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*  Brain has JC virus and PML - Forum on AIDS-Related Cancers - TheBody.com
The JC virus is a virus which infects the brain of advanced cancer patients and causes PML-- progressive multifocal ... The JC virus is a virus which infects the brain of advanced cancer patients and causes PML-- progressive multifocal ... Brain has JC virus and PML. Oct 5, 2002 My elder brother is an AIDS patient who has been in Hong Kong hospital over 3 months. ... Recently his doctor discovered his right brain has shadow and think it's JC virus (or disease:PML). Now his left side cannot ...
http://www.thebody.com/Forums/AIDS/Cancer/Q142002.html
*  Jc Virus Infection - Articles on Medical Diseases and Conditions
Jc Virus Infection. Jul.26, 2009 in Viral Infections The JC virus belongs to the polyoma virus group of the papovavirus family ... BK virus is also in the polyoma virus group. It appears that infection by both viruses occurs during childhood or adolescence, ... One report applied a homemade nucleic acid probe with PCR amplification to urine of JC virus patients and obtained an excellent ... If a patient becomes immunosuppressed, especially during AIDS, reactivated JC virus can infect lymphocytes, be carried to the ...
http://med-life.net/2009/07/26/jc-virus-infection/
*  Viral Trafficking pathways of JC virus to the brain in progressive multifocal leukoencephalopathy
... DSpace/Manakin Repository. ... the mechanisms of JC virus infection remain largely uncertain and current understanding in pathogenesis is obtained from human ... demyelinating disease of the brain caused by lytic infection of oligodendrocytes with the JC polyomavirus (JCPyV). Emergence of ...
https://dspace.library.uu.nl/handle/1874/322745
*  Neuroimmune regulation of neurotropic JC virus by SF2/ASF in glial cells - Ilker Sariyer
... is a fatal demyelinating disease caused by human neurotropic JC virus. JCV infects more than 80% of human popul... ... Neuroimmune regulation of neurotropic JC virus by SF2/ASF in glial cells Sariyer, Ilker Kudret Temple University, Philadelphia ... Neuroimmune regulation of neurotropic JC virus by SF2/ASF in glial cells. Sariyer, Ilker Kudret / Temple University. $382,500. ... Neuroimmune regulation of neurotropic JC virus by SF2/ASF in glial cells. Sariyer, Ilker Kudret / Temple University. $359,550. ...
http://grantome.com/grant/NIH/R01-AI101192-01
*  Natalizumab treatment in patients with multiple sclerosis associated with JC virus infection | Liberation Treatment CCSVI
... appears linked with JC virus (JCV) infection, which can lead to a rare and often fatal demyelinating disease of the central ... Treatment with natalizumab in patients with multiple sclerosis (MS) appears linked with JC virus (JCV) infection, which can ... Natalizumab treatment in patients with multiple sclerosis associated with JC virus infection. ... Natalizumab treatment in patients with multiple sclerosis associated with JC virus infection ...
http://liberationtreatmentccsvi.com/2014/03/natalizumab-treatment-in-patients-with-multiple-sclerosis-associated-with-jc-virus-infection/
*  Progressive Multifocal Leukoencephalopathy: a Case Study - Redorbit
JC Virus The human polyomavirus JC was named after the initials of the patient from whom the particles were recovered in 1971.4 ... The herpes simplex virus and enterovirus by polymerase chain reaction (PCR) testing were also negative. JC virus (JCV) ... We present a study, in which the JC virus was found in a 68-year-old man who had received a postorthotopic heart transplant 3 ... 7. Behzad-Behbahani A, Klapper P, Vallely P, Cleator O, Khoo S. Detection of BK vims and JC virus DNA in urine samples from ...
http://www.redorbit.com/news/health/972551/progressive_multifocal_leukoencephalopathy_a_case_study/
*  Leucoencefalopatia multifocal progressiva como manifestação inicial da síndrome da imunodeficiência adquirida
Keywords : Progressive multifocal leukoencephalopathy; Acquired immunodeficiency syndrome; Central nervous system; JC virus. ... in the brain after gross and microscopical examination as well as by immunohistochemistry with an antibody against JC virus. ...
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0037-86821998000600011&lng=en&nrm=iso&tlng=en
*  Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus - Itoh - 2006 - Arthritis &...
