JCI - Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab. 2011;13(2):183-194.. View this article via: PubMed ...
JCI - Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of...
Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 320:1492-1496. View this article via: CrossRef ...
JCI - Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD
A second way to reduce liver lipogenesis is to improve insulin resistance through weight loss (1). To date, weight loss either ... Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice. J Lipid Res. 2018; ... Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. J Clin Invest. 2020;130(3):1453-1460 ... In contrast with previously published studies, we did not find that the deletion of CB-1 in hepatocytes altered lipogenesis, ...
JCI - Welcome
Enhanced de novo lipogenesis mediated by sterol regulatory element-binding proteins (SREBPs) is thought to be involved in ... Thus, excessively strong and broad lipogenesis inhibition was counterproductive for NASH therapy, which will have important ...
JCI - Peroxisome proliferator-activated receptor-γ haploinsufficiency enhances B cell proliferative responses and exacerbates...
The primary role of PPARγ, which is mainly expressed in adipose tissue, is to promote lipogenesis under anabolic conditions (1- ...
JCI - Insulin sensitivity: modulation by nutrients and inflammation
... levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; ...
JCI - Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis
... promoting lipogenesis and reprogramming of glutamine metabolism. Glutamine-mediated nutrient signaling activated SRC-2 via ... drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. SRC-2 was highly ...
JCI - Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis
... promoting lipogenesis and reprogramming of glutamine metabolism. Glutamine-mediated nutrient signaling activated SRC-2 via ... drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. SRC-2 was highly ...
JCI - Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis
42) showed in humans that, when a meal made of 50% fructose was served for breakfast, it did not affect de novo lipogenesis in ...
JCI Insight - Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery
Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production. ... with regard to hepato-preferential insulin analogs is the potential for insulin-stimulated activation of hepatic lipogenesis ...
JCI Insight - Comments
IIH adipocytes appear transcriptionally and metabolically primed toward depot-specific lipogenesis.CONCLUSION These data show ...