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*  Cardiac transient outward potassium current - Wikipedia
... while the channel responsible for Ito1,s is composed of Kv1.4 (KCNA4) subunits. In addition, several regulatory subunits and ... gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome". Heart Rhythm. 8 (7): 1024-1032. ... There are two kinetic variants of cardiac Ito1: fast Ito1, called Ito1,f, and slow Ito, called Ito1,s. The channel responsible ... The cardiac transient outward potassium current (referred to as Ito1 or Ito ) is one of the ion currents across the cell ...
https://en.wikipedia.org/wiki/Cardiac_transient_outward_potassium_current
*  Voltage-gated potassium-channel Kv1.4 IRES - Wikipedia
This family represents the Kv1.4 voltage-gated potassium channel internal ribosome entry site (IRES). This region has been ... Page for Voltage-gated potassium-channel Kv1.4 IRES at Rfam. ... noncoding region of a voltage-gated potassium channel mRNA". J ... tissues known to express Kv1.4 mRNA species. Jang, GM; Leong LE; Hoang LT; Wang PH; Gutman GA; Semler BL (2004). "Structurally ...
https://en.wikipedia.org/wiki/Voltage-gated_potassium-channel_Kv1.4_IRES
*  kcna4 - Kv1.4 potassium channel - Xenopus laevis (African clawed frog) - kcna4 gene & protein
Kv1.4 potassium channelImported. ,p>Information which has been imported from another database using automatic procedures.,/p> , ... Ion channel, Potassium channelSAAS annotation. ,p>Information which has been generated by the UniProtKB automatic annotation ... tr,Q98TW3,Q98TW3_XENLA Kv1.4 potassium channel OS=Xenopus laevis OX=8355 GN=kcna4 PE=2 SV=1 ... IPR020467 K_chnl_volt-dep_Kv1.4. IPR012897 K_chnl_volt-dep_Kv1.4_TID. IPR037065 K_chnl_volt-dep_Kv1.4_TID_sf. IPR011333 SKP1/ ...
https://www.uniprot.org/uniprot/Q98TW3
*  Larsen M[au] - PubMed - NCBI
Regulation of Kv1.4 potassium channels by PKC and AMPK kinases.. Andersen MN, Skibsbye L, Saljic A, Larsen MZ, Rasmussen HB, ... Channels (Austin). 2018 Jan 1;12(1):34-44. doi: 10.1080/19336950.2017.1405196. Epub 2017 Dec 22. ...
https://www.ncbi.nlm.nih.gov/pubmed?access_num=Larsen+M&link_type=AUTHORSEARCH&cmd=search&term=Larsen+M%5Bau%5D&dispmax=50
*  Insig1 Blocking Peptide - Gentaur.com
Kv1.4 Potassium Channel, Polyclonal Antibody. Supplier:Exalpha. Price:454.50USD. Brucella canis Carbamoyl phosphate synthase ...
https://gentaur.com/prod/insig1-blocking-peptide/biovision/797160333
*  Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression | Journal of Neuroscience
Jugloff DG, Khanna R, Schlichter LC, Jones OT (2000) Internalization of the Kv1.4 potassium channel is suppressed by clustering ... and Kv1.4 and Kir5.1 potassium channels (Jugloff et al., 2000; Tanemoto et al., 2002), and a chimeric Tac-NR2B construct (Roche ... Coexpression of PSD-95 increased the number of active channels times channel open probability, npo (calculated as total channel ... PSD-95 increases channel opening rate and delivers new channels to the surface. The results reported thus far suggest that PSD- ...
http://www.jneurosci.org/content/24/45/10138
*  Action Potential Characteristics and Arrhythmogenic Properties of the Cardiac Conduction System of the Murine Heart |...
