Angiotensin-Converting Enzyme Inhibitor Dose Optimization and Its Asso | VHRM
... chronic kidney disease; COR, crude odds ratio; CI, confidence interval; DM, diabetes mellitus; FHCSRH, Felege Hiwot ... chronic rheumatic heart disease (CRHD), anemia, chronic obstructive pulmonary disease, thyroid disorder, and renal disease), ... ischemic heart disease; NYHA, New York Heart Association; RVHD, rheumatic valvular heart disease; SD, standard deviation; VHD, ... It serves as a specialized and follow-up clinic for patients with chronic diseases. Chronic illness care is one of the services ...
Therapeutics and Clinical Risk Management | Volume 16 - Dove Press
ReviewsSystematic reviews of individual new or important drugs where a change in therapeutic management of a disease may be ... including modelingDrug management of specific diseases, clinical guidelines, formulary management, and drug utilization ... formulationsSafety and post-marketing surveillance studiesOutcomes studies and economic analyses of drug treatment and disease ... Safe Use of Opioids in Chronic Kidney Disease and Hemodialysis Patients: Tips and Tricks for Non-Pain Specialists Coluzzi F, ...
Patient Preference and Adherence | Volume 14 - Dove Press Open Access Publisher
... and their role in developing new therapeutic modalities and compounds to optimize clinical outcomes for existing disease states ... Refinement and Evaluation of a Chinese and Western Medication Adherence Scale for Patients with Chronic Kidney Disease: Item ... and Validity of the Home Blood Pressure Monitoring Adherence Scale for Patients with Chronic Kidney Disease Wang Y, Li K, Li H ... Rheumatic Heart Disease Patients Adherence to Secondary Prophylaxis and Associated Factors at Hospitals in Jimma Zone, ...
MTB and rifampicin resistance MTB using Xpert-MTB/RIF | IDR
Evaluation of cardiovascular risk factors in patients with chronic kidney disease. Port Harcourt Med J. 2017;11(2):60. doi: ... In: Open Forum Infectious Diseases. US: Oxford University Press; 2019.. 27. Dagnra A, Mlaga K, Adjoh K, Kadanga E, Disse K, ... The early diagnosis and treatment of TB patients are mandatory to reduce transmission of the disease. Millions of people are ... 25. Tahiri L, Azzouzi H, Squalli G, Abourazzak F, Harzy T. Celiac disease causing severe osteomalacia: an association still ...
Diffusion Tensor Tractography Characteristics of White Matter Tracts a | NDT
... liver and kidney insufficiency, or end-stage diseases; and v) Subjects with contraindications of MRI. ... Family history of serious mental diseases or neurological diseases in the first-degree relatives of subjects; iv) Subjects with ... Ng et al29 suggested that in the course of Parkinsons disease, patients are prone to depression, anxiety, and other negative ... 29. Ng A, Chander RJ, Tan LC, Kandiah N. Influence of depression in mild Parkinsons disease on longitudinal motor and ...
Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Medi | DDDT
2 In the fibrotic hearts of patients with chronic kidney disease, nearly 20% of the fibroblasts were transformed via EndMT.3 ... sex-related differences are prevalent in cardiovascular disease risk, pathophysiology, disease manifestation, response to ... 18. Djamali A, Vidyasagar A, Adulla M, Hullett D, Reese S. Nox-2 is a modulator of fibrogenesis in kidney allografts. Am J ... TMZ is a clinically effective anti-ischemic drug that has been widely used in ischemic heart disease. Previous studies have ...
Comparative Effects of Repetitive Odor Identification | NDT
... eg end-stage kidney disease and congestive heart failure). For exclusion purposes, neurological diseases were ascertained ... absence of cerebrovascular disease or other neurologic disease (eg multiple sclerosis, Parkinsons disease, Lewy body dementia ... Olfactory capacities in aging and Alzheimers diseasea. Ann N Y Acad Sci. 1991;640:20-27. doi:10.1111/j.1749-6632.1991.tb00185. ... 2. Toepper M. Dissociating normal aging from Alzheimers disease: a view from cognitive neuroscience. J Alzheimers Dis. 2017;57 ...
Symptoms and impact of symptoms on function and health in patients wit | COPD
Keywords: chronic obstructive pulmonary disease, chronic heart failure, symptom, function, health ... Patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) seem to have several symptoms in ... Symptoms and impact of symptoms on function and health in patients with chronic obstructive pulmonary disease and chronic heart ... kidney disease, liver disease, diabetes, cancer, COPD [only CHF group], CHF [only COPD group], or other). ...
