"Lipoylation" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Lipoylation" by people in this website by year, and whether " ... Below are the most recent publications written about "Lipoylation" by people in Profiles. ...

This led me to ask if LplA1 and LplA2 ligases can use lipoamide as a source of lipoic acid for protein lipoylation. Through ... Previously attempts to purify LipL and study it in a lipoylation assay led to no observable function of the protein, and ... biochemical lipoylation assays, we discovered that these enzymes are unable to directly use lipoylated peptides; instead, S. ... This led me to ask if LplA1 and LplA2 ligases can use lipoamide as a source of lipoic acid for protein lipoylation. Through ...

FDX1 regulates cellular protein lipoylation through direct binding to LIAS FDX1 regulates cellular protein lipoylation through ... Here we show that FDX1 regulates protein lipoylation by directly binding to the lipoyl synthase (LIAS) enzyme and not through ... Together, our findings establish that FDX1 directly engages with LIAS, promoting cellular protein lipoylation, a process ... FDX1 regulates cellular protein lipoylation through direct binding to LIAS. bioRxiv. 2023. ...

Posner, Mareike G.; Upadhyay, Abhishek; Bagby, Stefan; Hough, David W.; Danson, Michael J. (2009). "A unique lipoylation system ...

Lipoylation / genetics* * Membrane Proteins / genetics* * Membrane Proteins / metabolism * Phylogeny * Polymorphism, Genetic* * ...

Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p ... Lipoate-protein ligase involved in protein lipoylation; localized to mitochondria. View computational annotations ...

... lipoylation on PDHE2; C8:ACP = octanoyl:acyl carrier protein; [FE-S]=iron sulphur cluster; PEP = phosphoenolpyruvate; e-= ...

Lipoate-Protein Ligase and Octanoyltransferase Are Essential for Protein Lipoylation in Mitochondria of Arabidopsis1[W][OPEN]. ...

Lipoate-Protein Ligase and Octanoyltransferase Are Essential for Protein Lipoylation in Mitochondria of Arabidopsis1[W][OPEN]. ...

This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid [7]. ... Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate.. ...

TY - JOUR. T1 - Heart failure leads to altered β 2 -adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain. AU - Bastug-Özel, Zeynep. AU - Wright, Peter T.. AU - Kraft, Axel E.. AU - Pavlovic, Davor. AU - Howie, Jacqueline. AU - Froese, Alexander. AU - Fuller, William. AU - Gorelik, Julia. AU - Shattock, Michael J.. AU - Nikolaev, Viacheslav O.. N1 - The work was supported by the Deutsche Forschungsgemeinschaft (IRTG1816 to V.O.N. and M.J.S.), Wellcome Trust (109604/Z/15/Z to D.P.), British Heart Foundation (RG/12/18/30088 to J.G.) and the Gertraud und Heinz-Rose Stiftung (to V.O.N.).. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Aims: Cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling by acting in microdomains associated with sarcolemmal ion channels. However, local real time cAMP dynamics in such microdomains has not been visualized before. We sought to directly monitor cAMP in a microdomain formed around ...

Lipoylation Medicine & Life Sciences 85% * Retinal Pigments Medicine & Life Sciences 73% * Glycosylation Medicine & Life ...

... and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [ (PUBMED: ...

Ilipo-pseaac: Identification of lipoylation sites using statistical moments and general pseaac. Baig, T. I., Khan, Y. D., Alam ...

Lipoylation - Preferred Concept UI. M0508576. Scope note. Covalent attachment of LIPIDS and FATTY ACIDS to other compounds and ...

The Immunity-Related GTPases (IRG) are a family of large GTPases that mediate innate immune responses. Irgm1 is particularly critical for immunity to bacteria and protozoa, and for inflammatory homeostasis in the intestine. Although precise functions for Irgm1 have not been identified, prior studies have suggested roles in autophagy/mitophagy, phagosome remodeling, cell motility, and regulating the activity of other IRG proteins. These functions ostensibly hinge on the ability of Irgm1 to localize to intracellular membranes, such as those of the Golgi apparatus and mitochondria. Previously, it has been shown that an amphipathic helix, the αK helix, in the C-terminal portion of the protein partially mediates membrane binding. However, in absence of αK, there is still substantial binding of Irgm1 to cellular membranes, suggesting the presence of other membrane binding motifs. In the current work, an additional membrane localization motif was found in the form of palmitoylation at a cluster of ...

Lipoylation. Covalent attachment of LIPIDS and FATTY ACIDS to other compounds and PROTEINS.. ... AcylationOxidation-ReductionLipoylationLipid MetabolismEsterificationKineticsLipolysisOxygen ConsumptionEnergy Metabolism ... NonesterifiedOleic AcidAcylationOxidation-ReductionGlucoseLipoylationPalmitoyl Coenzyme ATriglyceridesCaprylatesOleic Acids ...

Dive into the research topics where George N DeMartino is active. These topic labels come from the works of this person. Together they form a unique fingerprint ...

Mendoza-Viveros, L., Chiang, C. K., Ong, J. L. K., Hegazi, S., Cheng, A. H., Bouchard-Cannon, P., Fana, M., Lowden, C., Zhang, P., Bothorel, B., Michniewicz, M. G., Magill, S. T., Holmes, M. M., Goodman, R. H., Simonneaux, V., Figeys, D. & Cheng, H. Y. M., Apr 18 2017, In: Cell Reports. 19, 3, p. 505-520 16 p.. Research output: Contribution to journal › Article › peer-review ...

Lee, C. W., Hsu, L. F., Wu, I. L., Wang, Y. L., Chen, W. C., Liu, Y. J., Yang, L. T., Tan, C. L., Luo, Y. H., Wang, C. C., Chiu, H. W., Yang, T. C. K., Lin, Y. Y., Chang, H. A., Chiang, Y. C., Chen, C. H., Lee, M. H., Peng, K. T. & Huang, C. C. Y., 15 May 2022, In: Journal of Hazardous Materials. 430, 128431.. Research output: Contribution to journal › Article › peer-review ...

Dive into the research topics of Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. Together they form a unique fingerprint. ...

Lipoylation Medicine & Life Sciences 54% * Neurons Medicine & Life Sciences 53% * Proteins Medicine & Life Sciences 51% ...

A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...

Lipoylation Medicine & Life Sciences 24% * Prenylation Medicine & Life Sciences 23% * Guanine Nucleotide Exchange Factors ...

Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. Curr Opin Chem Biol. 2018;42:76-85 ... FDX1 regulates cellular protein lipoylation through direct binding to LIAS. bioRxiv. 2023 ... a crucial regulator of lipoylation-related proteins, prevents Cu-induced cell death [25]. Cu toxicity is closely related to ...

A dual-function chemical probe for detecting erasers of lysine lipoylation. Journal:Frontiers of Chemical Science and ...

N-Linked Glycosylation at Asn, Lipoylation, Palmitoylation, Phosphorylation at Ser/Thr. Site(s) of PTM(s) N-glycosylation, O- ...

2022 Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth * Mukha Dzmitry, Fokra Mariam, ...