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*  isocitrate(3-) (CHEBI:16087)
D-erythro-isocitrate(3−) (CHEBI:15563) is a isocitrate(3−) (CHEBI:16087). D-threo-isocitrate(3−) (CHEBI:15562) is a isocitrate( ... L-erythro-isocitrate(3−) (CHEBI:30897) is a isocitrate(3−) (CHEBI:16087). L-threo-isocitrate(3−) (CHEBI:30896) is a isocitrate( ... isocitrate(3−) (CHEBI:16087) has role Saccharomyces cerevisiae metabolite (CHEBI:75772) isocitrate(3−) (CHEBI:16087) has role ... isocitrate(3−) (CHEBI:16087) is a tricarboxylic acid trianion (CHEBI:27092) isocitrate(3−) (CHEBI:16087) is conjugate base of ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:24884
*  Anti-Isocitrate dehydrogenase antibody (ab116609)
Goat polyclonal Isocitrate dehydrogenase antibody validated for WB and tested in Sc. Immunogen corresponding to synthetic ... All lanes : Anti-Isocitrate dehydrogenase antibody (ab116609) at 0.5 µg/ml. Lane 1 : S. cerevisae isocitrate dehydrogenase ... Lane 2 : S. cerevisae isocitrate dehydrogenase wildtype lysate. Lysates/proteins at 35 µg per lane.. Developed using the ECL ... Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha- ...
http://www.abcam.com/isocitrate-dehydrogenase-antibody-ab116609.html
*  Species: Isocitrate lyase/phosphorylmutase, conserved site (IPR018523) | InterPro | EMBL-EBI
Species: Isocitrate lyase/phosphorylmutase, conserved site (IPR018523). Key Species. Key species. Number of proteins. FASTA. ...
http://www.ebi.ac.uk/interpro/entry/IPR018523/taxonomy
*  Synpcc7942 1719 isocitrate dehydrogenase [Synechococcus elongatus PCC 7942] - Gene - NCBI
isocitrate dehydrogenase. Locus tag. Synpcc7942_1719. Gene type. protein coding. RefSeq status. VALIDATED. Organism. ... Synpcc7942_1719 isocitrate dehydrogenase [ Synechococcus elongatus PCC 7942 ] Gene ID: 3775419, discontinued on 5-Feb-2015 * ...
https://www.ncbi.nlm.nih.gov/gene/3775419
*  Isocitrate Dehydrogenase Assay Kit (Colorimetric) (ab102528) Protocols
Abcam provides general protocols for Isocitrate Dehydrogenase Assay Kit (Colorimetric) (ab102528). Please download our pdf ...
http://www.abcam.com/isocitrate-dehydrogenase-assay-kit-colorimetric-ab102528-protocols.html
*  IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic [Homo sapiens (human)] - Gene - NCBI
PTZ00435; isocitrate dehydrogenase; Provisional. * NM_001282387.1 → NP_001269316.1 isocitrate dehydrogenase [NADP] cytoplasmic ... isocitrate dehydrogenase [NADP] cytoplasmic. Names. NADP(+)-specific ICDH. NADP-dependent isocitrate dehydrogenase, cytosolic. ... Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two ... IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic [Homo sapiens] IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic [Homo ...
https://www.ncbi.nlm.nih.gov/gene/3417
*  Apparent isocitrate lyase activity in Leishmania amazonensis : Acta Parasitologica
However, these results have been underestimated because genes for the two key enzymes of the cycle, isocitrate lyase (ICL) and ... Apparent isocitrate lyase activity in. *Anti-angiogenic and anti-lymphangiogenic role of praziquantel and artemether in ... Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera. Journal of Bacteriology, 131, 136-144PubMedGoogle ... Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis. Microbiology, 155, 3166-3175. ...
https://www.degruyter.com/view/j/ap.2017.62.issue-4/ap-2017-0084/ap-2017-0084.xml
*  aceA - Isocitrate lyase - Escherichia coli (strain K12) - aceA gene & protein
Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which ... Kcat is 28.5 sec(-1) for isocitrate lyase activity with threo-D-isocitrate as substrate (at pH 7.3).1 Publication. ,p>Manually ... IPR006254. Isocitrate_lyase. IPR018523. Isocitrate_lyase_ph_CS. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. ... IPR006254. Isocitrate_lyase. IPR018523. Isocitrate_lyase_ph_CS. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. ...
