Expanding roles for leukotrienes in airway inflammation | SpringerLink
... are lipid mediators derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Cysteinyl (cys) LTs C4, D4, and E4 ... Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Cysteinyl (cys) ... Islam SA, Thomas SY, Hess C, et al.: The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in ...
Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors | SpringerLink
2010). Different mechanisms of cis-9, trans-11- and trans-10, cis-12- conjugated linoleic acid affecting lipid metabolism in ... 2011). Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer ... Pike, L. J. (2003). Lipid rafts: bringing order to chaos. Journal of Lipid Research, 44(4), 655-667. ... PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nature ...
Fibrosis as a Cause or a Consequence of White Adipose Tissue Inflammation in Obesity | SpringerLink
Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes. 2010; ... This study demonstrates in a mouse model the crucial role of collagen VI in WAT fibrosis and metabolism disorders. ... VEGF A in WAT have also an increase of vessel density and display an improvement of their glucose and lipid metabolism [59]. ... However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the ...
Cellular stress response mechanisms of Rhizoma coptidis: a systematic review | Chinese Medicine
AMPK participates in the regulation of lipid metabolism, which is related to SREBP1C [40]. AMPK plays a major role in the ... Akt is an important kinase that mediates glucose metabolism stimulated by insulin, and the deficiency of Akt can lead to ... Glucose transportation is the speed limiting step of glucose metabolism and can be activated in the peripheral tissue by two ... AMPK pathways exist in most of eukaryotic cells and metabolism related tissues and organs [31]. AMP-activated protein kinase ( ...
Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer's disease | SpringerLink
Brain lipid metabolism in the cPLA2 knockout mouse. J Lipid Res 44:109-117 ... Gattaz WF, Levy R, Cairns NJ, Forstl H, Braus DF, Maras A (1996) Relevance of metabolism of membrane phospholipids for ...
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues | Diabetologia
Failure of molecular effectors of lipid metabolism could at least partly explain dysregulated lipid storage and mobilisation. ... There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be ... During adipogenesis, formation and expansion of the lipid droplet requires a morphological change of the fibroblastic pre- ... Cao Y (2013) Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity. Cell ...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism |...
Pang S, Lynn DA, Lo JY, Paek J, Curran SP (2014) SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during ... For example, Nrf2 abrogates mir-1 and miR-206 and affects lung carcinoma metabolism by reprogramming glucose metabolism toward ... This factor up-regulates lipid metabolism genes in starvation or dietary conditions, which induces fat mobilization. SKN-1 ... Loboda A, Jozkowicz A, Dulak J (2015) HO-1/CO system in tumor growth, angiogenesis and metabolism-targeting ho-1 as an anti- ...
HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD | Journal of...
This likely explains the lower degree of downregulation of hepatic lipid metabolism genes in the Hif-p4h-2gt/gt mice on the HF- ... 2h). In agreement, many hepatic lipid metabolism mRNAs were downregulated in the Hif-p4h-2gt/gt livers compared with those in ... These included the key regulators of glucose metabolism and lipid synthesis, the glucose-activated Chrebp and the insulin- ... the master regulators of hepatic lipid metabolism Ppara and Pparg along with their target genes Acsl1, Dgat1, Pnpla2, Pnpla3, ...
New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis | Journal of Microbiology
The effects of two Lactobacillus plantarum strains on rat lipid metabolism receiving a high fat diet. Sci. World J. 2013, ... Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J ... Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet ... Gut-brain axis i 2016: Brain-gutmicrobiota axis - mood, metabolism and behaviour. Nat. Rev. Gastroenterol. Hepatol. 14, 69-70. ...
Impact of Endocrine Disorders on Autoimmune Diseases | SpringerLink
A favorable effect of hydroxychloroquine on glucose and lipid metabolism beyond its anti-inflammatory role. Ther Adv Endocrinol ... Bilge SY, Korkmaz C. Calcium metabolism disorders simulating rheumatologic diseases. Rheumatol Int. 2012;32:1503-5. ...
Modulation of postprandial lipaemia by a single meal containing a commonly consumed interesterified palmitic acid-rich fat...
Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism. Am J Clin Nutr 94(6): ... Dietary fat manipulation has a greater impact on postprandial lipid metabolism than the apolipoprotein E (epsilon) genotype- ... Effect of interesterification of palmitic acid-rich triacylglycerol on postprandial lipid and factor VII response. Lipids 42(4 ... Redgrave TG, Kodali DR, Small DM (1988) The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and ...