The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol. 1998; 509 (pt 1): 171-182. ... Developmental changes in the delayed rectifier K+ channels in mouse heart. Circ Res. 1996; 79: 79-85. ... Developmental changes in ionic channel activity in the embryonic murine heart. Circ Res. 1996; 78: 15-25. ... Heterogeneity of action potential waveforms and potassium currents in rat ventricle. Cardiovasc Res. 1993; 27: 1795-1799. ...
http://circres.ahajournals.org/content/89/4/329
*  Monteiro, Mervyn | University of Maryland School of Medicine
1999) Inactivation gating and 4-AP sensitivity in human brain Kv1.4 potassium channel. Brain Res, 831:43-54.. Janicki SM and ... Determinants of 4-aminopyridine sensitivity in a human brain kv1.4 k(+) channel: phenylalanine substitutions in leucine heptad ... a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel. J Biol Chem, 281:20825-20833. ... repeat region stabilize channel closed state. Mol Pharmacol, 61:913-920.. Mah AL, Perry G, Smith MA and Monteiro MJ (2000) ...
https://www.medschool.umaryland.edu/profiles/Monteiro-Mervyn/
*  Dystrophin Dp71 Is Critical for the Clustered Localization of Potassium Channels in Retinal Glial Cells | Journal of...
... syntrophin PDZ domains can bind the voltage-gated potassium channel Kv1.4 and C-terminal peptides from NMDA receptor subunit ... inward-rectifying potassium channel. Discrete and clustered localization of ion channels and receptors are critical for the ... The inwardly rectifying potassium channel Kir4.1 is the primary K+ conductance of the Müller cell (Kofuji et al., 2000) and has ... Focal extracellular potassium increases in isolated Müller cells shows that Kir channels in the mdx3Cv cells, as opposed to ...
http://www.jneurosci.org/content/22/11/4321
*  Plus it
1996) Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene. J Biol Chem 271:15629- ... 1999) The pharmacology of ion channels: with particular reference to voltage-gated Ca2+ channels. Eur J Pharmacol 375:311-325. ... Opioids act on both the presynaptic Ca channels that we have studied and on postsynaptic K channels of nociceptive synapses ( ... Because L-channel expression varied from 20 to 50% of the total Ca2+ current in different cells, we blocked L channels so that ...
http://www.jneurosci.org/content/23/1/34
*  Plus it
1998) Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus. J ... 1995) The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons ... After 6-20 trials were recorded in control ACSF, a voltage-gated potassium channel antagonist, tetraethyl ammonium (TEA, 1 mm ... 2001) The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in ...
http://www.jneurosci.org/content/31/43/15490
*  KAKEN - Researchers | SUZUKI Shigeaki (50276242)
... 抗Kv1.4抗体,炎症性筋疾患,cerebral ... Journal Article] Anti-voltage-gated potassium channel Kv1.4 ... Journal Article] Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis2012. *. Author(s). Romi F, Suzuki S ... Journal Article] Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis2005. *. ... 免疫沈降法 / 重症筋無力症 / 自己抗体 / 抗Kv1.4抗体 / 炎症性筋疾患 / 筋病理 / 脳虚血 / 壊死性ミオパチー / スタチン / LIF
https://nrid.nii.ac.jp/nrid/1000050276242/
*  KCNA4 - Wikipedia
Voltage-gated potassium channel Voltage-gated potassium-channel Kv1.4 IRES GRCh38: Ensembl release 89: ENSG00000182255 - ... Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the KCNA4 ... Kv1.4 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH) KCNA4 protein, human at the US ... Philipson LH, Eddy RL, Shows TB, Bell GI (1993). "Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome ...
https://en.wikipedia.org/wiki/KCNA4
*  Frontiers | Excitation control: balancing PSD-95 function at the synapse | Frontiers in Molecular Neuroscience
... ion channels, cytoskeletal elements and signaling molecules at postsynaptic sites. In this review we will highlight mechanisms ... ion channels, cytoskeletal elements and signaling molecules at postsynaptic sites. In this review we will highlight mechanisms ... but not for binding to potassium channel Kv1.4. J. Biol. Chem. 274, 532-536. ... This alternative form does not cluster with potassium channels when expressed in heterologous cells, but it does efficiently ...
https://www.frontiersin.org/articles/10.3389/neuro.02.004.2008/full
*  Transcriptome analysis of porcine M. semimembranosus divergent in intramuscular fat as a consequence of dietary protein...