http://www.uniprot.org/uniprot/P0A9G6
*  icd - Isocitrate dehydrogenase [NADP] - gamma proteobacterium HdN1 - icd gene & protein
Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation. ,p>Information which has been generated by the UniProtKB ... Isocitrate dehydrogenase [NADP]UniRule annotation. ,p>Information which has been generated by the UniProtKB automatic ... tr,E1VK08,E1VK08_9GAMM Isocitrate dehydrogenase [NADP] OS=gamma proteobacterium HdN1 OX=83406 GN=icd PE=4 SV=1 ...
http://www.uniprot.org/uniprot/E1VK08
*  RCSB PDB - Protein Feature View - Isocitrate dehydrogenase [NADP] - P16100 (IDH AZOVI)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/protein/P16100
*  WikiGenes - IDH1 - isocitrate dehydrogenase 1 (NADP+), soluble
Somatic cell genetic assignment of the human gene for mitochondrial NADP-linked isocitrate dehydrogenase to the long arm of ... Bistability in the isocitrate dehydrogenase reaction: an experimentally based theoretical study. Guidi, G.M., Carlier, M.F., ... Crystallization and preliminary X-ray diffraction studies of monomeric isocitrate dehydrogenase by the MAD method using Mn ... The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. Geisbrecht, B.V., Gould, ...
http://www.wikigenes.org/e/gene/e/3417.html
*  Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7 | SpringerLink
... is a mitochondrial NADP-dependent isocitrate dehydrogenase and has been found to be a tumor suppressor in several types of ... Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase and has been found to be a tumor ... Isocitrate dehydrogenase 2 (IDH2) NF-κB Matrix metalloproteinase 7 (MMP7) Gastric cancer (GC) Metastases ... Reitman ZJ, Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J ...
https://link.springer.com/article/10.1007/s13277-015-4358-2
*  Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma | SpringerLink
... are key metabolic enzymes that convert isocitrate to α-ketoglutarate. Somatic point mutations in IDH1/ 2confer a gain-of- ... Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. Somatic ... Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov. 2013;3(7):730-41. ... Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor ...
https://link.springer.com/article/10.1007%2Fs12032-018-1229-x
*  Browsing Department of Biomedicine by Subject "Isocitrate Dehydrogenase"
Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are ... Browsing Department of Biomedicine by Subject "Isocitrate Dehydrogenase". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. ...
http://bora.uib.no/handle/1956/934/browse?value=Isocitrate+Dehydrogenase&type=subject
*  JCI - Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas. Gary Kohanbash,1 Diego A. Carrera,1 ... Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the ... They show that the oncometabolite 2-hydroxyglutarate (2HG), generated by mutated forms of isocitrate dehydrogenase (IDH1 and ... mutations in the isocitrate dehydrogenase IDH1 and IDH2 genes are of particular interest. These mutations have been found to be ...
https://www.jci.org/articles/view/90644
*  Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer | Clinical Cancer Research
Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer. Owen Clark, Katharine Yen and Ingo K. Mellinghoff ... Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat Med 2015;21:178-84. ... Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer Message Subject (Your Name) has forwarded a page to you from ... Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice. Leukemia 2014;28:1343-6. ...
http://clincancerres.aacrjournals.org/content/22/8/1837?ijkey=b3ca8f02ad6860a757b794f5103cc4737ff90a7f&keytype2=tf_ipsecsha
*  JCI - Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
Downloading a figure as powerpoint requires a browser with javascript support. Enable javascript and try again For help please contact sysadmin@the-jci.org ...
https://www.jci.org/assets/326759/powerpoint
*  Isocitrate lyase - Wikipedia
Isocitrate lyase (EC 4.1.3.1), or ICL, is an enzyme in the glyoxylate cycle that catalyzes the cleavage of isocitrate to ... ICL competes with isocitrate dehydrogenase, an enzyme found in the TCA cycle, for isocitrate processing. Flux through these ... Deactivation of isocitrate dehydrogenase by phosphorylation thus leads to increased isocitrate channeling through ICL, as seen ... threo-Ds-isocitrate glyoxylate-lyase, and isocitrate glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate ...
