A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity | PNAS
Like T cells, natural killer (NK) cells are cytotoxic effector cells that play a key role in the antitumor response. To advance ... p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J. Exp. Med. 186, 1129-1136 (1997).. ... Multifunctional natural killer cell engagers targeting nkp46 trigger protective tumor immunity. Cell 177, 1701-1713.e16 (2019). ... Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell. Cell. Immunol. 276, 122-127 (2012 ...
Multispecific targeting of glioblastoma with tumor microenvironment-responsive multifunctional engineered NK cells | PNAS
Here, we describe an immunotherapy centered around human natural killer (NK) cells engineered to simultaneously target these ... a cooperative multifunctional immunotherapy based on genetically engineered human natural killer (NK) cells bearing multiple ... and poor immune cell homing. We engineered dual-specific chimeric antigen receptor (CAR) NK cells to bear a third functional ... These engineered NK cells are able to block adenosine signaling in GBM via CD73 while avoiding antigen escape. We also uncover ...