infliximab in fistulising CD. In the first placebo controlled trial an induction regimen induced closure of at least 50% of fistulas for at least 4 weeks in 56-68% of patients compared with 26% treated with placebo (p=0.002 and p = 0.02, respectively). Closure of all fistulas was achieved in 38-55% on infliximab.67 The ACCENT II trial further evaluated infliximab maintenance therapy for this indication. Week 14 responders to the induction regimen were randomised to further treatment with placebo or infliximab 5 mg/kg every 8 weeks.68 Time to loss of response ...

Experience with transjugular liver biopsy. (1 November, 1983) Free H J Bull, I T Gilmore, R D Bradley, J H Marigold, R P ...

We are living with a tremendous amount of microorganisms in our guts, ranging from bacteria, archaea to virus and fungi. There ... Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. Br J Cancer 2012;107:1337-44.doi:10.1038/bjc. ... Gut microbiome and liver diseases. Gut 2016;65:2035-44.doi:10.1136/gutjnl-2016-312729 ... Probiotics: These are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host.129 ...

Correlations between liver NADPHox mRNA and (C) liver CD68 mRNA, (D) TLR4 mRNA or (K) plasma MCP-1 levels. Correlations between ... Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, ... Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995;108:218-24. ... G) Correlation between liver CD68 mRNA and TLR4 mRNA concentrations (p,0.05) the inset corresponds to Pearsons r correlation ...

Correlations between liver NADPHox mRNA and (C) liver CD68 mRNA, (D) TLR4 mRNA or (K) plasma MCP-1 levels. Correlations between ... Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, ... Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995;108:218-24. ... G) Correlation between liver CD68 mRNA and TLR4 mRNA concentrations (p,0.05) the inset corresponds to Pearsons r correlation ...

Am J Physiol Gastrointest Liver Physiol 2005;288:G403-6.. OpenUrlAbstract/FREE Full Text ...

... using the abdominal aorta and the left lobe of the liver as internal landmarks.24 For both the longitudinal (D1) and ...

Fatty liver: a study of 270 patients with biopsy proven fatty liver and a review of the literature. Medicine 1962;41:249-76. ... Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes? Ann Intern Med 1989;111:473-8. ... Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J Hepatol 2001;35: ... Liver damage in severely obese patients: a clinical-biochemical-morphologic study on 1,000 liver biopsies. Obes Surg 2004;14: ...

The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol 2006;101:2128-38. ...

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The death rates were expressed per million living population. The age-specific deaths rates were plotted against the period of ... subjects aged 45-54 was divided by the corresponding number of the total resident population of the same age group and living ...

Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute, Stockholm, Sweden; M Shimizu, Department of ...