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*  Patent US6451983 - Tumor necrosis factor antibodies - Google Patents
... characterization and comparison with the actions of interleukin 1," Proc. Natl. Acad. Sci. USA Medical Sciences 83:4533-4537. ... 6. *. Fendly et al. Hybridoma 1987; 6:359-370.*. 7. Geysen, H.M. et al. (Jul. 1984). "Use of peptide synthesis to probe viral ... 6 Dec 2016. Abbvie Biotechnology Ltd.. Use of TNFα inhibitor. US9522953. 28 Jan 2016. 20 Dec 2016. Abbvie, Inc.. Low acidic ... 6 Jan 2011. Min Wan. Antibody purification. US20110150891 *. 16 Dec 2010. 23 Jun 2011. Philip Bosch. Methods of Treating ...
http://www.google.co.uk/patents/US6451983
*  Systemic cytokine response after major surgery - Oxford Big Data Institute
The IL-1 beta peak preceded a more marked interleukin 6 (IL-6) response that peaked 4-48 h after surgery. IL-6 levels had ... IL-6 levels in this group were significantly higher than those of the other patients undergoing aortic surgery within 6-8 h of ... The IL-6 peaks were significantly lower after hernia surgery than after major aortic operations (P , 0.001); IL-1 beta was not ... These rises in plasma IL-6 levels preceded the clinical onset of major complications by 12-48 h. The systemic IL-1 beta and IL- ...
https://www.bdi.ox.ac.uk/publications/383364
*  Immobilization increases interleukin-6, but not tumour necrosis factor-a, release from the leg during exercise in humans -...
Immobilization increases interleukin-6, but not tumour necrosis factor-a, release from the leg during exercise in humans. * ... Data on interleukin-6 (IL-6) and tumour necrosis factor-a (TNF-a) release during acute exercise are not conclusive, and ... Exercise; Exercise Test; Femoral Vein; Humans; Immobilization; Interleukin-6; Leg; Male; Oxygen Consumption; Regional Blood ... Interleukin-6 release occurred after 15 min of exercise, and the release from the IM leg was significantly greater compared ...
http://www.forskningsdatabasen.dk/catalog/236579463
*  TNF Blockade Unable to Halt OA Joint Erosion | Medpage Today
... are thought to result from actions of cytokines such as TNF and interleukin-1 on osteoclasts and effects on bone remodeling. ...
https://www.medpagetoday.com/rheumatology/arthritis/32744
*  IL6RA, Interleukin-6 Receptor Subunit Alpha | SpringerLink
Interleukin-6 receptor subunit alpha The interleukin-6 receptor (IL-6R) is a type I transmembrane protein that was cloned and ... CD126; Glycoprotein 80; gp80; IL-6R; IL-6Rα; Interleukin-6 receptor subunit alpha ... Proteolytic cleavage governs interleukin-11 trans-signaling. Cell Rep. 2016;14:1761-73.CrossRefPubMedGoogle Scholar ... Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988;241:825-8.CrossRefPubMedGoogle ...
https://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101661
*  Interleukin-6 and Diabetes | Diabetes
Kanemaki T, Kitade H, Kaibori M, Sakitani K, Hiramatsu Y, Kamiyama Y, Ito S, Okumura T: Interleukin 1beta and interleukin 6, ... The human interleukin-6 gene (IL6, Online Mendelian Inheritance in Man #147620) maps to chromosome 7p21. IL6 has a high degree ... Interleukin (IL)-6 is a pleiotropic cytokine with a key impact on both immunoregulation and nonimmune events in most cell types ... Rotter V, Nagaev I, Smith U: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor ...
http://diabetes.diabetesjournals.org/content/54/suppl_2/S114
*  Il6 interleukin 6 [Rattus norvegicus (Norway rat)] - Gene - NCBI
Signaling by Interleukins, organism-specific biosystem (from REACTOME) Signaling by Interleukins, organism-specific biosystem ... interleukin 6provided by RGD. Primary source. RGD:2901 See related. Ensembl:ENSRNOG00000010278 Gene type. protein coding. ... Angiotensin II induces interleukin-6 expression in astrocytes: Role of reactive oxygen species and NF-κB. Gowrisankar YV, et al ... The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. Jurečeková J, et al. ...
https://www.ncbi.nlm.nih.gov/gene/24498
*  Antibody to human interleukin-6 receptor - KISHIMOTO; TADAMITSU
... which are capable of specifically binding to a human interleukin-6 receptor. Also included are monoclonal antibodies which ... Interleukin-6 (hereinafter abbreviated to "IL-6") is a protein having various important physiological activities and ... A process for the preparation of a polyclonal antibody directed against human interleukin-6 receptor, comprising the steps of 1 ... The present invention further provides a process for the preparation of an antibody to a human interleukin-6 receptor, which ...
