Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD ... One of the key promoters of B cell expansion is A PRoliferation-Inducing Ligand (APRIL). APRIL has been strongly linked to non ... Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD ... Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD ...
This article is about ligands in biochemistry. For ligands in inorganic chemistry, see Ligand. For other uses, see Ligand ( ... Bivalent ligand[edit]. Bivalent ligands consist of two drug-like molecules (pharmacophores or ligands) connected by an inert ... High-affinity ligand binding implies that a relatively low concentration of a ligand is adequate to maximally occupy a ligand- ... In the example shown to the left, ligand-binding curves are shown for two ligands with different binding affinities. Ligand ...
4-1BB+Ligand at the US National Library of Medicine Medical Subject Headings (MeSH) ... 4-1BBL (4-1BB ligand) is found on APCs (antigen presenting cells) and binds to 4-1BB. ... Retrieved from "https://en.wikipedia.org/w/index.php?title=4-1BB_ligand&oldid=842807712" ...
EGF like ligands; Growth Factors Epidermal growth factor (EGF-)-like family members bind to and activate EGF receptor tyrosine ... Harris RC, Chung E, Coffey RJ (2003) EGF receptor ligands. Exp Cell Res 284:2-13CrossRefPubMedGoogle Scholar ... Wu WK, Tse TT, Sung JJ, Li ZJ, Yu L, Cho CH (2009) Expression of ErbB receptors and their cognate ligands in gastric and colon ... Dong J, Wiley HS (2000) Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their ...
... is concerned with the identification of ligands (drugs) that bind nucleic acids (NA) and provide users with sets of specific ... The nucleic acids and ligands database (NALD) is concerned with the identification of ligands (drugs) that bind nucleic acids ( ... classes and links to diseases may be in association with the ligands. These were calculated from entries of NA/Ligand complexes ... Bioinformatics Database Data mining Data integration Nucleic acids Binding motifs Ligands Drugs Diseases ...
Definition of addressin ligands. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions ...
ligand, pioglitazone, in rats," Redox Report, vol. 7, no. 5, pp. 294-299, 2002. View at Publisher · View at Google Scholar ... ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-κB- ... ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells," Cancer Science, vol. 94, no. 4, pp. ... ligand, inhibits aspirin-induced gastric mucosal injury in rats," Alimentary Pharmacology and Therapeutics, vol. 15, no. 6, pp ...
Ligand "noninnocence" in coordination complexes vs. kinetic, mechanistic, and selectivity issues in electrochemical catalysis ...
The Eph family receptors and ligands.. Zhou R1.. Author information. 1. Laboratory for Cancer Research, College of Pharmacy, ... The Eph family is the largest of all known tyrosine kinase receptor-ligand systems. They are expressed in distinct, but ...
... N. V. Kostiuk,1 M. B. Belyakova,2 D. V. Leshchenko,2 V. V. ...
... An important aspect of simple Crystal Field Theory is the orientation of the d-orbital lobes with respect ... If you know the author of Ligand Field Theory, please help us out by filling out the form below and clicking Send. ... Note that the lobes point towards either the centres of the faces (where the ligands would sit for an octahedral complex) or ... You just viewed Ligand Field Theory. Please take a moment to rate this material. ...
Therefore, iron-haem complexes are ligands in the biochemical sense for the globin; and the oxygen is a ligand in the chemical ... providing some of its ligands.. Haem molecules occupy four ligand positions around the central iron atom, in a plane. When ...
Landis Ligands. By: William Sommer and Daniel Weibel, Aldrich ChemFiles 2008, 8.2, 84. ... Two of the essential components for highly active and selective catalysts are the ligand and the metal. Professor Landis and co ... Utilizing this newly developed ligand, Thomas and coworkers synthesized a series of oxazolines and imidazoles.1 Reacting vinyl ... Professor Landis and coworkers developed a new family of ligands based on 2,5‑disubstituted phospholane addressing these issues ...
Synthesis and ligand-based reduction chemistry of boron difluoride complexes with redox-active formazanate ligands M.-C. Chang ... From the themed collection: Non-Innocent Ligands The article was first published on 23 Dec 2014. Chem. Commun., 2015,51, 1553- ... From the themed collection: Non-Innocent Ligands The article was first published on 22 Jul 2014. Chem. Commun., 2014,50, 14290- ... From the themed collection: Non-Innocent Ligands The article was first published on 27 May 2014. Chem. Commun., 2014,50, 11440- ...
