Alpha-lipoic acid (thioctic acid) the magic antioxidant and much more | superhumangear
The alpha-ketoglutarate dehydrogenase complex catalyzes the conversion of alpha-ketoglutarate to succinyl CoA, another ... The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for ... The activity of the branched-chain ketoacid dehydrogenase complex results in the catabolism of the branched-chain amino acids, ... In each case, R-LA is covalently bound to a specific lysine residue in one of the proteins in the enzyme complex. ...https://superhumangear.wordpress.com/2010/06/16/alpha-lipoic-acid-thioctic-acid-the-magic-antioxidant-and-much-more/
alpha Ketoglutarate Dehydrogenase (alphaKGDHC) (AA 41-1023) protein (His tag)</span...
Recombinant alpha Ketoglutarate Dehydrogenase (alphaKGDHC) Protein (His tag). Species: Mouse (Murine). Source: Insect Cells. ... The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It ... alpha Ketoglutarate Dehydrogenase (alphaKGDHC) (AA 41-1023) protein (His tag) alpha Ketoglutarate Dehydrogenase (alphaKGDHC) ( ... More product categories related to alpha Ketoglutarate Dehydrogenase Protein * 54 anti-alpha Ketoglutarate Dehydrogenase ...http://www.antibodies-online.com/protein/3135266/alpha+Ketoglutarate+Dehydrogenase+alphaKGDHC+AA+41-1023+protein+His+tag/
Protein Metabolism- Online Textbook Chapter - Alyvea.com
Metabolism: Pyruvate Dehydrogenase Complex Deficiency and Phenylketonuria Pyruvate dehydrogenase complex deficiency (PDCD) and ... and α-ketoglutarate, amino acids can serve as a source of energy production through the Krebs cycle ([link]). [link] summarizes ... With low levels of the pyruvate dehydrogenase complex (PDC), the rate of cycling through the Krebs cycle is dramatically ... Nutrients follow a complex pathway from ingestion through anabolism and catabolism to energy production.. Disorders of the... ...http://alyvea.com/anatomy/protein-metabolism.php
User:RostyslavZvanych/The a-ketoglutarate dehydrogenase complex in Alzheimer's disease - Wikipedia
a b c d e f g h i Mastrogiacoma, F., Bergeron, C. and Kish, S.J., (1993) Brain α-ketoglutarate dehydrogenase complex activity ... The α-ketoglutarate dehydrogenase complex. The α-KGDHC is found in the tricarboxylic acid cycle (TCA), which situated ... The α-ketoglutarate dehydrogenase complex (KGDHC) is an enzyme involved in the citric acid cycle that consists of three ... 1. "Brain α-ketoglutarate dehydrogenase complex activity in Alzheimer's disease" by Mastrogiacoma, F., Bergeron, C. and Kish, S ...https://en.wikipedia.org/wiki/User:RostyslavZvanych/The_a-ketoglutarate_dehydrogenase_complex_in_Alzheimer%E2%80%99s_disease
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species - Repository of the Academy's Library
... ketoglutarate. Isolated mitochondrial � -ketoglutarate dehydrogenase (KGDHC) and pyruvate dehy- drogenase (PDHC) complexes ... Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. JOURNAL OF NEUROSCIENCE, 24 (36). pp ... The molecular sites of mitochondrial ROS production are not well established but are generally thought to be located in complex ... ketoglutarate supported the highest rate of H 2 O 2 production. In the absence of ADP or in the presence of rotenone, H 2 O 2 ...http://real.mtak.hu/56650/
RCSB PDB - 1CW4: CRYSTAL STRUCTURE OF K230M ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ALPHA-KETOGLUTARATE Literature...
Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase. ... CRYSTAL STRUCTURE OF K230M ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ALPHA-KETOGLUTARATE. *DOI: 10.2210/pdb1cw4/pdb ... ISOCITRATE DEHYDROGENASE A 416 Escherichia coli EC#: 22.214.171.124 IUBMB Mutation: K230M Gene Name(s): icd icdA icdE b1136 JW1122 ... Protein-ligand complexes in two dimensions, ACS Med. Chem. Lett., DOI: 10.1021/ml100164p. Ions and some metal complexes are ...http://www.rcsb.org/pdb/explore/litView.do?structureId=1CW4
RCSB PDB - 3O9Z: Crystal structure of the WlbA (WbpB) dehydrogenase from Thermus thermophilus in complex with NAD and alpha...
