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*  Abstract 19081: 5-lipoxygenase Inhibitor Via-2291 (atreleuton) Reduces Inflammation and Coronary Necrotic Core Plaque and...
Abstract 19081: 5-lipoxygenase Inhibitor Via-2291 (atreleuton) Reduces Inflammation and Coronary Necrotic Core Plaque and ... Abstract 19081: 5-lipoxygenase Inhibitor Via-2291 (atreleuton) Reduces Inflammation and Coronary Necrotic Core Plaque and ... Abstract 19081: 5-lipoxygenase Inhibitor Via-2291 (atreleuton) Reduces Inflammation and Coronary Necrotic Core Plaque and ... Abstract 19081: 5-lipoxygenase Inhibitor Via-2291 (atreleuton) Reduces Inflammation and Coronary Necrotic Core Plaque and ...
http://circ.ahajournals.org/content/126/Suppl_21/A19081
*  15-Hydroxyeicosatetraenoic acid - Wikipedia
... inhibitor of 12-lipoxygenase but not other human lipoxygenases. This effect could also have anti-inflammatory and anti- ... 15-Lipoxygenase-1: Cells metabolize arachidonic acid with 15-lipoxygenase-1 (i.e., 15-LO-1, ALOX15) to form 15(S)-HpETE as a ... Sadeghian H, Jabbari A (2016). "15-Lipoxygenase inhibitors: a patent review". Expert Opinion on Therapeutic Patents. 26 (1): 65 ... Oxygenated by 5-lipoxygenase (ALOX5 to form its 5,6-trans epoxide derivative which may then rearrange to the lipoxins (LX), ...
https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid
*  Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta. | Hypertension
Treatment with the lipoxygenase inhibitor nordihydroguaiaretic acid completely blocked but the cytochrome P450 inhibitor ... Arachidonic acid elicited a concentration-related relaxation that was potentiated by the cyclooxygenase inhibitor indomethacin ...
http://hyper.ahajournals.org/content/20/5/682
*  Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. | Circulation Research
... a lipoxygenase inhibitor, and eicosatetraynoic acid, a lipoxygenase and cyclooxygenase inhibitor. Indomethacin, a ... Bromophenacyl bromide, a phospholipase A2 inhibitor, decreased relaxation due to adenosine triphosphate, thrombin, and trypsin ... cyclooxygenase inhibitor, potentiated relaxation to these agents, whereas the increased levels of cyclic nucleotides due to ...
http://circres.ahajournals.org/content/55/4/468
*  LOX-DB - LipOXygenases DataBase - Literature
Increased lipoxygenase activity was paralleled by an increase of its protein and mRNA level. Lipoxygenase inhibitors ... Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmed cell death. ... The commitment of cells to apoptosis caused by H2O2 was characterized by an early increase of lipoxygenase activity, of ... Inhibitory anti-lipoxygenase monoclonal antibodies, introduced into the protoplasts by electroporation, protected cells against ...
http://www.glycosciences.de/spec/lox-db/show-literature.php?lit_id=162
*  JCI - Leukotrienes and sex: strange bedfellows?
Rask-Madsen J, Bukhave K, Laursen LS, Lauritsen K. 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease. ... Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males. J Clin Invest. 2017;127(8):3167- ... There is a recent interest in using higher doses of leukotriene modifiers and in delivering these inhibitors directly to the ... If the clinical studies identify a sex-specific effect on leukotriene synthesis inhibitors, it would validate the results of ...
https://j8k9.com.www.mobile.jci.org/articles/view/95717
*  Repositorio da Producao Cientifica e Intelectual da Unicamp: Leukotrienes play a role in the control of parasite burden in...
... treating Strongyloides stercoralis-infected patients presenting asthma-like symptoms because use of 5-lipoxygenase inhibitors ... In infected Swiss mice treated with MK886, a leukotriene synthesis inhibitor, numbers of adult worms, and eggs/g/feces were ... Similarly, parasite burdens and eggs/g/feces were greater in 5-lipoxygenase(-/-) mice than in wild-type animals. These ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/80873
*  Novel 5-Lipoxygenase Inhibitors in Inflammation and Asthma | SpringerLink
The discovery of mammalian lipoxygenases which convert arachidonic acid to oxygenated products with potent inflammatory and ... Higgs G.A. (1989) Novel 5-Lipoxygenase Inhibitors in Inflammation and Asthma. In: Samuelsson B., Berti F., Folco G.C., Velo G.P ... Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors. J. Med. Chem., 31: 499-500.Google Scholar ... The effects of a novel series of selective inhibitors of arachidonate 5-lipoxygenase on anaphylactic and inflammatory responses ...
