Moe SM, Drueke T, Lameire N, Eknoyan G. Chronic kidney disease-mineral-bone disorder: a new paradigm. Adv Chronic Kidney Dis. ... The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease. Br J Clin Pharmacol. ... Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22(1):124-136.. View this ... Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc ...

Our index patient had FSGS, and progression of the disease resulted in end-stage kidney disease. The subsequently identified ... a progressive glomerular disease, and over decades patients may develop FSGS and end-stage kidney disease (5-7). The prevalence ... Kidney diseases related to mutations in COL4A1, COL4A3, COL4A4, and COL4A5 are called collagen IV nephropathies. Alport ... Thin basement membrane disease with heavy proteinuria or nephrotic syndrome at presentation. Am J Kidney Dis. 2000;35(4):E15. ...

In human disease, LXs are generated in airway, kidney, joints, liver, and vessels (ref. 58; see also review, ref. 55 and ... Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997. 336:973-979. View ... The transformation of PGH2 by cytochromes P450 in different tissues and disease states has not yet been fully investigated. In ... n-3 fatty acids and vascular disease. Springer-Verlag. London, United Kingdom. 1-166.. View this article via: PubMed Google ...

This work was funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant RO1-DK-18243. Hormone ...

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland, USA. ... National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland, USA. ...

... such as kidney (resulting in polycystic kidney disease) and skin (resulting in palmoplantar keratodermas), as well as a variety ... These studies set the stage to potentially reclassify desmosomal diseases, such as ARVD/C, as diseases of desmosomal protein ... Desmosomes in human disease. Annu Rev Pathol. 2018;13:51-70.. View this article via: PubMed CrossRef Google Scholar ... Cardiac-specific loss of CSN6 in mice results in sudden death and recapitulates key disease features of ARVD/C. (A and B) ...

Extensive kidney fibrosis occurs in several types of chronic kidney diseases. PBI-4050, a potentially novel first-in-class ... To determine the potential role of PBI-4050 on diabetic kidney disease, we utilized an accelerated model of type 2 diabetic ... 2Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ... 2Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ...

Rats treated with high-salt diet (5-9 weeks after I/R) manifested progressive disease indicated by enhanced inflammation, ... When kidney CD4+ cells of post-acute kidney injury (post-AKI) rats were stimulated with angiotensin II and elevated Na+ (10-7 M ... Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury. ... Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury. ...

Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, ... ER stress has emerged as a signaling platform underlying the pathogenesis of various kidney diseases. ... Most importantly, urinary CRELD2 elevation occurs in patients with autosomal dominant tubulointerstitial kidney disease caused ... Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. ...

... that low nephron number contributes to glomerular hypertension and hyperperfusion injury in progressive chronic kidney disease ... Fifty-nine Japanese kidneys were collected at autopsy. Nine kidneys with CKD were selected according to eGFR less than 60 ml/ ... Autopsy kidneys from age-matched Japanese men (9 normotensives, 9 hypertensives, 9 CKD) had nephron number and VglomNSG ...

... and Kidney Diseases of the NIH under award number P30DK096493; and the Mandel Center for Hypertension and Atherosclerosis at ... and Kidney Diseases of the NIH under award number P30DK096493; and the Mandel Center for Hypertension and Atherosclerosis at ... Lee L, Horowitz J, Frenneaux M. Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. Eur Heart J. ... Grossly, the FXN-KO and dKO mice appeared no different over the course of disease progression (data not shown). FXN-KO is a ...

... biogenesis and function and discuss in detail the role of miRNAs in kidney morphogenesis and developmental kidney diseases, ... miRNA expression disrupts early kidney development and has been implicated in the pathogenesis of developmental kidney diseases ... Although the lungs are the main organs involved in COVID-19, systemic disease with a wide range of clinical manifestations also ... Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their ...

... the most important early marker of diabetic kidney disease, the information content of the MRI images is also highly relevant ... Obesity is one of the main drivers of type 2 diabetes, but it is not uniformly associated with the disease. The location of fat ... There might be further, hitherto unknown, features of body fat distribution that could additionally contribute to the disease. ... 3Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany. ...

In order to evaluate the role of this protein in human inherited diseases such as cystinuria, we have isolated a human D2 clone ... We have recently cloned, sequenced, and characterized a rat kidney cDNA (D2) that stimulates cystine as well as dibasic and ... Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.. ... Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.. ...

Uncertainty still exists as to why some individuals with long-standing T1D develop diabetic kidney disease (DKD) while others ... ANGII, angiotensin II; DKD, diabetic kidney disease, RA, renal afferent arteriolar vasoconstriction; RAAS, renin-angiotensin- ... In T1D participants without DKD (DKD resistors), locally within the kidney there is relatively more endogenous intrarenal RAAS ...

Sodium glucose cotransporter 2 (SGLT2) inhibitors are beneficial in halting diabetic kidney disease; however, the complete ... CD-1 mice with streptozotocin-induced diabetes displayed kidney fibrosis that was associated with the EMT at 4 months after ... Here, we hypothesized that the SGLT2 inhibitor empagliflozin restores normal kidney histology and function in association with ... Empagliflozin also suppressed the accumulation of glycolysis byproducts in diabetic kidneys. Another SGLT2 inhibitor, ...

