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Six ketoprofen (CAS 22071-15-4) atkylazacycloalkan-2-one ester derivatives (I-VI) were synthesized and evaluated for their anti ... Six ketoprofen (CAS 22071-15-4) atkylazacycloalkan-2-one ester derivatives (I-VI) were synthesized and evaluated for their anti ... 1-ethyl and 1-propylazacycloalkan-2-one ester prodrugs of ketoprofen - Synthesis, chemical stability, enzymatic hydrolysis, ... similar to that of ketoprofen, although at higher doses. They were significantly less irritating to the gastric mucosa than the ...
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Abstract: Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic ... From this point of view it is of interest to us to obtain new isoquinolines containing a ketoprofen residue in their structure ... SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES. Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G ... Keywords: ketoprofen, nsaids, 1,2,3,4-tetrahydroisoquinoline, in silico, α-amidoalkylation reaction, tfoh/sio2, heterogeneous ...
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Background: The disposition kinetics of ketoprofen into synovial fluid was estimated to predict the time course of ketoprofen ... Methods: After repeated oral doses of ketoprofen 100 mg twice daily, ketoprofen concentrations of plasma and synovial fluid ... Methods: After repeated oral doses of ketoprofen 100 mg twice daily, ketoprofen concentrations of plasma and synovial fluid ... Methods: After repeated oral doses of ketoprofen 100 mg twice daily, ketoprofen concentrations of plasma and synovial fluid ...
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