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*  Probable potassium channel protein elisa and antibody
Shop Probable potassium channel protein ELISA Kit, Recombinant Protein and Probable potassium channel protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=probable-potassium-channel-protein
*  Potassium Channel Function in Vascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
Most information currently available regarding vascular K+ channel function in diabetes concerns KATP channels. As for chronic hypertension, there are now several reports of impaired vascular relaxant responses to synthetic openers of KATP channels in long-term diabetes. These studies have mostly utilized the streptozotocin-injected rat model of diabetes and have examined vessels at 2.5 to 4 months after streptozotocin treatment. In this model in which plasma glucose levels are increased 3- to 4-fold, impaired relaxation of the isolated aorta122 123 124 and mesenteric vascular bed125 and reduced dilatation of large126 and small127 cerebral arteries in vivo typically develop. These changes are thought to be the result of a decreased number of vascular KATP channels and/or reduced sensitivity of these channels to synthetic openers. Nonspecific cytotoxic effects of streptozotocin seem an unlikely cause of these changes because, ...
http://atvb.ahajournals.org/content/21/1/28
*  Potassium Channel Function in Vascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
Most information currently available regarding vascular K+ channel function in diabetes concerns KATP channels. As for chronic hypertension, there are now several reports of impaired vascular relaxant responses to synthetic openers of KATP channels in long-term diabetes. These studies have mostly utilized the streptozotocin-injected rat model of diabetes and have examined vessels at 2.5 to 4 months after streptozotocin treatment. In this model in which plasma glucose levels are increased 3- to 4-fold, impaired relaxation of the isolated aorta122 123 124 and mesenteric vascular bed125 and reduced dilatation of large126 and small127 cerebral arteries in vivo typically develop. These changes are thought to be the result of a decreased number of vascular KATP channels and/or reduced sensitivity of these channels to synthetic openers. Nonspecific cytotoxic effects of streptozotocin seem an unlikely cause of these changes because, ...
http://atvb.ahajournals.org/content/21/1/28.full
*  In This Issue | Circulation Research
Sudden cardiac death caused by ventricular fibrillation claims the lives of approximately 300,000 North Americans each year, and in nearly 10% of cases the cause is unknown, or idiopathic. Recently, members of a Dutch family with idiopathic ventricular fibrillation (IVF) were found to over-express transcripts of the DPP6 gene. Because the DPP6 protein modulates potassium channel kinetics and trafficking, Xiao and colleagues questioned whether high levels of DPP6 might actually affect potassium channel function and, in turn, cause arrhythmia. The team found that over-expression of DPP6 in canine heart tissue did indeed affect channel function, causing an increase in the density of transient outward potassium currents. Interestingly, this increase occurred in Purkinje cells, and ventricular myocytes were unaffected. While DPP6 was responsible for binding potassium channels in ...
http://circres.ahajournals.org/content/112/10/1303
*  Potassium channel molecule - Stock Image C035/8257 - Science Photo Library
Potassium channel molecule. Computer model showing the structure of a bacterial potassium channel with four units arranged around an axis going through the first (and only visible) of four potassium ions (big purple sphere). From Bacillus cereus. - Stock Image C035/8257
http://www.sciencephoto.com/media/850665/view
*  What does kv1.1 potassium channel mean?
Definition of kv1.1 potassium channel in the Definitions.net dictionary. Meaning of kv1.1 potassium channel. What does kv1.1 potassium channel mean? Information and translations of kv1.1 potassium channel in the most comprehensive dictionary definitions resource on the web.
http://www.definitions.net/definition/kv1.1%20potassium%20channel
*  A scheme to account for the effects of Rb+ and K+ on inward rectifier K channels of bovine artery endothelial cells. | JGP
An electrochemical gating model is presented to account for the effects described in the companion paper by M. R. Silver, M. S. Shapiro, and T. E. DeCoursey (1994. Journal of General Physiology, 103:519-548) of Rb+ and Rb+/K+ mixtures on the kinetics and voltage dependence of an inwardly rectifying (IR) K+ channel. The model proposes that both Rb+ and K+ act as allosteric modulators of an intrinsically voltage dependent isomerization between open and closed states. Occupancy of binding sites on the outside of the channel promotes channel opening and stabilizes the open state. Rb+ binds to separate sites within the pore and plugs IR channels. Occupancy of the pore by Rb+ can modify the rates of isomerization and the affinity of the allosteric sites for activator ions. The model also incorporates the proposed triple-barreled nature of the IR channel (Matsuda, H., 1988. Journal of Physiology. 397:237-258.) by proposing that ...