https://en.wikipedia.org/wiki/Isocitrate_lyase
*  Isocitrate epimerase - Wikipedia
In enzymology, an isocitrate epimerase (EC 5.1.2.6) is an enzyme that catalyzes the chemical reaction (1R,2S)-1-hydroxypropane- ... Hoshiko S, Kunimoto Y, Arima K, Beppu T (1982). "Mechanism of L-alloisocitric acid fermentation: isocitrate epimerase activity ...
https://en.wikipedia.org/wiki/Isocitrate_epimerase
*  Plus it
... isocitrate dehydrogenase; IDPm, mitochondrial NADP+-dependent isocitrate dehydrogenase; HEK, human embryonic kidney; DTT, ... Mitochondrial NADP+-Dependent Isocitrate Dehydrogenase Protects Cadmium-Induced Apoptosis. In Sup Kil, Seoung Woo Shin, Hyun ... Mitochondrial NADP+-Dependent Isocitrate Dehydrogenase Protects Cadmium-Induced Apoptosis. In Sup Kil, Seoung Woo Shin, Hyun ... Mitochondrial NADP+-Dependent Isocitrate Dehydrogenase Protects Cadmium-Induced Apoptosis. In Sup Kil, Seoung Woo Shin, Hyun ...
http://molpharm.aspetjournals.org/content/70/3/1053
*  Isocitrate Dehydrogenase 3 (NAD ) alpha Isocitrate Dehydrogenase 3 (NAD+) alpha ELISA Kits | Biocompare.com
... alpha Isocitrate Dehydrogenase 3 (NAD+) alpha ELISA Kits from leading suppliers on Biocompare. View specifications, prices, ... Isocitrate Dehydrogenase 3 (NAD ) alpha Isocitrate Dehydrogenase 3 (NAD+) alpha ELISA Kits. Clear ... Human Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, IDH3A ELISA Kit *Detection Target: isocitrate dehydrogenase ... Mouse Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, IDH3A ELISA Kit *Detection Target: isocitrate dehydrogenase ...
https://www.biocompare.com/pfu/110627/soids/2-39925/Assay_Kit/ELISA_Isocitrate_Dehydrogenase_3_NAD_alpha
*  RCSB PDB - 1ISO: ISOCITRATE DEHYDROGENASE: STRUCTURE OF AN ENGINEERED NADP+--> NAD+ SPECIFICITY-REVERSAL MUTANT...
Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity- ... Isocitrate/Isopropylmalate dehydrogenase- like Isocitrate/Isopropylmalate dehydrogenase- like Dimeric isocitrate & ...
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1ISO
*  Mutational analysis of isocitrate dehydrogenase 1/2 in | Open-i
Mutational analysis of isocitrate dehydrogenase 1/2 in giant cell tumor of bone. (a) DNA direct sequencing of giant cell tumor ... fig02: Mutational analysis of isocitrate dehydrogenase 1/2 in giant cell tumor of bone. (a) DNA direct sequencing of giant cell ... fig02: Mutational analysis of isocitrate dehydrogenase 1/2 in giant cell tumor of bone. (a) DNA direct sequencing of giant cell ... Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317903_cas0105-0744-f2&req=4
*  Partial purification and characterization of an Ls-NADP:isocitrate oxidoreductase from embryonic chick liver
An Ls-isocitrate:NADP oxidoreductase has been isolated and purified from embryonic chicken liver. The enzyme was purified 200 ... In the presence of 8mM isocitrate the molecular weight of the enzyme was not altered by an increase in temperature from 4° C to ... The presence of 8 mM isocitrate or 0.42 M ammonium sulfate stabilized the enzyme against inactivation by heating, but did not ... Partial purification and characterization of an Ls-NADP:isocitrate oxidoreductase from embryonic chick liver Public Deposited ...
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/gb19f926r
*  The ΔG°' for the reaction Citrate isocitrate is +6.64 kJmol-1= +1.59 kcalmol-1.
... The ΔG°' for the reaction Isocitrate α- ... One of the key steps is an oxidation catalyzed by the enzyme isocitrate dehydrogenase and the oxidizing agent NAD+. Under ...
https://www.jiskha.com/questions/1379055/The-G-for-the-reaction-Citrate-isocitrate-is-6-64-kJmol-1-1-59-kcalmol-1