https://link.springer.com/chapter/10.1007/978-1-4684-7938-6_22
*  DailyMed - Search Results for 5-Lipoxygenase Inhibitor
SEARCH RESULTS for: 5-Lipoxygenase Inhibitor [Drug Class] (4 results) * Share : JavaScript needed for Sharing tools. Bookmark ...
https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=5-Lipoxygenase%20Inhibitor&searchdb=class
*  Lipoxygenase Inhibitors as Potential Cancer Chemopreventives | Cancer Epidemiology, Biomarkers & Prevention
... a cyclooxygenase-2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea-induced mammary carcinogenesis ... Lipoxygenase Inhibitors as Potential Cancer Chemopreventives. Vernon E. Steele, Cathy A. Holmes, Ernest T. Hawk, Levy ... Lipoxygenase Inhibitors as Potential Cancer Chemopreventives. Vernon E. Steele, Cathy A. Holmes, Ernest T. Hawk, Levy ... Lipoxygenase Inhibitors as Potential Cancer Chemopreventives. Vernon E. Steele, Cathy A. Holmes, Ernest T. Hawk, Levy ...
http://cebp.aacrjournals.org/content/8/5/467.long
*  Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. - PubMed ...
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.. Dahlén B1 ... The study also suggests that addition of a leukotriene pathway inhibitor such as zileuton may bring about greater control of ... we examined the effects of 6 wk of treatment with the leukotriene-pathway inhibitor zileuton (600 mg, four times daily) in 40 ... it has yet not been shown if subjects with AIA respond favorably to clinical treatment with leukotriene inhibitors. Therefore, ...
https://www.ncbi.nlm.nih.gov/pubmed/9563738?dopt=Abstract
*  Arachidonate 5-lipoxygenase inhibitor - Wikipedia
Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5- ... Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82016859. ... Zileuton is a specific inhibitor of 5-lipoxygenase and thus inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. Both ... Hyperforin turned out to be a novel type of 5-lipoxygenase inhibitor with high effectivity in vivo [55] and suppressed ...
https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase_inhibitor
*  The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic...
An inhibitor of cyclooxygenase and lipoxygenase pathways in lung and platelets. Prostaglandins16, 417-425 (1978).PubMedGoogle ... We have studied the effects of LT antagonists, 5-lipoxygenase inhibitors and selected standards in a model of LT-mediated ... The inactivity of many 5-lipoxygenase inhibitors in this model suggests they do not inhibit LT formationin vivo. ... The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic ...
https://link.springer.com/article/10.1007/BF01967398
*  Prevention of hydroxybutyl(butyl)nitrosamine(OH-BBN)-induced urinary bladder cancer in Fischer-344 rats by cyclooxygenase and...
... induced urinary bladder cancer in Fischer-344 rats by cyclooxygenase and lipoxygenase inhibitors.. Vernon E. Steele, Ronald A. ... a LOX inhibitor) at 1200 mg/kg diet, naproxen (a nonspecific COX inhibitor) at 200 or 400 mg/kg diet, aspirin (a COX1 inhibitor ... induced urinary bladder cancer in Fischer-344 rats by cyclooxygenase and lipoxygenase inhibitors. ... induced urinary bladder cancer in Fischer-344 rats by cyclooxygenase and lipoxygenase inhibitors. ...
http://cebp.aacrjournals.org/content/15/12_Supplement/B83
*  Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5...
... against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor. ... a selective COX-2 inhibitor, and CJ-13,610, a 5-LO inhibitor, to carbon tetrachloride-treated mice significantly reduced ... In this study, we examined the relative contribution of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO), two major ... addition of SC-236 and CJ-13,610 resulted in a higher inhibitory profile on PGE2 biosynthesis than the dual COX/5-LO inhibitor ...
https://www.sigmaaldrich.com/catalog/papers/17766677
*  Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema | Springer for Research &...
It inhibits synthesis of prostaglandins and leukotrienes by inhibition in the cyclooxygenase and lipoxygenase pathways of... ... Higgs GA, Mugridge KG, Moncada S, Vane JR (1984) Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C ... Ikeda Y., Long D.M. (1990) Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema ... Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema. ...
https://rd.springer.com/chapter/10.1007/978-3-7091-9115-6_23
*  Anti-Inflammatory Activity of a Potent, Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase...
The data presented here reveal a potential therapeutic advantage of LTA4H inhibitors versus 5-lipoxygenase or FLAP inhibitors, ... Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton. Navin L. Rao, Paul J. ... Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton. Navin L. Rao, Paul J. ... Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton. Navin L. Rao, Paul J. ...
http://jpet.aspetjournals.org/content/321/3/1154
*  ML 355 | Lipoxygenase inhibitor | ML355 | ML-355 | CAS [1532593-30-8] | Axon 2873 | Axon Ligand™ with |98% purity available...