The Synergistic Antitumor Activity of Chidamide in Combination with Bo | OTT
Henan Key Library for Kidney Disease and Immunology, Henan Provincial Peoples Hospital, Peoples Hospital of Zhengzhou ... Results are shown as mean ± SEM (n = 5). (D) Paraffin sections of kidney and liver of MGC-803 xenografts were stained with ... We found that the combination of chidamide and bortezomib did not increase liver or kidney injury compared with giving each ... the liver and kidney HE staining confirmed that the combination of the two drugs did not produce the change of liver and kidney ...
Adipokines and Arterial Stiffness in the Elderly | VHRM
... kidney and thyroid diseases, and had no evidence of cardiovascular disease (CVD) except hypertension, which was diagnosed after ... 7. Kofler S, Nickel T, Weis M. Role of cytokines in cardiovascular disease: a focus on endothelial responses to inflammation. ... Subjects were eligible if free of known CV diseases and did not assume any medications affecting arterial compliance, such as ... Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation. 2002;106: ...
Role of apolipoprotein E in neurodegenerative diseases | NDT
... s disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular ... This review will summarize the updated research progress on APOE functions and its role in Alzheimer’s disease, Parkinson ... and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic ... and treatment of various neurodegenerative and cardiovascular diseases in humans. Keywords: apolipoprotein E, pathogenesis, ...
A Contrast Examination of Proinflammatory Effects on Kidney Function f | IJN
A Contrast Examination of Proinflammatory Effects on Kidney Function for γ-Fe2O3 NP and Gadolinium Dimeglumine ... and drugs or ways to treat the disease were involved. Due to above reasons, chronic kidney diseases are highly prevalent in all ... Chronic kidney disease diagnosis and management: a review. J Am Med Assoc. 2019;322(13):1294-1304. doi:10.1001/jama.2019.14745 ... For patients, many factors were able to cause kidney damage, regardless the disease itself, ages, hypertension, diabetes, ...
Utility of opicapone in management of Parkinson's disease | DNND
There was a very long and strong peripheral COMT activity inhibition (,80%), both of the hepatic and kidney enzymes.11 Upon ... Parkinsons disease is the second most common neurodegenerative disease worldwide.1 Although no available therapies alter the ... Noninvasive options for wearing-off in Parkinsons disease: a clinical consensus from a panel of UK Parkinsons disease ... Parkinsons disease with end-of-dose motor fluctuations: opicapone; 2017. Available from: nice.org.uk/guidance/es9. Accessed ...
Randomized Controlled Trial Of Lichtenstein Repair Of Indirect Inguina | TCRM
... skin diseases around the surgical incision; 6) serious diseases that caused increased intra-abdominal pressure (such as severe ... liver and kidney dysfunction (heart function: grade II and above; ALT or AST,2.5 times of the upper limit of normal; serum ... brain system diseases, cancer, or AIDS; 10) specific allergic condition; 11) life expectancy less than 6 months; 12) mental ... 1 Hernia is a common and frequently occurring disease, and its incidence increases with age. Adult hernia is not self-healing ...
Multiple Factor Analysis of Depression and/or Anxiety in Patients with | COPD
Multiple Factor Analysis of Depression and/or Anxiety in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease ... kidney disease and cardiovascular disease.45,48-55 Likewise PLR, MLR and RDW are also used as inflammatory markers by scholars ... diseases coexisting with COPD, such as heart disease, gastroesophageal reflux disease, lung cancer, etc., also make the ... Chronic obstructive pulmonary disease (COPD) is the most frequent respiratory disease in middle-aged and old people in both ...
Strengthening Primary Health-Care Services to Help Prevent and Control | RMHP
Non-Communicable Diseases in Low- and Middle-Income Countries ... DALYs for a disease or health condition are calculated as the ... or kidney are damaged, with an individual typically first presenting with acute myocardial infarction, stroke, or renal failure ... ischemic heart and brain disease), cancers, chronic respiratory diseases [eg, chronic obstructive pulmonary disease (COPD), and ... An overview of disease surveillance and notification system in Nigeria and the roles of clinicians in disease outbreak ...