http://jgp.rupress.org/content/103/4/549
*  Potassium Voltage Gated Channel Subfamily C Member 1 - Pipeline
Global Markets Direct's, 'Potassium Voltage Gated Channel Subfamily C Member 1 (Voltage Gated Potassium Channel Subunit Kv3.1 or Voltage Gated Potassium Channel Subunit Kv4 or KCNC1) - Pipeline
http://www.sbwire.com/press-releases/potassium-voltage-gated-channel-subfamily-c-member-1-727767.htm
*  New operating principle of potassium channels discovered
This enabled them to draw conclusions about its mechanism of action, which they describe in the current issue of "Nature Communications". Neurons conduct information by way of electrical impulses through our body. Potassium channels are a key component of this electrical circuit and are controlled either by an electrical impulse or through signaling molecules. In man, the dysfunction of the so-called HCN potassium channels is associated with neurological disorders such as epilepsy and depression. Prof. Henning Stahlberg's team at the Biozentrum of the University of Basel has now elucidated the full structure of a bacterial counterpart of this type of potassium channel, which has provided new insights into its functioning.. ...
http://www.innovations-report.com/html/reports/life-sciences/operating-principle-potassium-channels-discovered-225394.html
*  Potassium Channels as a Target for Clinical Therapeutics:: volume 1 | BenthamScience
This e-book presents an overview of the different substances capable of modulating potassium channels in relation to various clinical indications in cardiology, pulmonology, endocrinology and neurology. The possible benefits and side effects of potassium channel modulators is discussed in correlation with biophysical and pharmacological properties of ion channels. Readers will learn how mutation of K+ channels can be conferred by molecular processes such as alternative splicing, RNA editing and posttranslational modifications. Altogether, this e-book will be of use to clinical practitioners, electrophysiologists and pharmacologists interested in the complicated but fascinating science of potassium channels.. ...
http://www.eurekaselect.com/100706
*  Department of Bioenergetics
Energy dissipating systems (uncoupling proteins - UCPs, alternative oxidase - AOX, mitochondrial potassium channels) in physiological and pathological conditions: the activity of UCPs and AOXs in different eukaryotic organisms, UCP proteins in inflammation and circulatory diseases, mitochondrial potassium channels in cytoprotection, mitochondria and the endurance ...
http://ibmib.home.amu.edu.pl/en/department-of-bioenergetics/
*  CiNii 論文 - Effects of KRN4884, a Novel K^+ Channel Opener, on Ionic Currents in Rabbit...
Effects of KRN4884 (5-amino-,i,N,/i,-[2-(2-chlorophenyl)ethyl]-,i,N',/i,-cyano-3-pyridinecarboxamidine), a novel K,sup,+,/sup, channel opener, on ionic currents were examined in rabbit femoral arterial myocytes (RFAMs). Under whole-cell clamp conditions where cells were superfused with 5.9 mM K,sup,+,/sup, bathing solution, KRN4884 elicited an outward current at −30 mV. KRN4884-induced current had a reversal potential of −78 mV and was abolished by application of glibenclamide (glib). KRN4884 was approximately 43 times more potent than levcromakalim in activating an ATP-sensitive K,sup,+,/sup, current (I,sub,K-ATP,/sub,). On the other hand, KRN4884 affected neither voltage-dependent Ca,sup,2+,/sup, nor delayed rectifier K,sup,+,/sup, channel currents. In the inside-out patch clamp configuration where cells were superfused with the symmetrical 140 mM K,sup,+,/sup, solution, KRN4884 activated 47 pS K,sup,+,/sup, channels in the presence of adenosine ...
http://ci.nii.ac.jp/naid/10012544997
*  Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy Reveals the Existence of Two...