Arachidonic acid potently inhibits both postsynaptic-type Kv4.2 and presynaptic-type Kv1.4 I-A potassium channels. Eur J ... potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2) [30]. Ramayo-Caldas et al. [31] also observed that ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-453
*  KCNA5 - Wikipedia
"A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2 ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans ... Kv1.5 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH) KCNA5 protein, human at the US ...
https://en.wikipedia.org/wiki/KCNA5
*  Three Types of Striational Antibodies in Myasthenia Gravis
S. Suzuki, T. Satoh, H. Yasuoka et al., "Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of ... Voltage-gated K channel (VGKC) consists of four transmembrane α-subunits that combine as homo- or heterotetramers. Kv1.4 is an ... K. M. Tan, V. A. Lennon, C. J. Klein, B. F. Boeve, and S. J. Pittock, "Clinical spectrum of voltage-gated potassium channel ... We emphasize that special attention should be paid to MG patients with anti-Kv1.4 antibodies. Although various Kv channels are ...
https://www.hindawi.com/journals/ad/2011/740583/
*  Plus it
... but not for binding to potassium channel Kv1.4. J Biol Chem 274: 532-536. ... N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Neuron 20 ... Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51: 7-61. ... Kornau HC, Seeburg PH, Kennedy MB (1997) Interaction of ion channels and receptors with PDZ domain proteins. Curr Opin ...
http://www.jneurosci.org/content/24/4/916
*  Plus it
... including the Kv1.4 potassium channel (Kim et al., 1995), NR2 subunits of NMDA receptors (Kornau et al., 1995), and neuronal ... a multi-PDZ protein known to interact with membrane proteins including the Kv1.4 potassium channel, the NMDA receptor 2B (NR2B ... 1995) Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 378: ... 1996) Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate ...
http://www.jneurosci.org/content/22/13/5253
*  Endocannabinoid system - Wikipedia
"Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the ... Immunohistochemistry experiments demonstrated that CB1 is co-localized with GIRK and Kv1.4 potassium channels, suggesting that ... "Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 ... Recent studies have found that CB1 activation specifically facilitates potassium ion flux through GIRKs, a family of potassium ...
https://en.wikipedia.org/wiki/Endocannabinoid_system
*  Regulation of Excitability by Potassium Channels | SpringerLink
... channels with distinct biophysical and biochemical properties. Possibly, this diversity reflects the need to regulate and... ... Neurons express a large number of different voltage-gated potassium (Kv) ... Roeper J, Lorra C, Pongs O (1997) Frequency-dependent inactivation of mammalian A-type K+ channel Kv1.4 regulated by Ca2+/ ... Delmas P, Brown DA (2005) Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 6:850-862 PubMedCrossRef ...
https://link.springer.com/chapter/10.1007%2F400_2007_032
*  Short-Term Effects of Rapid Pacing on mRNA Level of Voltage-Dependent K+ Channels in Rat Atrium | Circulation
Shaker-related potassium channel, Kv1.4, mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 ... Cloning and expression of a rat delayed rectifier potassium channel. Proc Natl Acad Sci U S A. 1991;88:7892-7895. ... DNA templates of 9 voltage-dependent K+ channels known to be expressed in rat hearts (Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2, Kv4.3 ... Mori Y, Matsubara H, Folco E, Siegel A, Koren G. The transcription of a mammalian voltage-gated potassium channel is regulated ...
http://circ.ahajournals.org/content/101/16/2007
*  Glucocorticoids Regulate V1a Vasopressin Receptor Expression by Increasing mRNA Stability in Vascular Smooth Muscle Cells |...
Shaker-related potassium channel, Kv1.4 mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 and ... Mori Y, Matsubara H, Folco E, Siegel A, Koren G. The transcription of a mammalian voltage-gated potassium channel is regulated ...
http://hyper.ahajournals.org/content/26/4/665
*  Human KCNA4 Stable Cell Line-HEK293 CSC-RI0129 - Creative BioMart
... which has been transfected with a human potassium voltage-gated channel, shaker-related subfamily, member 4 (KCNA4) to allow ... Kv1.4; potassium channel 2; type A potassium channel; cardiac potassium channel; voltage-gated K(+) channel HuKII; voltage- ... shaker-related potassium channel Kv1.4; fetal skeletal muscle potassium channel; voltage-gated potassium channel subunit Kv1.4 ... gated potassium channel HK1; voltage-gated potassium channel HBK4; rapidly inactivating potassium channel; ...
https://www.creativebiomart.net/description_146151_286.htm