Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis. Although two ubiquitin ligases that ... and stabilizes IRP2 protein in an iron-independent manner. Depletion of OTUD3 results in a disorder of iron metabolism. OTUD3 ... Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the ... these findings demonstrate that OTUD3 is a bona fide deubiquitylase for IRP2 and plays a critical role in the nigral iron ...

... crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA". Iron-Responsive+Element+Binding+Proteins at ... "Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2". EMBO J. 14 (21): 5350-7. ... "Molecular characterization of a second iron-responsive element-binding protein, iron regulatory protein 2. Structure, function ... Eisenstein RS (2000). "Iron regulatory proteins and the molecular control of mammalian iron metabolism". Annu. Rev. Nutr. 20: ...

Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Nutrition. 2012 ... Once within tissues, retinol is bound by cellular retinoid-binding proteins, cellular retinoid-binding protein I (CRBPI) and ... Retinol is transported in the plasma on a specific protein called retinol-binding protein. ... Anaemia, iron status and vitamin A deficiency among adolescent refugees in Kenya and Nepal. Public Health Nutr. 2006 Feb. 9(1): ...

Deubiquitylase OTUD3 prevents Parkinsons disease through stabilizing iron regulatory protein 2. Jia F, et al. Cell Death Dis, ... Deubiquitylase OTUD3 prevents Parkinsons disease through stabilizing iron regulatory protein 2. Title: Deubiquitylase OTUD3 ... General protein information Go to the top of the page Help Preferred Names. OTU domain-containing protein 3. NP_001364018.1. * ... mRNA and Protein(s) * XM_017320408.3 → XP_017175897.1 OTU domain-containing protein 3 isoform X2 ...

Our AD diagnostic is based on identifying the presence of the iron-regulatory protein 2 gene [IRP-2] in the brain. The goal is ... Post-mortem analysis shows that free iron in the brain is very toxic, Haider says. ... is that these human embryonic stem cell lines have been grown in such a way that they are contaminated by animal protein and ...

We aim to understand how mammals regulate intracellular and systemic iron metabolism. Iron-regulatory proteins 1 and 2 (IRP1 ... regulate the expression of numerous proteins of iron metabolism. In iron-depleted cells, the proteins bind to RNA stem-loops in ... IRP1 is an iron-sulfur protein that functions as an aconitase in iron-replete cells. IRP2 is homologous to IRP1 but undergoes ... Early work involved cloning and characterization of iron regulatory proteins 1 and 2 (IRPs), and elucidation of how these ...

B-RAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumourigenesis, Cancer ... Thus this evidence has led us to explore the use of iron chelators in particular focussing on naturally occurring iron ... Lal, N, Willcox, C, Beggs, A, Taniere, P, Middleton, G, Tselepis, C & Willcox, B 2017, Endothelial protein C receptor is ... Horniblow, RD, Pathak, P, Balacco, DL, Acharjee, A, Lles, E, Gkoutos, G, Beggs, AD & Tselepis, C 2022, Iron-mediated ...

Aconitase/iron regulatory protein 2 IPR006249 - 0.0. - Sma3. Aconitase/3-isopropylmalate dehydratase, swivel IPR015928 - 0.0. ... Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase IPR015934 - 0.0. - Sma3. Aconitase/isopropylmalate ... Protein Length: 93 Fln nts: A. A. T. G. T. A. T. G. G. T. C. T. A. C. T. T. T. A. T. C. C. G. G. A. T. A. G. T. G. T. T. G. T. ... Fln protein: M. Y. G. L. L. Y. P. D. S. V. V. G. T. D. S. H. T. T. M. I. D. G. L. G. V. A. G. W. G. V. G. G. I. E. A. E. A. A. ...

... iron regulatory binding protein 2), and AGER (advanced glycation end product-specific receptor). ... Protein and Fats. People with body wasting (cachexia) lack enough protein. Although most healthy diets emphasize proteins from ... Beta-2-agonists When your symptoms do not occur very often and your COPD is not severe, you may use a bronchodilator medicine ... 2015;(2):CD003793. PMID: 25705944 pubmed.ncbi.nlm.nih.gov/25705944/. Minervini F, Kestenholz PB, Paolini V, et al. Surgical and ...

Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive ... Iron is part of hemoproteins, iron-sulfur (Fe-S) proteins, and other proteins with functional groups that require iron as a ... iron is essential for oxygen transport and significant iron deficiency leads to anemia. Eukaryotic cells require iron for ... This would improve our understanding of an iron regulatory network. For these purposes we used microarray gene expression data ...

Iron regulatory proteins, iron responsive elements and iron homeostasis. The Journal of Nutrition 128: 2295-2298. ... Regulatory Toxicology and Pharmacology 22:76-94.. Texas Parks and Wildlife Commission. 2003. "Artificial Reefs: Artificial ... Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, ... Last accessed 2/14/03.. Torres-Gonzalez S. 1989. Reconnaissance of the ground-water resources of Vieques Island, Puerto Rico. ...

... loop/bulge and hairpin loop of the iron-responsive element of ferritin mRNA contribute to maximal iron regulatory protein 2 ... Iron regulatory element and internal loop/bulge structure for ferritin mRNA studied by cobalt (III) hexammine binding, ... Contributions of Stacking, Preorganization, and Hydrogen Bonding to the Thermodynamic Stability of Duplexes between RNA and 2′- ...

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes Dev. 2017, 31, 1243- ... Iron metabolism vice versa regulates p53 functions, with iron excess being able to downregulate p53 protein levels and activity ... A master role in the iron metabolism-p53 axis is ferroptosis, an iron-mediated caspase-independent type of cell death that ... Iron metabolism requires a special mention in the context of the TP53 mutated AML metabolism. Besides its crucial role for ...

Iron deposits are neuropathological hallmark of Parkinsons disease (PD). Iron regulatory protein 2 (IRP2) is a key factor in ... Deubiquitylase OTUD3 prevents Parkinsons disease through stabilizing iron regulatory protein 2. Jia, Fengju; Li, Hongchang; ... and stabilizes IRP2 protein in an iron-independent manner. Depletion of OTUD3 results in a disorder of iron metabolism. OTUD3 ... protein phosphatase 3 catalytic subunit beta; RPS6KB1/p70S6K: ribosomal protein S6 kinase B1; SMURF1: SMAD specific E3 ...

Manganese alters cellular iron homeostasis by stabilizing iron regulatory protein 2. This may occur by manganese competing ... Major prion protein. Putative testis-specific prion protein Manganese binds to the prion protein, altering its conformation, ... directly for an iron-binding site on the iron binding protein, disrupting the cellular mechanisms responsible for its iron- ... cluster of aconitase by manganese produces iron regulary protein 1, resulting in alterations in cellular iron homeostasis. ( ...

We aim to understand how mammals regulate intracellular and systemic iron metabolism. Iron-regulatory proteins 1 and 2 (IRP1 ... regulate the expression of numerous proteins of iron metabolism. In iron-depleted cells, the proteins bind to RNA stem-loops in ... IRP1 is an iron-sulfur protein that functions as an aconitase in iron-replete cells. IRP2 is homologous to IRP1 but undergoes ... We cloned, expressed, and characterized two essential iron-sensing proteins, IRP1 and IRP2. IRPs bind to IREs when iron levels ...

Khan discusses the importance of Iron Regulatory Protein and Element (IRE)-mRNA to Iron homeostasis in the human body. The ... Dr Mateen Ahmad Khan recently published his research work on the Iron Regulatory Protein in Scientific Report, a Nature ... Alfaisal Faculty Member Publishes Paper on Iron Regulatory Protein. ... About 30% of the world suffers from iron related diseases. Iron is a "cant live without it or cant live with it" element. ...

Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Nutrition. 2012 ... Once within tissues, retinol is bound by cellular retinoid-binding proteins, cellular retinoid-binding protein I (CRBPI) and ... Retinol is transported in the plasma on a specific protein called retinol-binding protein. ... Anaemia, iron status and vitamin A deficiency among adolescent refugees in Kenya and Nepal. Public Health Nutr. 2006 Feb. 9(1): ...