... dehydrogenase from Thermus thermophilus in complex with NAD and alpha-ketoglutarate at 1.45 angstrom resolution ... Crystal structure of the WlbA (WbpB) dehydrogenase from Thermus thermophilus in complex with NAD and alpha-ketoglutarate at ... the enzyme in a complex with NAD(H) and alpha-ketoglutarate, and the enzyme in a complex with NAD(H) and its substrate (UDP-N- ... Both alpha-ketoglutarate and the UDP-linked sugar bind in the WlbA active site with their carbon atoms (C-2 and C-3', ...https://www.rcsb.org/structure/3O9Z
OGDH - Wikipedia
"Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity". The ... Alpha-ketoglutarate dehydrogenase also known as 2-oxoglutarate dehydrogenase E1 component, mitochondrial is an enzyme that in ... This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2- ... Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components". The ...https://en.wikipedia.org/wiki/OGDH
Maimone and Cross Important Stuff Flashcards by Katie Howe | Brainscape
2) via alpha-ketoglutarate dehydrogenase complex. 3) oxidative decarboxylation (5 carbons-->4 carbons) and thioester formation ... 2) Fe2S2 in complex III (cytochrome bc complex). 3) Fe4S4 in succinate dehydrogenase. 4) H2S formed from acidification causes ... 2) pyruvate dehydrogenase phosphatase activated by Ca+2 to reactivate E1 (pyruvate dehydrogenase active), part of fight-or- ... 1) isocitrate-->oxalosuccinate-->alpha-ketoglutarate. 2) via isocitrate dehydrogenase. 3) oxidative decarboxylation (6 carbons ...https://www.brainscape.com/flashcards/maimone-and-cross-important-stuff-2086756/packs/3747835
DLST - Wikipedia
1998). "Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the ... of human alpha-ketoglutarate dehydrogenase complex". Somat Cell Mol Genet. 20 (2): 99-105. doi:10.1007/BF02290679. PMID 8009371 ... 1990). "Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing ... Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial is an enzyme ...https://en.wikipedia.org/wiki/DLST
Structural Biochemistry/Krebs Cycle (Citric Acid cycle) - Wikibooks, open books for an open world
Alpha-ketoglutarate is converted to succinyl-CoA and CO2 by the action of the α-ketoglutarate dehydrogenase complex. NAD+ is ... α-ketoglutarate+ CoA + NAD+ -(α-ketoglutarate dehydrogenase complex)-, succinyl-CoA + CO2A +NADH 5. Conversion of Succinyl-CoA ... The pyruvate dehydrogenase complex is composed of three different enzymes. Its complex is composed of members of a family of ... homologous complexes which include citric acid cycle enzyme a-ketoglutarate dehydrogenase complex. These complexes are very ...https://en.wikibooks.org/wiki/Structural_Biochemistry/Krebs_Cycle_
DBT - Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor -...
... and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to ... The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2 ... mitochondrial alpha-ketoglutarate dehydrogenase complex Source: ProtInc ,p>Traceable Author Statement,/p> ,p>Used for ... The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. ...https://www.uniprot.org/uniprot/P11182
Biotin - DrugBank
Mitochondrial Complex II Deficiency. Disease. 2-Ketoglutarate Dehydrogenase Complex Deficiency. Disease. Fructose-1,6- ... Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring, which ...https://www.drugbank.ca/drugs/DB00121
Pyruvic acid - DrugBank
2-ketoglutarate dehydrogenase complex deficiency. Disease. Warburg Effect. Metabolic. Argininosuccinic Aciduria. Disease. ... Pyruvate dehydrogenase activity. Specific Function. The pyruvate dehydrogenase complex catalyzes the overall conversion of ... Another is activation of pyruvate dehydrogenase, promoting its own oxidation by inhibiting pyruvate dehydrogenase kinase. ... UPyruvate dehydrogenase E1 component subunit beta, mitochondrial. Not Available. Human. UPyruvate kinase PKM. Not Available. ...https://www.drugbank.ca/drugs/DB00119
PRODUCTION OF 1,4 BUTANEDIOL IN A MICROORGANISM - MICROBIA, INC.