Lipoxygenase inhibitor , ML355 , ML-355 , CAS [1532593-30-8] , Axon 2873 , Axon Ligand™ with >98% purity available from ... Potent and selective inhibitor of 12/15-lipoxygenase (LOX) €125.00 2844 ThioLox Inhibitor of 15-lipoxygenase-1 (15-LOX-1) € ... Lipoxygenase inhibitor , ML355 , ML-355 , CAS [1532593-30-8] , Fatty acid (Arachidonic acid) , LOX , Inhibitor , Enzymes , ... Potent and selective inhibitor of 12-lipoxygenase (LOX) Chemical name. N-(Benzo[d]thiazol-2-yl)-4-(2-hydroxy-3- ...
https://www.axonmedchem.com/product/2873
*  AA1777 | CAS# 90316-11-3| 5-Lipoxygenase Inhibitor | MedKoo
A1777 is a selective 5-lipoxygenase inhibitor that reduces leukocytes proliferation without affecting the eosinophils of mast ... Description: A1777 is a selective 5-lipoxygenase inhibitor that reduces leukocytes proliferation without affecting the ... Leading supplier of anticancer chemical reagents and kinase inhibitors Tel: +1-919-636-5577 Fax: +1-919-980-4831 Email: sales@ ...
https://www.medkoo.com/products/15735
*  Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets | Molecular...
Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Marco S Doucet, ... Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Marco S Doucet, ... Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Marco S Doucet, ... Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets ...
http://molpharm.aspetjournals.org/content/early/2018/11/07/mol.118.113480
*  Effects Of Pravastatin Or 12/15 Lipoxygenase Pathway Inhibitors On Indices Of Diabetic Nephropathy In An Experimental Model Of...
Effects of pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of diabetic nephropathy in an experimental model of ... streptozotocin-induced diabetes on renal functions through supplementation of either pravastatin or 12/15-LO pathway inhibitors ...
https://www.omicsonline.org/proceedings/effects-of-pravastatin-or-1215-lipoxygenase-pathway-inhibitors-on-indices-of-diabetic-nephropathy-in-an-experimental-model-of-diabetic-renal-disease-24970.html
*  Treatment of Hyperkeratotic Skin Diseases With R 68151, a Topical 5-Lipoxygenase Inhibitor: Four Case Reports | JAMA...
The evidence is substantial that 5-lipoxygenase metabolites of arachidonic acid are involved in the pathophysiology of ... Treatment of Hyperkeratotic Skin Diseases With R 68151, a Topical 5-Lipoxygenase Inhibitor: Four Case Reports. ... is an in vitro inhibitor of 5-lipoxygenase.2 In the first clinical trial, in 88 patients with psoriasis, 2% R 68151 ointment ... a Topical 5-Lipoxygenase Inhibitor: Four Case Reports. Arch Dermatol. 1992;128(7):993-994. doi:10.1001/archderm. ...
https://jamanetwork.com/journals/jamadermatology/article-abstract/554259
*  RIHUC: The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage
The_Novel_5_Lipoxygenase_Inhibitor_ABT_761.32.pdf. 200,9 kB. Adobe PDF. Ver/Abrir. ... This study examined the effects of ABT-761, a new 5-lipoxygenase inhibitor, on cerebral vasospasm in an in vivo rabbit model of ... The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage. ... resulting from the 5-lipoxygenase activity on arachidonic acid metabolism. ...
http://rihuc.huc.min-saude.pt/handle/10400.4/943
*  The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human...
... a small inhibitor binding the Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain of the X-linked inhibitor of ... The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human ... The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and ... synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase. Eur J Med ...
https://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0440-x
*  Effects of Intravenous 5-Lipoxygenase Inhibitor Quercetin Therapy on Endothelial Function, Severity of Systemic Inflammation...
Effects of Intravenous 5-Lipoxygenase Inhibitor Quercetin Therapy on Endothelial Function, Severity of Systemic Inflammation ... The objective was to evaluate the antioxidant and anti-inflammatory activity of 5-lipoxygenase inhibitor quercetin, as well as ... Thus, the administration of 5-lipoxygenase inhibitor quercetin to AMI patients with ST-segment elevation has not additional ... Effects of Intravenous 5-Lipoxygenase Inhibitor Quercetin Therapy on Endothelial Function, Severity of Systemic Inflammation ...
http://emergency.zaslavsky.com.ua/article/view/74473