http://www.freepatentsonline.com/5670373.html
*  Interleukin 6 - Wikipedia
Other cytokines that signal through receptors containing gp130 are Interleukin 11 (IL-11), Interleukin 27 (IL-27), ciliary ... IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation ... Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In ... Interleukin 6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma, ...
https://en.wikipedia.org/wiki/Interleukin_6
*  Study Links Interleukin-6 With Coronary Heart Disease
... at the University of Cambridge have found that there is a link between coronary heart disease and levels of interleukin-6 (IL-6 ... IL-6 is a protein that triggers the cascade of immune cells to the injury site and is produced wherever there is inflammation. ... Lead researcher John Danesh and colleagues also suggest that IL-6 could be a target for the development of drugs to fight ... at the University of Cambridge has revealed the existence of a link between coronary heart disease and levels of interleukin-6 ...
https://www.medindia.net/news/Study-Links-Interleukin-6-With-Coronary-Heart-Disease-35202-1.htm
*  Interleukin-6 gene polymorphism and insulin sensitivity. | Diabetes
Interleukin-6 gene polymorphism and insulin sensitivity.. J M Fernández-Real, M Broch, J Vendrell, C Gutiérrez, R Casamitjana, ... Interleukin-6 gene polymorphism and insulin sensitivity.. J M Fernández-Real, M Broch, J Vendrell, C Gutiérrez, R Casamitjana, ... We aimed to study an interleukin-6 (IL-6) gene polymorphism in relation to insulin sensitivity (IL-6 is the main cytokine ... 37.6+/-4.6 mg/l, P = 0.03). In summary, a polymorphism of the IL-6 gene influences the relationship among insulin sensitivity, ...
http://diabetes.diabetesjournals.org/content/49/3/517
*  Interleukin-6 induces vascular en... preview & related info | Mendeley
Interleukin-6 (IL-6) is a multifunctional cytokine that is associated... ... Interleukin-6 (IL-6) is a multifunctional cytokine that is associated with the disease status and outcomes of cancers. However ... Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal- ... Here we found that the IL-6 and VEGF expression was correlated with tumor stage and significantly higher than that in normal ...
https://www.mendeley.com/research-papers/interleukin6-induces-vascular-endothelial-growth-factor-expression-promotes-angiogenesis-through-apo-1/
*  Interleukin-6 receptor - Wikipedia
The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528-35. doi:10.1074/jbc. ... "Entrez Gene: IL6R interleukin 6 receptor". Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J (Jan 2004). "Direct ... Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 ... Szpirer J, Szpirer C, Rivière M, Houart C, Baumann M, Fey GH, Poli V, Cortese R, Islam MQ, Levan G (1991). "The Interleukin-6- ...
https://en.wikipedia.org/wiki/Interleukin-6_receptor
*  Interleukin-6 - Biology-Online Dictionary
Interleukin-6 is a cytokine that contains a monomer of 184 amino acids produced by T-cells endothelial cells and macrophages ... Interleukin-6 is released in retort to infection, trauma, neoplasia and burns that role out in acute phase protein induction to ... Interleukin-6 has direct effects on cells where it intercede the property of other cytokines and interacts with glucocorticoid ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Interleukin-6&oldid=99524" ...
https://www.biology-online.org/dictionary/Interleukin-6
*  Interleukin-6 signaling pathway in targeted therapy for cancer. - PubMed - NCBI
Interleukin-6 signaling pathway in targeted therapy for cancer.. Guo Y1, Xu F, Lu T, Duan Z, Zhang Z. ... Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide range of biologic activities in ... IL-6 is involved in the host immune defense mechanism as well as the modulation of growth and differentiation in various ... Therefore, blocking IL-6 signaling is a potential therapeutic strategy for cancer (i.e., anti-IL-6 therapy) characterized by ...
https://www.ncbi.nlm.nih.gov/pubmed/22651903
*  'receptors interleukin 6' Protocols and Video...
