Expression and characterization of manganese lipoxygenase of the rice blast fungus reveals prominent sequential lipoxygenation...
1. The structural basis for the catalytic specificity of manganese lipoxygenases: 3D structure analysis of the lipoxygenase of ... Open this publication in new window or tab ,,The structural basis for the catalytic specificity of manganese lipoxygenases: 3D ... Lipoxygenases (LOX) catalyze regio- and stereospecific oxygenation of polyunsaturated fatty acids to hydroperoxides. These ... oxylipin, lipoxygenase, crystal structure, crystallography, HPLC, mass spectrometry, yeast, site-directed mutagenesis, fungi ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:853452
Repositorio da Producao Cientifica e Intelectual da Unicamp: Leukotrienes play a role in the control of parasite burden in...
Similarly, parasite burdens and eggs/g/feces were greater in 5-lipoxygenase(-/-) mice than in wild-type animals. These ... physicians treating Strongyloides stercoralis-infected patients presenting asthma-like symptoms because use of 5-lipoxygenase ...http://repositorio.unicamp.br/jspui/handle/REPOSIP/80873
ω-Oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the...
During oxygenation by 15-lipoxygenases, polyenoic fatty acids are bound at the active site in such a way that the ω-terminus of ... Arg403 of the human 15-lipoxygenase has been implicated in fatty acid binding by forming a salt bridge with the carboxylate ... The prepared Arg403 → Leu mutant of the rabbit 15-lipoxygenase was found to be a less effective catalyst of linoleic acid ... We studied the oxygenation kinetics of ω-modified fatty acids by 15-lipoxygenases and found that ω-hydroxylation strongly ...http://www.biochemj.org/content/336/2/345
LOX-DB - LipOXygenases DataBase - Literature
Increased lipoxygenase activity was paralleled by an increase of its protein and mRNA level. Lipoxygenase inhibitors ... Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmed cell death. ... The commitment of cells to apoptosis caused by H2O2 was characterized by an early increase of lipoxygenase activity, of ... Inhibitory anti-lipoxygenase monoclonal antibodies, introduced into the protoplasts by electroporation, protected cells against ...http://www.glycosciences.de/spec/lox-db/show-literature.php?lit_id=162
Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia - Full Text View - ClinicalTrials.gov
The dose of Terameprocol (EM-1421) will be escalated in successive cohorts of 3 patients. Patients will be entered sequentially on each dose level. If none of the first 3 patients at a dose level experience first cycle drug related dose-limiting toxicity (DLT), new patients may be entered at the next higher dose level. If 1 of 3 patients experience first cycle DLT, up to 3 more patients are started at that same dose level. If 2 or more experience first cycle DLT, no further patients are started at that dose. The MTD is the highest dose level in which ,2 patients of 6 develop a first cycle DLT. New dose levels may begin accrual only if all patients at the current dose level have been observed for a minimum of 3 weeks after the last infusion of Terameprocol (EM-1421). The recommended phase 2 dose (RP2D) will be the MTD unless significant clinical activity is seen below the MTD.. During the observation period of 3 weeks, additional accrual to a previously assessed lower dose level, with no ...https://clinicaltrials.gov/ct2/show/NCT00664677?cond=%22Leukemia%22&rank=4
Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors | Journal of...
... rat liver microsomal CYP-dependent oxygenase reactions without affecting ram seminal vesicle COX or soybean lipoxygenase ...http://jpet.aspetjournals.org/content/284/3/966?ijkey=2efe7dbbff8d2e7a988deeead0c1db7cecc7b357&keytype2=tf_ipsecsha
Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta. | Hypertension
Treatment with the lipoxygenase inhibitor nordihydroguaiaretic acid completely blocked but the cytochrome P450 inhibitor ...http://hyper.ahajournals.org/content/20/5/682
20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin Ii-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells |...