Ligand Efficacy.. In the functional assay, 5 of the 6 ligands behaved as inverse agonists (Fig. 5); the activity of the sixth ... The combination of potent new ligands that resemble known antagonists and structures dissimilar to previously explored ligands ... for kinase-like ligands, 0.9% for LGIC-like ligands, and an even smaller proportion that resembles biogenic molecules such as ... using ligand probe charges in an electrostatic potential calculated by DelPhi (13, 21, 22)], corrected for ligand desolvation ( ...
These chelating ligands form catalytically active complexes with Pd and Pt and can efficiently be utilized in the ... Only recently, have sp2-hybridized phosphorus compounds been utilized as ligands for transition metals in catalysis. The ... Even polysubstituted alkenes can be converted which is not possible using classical lambda3-sigma3-phosphane ligands. ... Our research is aimed at the synthesis on development of novel chelating ligands that exhibit low-coordinate trivalent ...
Dr James Firth, lead chemist on the project, said: "Our approach to the family of sparteine chiral ligands allows synthesis of ... Their route uses common feedstock chemicals to make these chiral ligands on an unprecedented scale, moving away from the ... Sparteine and the sparteine surrogate, developed in York in 2002, are chiral ligands with the potential to synthesise mirror- ... York chemists solve long-term supply issues of sparteine chiral ligands. Posted on 30 January 2018 ...
Overall, 800 ligand-target predictions of prospectively designed ligands were tested experimentally, of which 75% were ... Automated design of ligands to polypharmacological profiles.. Besnard J1, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang ... a) Closed loop of automated ligand design algorithm by multi-objective evolutionary optimisation. (b) Multi-objective ... Here we describe a new approach for the automated design of ligands against profiles of multiple drug targets. The method is ...
Novel compounds show high affinity for specific cocainereceptors in the brain, particularly dopamine transporter sites,and have the formula ##STR1## Wherein Y=CH.sub.2 R.sub.3, CO.sub.2R.sub.2 or ##STR2## R.sub.1 =hydrogen, C.sub.1-5 alkyl, R.sub.2=hydrogen, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.1-4 alkoxy,C.sub.1-6 alkynyl, halogen or amine, R.sub.3 =OH,
The ligand chosen for the reaction has showed outstanding results in a variety of cross-coupling transformations. Utilizing P(t ... Since the late 1990s several research groups have shown the versatility and efficiency of trialkyl phosphine ligands for a ... of ligand and 1.5 mol% of Pd2(dba)3, the reaction produced the desired biaryls with good to excellent yields (Table 1). It is ... Fu and coworkers explored the Hiyama transformation using one of their most versatile ligands, P(t-Bu)2Me.3 The Hiyama coupling ...
The invention relates to novel compounds which show highaffinity for cocaine receptors in the brain, particularly dopamineand serotonin transporter sites. The compounds may be used asimaging or pharmaceutical agents, in the diagnosis and treatment ofdrug addiction, depression, anorexia and neurodegenerativediseases.
... Dr E. Buxbaum EB15 at le.ac.uk Mon Mar 2 13:22:52 EST 1998 *Previous message: Algal Biliproteins ... Louis Hom wrote: , , Basic question: , Is there an activation energy associated with ligand binding? Yes, there is, and it is ...
Ligand Expo An RCSB PDB resource for searching, exploring, and downloading information and coordinates about the chemical ... GET as free ligands, exist in 10 entries. Examples include 1MWL, 1NJJ, 3TD1 ... An encyclopedia dedicated to a ligand oriented view that integrates different information about drug-likeness or binding ...
TA8 as free ligands, exist in 1 entries. Examples include 4A6R, Find related ligands: Stereoisomers Similar ligands Chemical ... Ligand Expo An RCSB PDB resource for searching, exploring, and downloading information and coordinates about the chemical ... An encyclopedia dedicated to a ligand oriented view that integrates different information about drug-likeness or binding ...
... and Welfare gave its approval to Ligand partner GlaxoSmithKlines ... San Diegos Ligand Pharmaceuticals (NASDAQ: LGND) says Japans ... San Diegos Ligand Pharmaceuticals (NASDAQ: ]) says Japans Ministry of Health, Labor, ... Ligand says eltrombopag is the first oral treatment that stimulates the production of blood platelets, considered essential to ... Ministry of Health, Labor, and Welfare gave its approval to Ligand partner GlaxoSmithKlines (NYSE: GSK) application for ...