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or PKD2, triggering progressive ... Recent patient data suggest that the disease is dosage dependent, where incompletely penetrant alleles influence disease ... Here, we have developed a knockin mouse model matching a likely disease variant, PKD1 p.R3277C (RC), and have proved that its ... Altogether, this study highlights the role that in trans variants at the disease locus can play in phenotypic modification of ...

... which may prove as useful predictors of disease progression following kidney transplantation and kidney injury. This generally ... Our previous work demonstrated a protective role of protein S in early diabetic kidney disease (DKD). Protein S exerts ... The molecular map generated by this computational approach highlighted early markers of kidney disease progression and ... The data were compared with the response to IRI in a mouse model of the acute to chronic kidney injury transition. RESULTS. In ...

Extensive kidney fibrosis occurs in several types of chronic kidney diseases. PBI-4050, a potentially novel first-in-class ... PBI-4050 inhibited kidney macrophage infiltration, oxidative stress, and TGF-β-mediated fibrotic signaling pathways, and it ... To confirm a direct antiinflammatory/antifibrotic effect in the kidney, further studies with a nondiabetic model of EGFR- ... Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. ...

... stabilizer and is being used clinically to treat chronic kidney disease (CKD) anemia. In the present study, we evaluate the ... and kidney injury; downregulated AGTR1 expression; and enhanced AGTR2, endothelial NO synthase (eNOS), and HIF1α protein levels ...

Uncertainty still exists as to why some individuals with long-standing T1D develop diabetic kidney disease (DKD) while others ...

The prevalence of chronic kidney disease (CKD) is increasing worldwide. The identification of factors contributing to its ... Plasma copeptin and chronic kidney disease risk in 3 European cohorts from the general population. ... Plasma copeptin and chronic kidney disease risk in 3 European cohorts from the general population. ... higher risk for kidney function decline, as defined by the KDIGO criterion (P , 0.0001); a 79% higher risk for rapid kidney ...

Diabetes is associated with increased risk for kidney and liver diseases, congestive heart failure, and mortality. Urinary ... possibly explaining the protective effects against kidney, liver, and heart diseases. Collectively, our findings suggest that ... We found that in diabetes, glycolysis and glucose oxidation are impaired in the kidney, liver, and heart. Treatment with ... SGLT2 inhibition increased glucose oxidation in all organs; in the kidney, this effect was associated with modulation of the ...

Human kidney organoids derived from pluripotent stem cells (PSCs), a potentially new model for disease and regeneration, ... Podocyte injury is central to many forms of kidney disease, but transcriptional signatures reflecting podocyte injury and ... in the human kidney and that transcriptional profiles seen in developing podocytes are reactivated in glomerular disease. Our ... Here, transcriptional profiling of more than 12,000 single cells from human PSC-derived kidney organoid cultures was used to ...

Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc ... Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained ... Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare ... Unique aspects of peripheral artery disease in patients with chronic kidney disease. Vasc Med. 2019;24(3):251-260.. View this ...

Renal fibrosis is a common pathogenic response to injury in chronic kidney disease (CKD). The receptor-interacting protein ... mice were subjected to sham operation or UUO, and kidneys were harvested at 7 days. (. A. ) Kidney tissue lysates were ... RIPK3 expression was highly regulated in human CKD kidney. In conclusion, we identify a pathway by which RIPK3 promotes kidney ... Mice genetically deficient in RIPK3 displayed decreased kidney fibrosis and improved kidney function relative to WT mice when ...

... and progression to chronic kidney disease (CKD). The nuclear factor erythroid-derived 2-related factor 2 (Nrf2) pathway senses ... NCT00862433.FUNDING National Institute of Diabetes and Digestive and Kidney Diseases and NIH grants DK053213-13, DK067494, and ... Colitis, an inflammatory bowel disease, is caused by a variety of factors, but luminal microbiota are thought to play crucial ... In the mouse renal IRI model, cardiac glycosides reduced numbers of autotic cells in the kidney and improved clinical outcome. ...

Immunohistochemistry for α-SMA showed hypertrophic arterioles in Ren1c-KO mouse kidneys. Scale bars: 20 μm. Kidney sections ... and tubule interstitial disease (24). Biglycan (Bgn) was reported to be increased in several types of renal diseases (25). We ... To compare the intensity of the signals, we placed the kidney sections of both the right and left kidneys from the same mice on ... Isolation of single cells. Cells were isolated from the kidney cortex using FACS (9). The kidneys were excised and decapsulated ...

SGLT2 inhibitors display renoprotective effects in diabetic kidney disease, which creates a rationale for testing the ... therapeutic potential of this drug class in nondiabetic chronic kidney disease. Here, we have shown that dapagliflozin provided ... Whether SGLT2 inhibitors represent a possible future therapeutic option for some patients with proteinuric glomerular disease ...

... the term mitochondrial tubulointerstitial kidney disease (MITKD) was introduced to describe tubulointerstitial kidney disease ... Inherited kidney diseases are the fifth most common cause of end-stage renal disease (ESRD). Mitochondrial dysfunction plays a ... Inherited kidney diseases are the fifth most common cause of end-stage renal disease (ESRD) after diabetes, hypertension, ... Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int. ...