In this study a large dataset of human intestinal absorption was collated along with in vitro permeability, aqueous solubility ... The dataset allowed a permeability threshold to be established objectively to predict high or low intestinal absorption. Using ... Poorly permeable compounds with high solubility show low intestinal absorption, whereas poorly water soluble compounds with ... which are commonly used as indicators of human intestinal absorption. Despite this, the nature and exact characteristics of the ...