Clinical outcome of incident peritoneal dialysis patients with diabetic kidney disease | Clinical and Experimental Nephrology
Effects of peritoneal dialysis with an overnight icodextrin dwell on parameters of glucose and lipid metabolism. Perit Dial Int ...
The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: the possible role of dietary...
Yamashita H, Maruta H, Jozuka M et al (2009) Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 ... regulation of glucose and lipid metabolism, and immune function [1].. Therefore, it has been suggested that the modulation of ... Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes. ... Main mechanisms of action of short-chain fatty acids on glucose metabolism. GLP-1 Glucagon-like peptide‑1, GLUT-4 Activated ...
The Influence of Selected Insecticides on the Oxidative Response of Atta sexdens (Myrmicinae, Attini) Workers | Neotropical...
Most of the insects intermediary metabolism takes place in this organ, including lipid and carbohydrate metabolism, protein ... 1985) and the methodology is based on measurements of induction times in the oxidation of a lipid dispersion exposed to a free ... Üner N, Oruç EÖ, Sevgiler Y et al (2006) Effects of diazinon on acetylcholinesterase activity and lipid peroxidation in the ... Niki E (1990) Free radical initiators as source of water- or lipid-soluble peroxyl radicals. Methods Enzymol 186:100-108. https ...
Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients...
Feingold KR, Staprans I, Memon RA et al (1992) Endotoxin rapidly induces changes in lipid metabolism that produce ... Buhl M, Bosnjak E, Vendelbo MH et al (2013) Direct effects of locally administered lipopolysaccharide on glucose, lipid, and ... protein metabolism in the placebo-controlled, bilaterally infused human leg. J Clin Endocrinol Metab 98:2090-2099 ... increased in patients with type 2 diabetes and showed positive correlation with inflammatory markers and poor glycemic/lipid ...
Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum | Metabolomics
... including biomarkers of lipid and glucose metabolism, amino acids, ketone bodies and glycoprotein acetyls (GlycA), a marker of ... cholesterol esters to total lipids ratio in very large HDL particles, acetoacetate, free cholesterol to total lipids ratio in ... Maternal metabolism changes during pregnancy to meet the demands of the mother and the feto-placental unit (Lain & Catalano, ... Bódis, K., & Roden, M. (2018). Energy metabolism of white adipose tissue and insulin resistance in humans. European Journal of ...
Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β | Nutrition...
... metabolism and low grade inflammation. 47 eight-week-old male C57BL/6 mice were fed a high fat diet (HFD) for 23 weeks to ... The possibility is that including CR in HFD-fed mice might have induced oxidative/lipid stress resulting in a shorter telomere ... 4, P , 0.05), we performed HPLC-MS/MS analysis to evaluate whether this phenomenon depends on the alteration of Cur metabolism ... Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomark Prev. 2002;11:105- ...
Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review | Calcified Tissue...
... bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf) 63(3):280-293. https://doi. ... a review for muscle-derived myokines regulating bone metabolism. Calcif Tissue Int 100(2):184-192. https://doi.org/10.1007/ ...
Acne and Genetics | SpringerLink
Testosterone metabolism to 5α-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome ... Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling. FASEB ... Androgen metabolism in the skin of hirsute women. J Clin Endocrinol Metab. 1974;38:811-9. ... Expression of perilipin A on the surface of lipid droplets increases along with the differentiation of hamster sebocytes in ...
The Gut-Eye Axis: Lessons Learned from Murine Models | Ophthalmology and Therapy
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. ... metabolism, and immune defense/tolerance [5, 6]. The massive complexity of this system is necessary to properly maintain the ... lipid levels, and satiety hormones via modification of the gut microbiota, circadian rhythms, and lifestyle factors such as ... IF altered bile acid metabolism in db/db-IF by increased generation of beneficial secondary metabolites, such as ...
Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings | 3 Biotech
The effect of Sargassum polycystum crude SP extract on lipid metabolism was examined against acetaminophen-induced ... The SP-treated groups (5 mg/kg body weight, subcutaneously) showed a normalized lipid profile and lipid metabolizing enzymes. ... Lipid lowering. Fucoidan has been reported to affect the development of adipocytes. To elucidate the role of fucoidan in ... As a side effect of the drug, lipid profile showed fluctuation resulting in nephrotoxicity manifested by the enhanced urinary ...
Resveratrol protects against arsenic trioxide-induced nephrotoxicity by facilitating arsenic metabolism and decreasing...
Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats. Toxicol Ind Health. doi: ... The present study aimed to investigate the effect of resveratrol on As2O3-induced nephrotoxicity and arsenic metabolism. ... Brazy PC, Balaban RS, Gullans SR, Mandel LJ, Dennis VW (1980) Inhibition of renal metabolism. Relative effects of arsenate on ... Thomas DJ, Styblo M, Lin S (2001) The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharm 176:127-144 ...
Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation | Cancer and...
Such benefits range from the cellular level to global metabolism, and underline the link between tumor cell metabolism and that ... Increased lipid oxidation resulting from AMPK activation also increases the NAD+/NADH ratio thus amplifying the activity of the ... there has been recent enthusiasm towards metabolism-based therapies targeting whole-body metabolism, cellular kinases and ... Feinman, R. D. (2005). When is a high fat diet not a high fat diet? Nutrition and Metabolism, 2, 27. ...
Reciprocal Interaction of Cancer Stem Cells of Cholangiocarcinoma with Macrophage | Stem Cell Reviews and Reports
2017). Lipid desaturation is a metabolic marker and therapeutic target of ovarian Cancer stem cells. Cell Stem Cell, 20(3), 303 ... GSEA analysis of Hippo, NOTCH, cholesterol metabolism, ERBB pathway of upregulated genes in SORE6+ HuCC-T1 cells in comparison ... cholesterol metabolism, and MAPK signaling pathways (Fig. 3D, Supplemental Fig. S2). These results showed concordance with the ... cholesterol metabolism has a vital role in determining the fate of CSCs of breast cancer, ovarian cancer and hepatocellular ...
Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis | SpringerLink
Jones G, Prosser DE, Kaufmann M. Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res. 2014;55:13-31. ... Vitamin D: metabolism. Endocrinol Metab Clin North Am. 2010;39:243-253 (table of contents). ... Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 1983;72:1856-1860. ... Sakaki T, Kagawa N, Yamamoto K, Inouye K. Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005;10:119-134. ...
Dietary Supplements and Sports Performance: Herbals | Journal of the International Society of Sports Nutrition
International Journal of Sport Nutrition and Exercise Metabolism. 2004, 14: 586-93. ... increasing catecholamine secretion and enhancing lipid oxidation, sparing the use of glycogen. ... International Journal of Sport Nutrition and Exercise Metabolism. 2005, 15: 75-83. ... International Journal of Sport Nutrition and Exercise Metabolism. 2000, 10: 208-215. ...
Assessment and management of obesity and metabolic syndrome in children with CKD stages 2-5 on dialysis and after kidney...
Cardio-protective mechanisms of the Mediterranean and DASH diets are largely driven by improved lipid, glycemic, and BP control ... Decreasing the dose, stopping, or changing medications associated with abnormal glucose metabolism (e.g., steroids, calcineurin ... We do not suggest the routine use of statins and other lipid lowering agents (level D; weak recommendation). ... Wanner C, Tonelli M (2014) KDIGO Clinical Practice Guideline for Lipid Management in CKD: summary of recommendation statements ...
A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection...
DCF metabolites tend to cleave off parts of the molecule which were attached during metabolism even at low collision energies. ... lipid lowering drugs) in the mode plant garden cress (Lepidium sativum). J Chromatogr A. 2019;1592:122-32. ... Metabolism of ibuprofen by Phragmites australis: uptake and Phytodegradation. Environ Sci Technol. 2017;51:4576-84. ... Bartha B, Huber C, Schröder P. Uptake and metabolism of diclofenac in Typha latifolia - how plants cope with human ...
NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte...
PKM: prepared the lipids for delivery. LK, JXJ, BHF, and MMR: performed MCAo. NGB, MMR, and LB: wrote the manuscript with the ... 2021). They exert multiple biological functions, including limiting excessive inflammatory responses, regulating metabolism and ... Int J Mol Sci 21:678, 2020). Overall, we uncovered that protection after middle cerebral artery occlusion (MCAo) by the lipid ... Additionally, investigation of each of the lipids effect on gene expression independently is planned to determine if NPD1 and ...
The nutritional value of holothurians | Russian Journal of Marine Biology
Hu, X.Q., Xu, J., Xue, Y., et al., Effects of bioactive components of sea cucumber on the serum, liver lipid profile and lipid ... Hu, S.W., Tian, Y.Y., Chang, Y.G., et al., Fucosylated chondroitin sulfate from sea cucumber improves glucose metabolism and ... Svetashev, V.I., Levin, V.S., Lam, C.N., and Nga, D.T., Lipid and fatty acid composition of holothurians from tropical and ... Drazen, J.C., Phleger, C.F., Guest, M.A., and Nichols, P.D., Lipid, sterols and fatty acid composition of abyssal holothurians ...