Enhanced antifungal effects of amphotericin B-TPGS-b-(PCL-ran-PGA) nan | IJN
Notes: The liver (A) and kidney (B) of the AMB-NP-treated mice had no fungus. (C) C. albicans-uninfected heart section of the ... Pulmonary fungal infections are serious life-threatening diseases. To improve the treatment of pulmonary infections, several ... As shown in Figure 5, the liver and kidney of the AMB-NP-treated mice were uninfected by fungus, but there were fungi in the ... AMB has common ADRs of the digestive system and serious toxicity to the kidney and may even cause leukopenia and liver damage. ...
Targeting of a platinum-bound sunitinib analog to renal proximal tubul | IJN
... the capability of the kidney-directed conjugate to accumulate in the kidneys was studied in mice. Potential antifibrotic ... Multikinase inhibitors like sunitinib can be of benefit in the treatment of fibrotic diseases, provided that their safety can ... Upon intravenous injection, 17864-lysozyme rapidly accumulated in the kidneys and provided sustained renal drug levels for up ... Pharmacological activity of 17864-lysozyme was evaluated in human kidney proximal tubular cells (HK-2); ...
Personalized therapeutics for levofloxacin: a focus on pharmacokinetic | TCRM
Hurley M, Smyth A. Fluoroquinolones in the treatment of bronchopulmonary disease in cystic fibrosis. Ther Adv Respir Dis. 2012; ... Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J ... Cyclosporin and tacrolimus are two immunosuppressive agents with similar mechanisms of action and are widely used in kidney ... A population pharmacokinetics study of LVX in 522 subjects, including normal individuals and patients with infectious diseases ...
Efficacy of humanized single large doses of caspofungin on the lethali | IDR
Fungal kidney tissue burden experiments. At the beginning of the therapy, fungal kidney burden was determined after dissection ... Clinical practice guideline for the management of candidiasis: update by the Infectious Diseases Society of America. Clin ... and decreased the mean fungal kidney burdens of both species compared to controls. However, fungal kidney burden decreases were ... Fungal kidney tissue burden. At the beginning of therapy, the mean fungal tissue burden ranges were 2.6×105-3.1×105, 9.8×104- ...
Pharmacotherapy for uveitis: current management and emerging therapy | OPTH
It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent ... It is useful to consider the concept of disease activity versus damage when treating inflammatory disease.18,19 "Activity" ... Javaid MM, Chowdhury S, Henderson A, Olsburgh J. Advanced native kidney renal cell carcinoma in renal transplant recipients: ... Local therapy may be sufficient to control the disease, but in more severe inflammation, or in the presence of systemic disease ...
Self-Assembled Dual-Targeted Epirubicin-Hybrid Polydopamine Nanopartic | IJN
The mice were euthanized in groups of three at 1, 6, and 24 h, and heart, liver, spleen, lungs, kidneys, brain, and tumor ... Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients. NPJ ... Hearts, livers, spleens, lungs, kidneys, brains, and tumors were collected from each group and stained using a H&E staining kit ... and E/PCF-NPs groups with or without NIR showed no obvious kidney injury, pulmonary toxicity, cardiac damage, or inflammatory ...
99mTc-Radiolabeled Silica Nanocarriers for Targeted Detection and Trea | IJN
... all nanoparticles sets showed DOX concentration mainly in liver and kidney, as expected,34 with a notable increase in kidney ... Diseases of the Chest, Breast, Heart and Vessels 2019-2022: Diagnostic and Interventional Imaging. Cham (CH); 2019:167-178. ... However, at this time, radioactivity concentration in kidney was higher for SiNPs-TZ (1:2 Hc-TZ) when compared to SiNPs-TZ (1:8 ... 45. Mekahli D, Bultynck G, Parys JB, De Smedt H, Missiaen L. Endoplasmic-reticulum calcium depletion and disease. Csh Perspect ...
Efficiently engineered cell sheet using a complex of polyethylenimine& | IJN
Kidney of CS group (×200). (F) Kidney of BMP/CS group (×200).. Abbreviations: BMP/CS, bone morphogenetic protein 2 gene- ... Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused ... Liver, spleen, and kidney samples were obtained on day 7 after surgery. The hematological parameters (white blood cell number, ... Figure 7 Hematoxylin and eosin staining of liver, spleen, and kidney from rats treated with CS and BMP/CS at 7 days after ...