b) CoA-independent succinic semialdehyde dehydrogenase;. (c) α-ketoglutarate dehydrogenase complex;. (d) 4-aminobutyrate ... hydroxybutyrate dehydrogenase, a 1 ,3 propanediol dehydrogenase, cinnamyl-alcohol dehydrogenase, or an alcohol dehydrogenase. ... 3 propanediol dehydrogenase, cinnamyl-alcohol dehydrogenase, or an alcohol dehydrogenase; the polypeptide that catalyzes the ... CoA-dependent succinic semialdehyde dehydrogenase; (7) 4- hydroxybutanoate dehydrogenase; (8) [alphaj-ketoglutarate ...http://www.sumobrain.com/patents/wipo/Production-14-butanediol-in-microorganism/WO2010085731.html
Human Metabolome Database: Showing metabocard for Fumaric acid (HMDB0000134)
2-Ketoglutarate dehydrogenase complex deficiency. *Bonnefont JP, Chretien D, Rustin P, Robinson B, Vassault A, Aupetit J, ... Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron ... Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron ... Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron ...http://www.hmdb.ca/metabolites/HMDB0000134
Excitatory Amino Acid Neurotoxicity | Springer for Research & Development
The alpha-ketoglutarate dehydrogenase complex. Ann NY Acad Sci 1999; 893 61-78.CrossRefGoogle Scholar ... The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochem ... Herrero A, Barja G. ADP-regulation of mitochondria] free radical production is different with complex I- or complex II-linked ... A model of 02.-generation in the complex III of the electron transport chain. Mol Cell Biochem 1998; 184(1-2):21-33.PubMed ...https://rd.springer.com/chapter/10.1007/978-1-4615-0123-7_1
Frontiers | Reconstruction of the Metabolic Potential of Acidophilic Sideroxydans Strains from the Metagenome of an...
Subunit interactions in the mammalian α-ketoglutarate dehydrogenase complex. Evidence for direct association of the α- ... The third subunit (E3) encoding the dihydrolipoamide dehydrogenase activity of the 2-oxoglutarate dehydrogenase enzyme complex ... ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components. J. Biol. Chem. 273, 24158-24164. doi: 10.1074/jbc. ... Berg, A., and de Kok, A. (1997). 2-Oxo acid dehydrogenase multienzyme complexes. The central role of the lipoyl domain. Biol. ...https://www.frontiersin.org/articles/10.3389/fmicb.2016.02082/full
Citric acid cycle - Wikipedia
Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex. ... inhibits pyruvate dehydrogenase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, and also citrate synthase. Acetyl-coA ... α-Ketoglutarate + NAD+ + CoA-SH Succinyl-CoA + NADH + H+ + CO2. α-Ketoglutarate. dehydrogenase Oxidative. decarboxylation ... Calcium also activates isocitrate dehydrogenase and α-ketoglutarate dehydrogenase. This increases the reaction rate of many ...https://en.m.wikipedia.org/wiki/Krebs_cycle
Difference between revisions of "Dahlquist:MAPP Archive" - OpenWetWare
2-ketoglutarate dehydrogenase complex. *Aromatic Compounds Degradation *Phenolic Compounds Degradation *Phenylacetate ...https://openwetware.org/wiki/?title=Dahlquist:MAPP_Archive&diff=prev&oldid=244851
KAKEN - Research Projects | Database of Supergene Family (KAKENHI-PROJECT-03558027)
Purification and molecular cloning of succinyltransferase of the rat a-ketoglutarate dehydrogenase complex.' J.Biol. Chem.266. ... Purification and molecular cloning of succinyltransferase of the rat α-ketoglutarate dehydrogenase complex.' J.Biol.Chem.266. ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03558027/
Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. J Biol Chem 2011;286:17640-17648pmid: ... The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity. J Mol Cell Cardiol 1997;29:2771-2778pmid: ... Flux through pyruvate dehydrogenase was decreased, as measured in vivo by hyperpolarized [1-13C]pyruvate MRS. Metabolomics ... OGDH is a subunit of the enzyme complex that converts 2-oxoglutarate to succinyl-CoA and CO2. This is the rate-limiting ...http://diabetes.diabetesjournals.org/content/67/6/1057
Similar articles for PubMed (Select 22719765) - PubMed - NCBI
Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. ... Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.. Shi Q, Xu H, Yu H, Zhang N, Ye Y, ... Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, ... Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=22719765
Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of...
Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. J Biol Chem. 2011;286(20):17640-8. ... pyruvate dehydrogenase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase [81-83]. In addition, the levels of ATP and ... Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation. ... An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann Neurol. 1994;35(2):204-10 ...https://www.intechopen.com/books/pluripotent-stem-cells-from-the-bench-to-the-clinic/nontargeted-metabolite-profiling-of-induced-pluripotent-stem-cells-ipscs-derived-neural-cells-insigh/
Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences, Progress in Retinal and Eye Research | 10.1016...
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. Starkov, A.A.; Fiskum, G.; ... Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death ... Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a ... Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is ...https://www.deepdyve.com/lp/elsevier/oxidative-stress-in-glaucomatous-neurodegeneration-mechanisms-and-GiyRcrRK6O?impressionId=5ce4a06b6aa4a&i_medium=docview&i_campaign=references&i_source=references