The transcription factor interferon regulatory factor (IRF)-3 is essential for viral-induced IFN-β synthesis. In this study, we ... inhibits type I interferon (IFN)-dependent signalling, as well as IFN synthesis. RSV non-structural protein NS1 plays a ... leading to disrupted association of IRF-3 to CBP and subsequent reduced binding of IRF-3 to the IFN-β promoter without blocking ... demonstrating that NS1 directly targets IRF-3. Our data also demonstrate that NS1 associates with IRF-3 and its transcriptional ...
IPR019817 Interferon regulatory factor, conserved site. IPR001346 Interferon regulatory factor, DNA-binding domain ... IPR019471 Interferon regulatory factor-3. ...
... cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. ... cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. ... cGAS recognizes the pathogenic DNA in the cytosol and then synthesizes 2′3′-cyclic GMP-AMP (2′3′cGAMP). As the second messenger ... The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various ...
"Interferon Regulatory Factor-7" by people in this website by year, and whether "Interferon Regulatory Factor-7" was a major or ... An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. IRF-7 ... Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection. J Virol. ... "Interferon Regulatory Factor-7" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
Media related to Interferon regulatory factors at Wikimedia Commons Interferon+regulatory+factors at the U.S. National Library ... Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression ... For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the ... Zhao GN, Jiang DS, Li H (February 2015). "Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease ...
Transcription factor p65/Interferon regulatory factor 7/Interferon regulatory factor 3 fusion protein. C [auth A]. 540. Homo ... Nuclear factor NF-kappa-B p105 subunit. D [auth B]. 314. Homo sapiens. Mutation(s): 0 Gene Names: NFKB1. ... An Atomic Model of the Interferon-beta Enhanceosome.. Panne, D., Maniatis, T., Harrison, S.C.. (2007) Cell 129: 1111-1123 ... These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN ...
Interferon-regulatory factor 3. Gene Ontology Annotation. Protein. Entry. Name Space. Description. ... Copyright © 2017 REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies ... transforming growth factor beta receptor signaling pathway. ENSOPRP00000011656. GO:0030509. biological_process. BMP signaling ... sequence-specific DNA binding transcription factor activity. ENSOPRP00000011656. GO:0046872. molecular_function. metal ion ...
Interferon-regulatory factor 3. Gene Ontology Annotation. Protein. Entry. Name Space. Description. ... transforming growth factor beta receptor signaling pathway. XP_001601460. GO:0005667. cellular_component. transcription factor ... Copyright © 2017 REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies ...
Fucoxanthin attenuates inflammation via interferon regulatory factor 3 (IRF3) to improve sepsis. ... Here, we found that 20S-protopanaxatriol (PPT) can alleviate cognitive deficits in an AlCl3-induced AD zebrafish model in Y and ...
Liu, X.Y.; Wei, B.; Shi, H.X.; Shan, Y.F.; Wang, C. Tom70 mediates activation of interferon regulatory factor 3 on mitochondria ... suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3 ... When the interferon regulatory factor (IRF)-3 binds to HSP90, it triggers the MAVS complex, E3 links tumor necrosis factor ... Furthermore, SARS-CoV-2 blocks interferon 1 and interferon 3 by interfering with the MAVS pathway [178]. The membrane protein ...
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. Gottipati K, Holthauzen LM, Ruggli N ... Small Regulatory RNAs of Rickettsia conorii. Narra HP, Schroeder CL, Sahni A, Rojas M, Khanipov K, Fofanov Y, Sahni SK. Sci Rep ... Regulation of transcription factors via natural decoys in genomic DNA. Kemme CA, Nguyen D, Chattopadhyay A, Iwahara J. ... RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation. Campos RK, Wong B, Xie X, ...
Description interferon regulatory factor 3 Also known as IIAE7 Species Homo sapiens ...
Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, ... Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma. Sci Rep ... Among these factors, the targets of EZH2 and SREBP2 revealed by Transcriptional Regulatory Relationships Unraveled by Sentence- ... Among these factors, the targets of EZH2 and SREBP2 revealed by Transcriptional Regulatory Relationships Unraveled by Sentence- ...
Proposed genetic factors include the following:. * Mutations in interferon regulatory factor 2, which contribute to the ... Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. J Invest ... This increase in IL-4 inhibits Th-1 cells and thus suppresses interferon-gamma secretion. Decreased interferon-gamma may ... Risk factors of atopic dermatitis patients for eczema herpeticum. J Invest Dermatol. 2007 May. 127(5):1261-3. [QxMD MEDLINE ...
