Nutrients | Free Full-Text | A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model...
Lamin A/C expression is shown as a loading control. (B) Interleukin 6 (IL-6) and (C) tumor necrosis factor alpha (TNFα) ... These results, therefore, encourage the evaluation of this type of non-pharmacological therapeutic strategy as a new treatment ... Lamin A/C expression is shown as a loading control. (B) Interleukin 6 (IL-6) and (C) tumor necrosis factor alpha (TNFα) ... Both cell types were exposed to serum free medium for 24 h to obtain quiescent cells before being exposed to lipopolysaccharide ...
Cardiogenetics | Free Full-Text | Genetic Screening of a Large Panel of Genes Associated with Cardiac Disease in a Spanish...
These proteins form type A nuclear lamins and are involved in cellular and nuclear integrity and in the regulation of gene ... Hasselberg, N.E.; Haland, T.F.; Saberniak, J.; Brekke, P.H.; Berge, K.E.; Leren, T.P.; Edvardsen, T.; Haugaa, K.H. Lamin A/C ... Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. J. Am. Coll. Cardiol. 2003, 41, 771-780. [Google ... The codon 190, located in the rod-domain lamin A/C, is the mutational hotspot. This would lead to molecular changes in the ...
IJMS | Free Full-Text | Quantification of the Lamin A/C Transcript Variants in Cancer Cell Lines by Targeted Absolute...
The different expressed Lamin A/C variants in different cell lines were measured and their levels were in concordance with qRT- ... Lamin A/C cumulative protein expression of all variants is reported by semi-quantitative Western blotting. To date, there have ... A signature peptide for each specific splice variant of Lamin A/C was selected. A LC-MS/MS assay based on the selected ... RT-qPCR assay was also used to quantitate and compare the mRNA expression of splice variants of Lamin A/C. The established and ...
Cells | May 2018 - Browse Articles
... lamin C, or progerin (Δ50) tails. Using mass spectrometry, we identified 11 O-GlcNAc sites in a sweet spot unique to lamin ... iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ... We report that lamin A is β-O-linked N-acetylglucosamine-(O-GlcNAc)-modified in human hepatoma (Huh7) cells and in mouse liver ... Double-mutant (S612A/T643A) lamin A tails were still robustly O-GlcNAc-modified at seven sites. By contrast, O-GlcNAcylation ...
Sci | Free Full-Text | Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics
Retrovirus-mediated wild-type P53 gene transfer to tumors of patients with lung cancer. Nat. Med. 1996, 2, 985-991. [Google ... Lamins, Interleukins. Involved in inflammation, apoptosis induction when overexpressed [58]. Caspase-2. Liver, CNS, kidney and ... Introduction of wild type p53 gene makes head and neck tumor cells, and prostate cancers sensitive to radiotherapy. [131]. ... Restore wild type activity of mutant p53. APR246. Yes. (Phase I). AML, esophageal carcinoma, ovarian cancer, melanoma. ...