Receptors, Interleukin-6: Cell surface receptors that are specific for Interleukin-6. They are present on T-Lymphocytes, ... The receptors are heterodimers of the Interleukin-6 receptor alpha subunit and the Cytokine receptor gp130. ...
https://www.jove.com/keyword/receptors+interleukin+6
*  IL6 (interleukin 6 (interferon beta 2))
... interleukin 6 (interferon beta 2)), Authors: Stefan Nagel, Roderick A F MacLeod. Published in: Atlas Genet Cytogenet Oncol ... Principles of interleukin (IL)-6-type cytokine signalling and its regulation.. Heinrich PC, Behrmann I, Haan S, Hermanns HM, ... Although interleukin-6 (IL-6) is considered as a key growth factor for myeloma cells, only a few subpopulations of tumor cells ... IL6 (interleukin 6 (interferon beta 2)). Written. 2007-03. Stefan Nagel, Roderick A F MacLeod. ...
http://atlasgeneticsoncology.org/Genes/GC_IL6.html
*  Definition of interleukin-6 - NCI Dictionary of Cancer Terms - National Cancer Institute
Interleukin-6 is made mainly by some T lymphocytes. ... interleukin-6 listen (in-ter-LOO-kin...) One of a group of ... Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by ... Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. ...
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/interleukin-6
*  Interleukin-6 Saliva Collection - Salimetrics
Levels of IL-6 in saliva may only represent individual differences in the degree of inflammation in the oral mucosal immune ... Studies show that levels of IL-6 in the oral fluid of healthy individuals do not reflect the levels of IL-6 in circulation. ... Refrigerate samples immediately (if possible) and freeze at or below -20°C (household freezer) as soon as possible (within 6 ...
https://salimetrics.com/analyte/salivary-interleukin-6/interleukin-6-saliva-collection/
*  Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages
... Christian R. Gomez,1 John Karavitis, ... Aging or IL-6 deficiency did not affected the percentage of F. 4. /. 80. +. macrophages, or the surface expression of Toll-like ... In contrast, when compared to macrophages from young IL-6 KO mice, LPS stimulation yielded higher levels of these cytokines by ... Overall, our results indicate that IL-6 plays a role in regulating the age-related defects in macrophages through alteration of ...
https://www.hindawi.com/journals/mi/2010/475139/abs/
*  Interleukin-6 and its receptor: from bench to bedside | SpringerLink
Interleukin-6 (IL-6) is an inflammatory cytokine with a well-documented role in inflammation and cancer. The cytokine binds to ... a membrane bound IL-6 receptor (IL-6R) and this complex associates with... ... Heinrich PC, Castell JV, Andus T (1990) Interleukin-6 and the acute phase response. Biochem J 265:621-636PubMedGoogle Scholar ... Hirano T, Kishimoto T (1992) Molecular biology and immunology of interleukin-6. Res Immunol 143:723-724PubMedCrossRefGoogle ...
https://link.springer.com/article/10.1007%2Fs00430-006-0019-9
*  RCSB PDB - Protein Feature View - Interleukin-6 receptor subunit beta - P40189 (IL6RB HUMAN)
The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK ...
http://www.rcsb.org/pdb/protein/P40189
*  NIOSHTIC-2 Publications Search - 20032184 - Interleukin 6 plays a critical role in cutaneous wound healing.
... such as interleukin 6 (lL-6), might intimately involved in this process. Herein, we demonstrate that IL6 deficient transgenic ... mice (lL-6 KO) displayed significantly delayed cutaneous wound healing compared to wild type control animals, requiring up to ... such as interleukin 6 (lL-6), might intimately involved in this process. Herein, we demonstrate that IL6 deficient transgenic ... Delayed wound healing in IL-6 KO mice was reversed with a single dose of recombinant murine IL6 or intradermal injection of an ...
https://www.cdc.gov/niosh/nioshtic-2/20032184.html
*  Wrist Worn Wearable Measures Glucose, Cortisol, and Interleukin-6 from Sweat | Medgadget
Wrist Worn Wearable Measures Glucose, Cortisol, and Interleukin-6 from Sweat. June 27th, 2017 Editors Medicine, Pediatrics ... These days, blood has to be drawn and levels of cortisol and interleukin-6 can only be measured once in a while and not ... and interleukin-6 in perspired sweat for up to a week. ...
https://www.medgadget.com/2017/06/wrist-worn-wearable-measures-glucose-cortisol-interleukin-6-sweat.html
*  Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. - PubMed - NCBI
Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects.. Suzuki S1, Tanaka K, ... Interleukin-6 (IL-6) is pleiotropic cytokine involved in many central nervous system disorders including stroke, and elevated ... IL-6 is implicated in the inflammation, which contributes to both injury and repair process after cerebral ischemia. However, ... The major IL-6 downstream signaling pathway is JAK-STAT, and Stat3 activation occurs mainly in neurons during postischemic ...
https://www.ncbi.nlm.nih.gov/pubmed/19018268