As an iron chaperone, it has excellent potential to treat Parkinsons disease as well as various Parkinsonian disorders such as ... A pathological hallmark of MSA is the accumulation of the protein α-synuclein within glia, the support cells of the central ... "The regulatory approvals in France and Austria will allow us to expand our footprint in Europe and are another important step ... Alterity Therapeutics Receives Regulatory Authorization in France and Austria to Proceed with ATH434 Phase 2 Clinical Trial. ...

Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive ... Iron Regulation and the Cell Cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell ...

... regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5- or 3 -UTRs of the mRNAs. To date, ... iron increases oxidative stress and regulates the expression of many mRNAs by affecting the conformation of iron ... HO-1 or HSP32, a major heat shock/stress response protein is ubiquitous and its mRNA as well as its activity can be increased ... iron and billiverdin that is immediately reduced to bilirubin. These products of the HO reaction have important physiological ...

Welcome to my world of relentless blah-blah-blah about how Iron ... o Iron Regulatory Proteins (IRP1-2) and Iron Response Elements ... o Anderson CP et al, 2012-Sep, "Mammalian iron metabolism and its control by iron regulatory proteins" ... Iron Toxicity Post #65: there is NO such thing as "Iron Metabolism." There is ONLY Copper<>Iron Metabolism. by Morley Robbins ... "Iron Metabolism." There is ONLY Copper,,Iron Metabolism, and as Ive noted MANY, MANY, MANY times, Iron is, for a fact, the ...

Host Factor 1 Protein. Iron Regulatory Protein 1. Iron Regulatory Protein 2 ...

Iron-regulatory protein-1 (IRP-1) plays a dual role as a regulatory RNA-binding protein and as a cytoplasmic aconitase. When ... Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in ... Here we show that loss of osk mRNA also affects the distribution of regulatory proteins, relaxing their association with large ... For 880 tagged proteins we created transgenic lines and for a total of 207 lines we assessed protein expression and ...

A lipid-soluble iron chelator alters cell cycle regulatory protein binding in breast cancer cells compared to normal breast ... We studied the effects of iron chelation with D-Exo on cell cycle regulatory proteins in cultures of NHMEC and MCF-7 breast ... Therefore differences in effects of iron chelation on cell cycle protein binding in cancer cells compared to normal cells may ... The lipid-soluble iron chelator desferri-exochelin (D-Exo) causes reversible cell cycle arrest in normal human mammary ...

abstract = "Iron regulatory proteins (IRPs) are cytoplasmic mRNA binding proteins involved in intracellular regulation of iron ... N2 - Iron regulatory proteins (IRPs) are cytoplasmic mRNA binding proteins involved in intracellular regulation of iron ... AB - Iron regulatory proteins (IRPs) are cytoplasmic mRNA binding proteins involved in intracellular regulation of iron ... Iron regulatory proteins (IRPs) are cytoplasmic mRNA binding proteins involved in intracellular regulation of iron homeostasis ...

... in the Iron Reactive Element/Iron Regulatory Protein (IRE/IRP) signaling pathway although iron and the interaction of VA and ... Effects of iron, vitamin A, and the interaction between the two nutrients on intestinal development and cell differentiation in ... Additionally, both VA and interaction of VA and iron increased the VH (P , 0.05) and surface area (P = 0.001). The results also ... Moreover, both VA and the interaction between VA and iron increased the number of endocrine cells in the villi (P = 0.05); 3) ...

IRF6: interferon regulatory factor 6. *IRGM: immunity related GTPase M. *ISCU: iron-sulfur cluster assembly enzyme ... IGFBP7: insulin like growth factor binding protein 7. *IGHMBP2: immunoglobulin mu DNA binding protein 2 ...

b.82.4: Regulatory protein AraC [51215] (1 family) automatically mapped to Pfam PF02311. ... Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold. *. b.82.3: cAMP-binding domain-like [51206] ( ... Class b: All beta proteins [48724] (180 folds). *. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies). one turn of ... SCOPe: Structural Classification of Proteins - extended. Release 2.08 (updated 2023-01-06, stable release September 2021) ...

Host Factor 1 Protein. *Iron Regulatory Protein 1. *Iron Regulatory Protein 2 ... "Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. In addition to binding to RNA ... This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year ...