Basal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Modalities and Guidelines, Topical Treatments
Interferon. Interferon alfa-2b is a protein product manufactured using recombinant DNA technology. It has shown some success in ... Interferon has not become a mainstay in BCC treatment because of its cost, the inconvenience of multiple visits, the discomfort ... In a small study by Greenway et al, 1.5 million IU interferon alfa-2b injected intralesionally 3 times per week for 3 weeks ... Several early studies have shown variable responses of BCC to intralesional interferon alfa. ...
Human Papillomavirus (HPV) Medication: Immunomodulators, Keratolytic Agents, Antineoplastics, Antimetabolite, Topical Skin...
Interferon for the treatment of genital warts: a systematic review. BMC Infect Dis. 2009 Sep 21. 9:156. [QxMD MEDLINE Link]. [ ... Intralesional interferon alfa-2b for the treatment of genital warts. Am J Obstet Gynecol. 1990 Feb. 162(2):348-54. [QxMD ... Interferon alfa is a protein product either manufactured from a single-species recombinant DNA process or obtained from pooled ... Interferon therapy for condylomata acuminata. N Engl J Med. 1986 Oct 23. 315(17):1059-64. [QxMD MEDLINE Link]. ...
Substance-Induced Mood Disorder: Overview, Substances Linked to Depression or Mania, Etiology
Interferon-alpha. Interferon-alpha (IFN-alpha) treatment has been associated with an increased risk of depression in randomized ... Can antidepressants prevent interferon-alpha-induced depression? A review of the literature. Gen Hosp Psychiatry. 2010 Jul-Aug ... Interferon-induced depression in chronic hepatitis C: a review of its prevalence, risk factors, biology, and treatment ... Interferon-induced depression in chronic hepatitis C: a review of its prevalence, risk factors, biology, and treatment ...
Malignant Melanoma Treatment & Management: Approach Considerations, Regional Lymph Node Dissection, Adjuvant Therapy
However, while high-dose interferon alfa-2b and pegylated interferon have been shown to improve relapse-free survival, neither ... analysis data show that ulceration and tumor stage are important predictors of response to interferon alfa/pegylated-interferon ... Interferon alfa-2b was approved in 1995 for adjuvant treatment after excision in patients who are free of disease but are at ... Interferon (IFN) alfa-2b was the first drug approved by the FDA, in 1995, for adjuvant treatment of melanoma after excision in ...
Human Papillomavirus (HPV) Treatment & Management: Approach Considerations, Considerations in Specific Patient Subgroups,...
Interferon alfa. Interferons have been used in the United States for the treatment of genital warts in various doses and ... Interferon for the treatment of genital warts: a systematic review. BMC Infect Dis. 2009 Sep 21. 9:156. [QxMD MEDLINE Link]. [ ... Intralesional interferon alfa-2b for the treatment of genital warts. Am J Obstet Gynecol. 1990 Feb. 162(2):348-54. [QxMD ... Interferon therapy for condylomata acuminata. N Engl J Med. 1986 Oct 23. 315(17):1059-64. [QxMD MEDLINE Link]. ...
Keloids: Definition and Historical Background, Epidemiology, Race
Interferon therapy. One of the newest therapeutic modalities is intralesional injection of INF-alpha, INF-beta, and INF-gamma. ... Ineffective treatment of keloids with interferon alpha-2b. Plast Reconstr Surg. 2006 Jan. 117(1):247-52. [QxMD MEDLINE Link]. ... Imiquimod induces local production of interferons at the site of application. It comes as a 5% cream and is started immediately ... Numerous studies have demonstrated that these interferons reduce fibroblast synthesis of collagen types I, III, and, possibly, ...
Hepatitis C Organism-Specific Therapy: Therapeutic Regimens, HCV Genotype 1a Infection, HCV Genotype 1b Infection
Since 2014, interferon-free therapy has been the norm. However, interferon may still play a role in particular treatment ... Pegylated interferon and ribavirin. Regimens containing pegylated interferon and ribavirin were the backbone of HCV therapy ... Monotherapy with pegylated interferon, ribavirin, or any direct-acting antiviral agent (eg, simeprevir, sofosbuvir) is not ... Below, the term pegylated interferon refers to either peginterferon alfa-2a 180 µg subcutaneously (SC) once weekly or ...