Renal JC virus DNA carries the archetype regulatory region, whereas the CNS JC virus DNA of PML patients contains various ... JC virus is a widespread pathogen in human populations. More than 70% of individuals are infected with JC virus ... caused by a human polyomavirus designated JC virus. JC virus has been recognized as a major pathogen of opportunistic ... The PML-type JC virus regulatory regions are shown with their deletions relative to the archetype as gaps. Duplication is ...
http://onlinelibrary.wiley.com/doi/10.1002/art.21721/full
*  Polyomavirus JC, multiple sclerosis, Tysabri, and an anti-malaria drug
How does JC virus fit into this story? Tysabri is the trade name for Natalizumab ... 4 months ago they took blood to test for the JC Virus. We found out last night she tested positive for the virus and 1 in 1,000 ... How does JC virus fit into this story?. Tysabri is the trade name for Natalizumab, a monoclonal antibody against the cellular ... Last year I tested negative for the JC Virus antibodies………& now I'm scheduled for every other month infusions of Tysabri.. I ...
http://www.virology.ws/2009/03/26/polyomavirus-jc-multiple-sclerosis-tysabri-and-an-anti-malaria-drug/
*  JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive...
Results: The overall JC virus seroprevalence was 65%. JC virus DNA copies were detected in the urine from 29-44% of subjects, ... The natural history of JC virus in patients with Crohn's disease is still unknown. Our study results show that JC virus latency ... JC viral loads were determined with quantitative real-time polymerase chain reaction (PCR), and JC virus seroprevalence with a ... caused by reactivation of latent JC virus infection. Athough anti-α4 integrin therapies are likely to be introduced in the ...
http://gut.bmj.com/content/57/10/1393
*  Progressive multifocal leukoencephalopathy | Health Encyclopedia | FloridaHealthFinder.gov
PML; John Cunningham virus; JCV. Causes. The John Cunningham virus, or JC virus (JCV) causes PML. By age 10, most people have ... Berger JR, Nath A. Cytomegalovirus, Epstein-Barr virus, and slow virus infections of the central nervous system. In: Goldman L ... JC, BK, and other polyomaviruses: progressive multifocal leukoencephalopathy (PML). In: Bennett JE, Dolin R, Blaser MJ, eds. ... been infected with this virus. But it hardly ever causes symptoms. But, people with a weakened immune system are at risk of ...
http://www.floridahealthfinder.gov/healthencyclopedia/Health%20Illustrated%20Encyclopedia/1/000674.aspx
*  Aids-related progressive multifocal leukoencephalopathy: a retrospective study in a referral center in São Paulo, Brazil
... from both BK virus and JC virus. The presence of the JC virus was confirmed by digestion of the PCR product using BamH1, as ... such as genomic diversity of JC virus strains, including the possibility of predominance of low virulent strains of JC virus16 ... of BK virus DNA in CSF and brain tissue. The polymerase chain reaction (PCR) for JC virus DNA in CSF samples was performed ... 7. FINK, M.C.; PENALVA DE OLIVEIRA, A.C.; MILAGRES, F.A. et al . - JC virus DNA in cerebrospinal fluid samples from Brazilian ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000400004&lng=en&nrm=iso&tlng=en
*  Progressive Multifocal Leukoencephalopathy | Blake Medical Center | Bradenton, FL
PML is caused by a specific papovavirus, known as John Cunningham (JC) virus. Many people get this infection in childhood. It ... There are no current guidelines to prevent exposure to the JC virus. If you have a suppressed immune system, follow your ... The virus damages oligodendrocytes, the cells in the central nervous system (CNS) which produce myelin, the material that wraps ...
https://blakemedicalcenter.com/hl/?/102904/Progressive-multifocal-leukoencephalopathy&com.dotmarketing.htmlpage.language=1
*  JC Antibody Status May Predict PML Risk for MS Drug | Medpage Today
... may soon sport a suggestion that patients be tested for JC virus infection, so that the risk of progressive multifocal ... The label for natalizumab (Tysabri) may soon sport a suggestion that patients be tested for JC virus infection, so that the ... Many people are infected with JC virus, which is ordinarily kept under control by the immune system and therefore causes no ... Another study indicated that 61% of a large number of multiple sclerosis patients in Sweden tested positive for anti-JC virus ...
https://www.medpagetoday.com/neurology/multiplesclerosis/24026
*  Progressive Multifocal Leukoencephalopathy | Memorial Hospital
PML is caused by a specific papovavirus, known as John Cunningham (JC) virus. Many people get this infection in childhood. It ... There are no current guidelines to prevent exposure to the JC virus. If you have a suppressed immune system, follow your ... The virus damages oligodendrocytes, the cells in the central nervous system (CNS) which produce myelin, the material that wraps ...
https://memorialhospitaljax.com/hl/?/102904/Progressive-multifocal-leukoencephalopathy&com.dotmarketing.htmlpage.language=1
*  Progressive multifocal leukoencephalopathy: Epidemiology, clinical manifestations, and diagnosis
JC virus). Asymptomatic primary infection with JC virus occurs in childhood and an ... is a severe demyelinating disease of the central nervous system that is caused by reactivation of the polyomavirus JC ( ... JC virus) [1-3]. Asymptomatic primary infection with JC virus occurs in childhood and antibodies can be found in 86 percent of ... JC virus remains latent in kidneys and lymphoid organs, but, in the context of profound cellular immunosuppression, JC virus ...
http://www.uptodate.com/contents/progressive-multifocal-leukoencephalopathy-epidemiology-clinical-manifestations-and-diagnosis
*  Interferon-α and -β Restrict Polyomavirus JC Replication in Primary Human Fetal Glial Cells: Implications for Progressive...
