Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis ... NK cells selectively induce apoptosis in those cells that do not exhibit MHC class I expression. Lack of mature signals of DCs ... In addition, NK cells selectively induce apoptosis in those cells that do not exhibit MHC class I expression [43]. In other ... They then can kill infected cells via perforin/ granzyme-mediated lysis and death receptor-induced apoptosis. Activated CD4+ ...
GSK3beta Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during ... Why Use the TiterRACS In Situ Apoptosis Detection Kit?. During the process of apoptosis, DNA fragmentation occurs following the ... Detection of Apoptosis in Staurosporine-treated ML-1 Cells. Human ML-1 myeloblastic leukemia cells were treated with 1 µM ... Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95) Authors: Q Chen, SPS Pandi, L ...
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells ... A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. ... Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer ... Intrinsic and extrinsic apoptotic pathways. Apoptosis can be triggered by the intrinsic mitochondrial pathway or through the ...
... of 0.32 micromol/L and preferentially induces apoptosis in melanoma cells compared with melanocytes. The intrinsic apoptotic ... Figure 1. Effect of VES+FBZ on the proliferation and apoptosis of human and mouse prostate cancer cell lines. (A) Growth in ... of live cells (vehicle control) and the gray peaks represent the c ell fraction undergoing apoptosis (FBZ+VES treated). As ... apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res ...
... component piceatannol induces apoptosis in DU145 human prostate cancer cells via the activation of extrinsic and intrinsic ... Kaur, M., Agarwal, R., and Agarwal, C. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate ... Mantena, S. K., Baliga, M. S., and Katiyar, S. K. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of ... The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in human SK-Mel-28 melanoma cells. Eur.J Nutr. 2004; ...
Biological activity was shown via assessment of on-target effects, in vitro growth, proliferation, and apoptosis analysis. ... Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem tumor for which radiation is the only treatment. Case ... Home , News , Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic ... Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine ...
Not only has the MAM provided insight into the mechanistic basis underlying such physiological processes as intrinsic apoptosis ... it stimulates the intrinsic pathway of apoptosis in part by collapsing the mitochondrial membrane potential required for ... McMillin JB, Dowhan W (December 2002). "Cardiolipin and apoptosis". Biochimica et Biophysica Acta (BBA) - Molecular and Cell ... receptor-mitochondria connection in apoptosis and autophagy". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. ...
infection include both changes to apoptosis and cell division [72, 77, 79]; these mechanisms are characteristic to cancer ... Maternal periodontitis may reflect an intrinsic inflammatory or innate immunity trait that places the woman at risk for severe ... These oncogenic changes drive a tumor-promoting inflammatory milieu through the intrinsic pathway that favors the development ... secretes a nucleoside diphosphate kinase (NDK) having an ATPase function and preventing ATP-dependent apoptosis mediated ...
Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise ...
p62 at the crossroads of autophagy, apoptosis, and cancer. Cell. 2009;137:1001-4 ... Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy. Proc Natl Acad Sci U ... Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 2015;162:1242-56 ... Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M, Wang T. C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 ...
Midazolam Induces Apoptosis through Activation of the Intrinsic Mitochondrial Pathway. As previously observed, dexmedetomidine ... The two main pathways of apoptosis for cells are extrinsic or intrinsic. The extrinsic pathway is initiated by the death ... Midazolam activates the intrinsic pathway of apoptosis independent of benzodiazepine and death receptor signaling. ... In contrast, midazolam suppressed cancer cell proliferation and migration, induced apoptosis via the intrinsic mitochondrial ...
Furthermore, immunoblotting studies revealed the activation of intrinsic and maybe extrinsic apoptosis pathways by OEO/thymol. ...
In summary we have shown the heterogeneity of p53 in extrinsic and intrinsic apoptosis signaling. The impact of the p53 status ... In summary we have shown the heterogeneity of p53 in extrinsic and intrinsic apoptosis signaling. The impact of the p53 status ... We investigated the importance of p53 in the intrinsic and extrinsic apoptosis signaling, via a variety of molecular biological ... We investigated the importance of p53 in the intrinsic and extrinsic apoptosis signaling, via a variety of molecular biological ...
Zhao Y,Li R,Xia W,Neuzil J,Lu Y,Zhang H,Zhao X,Zhang X,Sun C,Wu K.Bid integrates intrinsic and extrinsic signaling in apoptosis ... These results demonstrate that VALD-3 triggers apoptosis via a caspase-dependent intrinsic pathway. ... On the other hand, X-linked inhibitor of apoptosis protein (XIAP) and survivin are two factors showing the strongest apoptosis- ... Wang G,Zhang T,Sun W,Wang H,Yin F,Wang Z,Zuo D,Sun M,Zhou Z,Lin B, Xu J, Hua Y,Li H,Cai Z. Arsenic sulfide induces apoptosis ...
Ke FFS, Brinkmann K, Voss AK, Strasser A. Some mice lacking intrinsic, as well as death receptor induced apoptosis and ... Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. 2018 May 17;173(5):1217- ...
Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis. Lu Y, et al. Braz J Med ... through the extrinsic apoptotic pathway mediated by caspase-8 and the intrinsic apoptotic pathway mediated by caspase-9; study ... Title: Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis. ... on mechanisms underlying the effect of mutant variants A88V and G11R of the GJB6 gene on the induction of HaCaT cell apoptosis ...
The intrinsic pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV ... Apoptosis - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Show description , Download , Help ] ... Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases ( ... The central event in the intrinsic pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the ...
The G1 phase arrest and apoptosis by intrinsic pathway induced by valproic acid inhibit proliferation of BGC-823 gastric ... Hu X, Chen Z, Mao X, Tang S. Effects of phenytoin and Echinacea purpurea extract on proliferation and apoptosis of mouse ... Effects of valproic acid (VPA) and levetiracetam (LEV) on proliferation, apoptosis and hormone secretion of the human ... Sodium valproate induces mitochondria-dependent apoptosis in human hepatoblastoma cells. Chin Med J (Engl). 2011; 124: 2167- ...
... ncRNA-dependent regulation of apoptosis versus proliferation.. Collaborations:. Sinz A.: Analysis of SRSF1 associated proteins ... ncRNA-dependent regulation of apoptosis versus proliferation.. Collaborations:. Sinz A.: Analysis of SRSF1 associated proteins ...
... is a cytokine that has the capability to induce both pathways of apoptosis (first extrinsic and then intrinsic) in cancer cells ... Cancer and Apoptosis. Another major part of the research work performed in my laboratory has to do with cancer and the ... Recombinant human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand selectively induces apoptosis in malignant melanoma. ... Turner, K.A., Manouchehri, J.M., and Kalafatis, M. Sensitization of recombinant human tumor necrosis factor-related apoptosis- ...
Numerous extrinsic and intrinsic factors can trigger DED by negatively impacting tear film stability and tear hyperosmolarity; ... activating osmotic/mechanical stress mechanisms.14-17 This leads to apoptosis, ocular cell damage, and release of inflammatory ...
110238 Regulatory effects of dihydrolipoic acid against inorganic mercury-mediated cytotoxicity and intrinsic apoptosis in PC12 ... Neuropsychiatr Dis Treat 2022; 18:513-524 Senegenin Inhibits Aβ1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via ... Oncotarget 2016; 7 (5):6146-58 Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial ... triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in ...
The bacterial exotoxin AIP56 induces fish macrophage and neutrophil apoptosis using mechanisms of the extrinsic and intrinsic ... dos Santos, N. M. S., do Vale, A., Reis, M. I. R., & Silva, M. T. (2008). Fish and apoptosis: Molecules and pathways. Current ... Silva, M. T., do Vale, A., & dos Santos, N. M. S. (2008). Fish and apoptosis: Studies in disease and pharmaceutical design. ... Silva, M. T., do Vale, A., & Dos Santos, N. M. N. (2008). Secondary necrosis in multicellular animals: An outcome of apoptosis ...
Apoptosis is mediated by two pathways: the extrinsic pathway and the intrinsic pathway [28]. The extrinsic pathway induces ... whereas the intrinsic pathway involves the mitochondria and ER. Cell apoptosis of mitochondria pathway is mediated by Bcl-2 ... Apoptosis was measured by Hoechst 33258 staining. #P , 0.05 versus the control group; ▼P , 0.05 versus the ISO group. ... Apoptosis was measured by Hoechst 33258 staining. #P , 0.05 versus the control group; ▼P , 0.05 versus the ISO group. ...
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis- ... Many of these processes are controlled by the complex interplay between NSC intrinsic genetic programs with NSC extrinsic ... Neural stem cells (NSCs) have the ability to proliferate, differentiate, undergo apoptosis, and even enter and exit quiescence ... Every cellular activity from cell proliferation and apoptosis, development and ageing, to neuronal synaptic plasticity and ...
Magnolol Suppresses ERK/NF-κB Signaling and Triggers Apoptosis Through Extrinsic/Intrinsic Pathways in Osteosarcoma CHI-HUAN LI ... Magnolol Suppresses ERK/NF-κB Signaling and Triggers Apoptosis Through Extrinsic/Intrinsic Pathways in Osteosarcoma ($30) ...
Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways. A Sarkar, J Das, P ... Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. K Sinha, J Das, PB Pal, PC Sil ... Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and ... Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. J ...
Butein exhibits anti-tumor effect through intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem ... Butein exhibits anti-tumor effect through intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem ... A novel BRET based genetic coded biosensor for apoptosis detection at deep tissue level in live animal ...
The signaling events leading to apoptosis can be divided into two major pathways, involving either mitochondria (intrinsic) or ... including a subset of 53 genes known to be involved in apoptosis pathways, to determine which apoptosis and marker genes from ... In the present study, we have found that the initiation of apoptosis in wild-type mice was preceded by a redistribution of Bax ... Identification of Genes Involved in Apoptosis and Dominant Follicle Development During Follicular Waves in Cattle ...