A protein called isocitrate dehydrogenase (IDH1) is present at high levels in lung cancers and can be detected in the blood, ...
One of Agios first drug discovery programs is based on its scientists discovery that a mutation in isocitrate dehydrogenase 1 ...
... and isocitrate dehydrogenase (IDH). Analysis revealed a polymorphic locus for each system and high isoenzymatic variability ...
... alpha-ketoglutarate and isocitrate dehydrogenase. But when oxygen is not available in adequate amounts to accept electrons ( ...
Moreover, due to the fact that mutations in the Isocitrate dehydrogenase (IDH-1 and IDH-2) genes are more frequent in our IH- ...
ICL (ISOCITRATE LYASE). Encodes a glyoxylate cycle enzyme isocitrate lyase (ICL).. O.I.. C.G.. H.G.. Please select. TAIR ( ...
... the DNA methylation profiles of 12 intrahepatic cholangiocarcinomas harboring mutations in the genes encoding isocitrate ...
... an inhibitor of the isocitrate dehydrogenase 1 (IDH1) mutation.1 The results were reported at a Presidential Symposium during ... double-blind study of ivosidenib vs placebo in patients with advanced cholangiocarcinoma with an isocitrate dehydrogenase 1 ( ...
2HG is produced at high levels by the neomorphic activity conferred by isocitrate dehydrogenase-1 and -2 (IDH1/2) mutations in ...
... reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate ...
... isocitrate dehydrogenase (IDH1) and IDH2, and amplification of tyrosine kinase receptor 2, mesenchymal-epithelial transition ...
Best Recombinant Human Isocitrate dehydrogenase Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification ...
... will include participants with Isocitrate Dehydrogenase (IDH)-mutant glioma. - Dose expansion for Module 2 may be added in the ...
... which are defined by the mutational status of isocitrate dehydrogenase 1 and 2 (IDH) and the presence or absence of co-deletion ... Waitkus MS, Diplas BH, Yan H (2016) Isocitrate dehydrogenase mutations in gliomas. Neuro Oncol 18:16-26. https://doi.org/ ...
... isocitrate dehydrogenase (IDH) 1/2 mutation [42, 43, 77, 78], and tumor protein p53 (TP53) mutations [43, 79, 80]. Patients ...
Assessment of isocitrate dehydrogenase 1 genotype and cell proliferation in gliomas using multiple diffusion magnetic resonance ... Diffusion- and perfusion-weighted MRI radiomics model may predict isocitrate dehydrogenase (IDH) mutation and tumor ...
Myelodysplastic syndrome and sweets syndrome are associated with a mutation in isocitrate dehydrogenase 1. Snyder, R., Libby, ...
Coccioni, R., Montanari, A., Boschi, S., Catanzariti, R., Frontalini, F., Jovane, L., Kochhann, M. V. L., Pelosi, N., Sabatino, N., Savian, J. F. & Sprovieri, M., 2022 Jun 1, From the Guajira Desert to the Apennines, and from Mediterranean Microplates to the Mexican Killer Asteroid: Honoring the Career of Walter Alvarez. Koeberl, C., Claeys, P. & Montanari, A. (eds.). Geological Society of America, (Special Paper of the Geological Society of America; vol. 557).. Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review ...
No variation was observed in alphaglycerophosphate dehydrogenase, isocitrate dehydrogenase, eye lactate dehydrogenase or muscle ... No variation was observed in alphaglycerophosphate dehydrogenase, isocitrate dehydrogenase, eye lactate dehydrogenase or muscle ...
Isocitrate Dehydrogenase 1/2 (IDH1/2). NCT04521686 Advanced Solid Tumors IDH1/2 Inhibitor ...
Advantages of NADP+ dependent Isocitrate Dehydrogenase I came across a question (Q-5b) that asks: Isocitrate Dehydrogenase in ...
RNA editing-based classification of diffuse gliomas: Predicting isocitrate dehydrogenase mutation and chromosome 1p/19q ...
Dive into the research topics where Christopher Lawson is active. These topic labels come from the works of this person. Together they form a unique fingerprint ...
Pati, S., Singh, A., Rathore, S., Gastounioti, A., Bergman, M., Ngo, P., Ha, S. M., Bounias, D., Minock, J., Murphy, G., Li, H., Bhattarai, A., Wolf, A., Sridaran, P., Kalarot, R., Akbari, H., Sotiras, A., Thakur, S. P., Verma, R., Shinohara, R. T., & 5 othersYushkevich, P., Fan, Y., Kontos, D., Davatzikos, C. & Bakas, S., 2020, Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries - 5th International Workshop, BrainLes 2019, Held in Conjunction with MICCAI 2019, Revised Selected Papers. Crimi, A. & Bakas, S. (eds.). Springer, p. 380-394 15 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11993 LNCS).. Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review ...
98) Photoactivation of mutant isocitrate dehydrogenase 2 reveals rapid cancer-associated metabolic and epigenetic changes. J. ...
... and isocitrate dehydrogenase (141 KDa). After washing the column with same buffer, 1 mL of enzyme preparation was loaded. The ...
The Krebs cycle produces NADH, which delivers electrons to complex I, and NADPH for H\(_2\)O\(_2\) elimination via isocitrate ... The Krebs cycle produces NADH, which delivers electrons to complex I, and NADPH for H\(_2\)O\(_2\) elimination via isocitrate ... The Krebs cycle produces NADH, which delivers electrons to complex I, and NADPH for H\(_2\)O\(_2\) elimination via isocitrate ...
The present invention further discloses isocitrate reversal of iron deprivation. Type: Application ...