... cGAS impaired interferon signalling. Moreover, STING loss prevented the regression of abscopal tumours in the context of ... Inhibiting progression through mitosis or loss of pattern recognition by stimulator of interferon genes (STING)- ... Karpova, A. Y., Trost, M., Murray, J. M., Cantley, L. C. & Howley, P. M. Interferon regulatory factor-3 is an in vivo target of ... Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon- ...
Adaptations of interferon regulatory factor 3 with transition from terrestrial to aquatic life. ...
IRF3; interferon regulatory factor 3 [KO:K05411]. 115004 CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]. ... F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]. 2162 F13A1; coagulation factor XIII A chain [KO:K03917] [EC:2.3. ... IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]. 3455 IFNAR2; interferon alpha and beta receptor subunit 2 [KO ... HBEGF; heparin binding EGF like growth factor [KO:K08523]. 1956 EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1 ...
Interferon regulatory factor 5 (IRF5) has recently emerged as an important proinflammatory transcription factor involved in ... This macrophage differentiation is dependent on regulatory cascades controlled by interferon regulatory factors (IRFs) (11). ... Interferon-regulatory factors determine macrophage phenotype polarization. Mediators Inflamm. 2013;2013:731023. View this ... C) Correlative analyses of interferon regulatory factor 5 (IRF5) mRNA expression with mRNA expression of Fas, FasL, IL1β, and ...
Recombinant Interferon Regulatory Factor 3 By SDS-PAGE Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis. ...
The results of the miRNA-prognostic DEPRG-TF regulatory network showed that GSDMC, IRF1, and PLCG1 were regulated by both ... regulatory network was created via the miRNet online tool. A risk score model was created after each patient’s risk ... Y. Yan, L. Zheng, Q. du, B. Yan, and D. A. Geller, "Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression ... K. Alsamman and O. S. El-Masry, "Interferon regulatory factor 1 inactivation in human cancer," Bioscience Reports, vol. 38, no ...
IRF5: interferon regulatory factor 5. *IRF6: interferon regulatory factor 6. *IRGM: immunity related GTPase M ...
Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 transcription factors induced by several agonists of ... as well as interferon (IFN) regulatory factors (IRF) are key transcription factors in innate immune activation that regulate ... Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors. Immunology 2006, 25, 349-360. [Google ... Shi, J.-H.; Sun, S.-C. Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated ...
Within our dataset, Interferon regulatory factor 3 (IRF3) emerged as a leading candidate mediator of leptin-induced hunger- ... Cis-regulatory analysis of these integrated datasets enabled the identification of 28 putative hunger-promoting and 29 putative ... Identifying the relevant transcriptional regulatory pathways in these neurons has been a priority, yet such attempts have been ...
The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known. ... mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. These findings ... via other transcription factors such as AP-1 and SP1. ... The NF-κB and IRF transcription factor families are major ... The NEMO adaptor bridges the nuclear factor kappaB and interferon regulatory factor signaling pathways. Nat Immunol. 2007;8(6): ...
Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human ... a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription. Molecular and Cellular ... Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death. Cancer Research. 2003;. 63. (19):6424- ... Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells. FEBS Letters. 2009;. 583. (21 ...
Rat IRF4(Interferon Regulatory Factor 4) ELISA Kit Rat IRF4(Interferon Regulatory Factor 4) ELISA Kit. To Order Contact us: ... Description: A sandwich ELISA kit for detection of Interferon Regulatory Factor 4 from Rat in samples from blood, serum, plasma ... Description: A sandwich ELISA kit for quantitative measurement of Rat IRF4 (Interferon Regulatory Factor 4) in samples from ... Description: A competitive ELISA for quantitative measurement of Rat Interferon regulatory factor 1(IRF1) in samples from blood ...
... in interferon tau regulation of IRF-1. Roles of Stat1 - Texas A&M University (TAMU) Scholar profile, educations, publications, ... Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. Academic Article * ... including IFN regulatory factor-1 (IRF-1). The roles of Stat1, Stat2, and IRF-9 in IFNtau regulation of IRF-1 expression were ... Interferon tau (IFNtau) is the pregnancy recognition signal produced by the conceptus trophectoderm and acts in a paracine ...
Inhibition of Checkpoint Kinase 1 (CHK1) Upregulates Interferon Regulatory Factor 1 (IRF1) to Promote Apoptosis and Activate ... 3. Ning Zhang, Cailing Lu, Jiao Mo, Xinhang Wang, Simi Liao, Ningjing Liang, Mei Feng, Tingting Tang, Yijie Wu, Yunqing Li, ...
Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-γ-inducible expression of ... a signal transducer and activator of transcription factors in response to interferons. In order to find an explanation for this ... Billiau A, Matthys P. Interferon-γ: a historical perspective. Cytokine Growth Factor Rev. 2009; 20(2):97-113. PubMedhttps://doi ... Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J. 1991; 5(11):2516-22. ...