Inhibitors of lipoxygenase (baicalein, 5 μM) and CYP (ODYA, 5 μM) but not cycloxygenase (indomethacin, 10 μM) attenuated Ang II ... and lipoxygenase (LO), respectively, upon activation of cPLA2 by calcium calmodulin-dependent kinase II. The purpose of this ...http://hyper.ahajournals.org/content/36/Suppl_1/723.1
On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant
Manganese lipoxygenase (Mn-LO) oxygenates 18:3n-3 and 18:2n-6 to bis-allylic 11S-hydroperoxy fatty acids, which are converted ... On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant. Cristea, Mirela ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:51464
JCI - Leukotrienes and sex: strange bedfellows?
Rask-Madsen J, Bukhave K, Laursen LS, Lauritsen K. 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease. ... and small molecules were developed that inhibited leukotriene synthesis either by targeting 5-lipoxygenase (5-LO), 5-LO- ...https://j8k9.com.www.mobile.jci.org/articles/view/95717
anti-FLAP antibody, Internal | GeneTex
... arachidonate 5-lipoxygenase-activating protein) for IHC-P, WB. Anti-FLAP pAb (GTX89246) is tested in Human samples. 100% Ab- ... arachidonate 5-lipoxygenase-activating protein. Background. Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). ... MK886binding protein, FLAP, arachidonate 5-lipoxygenase-activating protein, arachidonate5lipoxygenaseactivating, ... five-lipoxygenase activating protein, MK 886 binding protein. ...http://www.genetex.com/FLAP-ALOX5AP-antibody-Internal-GTX89246.html
CREB-Mediated IL-6 Expression Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-Induced Vascular Smooth Muscle Cell Migration ...
Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. Eur J Biochem. ... The lipoxygenase products of polyunsaturated fatty acids (PUFA) were shown to play a role in these diseases. cAMP response ... Relation to lipoxygenase and prostacyclin synthase activities. Circ Res. 1994; 74: 197-205. ... Hugou I, Blin P, Henri J, Daret D, Larrue J. 15-Lipoxygenase expression in smooth muscle cells from atherosclerotic rabbit ...http://atvb.ahajournals.org/content/29/6/809
15-Hydroxyeicosatetraenoic acid - Wikipedia
15-Lipoxygenase-1: Cells metabolize arachidonic acid with 15-lipoxygenase-1 (i.e., 15-LO-1, ALOX15) to form 15(S)-HpETE as a ... inhibitor of 12-lipoxygenase but not other human lipoxygenases. This effect could also have anti-inflammatory and anti- ... Oxygenated by 5-lipoxygenase (ALOX5 to form its 5,6-trans epoxide derivative which may then rearrange to the lipoxins (LX), ... Ma, J; Zhang, L; Zhang, J; Liu, M; Wei, L; Shen, T; Ma, C; Wang, Y; Chen, Y; Zhu, D (2013). "15-lipoxygenase-1/15- ...https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid
Arachidonate 5-lipoxygenase - Wikipedia
Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. ... "Alox5 - arachidonate 5-lipoxygenase". WikiGenes.. *^ Fahel JS, de Souza MB, Gomes MT, Corsetti PP, Carvalho NB, Marinho FA, de ... "5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes". J. ...https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase
Proteins matched: LIPOXYGENASE 3 (PS51393) | InterPro | EMBL-EBI
Manganese lipoxygenase. Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus). Loading... ...http://www.ebi.ac.uk/interpro/ISignatureProteins?sig=PS51393&query=M
Novel 5-Lipoxygenase Inhibitors in Inflammation and Asthma | SpringerLink
The discovery of mammalian lipoxygenases which convert arachidonic acid to oxygenated products with potent inflammatory and ... For example, pulmonary tissues synthesize the peptido-leukotrienes (LTC4, D4 and E4), which are products of 5-lipoxygenase, in ... Higgs G.A. (1989) Novel 5-Lipoxygenase Inhibitors in Inflammation and Asthma. In: Samuelsson B., Berti F., Folco G.C., Velo G.P ... Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors. J. Med. Chem., 31: 499-500.Google Scholar ...https://link.springer.com/chapter/10.1007/978-1-4684-7938-6_22
Anti-5 Lipoxygenase antibody (ab59341) | Abcam
Rabbit polyclonal 5 Lipoxygenase antibody validated for WB, ELISA, IHC and tested in Human and Mouse. Referenced in 2 ... Belongs to the lipoxygenase family.. Contains 1 lipoxygenase domain.. Contains 1 PLAT domain. ... All lanes : Anti-5 Lipoxygenase antibody (ab59341) at 1/500 dilution. Lane 1 : Extracts from HuvEc cells without immunizing ... ab59341, at a 1/50 dilution, staining human 5 Lipoxygenase in skeletal muscle in the presence and absence of the immunizing ...http://www.abcam.com/5-lipoxygenase-antibody-ab59341.html
Anti-5 Lipoxygenase antibody (ab39347) References
Anti-5 Lipoxygenase antibody (ab39347) has been cited in 11 publications. References for Human, Mouse, Rat in ICC/IF, IHC, IHC- ... Xingfu W et al. Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus. Am J ... Chakrabarti SK et al. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker ...http://www.abcam.com/5-lipoxygenase-antibody-ab39347-references.html
DailyMed - Search Results for 5-Lipoxygenase Inhibitor
Lipoxygenase inhibitory activity of anacardic acids.
... inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 18.104.22.168, type 1) with an IC50 of 6.8 microM ... Lipoxygenase / metabolism. Lipoxygenase Inhibitors / pharmacology*. Molecular Structure. Soybeans / enzymology. Structure- ... 0/Anacardic Acids; 0/Lipoxygenase Inhibitors; 18654-18-7/anacardic acid; 2197-37-7/Linoleic Acid; EC 22.214.171.124/Lipoxygenase ... In addition, anacardic acid (C15:2) was also found to exhibit time-dependent inhibition of lipoxygenase-1. The alk(en)yl side ...http://www.biomedsearch.com/nih/Lipoxygenase-inhibitory-activity-anacardic-acids/15913294.html
Lipoxygenase metabolism: roles in tumor progression and survival. - PubMed - NCBI
Lipoxygenase metabolism: roles in tumor progression and survival.. Pidgeon GP1, Lysaght J, Krishnamoorthy S, Reynolds JV, ... Pharmacologic and natural inhibitors of lipoxygenases have been shown to suppress carcinogenesis and tumor growth in a number ... The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation of various biologically active ... Substantial evidence supports a functional role for lipoxygenase-catalyzed arachidonic and linoleic acid metabolism in cancer ...https://www.ncbi.nlm.nih.gov/pubmed/17943411
Formation and Role of Lipoxygenase Products in Human Platelets | SpringerLink
Arachidonic Acid Platelet Aggregation Human Platelet Lipoxygenase Activity Lipoxygenase Pathway These keywords were added by ... Nugteren, D.H., 1975, Arachidonate lipoxygenase in blood platelets, Biochim. Biophys. Acta 380:299-307.PubMedCrossRefGoogle ... A potent and selective inhibitor of platelet lipoxygenase, J. Biol. Chem. 255:5996-5998.PubMedGoogle Scholar ... Chang, W.C, Nakao, J., Orimo, H., and Murota, S., 1982, Effects of reduced glutathione on the 12-lipoxygenase pathway in rat ...https://link.springer.com/chapter/10.1007/978-1-4684-4946-4_8
Anti-15 Lipoxygenase 2 antibody (ab113488) Protocols
Abcam provides specific protocols for Anti-15 Lipoxygenase 2 antibody (ab113488) : Western blot protocols, Immunohistochemistry ...http://www.abcam.com/15-lipoxygenase-2-antibody-ab113488-protocols.html
Recombinant Human 12 Lipoxygenase protein (ab112250) | Abcam
Buy our Recombinant Human 12 Lipoxygenase protein. Ab112250 is a full length protein produced in Wheat germ and has been ... Belongs to the lipoxygenase family.. Contains 1 lipoxygenase domain.. Contains 1 PLAT domain. ... Recombinant Human 12 Lipoxygenase protein. See all 12 Lipoxygenase proteins and peptides. ...https://www.abcam.com/recombinant-human-12-lipoxygenase-protein-ab112250.html
Recombinant Human 5 Lipoxygenase protein (ab114310) References
References for Abcam's Recombinant Human 5 Lipoxygenase protein (ab114310). Please let us know if you have used this product in ...http://www.abcam.com/recombinant-human-5-lipoxygenase-protein-ab114310-references.html