Polycythemia Vera Treatment & Management: Approach Considerations, Medical Care, Phlebotomy
Interferon. Pegylated interferon is considered an alternative to hydroxyurea for certain patients, including the following [2] ... Interferon alpha therapy in essential thrombocythemia and polycythemia vera-a systematic review and meta-analysis. Leukemia. ... Interferon-alpha for treating polycythemia vera yields improved myelofibrosis-free and overall survival. Leukemia. 2021 Sep. 35 ... In patients whose PV is refractory to hydroxyurea or who cannot tolerate the drug, interferon alpha can be used as an ...
Urethral Warts: Overview, Epidemiology, HPV Transmission
Interferon alfa-2b. Intralesional interferon alfa-2b has some activity against condyloma and may be used for extensive and ... Imiquimod 5% cream stimulates the production of interferon and other cytokines and is topically applied 3 times weekly for as ... Reports have shown greater efficacy with combination therapies, using intralesional interferon alfa or topical 5-fluorouracil ...
Malignant Melanoma Medication: Antineoplastic Agents, Biological Response Modulators, Oncolytic Immunotherapy, ImmTACs
Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST ... Alfa interferons act through high-affinity cell surface receptors, which, once activated, are known to inhibit cellular growth ... Interferon and the chemotherapy agents dacarbazine, cisplatin, and vinblastine are approved by the US Food and Drug ... Randomized phase III study of 1 month versus 1 year of adjuvant high-dose interferon alfa-2b in patients with resected high- ...
Fixed Drug Eruptions: Background, Pathophysiology, Etiology
... arriving and residential CD8 cells likely perpetuate tissue damage by their production of the inflammatory cytokines interferon ...
Congenital Self-Healing Reticulohistiocytosis: Background, Pathophysiology, Etiology
Elevated levels of cytokines such as tumor necrosis factor-alpha; interferon gamma; granulocyte-monocyte colony-stimulating ...
Pediatric Myelofibrosis: Practice Essentials, Background, Pathophysiology
Reversal of bone marrow fibrosis in idiopathic myelofibrosis after treatment with alpha-interferon. Haematologica. 1998 Dec. 83 ...
Thyroxine: Reference Range, Interpretation, Collection and Panels
Thyroid function and autoimmunity during interferon beta-1b treatment: a multicenter prospective study. J Clin Endocrinol Metab ...
Non-Hodgkin Lymphoma Guidelines: Classification, Diagnosis, Staging
For multifocal lesions, low-dose methotrexate may be used, based on expert consensus; retinoids and interferon alpha are ... Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: ... interferon (IFN alfa-2bm or IFN gamma-1b), or retinoid; or TSEBT plus ECP. For higher-burden disease, options include those ...
Neurologic Disease and Pregnancy: Overview, General Considerations, New-Onset Neurologic Complications
Although interferon beta-1a (IFN-β1a) and interferon beta-1b (IFN-β1b) are category C agents, sufficient data are available ... Effect of interferon-beta1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: results of a ... European Study Group on Interferon-beta1b in secondary. Ann Neurol. 1999 Dec. 46(6):850-9. [QxMD MEDLINE Link]. ... The reproductive effects of beta interferon therapy in pregnancy: a longitudinal cohort. Neurology. 2005 Sep 27. 65(6):807-11. ...
Scleroderma Treatment & Management: Approach Considerations, Pruritus, Raynaud Phenomenon
Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, ...
Severe Acute Respiratory Syndrome (SARS): Practice Essentials, Pathophysiology, Etiology
Antiviral actions of interferons. Clin Microbiol Rev. 2001 Oct. 14(4):778-809, table of contents. [QxMD MEDLINE Link]. [Full ... The type I interferon (IFN-alfa/beta) system represents a powerful part of the innate immune system and has potent antiviral ... Interferons have been shown to efficiently reduce MERS-CoV replication in human airway epithelial cell cultures, suggesting a ... Elevated levels of interferon-inducible protein 10 (IP-10), monokine induced by IFN-gamma (MIG), and interleukin 8 (IL-8) ...
Dermatomyositis: Practice Essentials, Background, Pathophysiology
Dermatomyositis is an idiopathic inflammatory myopathy (IIM) with characteristic cutaneous findings. It is a systemic disorder that most frequently affects the skin and muscles, but may also affect the joints; the esophagus; the lungs; and, less commonly, the heart.
Pediatric Nephrotic Syndrome: Practice Essentials, Background, Pathophysiology
Pediatric nephrotic syndrome, also known as nephrosis, is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. Nephrotic-range proteinuria in adults is characterized by protein excretion of 3.
Ophthalmologic Manifestations of Myasthenia Gravis: Overview, Patient History, Physical Examination
... interferon; antibiotics including telithromycin, aminoglycosides, fluoroquinolones, and azithromycin; beta blockers; calcium ...