In the crystal structure of KcsA (Doyle et al., 1998), the TM2 helices cross over and form a tight bundle toward the intracellular face of the channel. Proton-dependent gating (Cuello et al., 1998; Heginbotham et al., 1999; Meuser et al., 1999) takes place through a significant rearrangement of the TM2 moving away from the fourfold axis of symmetry, as demonstrated from site-directed spin labeling in combination with electron paramagnetic resonance (EPR) spectroscopy (Perozo et al., 1998, 1999; Liu et al., 2001; Sompornpisut et al., 2001) and site-directed mass tagging (Kelly and Gross, 2003). This movement seems to be consistent with the open state structure of the calcium-dependent potassium channel from Methanobacterium thermoautrophicum, MthK, showing a wide open intracellular pore (16 Å) (Jiang et al., 2002b) and the archaea voltage-dependent K+ channel KvAP (Jiang et al., 2003a,b), although distance determinations suggest that helix ...
http://jgp.rupress.org/content/128/5/569
*  The ligand-sensitive gate of a potassium channel lies close to the selectivity filter. - Oxford Neuroscience
Potassium channels selectively conduct K(+) ions across cell membranes and have key roles in cell excitability. Their opening and closing can be spontaneous or controlled by membrane voltage or ligand binding. We used Ba(2+) as a probe to determine the location of the ligand-sensitive gate in an inwardly rectifying K(+) channel (Kir6.2). To a K(+) channel, Ba(2+) and K(+) are of similar sizes, but Ba(2+) blocks the pore by binding within the selectivity filter. We found that internal Ba(2+) could still access its binding site when the channel was shut, which indicates that the ligand-sensitive gate lies above the Ba(2+)-block site, and thus within or above the selectivity filter. This is in marked contrast to the voltage-dependent gate of K(V) channels, which is located at the intracellular mouth of the pore.
https://www.neuroscience.ox.ac.uk/publications/114062
*  TumorPortal
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport ...
http://www.tumorportal.org/view?geneSymbol=KCNK5
*  Chimera Image Gallery
Potassium channel (Protein Data Bank entry 1bl8) on a dark slate blue background with potassium ions shown in firebrick. The channel is comprised of four chains. Each chain has been rainbow-colored from blue at the N-terminus to red at the C-terminus, but only the surface of the channel is shown. The surface has been sliced with a per-model clipping plane. The surface cap color is plum except with opacity set to 0.8. The shininess and brightness have been set to 128 and 8, respectively, and the lights on the scene have been moved from their default positions. The subdivision quality (related to the smoothness of the spherical ions) is 5.0, and the molecular surface was computed with probe radius and vertex density set to 1.0 and 6.0, respectively. The entry Cavity and Tunnel Detection provides additional views of the same structure. ...
https://www.cgl.ucsf.edu/chimera/ImageGallery/entries/kchan/kchan.html
*  Endothelial biology and ATP-sensitive potassium channels.
This is the Author's Original Manuscript of an article published by Taylor & Francis in Channels on 02 Jan 2018 available online: https://doi.org/10.1080/19336950.2017.1412151 ...
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32204
*  AID 2432 - Mode of action assay - molecular determinants for ztz240, a potentiator of KCNQ2 potassium channels - PubChem
BioAssay record AID 2432 submitted by Johns Hopkins Ion Channel Center: Mode of action assay - molecular determinants for ztz240, a potentiator of KCNQ2 potassium channels.
https://pubchem.ncbi.nlm.nih.gov/bioassay/2432
*  AID 2258 - Summary of probe development for potentiators of KCNQ2 potassium channels - PubChem
BioAssay record AID 2258 submitted by Johns Hopkins Ion Channel Center: Summary of probe development for potentiators of KCNQ2 potassium channels.
https://pubchem.ncbi.nlm.nih.gov/bioassay/2258
*  Kv1.2 Potassium Channel - RightDiagnosis.com
Kv1.2 Potassium Channel information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
http://www.rightdiagnosis.com/medical/kv1_2_potassium_channel.htm
*  Potassium channels | Hello Bio
High quality reagents for receptor, ion channel and enzyme research including potassium channel tools from Hello Bio - a trusted, affordable life science reagents supplier.
https://www.hellobio.com/products/target/ion-channels/voltage-gated-ion-channel/potassium-channels.html
*  Differences in the mechanism of metabolic regulation of ATP-se...
Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits.: Kir6.1\SUR2B has intrinsic sensitivity
https://www.mysciencework.com/publication/show/differences-mechanism-metabolic-regulation-atp-sensitive-k+-channels-containing-kir6-1-kir6-2-subunits-6aaa8e9b