The Polyomavirus family includes two members, BK virus (BKV) and JC virus (JCV), that naturally infect humans. These viruses ... p53 in polyoma virus transformed REF52 cells. Mor, Orna; Read, Moira; Fried, Mike // Oncogene;12/18/97, Vol. 15 Issue 25, p3113 ... Human endothelial cells allow passage of an archetypal BK virus (BKV) strain � a tool for cultivation and functional studies ... To study the genetic variability of these viruses, an evolutionary analysis of the large T antigen, small t antigen, VP1, VP2 ...
http://connection.ebscohost.com/c/articles/26240133/interferon-and-restrict-polyomavirus-jc-replication-primary-human-fetal-glial-cells-implications-progressive-multifocal-leukoencephalopathy-therapy
*  The Radiology Assistant : Multiple Sclerosis
Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating disease caused by JC virus in immunosuppressed patients.. ... Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating disease caused by JC virus in immunosuppressed patients. ... Bot JC, Barkhof F, Polman CH, et al. Neurology 2004;62:226-233 ...
http://www.radiologyassistant.nl/en/p4556dea65db62
*  Virus Exploits a Serotonin Receptor | Science Signaling
JC virus (JCV) is a common human polyomavirus responsible for the fatal demyelinating disease progressive multifocal ...
http://stke.sciencemag.org/content/2004/260/tw425
*  Dimethyl fumarate (Tecfidera): updated advice on risk of progressive multifocal leukoencephalopathy - GOV.UK
It is caused by activation of the JC virus, which usually remains latent and typically only causes PML in immunocompromised ... If John Cunningham virus (JCV) testing is undertaken, consider that the influence of lymphopenia on the accuracy of the anti- ...
https://www.gov.uk/drug-safety-update/dimethyl-fumarate-tecfidera-updated-advice-on-risk-of-progressive-multifocal-leukoencephalopathy
*  Progressive multifocal leukoencephalopathy
It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms ... Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal ... is to perform a DNA test to identify the presence of the JC virus in cerebrospinal fluid (CSF). A 32-year-old woman with a 5- ... otherwise fatal viral infection of the white matter of the brain caused by the polyomavirus JC virus, which typically occurs ...
http://www.diseaseinfosearch.org/result/5983
*  What Is Microbiology - Progressive multifocal leukoencephalopathy - Medicalrealm
JC virus is detected by polymerase chain reaction of the brain biopsy or cerebral spinal fluid of the patient. ... JC virus may establish latent infection in multiple organs. JC virus may lead to opportunistic infection of the brain mostly in ... Progressive multifocal leukoencephalopathy is caused by human polyomavirus ( JC virus).. JC virus is detected by polymerase ... JC virus will be activated and spread to the brain. This will lead to lytic destruction of oligodendrocytes. ...
http://www.medicalrealm.net/what-is-microbiology---progressive-multifocal-leukoencephalopathy.html
*  Side Effect: Neurological (progressive multifocal leukoencephalopathy - PML)
PML is a rare and serious brain infection caused by the John Cunningham (JC) virus. The JC virus is a common virus that is ... PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who ... PML is an opportunistic viral infection of the brain caused by the John Cunningham (JC) virus that typically only occurs in ... Although no cases of PML were identified in OCREVUS clinical trials, JC virus infection resulting in PML has been observed in ...
http://www.drug-injury.com/druginjurycom/side-effect-neurological-progressive-multifocal-leukoencephalopathy-pml/
*  Natalizumab (Tysabri)
Tysabri can cause the activation of latent infection with the polyomavirus JC (often called JC virus). Activated JC virus in ... PML is caused activation by the polyomavirus JC virus. Many people are infected with the JC virus, but it is harmless because ... Suppressing the immune system can "wake up" the virus, and an activated JC virus can cause PML. Other drugs suppress the immune ... People need to be tested for antibodies against the JC virus before and during Tysabri treatment. ...
http://www.bwhcrohnscolitis.org/ibd-101/medications/natalizumab-tysabri/